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2 trates delayed kinetics of 35S, 27S, and 20S pre-rRNA processing with turnover of these intermediates
3 y amounts of 43S preribosomes containing 20S pre-rRNA accumulate in the cytoplasm of certain rps14 mu
5 strain was defective in the synthesis of 20S pre-rRNA and hence 18S rRNA, which led to reduced format
8 -resolution kinetic labeling showed that 20S pre-rRNA predominately undergoes methylation as nascent
9 opose that Fap7 mediates cleavage of the 20S pre-rRNA at site D by directly interacting with Rps14 an
12 sequence and structural features of the 20S pre-rRNA near the cleavage site of the nuclease, Nob1.
13 of Fap7 causes accumulation of only the 20S pre-rRNA, which could be detected not only in 43S prerib
15 NA hairpins that incorporate the 16S and 23S pre-rRNA stem sequences are efficiently cleaved by Tm-RN
19 is defective in the formation of 20S and 27S pre-rRNAs and in the accumulation of 18S and 25S mature
21 Prp43p-Q423N mutant immunoprecipitates 27SA2 pre-rRNA threefold more efficiently than the wild type,
23 ng triggers exonucleolytic trimming of 27SA3 pre-rRNA to generate the 5' end of 5.8S rRNA and drives
24 ent recruitment of factors required for 27SB pre-rRNA processing, namely, Nsa2 and Nog2, which associ
30 tion of NOP12 significantly inhibits 27SA(3) pre-rRNA processing, even though the A(3) factors are pr
34 Nog1 function inhibits the conversion of 32S pre-rRNA-containing complexes to a smaller form, resulti
35 onditional prp43 mutant alleles confer a 35S pre-rRNA processing defect, with subsequent depletion of
36 cold-sensitive prp43 mutant accumulates 35S pre-rRNA and depletes 20S, 27S, and 7S pre-rRNAs, precur
37 t the A0, A1, and A2 processing sites in 35S pre-rRNA, delayed processing of 20S rRNA to mature 18S r
38 1 temperature-sensitive mutant inhibited 35S pre-rRNA early processing at sites A(0), A(1) and A(2) a
39 negative mutants delay processing of the 35S pre-rRNA and cause accumulation of pre-rRNA species that
43 d with wild-type ES cells, the levels of 45S pre-rRNA are reduced in both Chd7(+/-) and Chd7(-/-) mou
47 umulation of the 5' extended from of 45S/47S pre-rRNA and 5'-01, A0-1 and E-2 fragments of pre-rRNA t
48 ls results in a significant reduction in 47S pre-rRNA levels, whereas synthesis of the first 40 nt of
49 in also exhibit the greatest increase in 47S pre-rRNA, consistent with a role for basonuclin in incre
51 B treatment rapidly blocked processing of 6S pre-rRNA to 5.8S rRNA, leading to TRAMP-dependent pre-rR
52 nuclear pre-60S particles containing the 6S pre-rRNA bind Nmd3 and Crm1 and are exported to the cyto
54 s 35S pre-rRNA and depletes 20S, 27S, and 7S pre-rRNAs, precursors to the small- and large-subunit rR
55 aining 27SA2, 27SA3, 27SB, and 25.5S plus 7S pre-rRNAs plus ribosome assembly factors and ribosomal p
57 ergence of a novel factor that facilitates a pre-rRNA processing event specific for higher eukaryotes
58 12p also showed robust in vitro binding to a pre-rRNA transcript, in addition to poly(A) and poly(U).
59 s suggests that the production of poly(A)(+) pre-rRNAs may be a general result of defects in rRNA pro
60 Strikingly, degradation of many aberrant pre-rRNA species, attributed mainly to 3' exonucleases i
61 that did not interact with B23 did not alter pre-rRNA synthesis and processing, suggesting that the i
63 cruitment of pol I transcription factors and pre-rRNA processing factors to elongating pre-rRNA on an
64 cessing confer similar defects on growth and pre-rRNA processing as do carboxy-terminal truncations o
69 ce factor, DNA-dependent RNA polymerase, and pre-rRNA processing protein revealed the isolate to be a
71 results indicate that rRNA transcription and pre-rRNA processing are coordinated via specific compone
73 coordinating ribosomal DNA transcription and pre-rRNA processing to allow for the efficient synthesis
74 ic neurons results in defective pre-tRNA and pre-rRNA processing and progressive neurodegeneration wi
79 he fibrillar components of nucleoli and bind pre-rRNA during transcription, triggering recruitment of
83 t Rcl1, conserved in all eukaryotes, cleaves pre-rRNA at so-called site A(2), a co-transcriptional cl
86 subunit triggers its release from the common pre-rRNA transcript by stimulating cleavage at the proxi
87 he Has1 DEAD-box RNA helicase in consecutive pre-rRNA processing and maturation steps for constructio
90 lar function; and (iv) resulted in defective pre-rRNA processing at the non-permissive temperatures.
92 rb1, destabilize the heterotrimer, and delay pre-rRNA processing and nuclear export of preribosomes.
96 ause mutations in the U3 snoRNA that disrupt pre-rRNA processing confer similar defects on growth and
97 that these enzymes are required for distinct pre-rRNA processing reactions leading to synthesis of 18
98 ing of snoRNAs and biogenesis factors during pre-rRNA processing, similar to its recycling role in pr
103 e activity of Grc3 is required for efficient pre-rRNA processing and that depletion of Grc3 leads to
105 nd pre-rRNA processing factors to elongating pre-rRNA on an as-needed basis rather than corecruitment
107 his trans mechanism is analogous to eukaryal pre-rRNA 2'-O-methylation guided by intron-encoded but t
108 onstrate that the role of Rcl1 in eukaryotic pre-rRNA processing is identical to that of RNase III in
111 The nuclear exosome is a key factor for pre-rRNA processing through the activity of its catalyti
113 erminal domain (CTD) of Rrp5 is required for pre-rRNA cleavage at sites A0-A2 on the pathway of 18S r
114 The 17 putative RNA helicases required for pre-rRNA processing are predicted to play a crucial role
115 box putative RNA helicases are required for pre-rRNA processing in Saccharomyces cerevisiae, althoug
118 ein inhibited the release of U14 snoRNA from pre-rRNA, just as was seen with Dbp4-depleted cells, ind
119 and promotes displacement of U8 snoRNA from pre-rRNA, which is necessary for the removal of the 3' e
124 tein (RNP) from HeLa cells cleaves the human pre-rRNA in vitro at at least one site used in cells, wh
127 l conserved eIF4A/eIF4G-like complex acts in pre-rRNA processing, adding to the established functions
128 g with dimethyl sulfate to detect changes in pre-rRNA structure upon genetic manipulation of the yeas
131 been identified in proteins that function in pre-rRNA processing, including human Puf-A and yeast Puf
132 Deleting gamma2-AMPK led to increases in pre-rRNA level, ER stress markers, and cell death during
133 d in this process, many proteins involved in pre-rRNA processing and ribosomal subunit maturation hav
137 aryotes, the enzyme performs a vital role in pre-rRNA processing in addition to its methylating activ
139 uctural analysis identified binding sites in pre-rRNA with the consensus (U/G)CCCG(A/G) in the contex
144 ls results in the appearance of intermediate pre-rRNAs species that reflect the processing of pre-rRN
145 mbly is a hierarchical process that involves pre-rRNA folding, modification, and cleavage and assembl
146 ctor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis in vascular
147 e how endonucleolytic cleavages of the mouse pre-rRNA transcript in the internal transcribed spacer 1
148 nuclease XRN2, a key coordinator of multiple pre-rRNA cleavages, driving mature rRNA formation and di
149 The mutant impairs processing of multiple pre-rRNA intermediates, resulting in the degradation of
150 leolar stress, as shown by decreased nascent pre-rRNA synthesis, fibrillarin perinucleolar cap format
151 elation between expression levels of nascent pre-rRNA and GPC5 (P = 0.001), but not a C13orf25 transc
155 ch binding of a methyltransferase to nascent pre-rRNAs is a prerequisite to processing, so that all c
156 n in vitro selected NRE (sNRE) and a natural pre-rRNA NRE (b2NRE) have revealed that sequence-specifi
160 f the 35S pre-rRNA and cause accumulation of pre-rRNA species that normally have low steady-state lev
163 ts demonstrate that quantitative analyses of pre-rRNA processing can yield important biological insig
164 orchestrate the modification and cleavage of pre-rRNA and are essential for ribosome biogenesis.
169 d machinery that orchestrates the folding of pre-rRNA that results in the assembly of the small ribos
171 ciate with preribosomes to enable folding of pre-rRNA, recruitment of ribosomal proteins, and process
174 lar disassembly occurs without inhibition of pre-rRNA transcription, a well known trigger for nucleol
180 In addition, NS regulates processing of pre-rRNA and consequently the level of total protein syn
182 nthesis: the transcription and processing of pre-rRNA and the transcription of ribosomal protein gene
184 ns, as well as Nob1-dependent protections of pre-rRNA in vitro and in vivo demonstrate that Nob1's bi
188 er, many protein effectors and regulators of pre-rRNA processing needed for rRNA maturation were also
190 d and annotated by means of a graphic set of pre-rRNA ratios, a technique we call Ratio Analysis of M
193 s suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by contro
194 ct that is transcribed, whereas subgroups of pre-rRNA processing factors are recruited to plasmids on
195 nucleoplasm and a concomitant suppression of pre-rRNA processing that leads to accumulation of the 5'
197 n 90S but also in site 2 cleavage in ITS1 of pre-rRNAs at early stages of human ribosome biogenesis;
198 rRNAs species that reflect the processing of pre-rRNAs through Pathway 2, a pathway that processes pr
201 17, L35 and L37 in folding and processing of pre-rRNAs, and binding of other proteins within assembli
207 hat copy numbers of ribosomal-RNA precursor (pre-rRNA) of specific pathogen species relative to genom
209 o establish domain I architecture to prevent pre-rRNA turnover and couples domain I folding with cons
210 ires multiple nuclease activities to process pre-rRNA transcripts into mature rRNA species and elimin
211 to phosphorylate Tif6p was unable to process pre-rRNAs efficiently, resulting in significant reductio
212 through Pathway 2, a pathway that processes pre-rRNAs in a different temporal order than the more of
215 pUL31 is necessary and sufficient to reduce pre-rRNA levels, and this was dependent on the dUTPase-l
218 inking identified numerous preribosomal RNA (pre-rRNA) binding sites for the large, highly conserved
219 nucleolar RNA (snoRNA) on pre-ribosomal RNA (pre-rRNA) is essential for rRNA processing to produce 18
220 iogenesis, functioning in pre-ribosomal RNA (pre-rRNA) processing as a component of the small ribosom
221 d analysis of human precursor ribosomal RNA (pre-rRNA) processing because surprisingly little is know
222 to multiple sites in the pre-ribosomal RNA (pre-rRNA) to promote early cleavage and folding events.
226 cleolar RNA (snoRNA) and the precursor rRNA (pre-rRNA) at multiple sites is a prerequisite for three
227 ribosomal proteins (RPLs) in precursor rRNA (pre-rRNA) processing correlates with their location in t
228 ot strictly required for the precursor rRNA (pre-rRNA) processing reactions but contributes to optima
229 ve been implicated in the processing of 20 S pre-rRNA and are necessary for survival of the cells.
237 uding transcription, editing, mRNA splicing, pre-rRNA processing, RNA transport and RNA decay, scanni
238 Our study demonstrates that steady-state pre-rRNA-analysis can be a valuable culture-independent
241 PK translocates into the nucleus to suppress pre-rRNA transcription and ribosome biosynthesis during
246 -like stem is not required, however, for the pre-rRNA processing or essential function of RNase MRP.
250 impairs the early cleavage reactions of the pre-rRNA and causes U14 small nucleolar RNA (snoRNA) to
252 ubstitution of the 5'-ETS nucleotides of the pre-rRNA involved in this initial base pairing interacti
253 hat the sequence-specific recognition of the pre-rRNA NRE is achieved by intermolecular hydrogen bond
254 rently high evolutionary conservation of the pre-rRNA processing pathway and ribosome synthesis facto
255 central pseudoknot and for cleavages of the pre-rRNA, both of which are required for 18S maturation.
256 esulted in a decrease in accumulation of the pre-rRNA, establishing a prominent role for L3 in riboso
262 he small subunit processome to dock onto the pre-rRNA, an event indispensable for ribosome biogenesis
264 vivo RNA structure probing revealed that the pre-rRNA processing defects are due to misfolding of 5.8
268 Notably, variation is not restricted to the pre-rRNA sequences removed during processing, but it is
269 al anchor that recruits the U3 snoRNA to the pre-rRNA, is a prerequisite for the subsequent interacti
270 te that it may function to bring Dbp8 to the pre-rRNA, thereby both regulating its enzymatic activity
272 cteria: to co-transcriptionally separate the pre-rRNAs destined for the small and large subunit.
273 9 different RNA helicases, but none of their pre-rRNA-binding sites were previously known, making the
275 24 is essential for early cleavages at three pre-rRNA sites in yeast (A0, A1 and A2) and humans (A0,
279 This complex contains proteins related to pre-rRNA processing, such as Pes1, DDX21, and EBP2, in a
281 oli YbeY protein: an endonuclease that trims pre-rRNAs to their mature forms and a sentinel that part
282 hemical and genetic analyses suggest that U3 pre-rRNA base-pairing interactions mediate endonucleolyt
283 ts mature structure because it contained U3, pre-rRNA, and a number of early-acting ribosome synthesi
284 By mediating formation of both essential U3-pre-rRNA duplexes, Imp3p and Imp4p may help the small su
287 external transcribed spacer from unprocessed pre-rRNA and for processing the 3' tail of snRNA U4.
288 Rio1-associated pre-40S particles, in vitro pre-rRNA cleavage was strongly stimulated by ATP and req
294 ol I transcription factor UBF interacts with pre-rRNA processing factors as analyzed by immunoprecipi
296 al interactions of many factors/snoRNAs with pre-rRNA for correct rRNA processing and ribosome assemb
297 In vitro selection and binding studies with pre-rRNA fragments have shown that the first two RNA-bin
298 ation of RNA polymerase I transcription with pre-rRNA processing, preribosomal particle assembly, and
300 Overlapping basepairing of snoRNAs with pre-rRNAs often necessitates sequential and efficient as
301 previous reports that modification of yeast pre-rRNA exclusively occurred on released transcripts.
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