ライフサイエンスコーパス: preadipocyte

1 marcated by H3K27me3 in both brown and white preadipocytes.

2 cause of stronger basal expression levels in preadipocytes.

3 is required for mitotic clonal expansion of preadipocytes.

4 e in restraining the adipogenic potential of preadipocytes.

5 uring in vitro adipogenesis of 3T3-L1 murine preadipocytes.

6 promotion of fibrogenesis in fibroblasts and preadipocytes.

7 that RA inhibits differentiation of cultured preadipocytes.

8 ed no effect on adipogenesis in nonsenescent preadipocytes.

9 n and mouse MSCs, as well as in mouse 3T3-L1 preadipocytes.

10 mediators of stem cell commitment to produce preadipocytes.

11 pro-adipogenic function of AGEs in senescent preadipocytes.

12 on in regulating p21 expression in senescent preadipocytes.

13 sis during adipogenesis in lipin-1-deficient preadipocytes.

14 ct binding between RAGE and p53 in senescent preadipocytes.

15 ced adipogenesis in MSCs and in mouse 3T3-L1 preadipocytes.

16 hr after inducing differentiation of 3T3-L1 preadipocytes.

17 e examined in explanted skin fibroblasts and preadipocytes.

18 sed in s.c. preadipocytes than in epididymal preadipocytes.

19 ox region of the C/EBPalpha gene promoter in preadipocytes.

20 dothelial precursor cells, immune cells, and preadipocytes.

21 and the defects in adipogenesis in Ezh2(-/-) preadipocytes.

22 eased expression of endogenous GLUT4 mRNA in preadipocytes.

23 ipocytes that subsequently activate adjacent preadipocytes.

24 olves direct NT proinflammatory responses in preadipocytes.

25 fibroblasts and differentiating human SW872 preadipocytes.

26 NT5A promoted the expression of IL6 in human preadipocytes.

27 l as in stromal vascular fraction and 3T3-L1 preadipocytes.

28 SIRT1 is a key regulator of proliferation in preadipocytes.

29 t cells differentiated from human neck brown preadipocytes.

30 SIRT1 is knocked down stably in mouse 3T3-L1 preadipocytes.

31 nhanced adipogenic differentiation of 3T3-L1 preadipocytes.

32 e depletion on the differentiation of 3T3-L1 preadipocytes.

33 icantly impairs adipocyte differentiation in preadipocytes.

34 d inflammation in healthy adipose tissue and preadipocytes.

35 in brown adipocytes differentiated from the preadipocytes.

36 ithin subpopulations of white adipocytes and preadipocytes.

37 ogenic defect caused by DPP8/9 inhibition in preadipocytes.

38 rs for identifying thermogenically competent preadipocytes.

39 ctive inhibitor 1G244 blocks adipogenesis in preadipocyte 3T3-L1 and 3T3-F422A, while DPP4 and FAP in

40 ession of >370 miRNAs during adipogenesis of preadipocyte 3T3-L1 cells and adipocytes from leptin def

41 Ectopic expression of miR-103 or miR-143 in preadipocytes accelerated adipogenesis, as measured both

42 Co-culture experiments found that preadipocytes activate Wnt signaling and decrease cleave

43 50% adipocytes (AD50) or approximately 100% preadipocytes (AD0) were suspended over wells containing

44 lated by the glucocorticoid receptor (GR) in preadipocytes, adipocytes, and adipose tissues and is re

45 Irs1 and Irs2 conditionally in 3T3-L1 murine preadipocytes/adipocytes to assess whether acute loss of

46 ouse embryonic fibroblasts (MEFs) and 3T3-L1 preadipocytes after forced manipulation of Txnip express

47 cts harboring AGPAT2 mutations and in 3T3-L1 preadipocytes after knockdown or overexpression of AGPAT

48 highly induced upon differentiation of human preadipocytes, along with SREBP-1.

49 lic profiling demonstrate that the Tbx15(Hi) preadipocyte and adipocyte subpopulations of cells are h

50 ell as stable shRNA knockdown (KD) in 3T3-L1 preadipocyte and C3H10T1/2 mesenchymal stem cells, promo

51 Notably, preadipocytes and adipocytes had higher formation rates

52 synthesis rates denote new cell formation of preadipocytes and adipocytes in each depot.

53 ls are highly glycolytic, whereas Tbx15(Low) preadipocytes and adipocytes in the same depot are more

54 esize the bulk of the fibrillar ECM, and the preadipocytes and adipocytes of the hypodermis.

55 ntaneous differentiation of 3T3-L1 and human preadipocytes and allowed NIH 3T3 fibroblasts to become

56 anti-adipogenic effect of 5-Aza-dC in 3T3-L1 preadipocytes and block the osteoblastogenic effect of 5

57 OLST also inhibits differentiation of 3T3-L1 preadipocytes and C2C12 myoblasts.

58 gated whether prostamide signaling occurs in preadipocytes and controls adipogenesis.

59 lls and not in adipocytes, and it is high in preadipocytes and decreases during adipogenesis.

60 e that PKCdeltaI expression level is high in preadipocytes and decreasing PKCdeltaI accelerated termi

61 represses Wnt1, -6, -10a, and -10b genes in preadipocytes and during adipogenesis.

62 activation and adipocyte differentiation in preadipocytes and embryonic fibroblasts isolated from AP

63 We observed rapid proliferation of preadipocytes and expansion of the dermal fat layer afte

64 FZ to activate PPARgamma, and we used 3T3-L1 preadipocytes and human multipotent mesenchymal stromal

65 cts as dual modulators of gene expression in preadipocytes and is required for early stage differenti

66 Preadipocytes and macrophages in adipose tissue also res

67 ombined, these data reveal the importance of preadipocytes and mature adipocytes on MM progression an

68 We also found that preadipocytes and mature adipocytes secrete many molecul

69 iption factors that bind to them in cultured preadipocytes and mature adipocytes.

70 bx15 expression is restricted to a subset of preadipocytes and mature white adipocytes.

71 hat supernatants from NT-exposed 3T3-L1-NTR1 preadipocytes and mesenteric fat obtained from wild-type

72 and differentiation assays employing 3T3-L1 preadipocytes and mouse bone marrow-derived mesenchymal

73 ic function of AGEs in replicative senescent preadipocytes and mouse embryonic fibroblasts, as well a

74 PGF2alphaEA is produced from anandamide in preadipocytes and much less so in differentiating adipoc

75 pressor, FOXC2-Eng, enhances adipogenesis of preadipocytes and multipotent mesenchymal precursors and

76 ic mixtures of contaminants in murine 3T3-L1 preadipocytes and polar bear adipose tissue-derived stem

77 -beta) and its selective ligand reprogrammed preadipocytes and precursor stem cells into brown adipos

78 effect of weight loss on differentiation of preadipocytes and secretory capacity of in vitro differe

79 inhibited fatty acid biosynthesis in 3T3-L1 preadipocytes and selective human breast cancer cell lin

80 ducing (DI) increased adipogenic capacity of preadipocytes and shifted their secretion toward lower i

81 m patients with MM indeed contains increased preadipocytes and significantly larger mature adipocytes

82 te transcriptomic and epigenomic profiles of preadipocytes and skeletal muscle satellite cells collec

83 ipocytes exhibited higher Hsp60 release than preadipocytes and SkMCs, which was further stimulated by

84 sic manner with high levels in postconfluent preadipocytes and terminally differentiated adipocytes.

85 ted by the basal transcription factor Sp1 in preadipocytes and that the magnitude of down-regulation

86 ately up-regulated in adipocytes relative to preadipocytes and that TZD treatment induces PGC-1beta a

87 adipose tissue-derived epididymal BK(L1/L1) preadipocytes and their differentiation to lipid-filled

88 RNA interference gene-silenced preadipocytes and Txnip(-/-) MEFs were markedly adipogen

89 ptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 17

90 adipogenesis, is expressed at low levels in preadipocytes, and its levels increase dramatically and

91 llow identification of thousands of putative preadipocyte- and adipocyte-specific cis-regulatory elem

92 Specifically, in human and 3T3-L1 preadipocytes, Ang(1-7)-Mas signaling promotes adipogene

93 Preadipocytes are fibroblastoid cells committed to becom

94 However, differentiating preadipocytes are highly heterogeneous in cellular and l

95 Because our published data demonstrated that preadipocytes are the primary instigators of inflammator

96 This was correlated with enhanced preadipocyte aromatase expression following incubation i

97 AR also binds to enhancers already active in preadipocytes as evidenced by an active chromatin state

98 Senescent human primary preadipocytes as well as human umbilical vein endothelia

99 Importantly, FABP4-null mouse preadipocytes as well as macrophages exhibited increased

100 Two sources of 3T3-L1 preadipocytes as well as OP9 preadipocytes were assessed

101 ipogenic differentiation in both MSCs and in preadipocytes at low nanomolar concentrations comparable

102 nduce adipogenic differentiation in MSCs and preadipocytes at low nanomolar concentrations.

103 at the zinc finger protein Evi1 increases in preadipocytes at the onset of differentiation prior to i

104 ssion using three experimental paradigms: 1) preadipocytes before and after differentiation into adip

105 Conversely, loss of Evi1 in preadipocytes blocks the induction of PPARgamma2 and sup

106 PPARgamma, when introduced into preadipocytes, bound only to regions depleted of repress

107 showed that the expression of EST was low in preadipocytes but increased upon differentiation.

108 AS160/TBC1D4 is expressed at low levels in preadipocytes but is induced in differentiation and prov

109 tein receptor (VLDLR) is virtually absent in preadipocytes but is strongly induced during adipogenesi

110 s a potent antiadipogenic factor in cultured preadipocytes, but evidence for its involvement in physi

111 ion of the cytokine IL-6 from adipocytes and preadipocytes, but not from macrophages.

112 iments demonstrated that factors secreted by preadipocytes, but not mature adipocytes, confer an ATM-

113 Inhibiting DNA methylation in 3T3-L1 preadipocytes by 5-Aza-dC significantly inhibited adipog

114 The cell fate specification of subcutaneous preadipocytes by canonical Wnt signaling was evaluated.

115 eral GR-regulated adipogenic genes in 3T3-L1 preadipocytes by glucocorticoid, it was not required for

116 Conversely, DAPK2 inhibition in human preadipocytes by small interfering RNA decreased LC3-II

117 Inherent differences in preadipocyte cell dynamics may contribute to the distinc

118 st cancer cells (T47D and Hs578T), and mouse preadipocyte cells (3T3-L1).

119 Fibroblastic preadipocyte cells are recruited to differentiate into n

120 In mouse NIH 3T3 L1 preadipocyte cells, TBMEHP inhibited rat hepatic microso

121 e to make predictions about how mouse 3T3-L1 preadipocytes choose between proliferation, differentiat

122 In addition, CM from macrophage/preadipocyte cocultures exposed to sera from obese patie

123 cg1 expression by RNA interference in 3T3-L1 preadipocytes compromised LPL-dependent TG accumulation

124 Reprogramming of preadipocytes could represent an adaptation to weight lo

125 lso inhibits adipogenesis in a human primary preadipocyte culture system.

126 educed lipid accumulation in maturing 3T3-L1 preadipocytes, demonstrating an inhibitory effect on lip

127 opening during adipogenesis of immortalized preadipocytes derived from mouse brown adipose tissue (B

128 idymal white adipose tissue (eWAT) mass, and preadipocytes derived from Tnmd transgenic mice display

129 ription factors, but the molecular basis for preadipocyte determination is not understood.

130 ies Zfp423 as a transcriptional regulator of preadipocyte determination.

131 lation early in adipogenesis is required for preadipocyte differentiation and whose levels remain low

132 d accumulation in 3T3-L1 cells and inhibited preadipocyte differentiation by down-regulation of the e

133 LCB reduced lipid accumulation during preadipocyte differentiation by down-regulation of the m

134 lation upregulates FGF10 levels and promotes preadipocyte differentiation into beige adipocytes.

135 We have developed a murine preadipocyte differentiation system for generating a nat

136 differentiation markers were analyzed during preadipocyte differentiation, and cell culture media wer

137 During 3T3-L1 and human preadipocyte differentiation, CCTalpha expression and PC

138 ctivation of Hh signaling blocks early brown-preadipocyte differentiation, inhibits BAT formation in

139 ased modeling was applied to data from human preadipocyte differentiation.

140 vated during the early phase of mouse 3T3-L1 preadipocyte differentiation.

141 ipogenesis comes from cell culture models of preadipocyte differentiation.

142 DPP9 attenuates PPARgamma2 induction during preadipocyte differentiation.

143 ould show that the total secretome inhibited preadipocyte differentiation.

144 Although adipose tissue contains numerous preadipocytes, differentiation into functionally compete

145 y phase of adipogenesis, piceatannol-treated preadipocytes displayed a delayed cell cycle entry into

146 TNMD expression increases in human preadipocytes during differentiation, whereas silencing

147 Remarkably, Ews null BATs and brown preadipocytes ectopically express myogenic genes.

148 ore, transfection of an miR-130 inhibitor in preadipocytes enhanced, whereas an miR-130 mimic blunted

149 sor, which leads to derepression of a potent preadipocyte enhancer and a doubling of IRX3 and IRX5 ex

150 Remarkably, differentiating SIRT1-silenced preadipocytes exhibit enhanced mitotic clonal expansion

151 The FABP4-null preadipocytes exhibited a remarkably enhanced adipogenes

152 gulated during adipogenesis, and TDAG51(-/-) preadipocytes exhibited greater lipogenic potential.

153 wn about the molecular circuits that control preadipocyte expansion.

154 Mouse 3T3-L1 preadipocytes express NTR1 and its expression is increas

155 The soluble form of the preadipocyte factor (also known as pref-1) delta-like 1

156 SAH did not alter preadipocyte factor 1 (Dlk1) or peroxisome proliferator-

157 The high level of adipogenic inhibitor preadipocyte factor 1 (Pref-1) in IRS-1-null cells was m

158 The preadipocyte factor 1 (Pref-1) is involved in the prolif

159 The imprinted Delta-like homolog 1 (Dlk1)/preadipocyte factor 1 (Pref1) gene encodes a complex pro

160 Ews mutant brown preadipocytes fail to differentiate due to loss of Bmp7

161 ntal and/or intrinsic inputs could influence preadipocyte fate decision making.

162 Although preadipocyte fibroblasts expressed Thy1 mRNA and protein

163 in vehicle in the adipocyte fraction and the preadipocyte fraction.

164 acological manipulation restrains the 3T3-L1 preadipocytes from fully differentiating into mature adi

165 Furthermore, isolated human preadipocytes from gluteofemoral AT displayed a higher c

166 Preadipocytes from HDAC9 gene knock-out mice exhibited a

167 Here we generated clones of brown and white preadipocytes from human neck fat and characterized thei

168 We found that differentiating preadipocytes from LBW individuals showed reduced leptin

169 its production may be decreased in immature preadipocytes from LBW individuals.

170 on was derived from exon DNA microarrays and preadipocytes from obesity-resistant and -sensitive mice

171 Preadipocytes from these mice likewise exhibit impaired

172 Adipocyte renewal from preadipocytes has been shown to occur throughout life an

173 , which places DLK1 as a master regulator of preadipocyte homeostasis, suggesting that DLK1 manipulat

174 l knockdown of Irs1 and Irs2 but not Insr in preadipocytes impaired differentiation to adipocytes.

175 Overexpression of Tbx15 in 3T3-L1 preadipocytes impairs adipocyte differentiation and decr

176 ) from (2)H2O into the DNA of adipocytes and preadipocytes in 25 women with overweight or obesity.

177 piceatannol inhibits adipogenesis of 3T3-L1 preadipocytes in a dose-dependent manner at noncytotoxic

178 educed proliferation and viability of 3T3-L1 preadipocytes in a dose-dependent manner.

179 re adipocytes compared with undifferentiated preadipocytes in both human and mouse subcutaneous adipo

180 pansion and differentiation of murine 3T3-L1 preadipocytes in the presence of SAH impaired both basal

181 pocytes was positively correlated to that of preadipocytes in the scABD and scFEM depots and was rela

182 e impaired adipogenic potential of senescent preadipocytes in vitro and ex vivo.

183 VEGF increased proliferation in brown preadipocytes in vitro by 70%, and blockade of VEGF sign

184 te differentiation from mouse-derived 3T3-L1 preadipocytes in vitro, and inhibits expression of genes

185 s is widely studied in differentiating 3T3L1 preadipocytes in vitro.

186 retinaldehyde, is specifically restricted to preadipocytes in white adipose tissue.

187 regulation known to promote adipogenesis in preadipocytes, in HSC transdifferentiation.

188 Conditioned medium (CM) from senescent human preadipocytes induced macrophage migration in vitro and

189 78 in mouse embryonic fibroblasts and 3T3-L1 preadipocytes induced to undergo differentiation into ad

190 er, siRNA-mediated Dies1 knockdown in 3T3-L1 preadipocytes inhibited adipogenic conversion.

191 Knockdown of Atg7 in 3T3-L1 preadipocytes inhibited lipid accumulation and decreased

192 Conversely, in LRP5 knockdown preadipocytes, insulin-induced phosphorylation of IRS1,

193 Irisin reportedly promotes the conversion of preadipocytes into "brown-like" adipocytes within subcut

194 bundance during the differentiation of human preadipocytes into adipocytes.

195 ory pathway that controls differentiation of preadipocytes into beige adipocytes.

196 Differentiation of preadipocytes into mature adipocytes capable of efficien

197 e impaired adipogenic potential of senescent preadipocytes is a hallmark of adipose aging and aging-r

198 We propose that prostamide signaling in preadipocytes is a novel anandamide-derived antiadipogen

199 rvations show that expression of CRABP-II in preadipocytes is repressed by all three components of th

200 se embryonic fibroblasts, as well as primary preadipocytes isolated from aged mice.

201 Consistent with these findings, human preadipocytes isolated from subcutaneous white fat also

202 In vitro experiments were conducted with preadipocytes isolated from VAT and SAT biopsies.

203 dipsin secretion or insulin action, while in preadipocytes it impaired adipogenesis.

204 embers of the KDM5 family in white and brown preadipocytes leads to deregulated gene expression and b

205 In cultured human white preadipocytes, leptin increased caveolin-1 expression, w

206 ed the expression of most adipocyte genes to preadipocyte levels.

207 impaired adipocyte functionality with a more preadipocyte-like gene expression profile.

208 siRNA-based silencing of APCDD1 in 3T3-L1 preadipocytes markedly increased the expression of Wnt s

209 se tissue from COX-2-deficient mice, whereas preadipocyte marker expression was increased.

210 EB cells proliferation and expression of the preadipocyte marker Pref-1 at the commitment stage.

211 ipocyte stem cell markers CD34 and Sca-1 and preadipocyte markers Gata2 and Pref-1, indicating an inc

212 Our findings are consistent with impaired preadipocyte maturation, contributing to an increased ri

213 We have developed a model of how preadipocytes may use the dynamic interplay of two trans

214 es on adipogenesis were determined in 3T3-L1 preadipocytes, mouse adipose-derived stromal-vascular fr

215 er in visceral as compared with subcutaneous preadipocytes, negatively correlating with their potenti

216 NT stimulation of 3T3-L1 preadipocytes overexpressing NTR1 causes PKCdelta phosph

217 3T3-L1 preadipocytes overexpressing Tbx15 also have a 15% reduc

218 A were higher in abdominal than femoral s.c. preadipocytes (P < 0.005 and P < 0.03, respectively), co

219 thine (IBMX) to promote cell death in 3T3-L1 preadipocytes placed under differentiation conditions.

220 ers, in populations of differentiating mouse preadipocytes, polarizing human neutrophil-like cells an

221 Here, we show that brown preadipocytes possess primary cilia and can respond to H

222 of Zfp423 expression in 3T3-L1 cells blunts preadipocyte Pparg expression and diminishes the ability

223 rmacological or genetic ablation of DEGS1 in preadipocytes prevented adipogenesis and decreased lipid

224 silencing identified TBX5 as a regulator of preadipocyte proliferation and adipogenic differentiatio

225 nversely, overexpression of miR-33b impaired preadipocyte proliferation and reduced lipid droplet for

226 le progression and thereby strongly inhibits preadipocyte proliferation in vitro.

227 ion; however, the impact of DLK1 isoforms on preadipocyte proliferation remains to be determined.

228 ometry and computed tomography) and baseline preadipocyte proliferation, differentiation [peroxisome

229 d assessed for triglyceride accumulation and preadipocyte proliferation.

230 exhibits a substantial repression effect on preadipocyte proliferation.

231 Additionally, KO of dicer in cultured brown preadipocytes promoted a white adipocyte-like phenotype

232 s in p53-regulated adipogenesis of senescent preadipocytes, providing new insights into aging-depende

233 We found no depot-differences in preadipocyte replication or apoptosis that would explain

234 his may be explained by a marked increase in preadipocyte replication.

235 onal knockdown of CHOP in polyamine-depleted preadipocytes restored PPARgamma and C/EBPalpha expressi

236 Wnt-10b infection of normal fibroblasts and preadipocytes resulted in blockade of adipogenesis and t

237 nin ubiquitination and degradation in murine preadipocytes, resulting in elevated beta-catenin levels

238 promotes MM growth, whereas co-culture with preadipocytes results in enhanced MM cell chemotaxis in

239 Isolated preadipocytes retained a depot-specific transcriptional

240 In preadipocytes, retinoic acid (RA) regulates gene express

241 Preadipocytes secrete several WNT family proteins that a

242 blasts, 3T3-L1 cells, and human subcutaneous preadipocytes, selective deficiency of Nrf2 impairs adip

243 e adult skeleton; both mature adipocytes and preadipocytes serve as endocrine cells that secrete a nu

244 GR-depleted preadipocytes show adipogenesis defects 1 week after ind

245 iation was extended to 3 weeks, GR-deficient preadipocytes showed levels of adipogenesis marker expre

246 ient primary or immortalized white and brown preadipocytes showed severely delayed adipogenesis 1 wee

247 ectively, confirmed that Sca1(+) cells had a preadipocyte signature and showed differential expressio

248 ymal stromal cells (MSC) and in vitro 3T3-L1 preadipocytes significantly increases their adipogenic d

249 find that adipogenesis is impaired in 3T3-L1 preadipocytes stably transfected with Siah2 shRNA and th

250 in vitro adipogenic conversion of committed preadipocytes, such as 3T3-L1, does not include BMP4 tre

251 tion, whereas HDAC9 overexpression in 3T3-L1 preadipocytes suppressed adipogenic differentiation, dem

252 15 is 260-fold more highly expressed in s.c. preadipocytes than in epididymal preadipocytes.

253 efine novel sets of gene signatures in human preadipocytes that could predict the thermogenic potenti

254 nversion of mesenchymal stem cells (MSCs) to preadipocytes that differentiate into adipocytes.

255 in cultures of primary human adipocytes and preadipocytes that lipopolysaccharide and trans-10,cis-1

256 2) insulin receptor (IR) or IGF1R knock-out preadipocytes that only express the complimentary recept

257 lineage-committed mesenchymal stem cells and preadipocytes that pairs H3K4me3 with H3K9me3 to maintai

258 cytosolic protein specifically expressed in preadipocytes that regulates adipocyte differentiation i

259 wild-type protein, and in stably transfected preadipocytes the mutant protein was associated with sma

260 Thus, the conversion of preadipocyte to adipocyte involves the formation of an e

261 Progression from brown preadipocytes to adipocytes engages two transcriptional

262 The differentiation of committed preadipocytes to adipocytes is controlled by PPARgamma a

263 or-activated receptor gamma and promoted the preadipocytes to assume an oxidative beige/brown adipose

264 wing commitment, exposure of growth-arrested preadipocytes to differentiation inducers [insulin-like

265 The mechanisms by which EDCs direct preadipocytes to form adipocytes are poorly understood.

266 n of mouse mesenchymal stem cells and 3T3-L1 preadipocytes to mature adipocytes and decreased inducti

267 Exposure of 3T3-L1 preadipocytes to noncytotoxic levels of arsenic, includi

268 Exposure of mouse 3T3-L1 or human preadipocytes to PGF2alphaEA/bimatoprost during early di

269 gest a role for VEGF in brown adipocytes and preadipocytes to promote survival, proliferation, and no

270 In undifferentiated 3T3-L1 preadipocytes, translocation of myc7-Glut4 was low regar

271 e UCP1 regulators, PREX1 and EDNRB, in brown preadipocytes using CRISPR-Cas9 markedly abolished the h

272 ular heterogeneity of differentiating 3T3-L1 preadipocytes using immunofluorescence microscopy.

273 I HDACs in the nuclear compartment of 3T3-L1 preadipocytes using two experimental approaches.

274 enic differentiation of both fibroblasts and preadipocytes was abrogated in the presence of TGF-beta;

275 ide fatty acid composition of isolated human preadipocytes was determined.

276 genome-wide histone methylation profiling in preadipocytes, we find that among gene loci encoding adi

277 al knockout mice and derived white and brown preadipocytes, we show that endogenous KLF4 and Krox20 a

278 Using 3T3L1 preadipocytes, we studied adipogenesis in vitro and show

279 urces of 3T3-L1 preadipocytes as well as OP9 preadipocytes were assessed for cell proliferation and t

280 pocyte lipid accumulation was inhibited when preadipocytes were co-cultured with CD45(+)Cd11b(+)Cd11c

281 ess the role of GPAT4 directly, neonatal BAT preadipocytes were differentiated to adipocytes.

282 3T3-L1 preadipocytes were grown and differentiated in medium co

283 To test this hypothesis, murine brown preadipocytes were induced to differentiate the fatty ac

284 from subcutaneous abdominal fat depots, and preadipocytes were isolated and cultured.

285 First, preadipocytes were treated with phenylephrine, an alpha-

286 Murine 3T3-L1 preadipocytes were used to assess adipogenic induction.

287 Skp2 re-expression in Akt-deficient preadipocytes, which are impaired in adipogenesis, is su

288 receptor substrate 1 (IRS-1)-deficient brown preadipocytes, which exhibit a severe defect in differen

289 In wild-type preadipocytes, which express predominantly IGF1R, microa

290 accumulation in differentiating human white preadipocytes, which was prevented by caveolin-1 overexp

291 Brown preadipocyte whitening was partially reversed by express

292 een insulin and Wnt signaling pathways using preadipocytes with and without knockdown of the Wnt co-r

293 We generated preadipocytes with different levels of DLK1 and examined

294 e to glucocorticoid, and treatment of 3T3-L1 preadipocytes with glucocorticoid alone induced GR occup

295 Adipogenic potential of preadipocytes with knockdown or absence of TDAG51 was as

296 By developing a coculture method of preadipocytes with primary subcutaneous and visceral adi

297 expression is increased after stimulation of preadipocytes with proinflammatory cytokines.

298 dipogenesis is induced by treating confluent preadipocytes with the adipogenic cocktail, which activa

299 In contrast, in explanted subcutaneous preadipocytes, Wnt-3a repressed adipogenesis and promote

300 ith increased beta-catenin levels in shSiah2 preadipocytes, Wnt10b is elevated in Siah2(-/-) adipose