ライフサイエンスコーパス: prechordal

1 can synergize with BMP antagonism to induce prechordal and axial mesoderm when expressed as an indep

2 zer Gsc represses CE as well: Gsc-expressing prechordal cells, which leave the organizer first, migra

3 Therefore the prechordal head is mostly composed of neural crest-deriv

4 suggest that cephalic mesendoderm, including prechordal mesendoderm and anterior paraxial mesendoderm

5 diencephalic ventral midline, lie above the prechordal mesendoderm and express Fgf10Fgf10(+) progeni

6 plate is normal, suggesting that ablation of prechordal mesendoderm selectively inhibits otic inducti

7 r embryonic structures, including notochord, prechordal mesendoderm, floor plate and forebrain.

8 es, namely the lateral head mesoderm and the prechordal mesendoderm, gradually induce placode progeni

9 ants, which are more completely deficient in prechordal mesendoderm, otic induction is delayed by 1.5

10 , which develop with a partial deficiency of prechordal mesendoderm, otic induction is delayed by up

11 gence from the node of a group of cells, the prechordal mesendoderm.

12 ng, such as anterior definitive endoderm and prechordal mesendoderm.

13 Furthermore, prechordal mesendodermal and prospective ventral telence

14 anteroposterior (AP) positional identity of prechordal mesendodermal inductive signals to the overly

15 ndow denuded of definitive endoderm, beneath prechordal mesoderm and a variable sector of anterior no

16 different regions: active cell migration of prechordal mesoderm and convergent extension of chordame

17 tial for formation of the notochordal plate, prechordal mesoderm and foregut endoderm during gastrula

18 of chordin to conjugate explant cultures of prechordal mesoderm and neural tissue prevents the rostr

19 functions of Dkk1: induction of chordal and prechordal mesoderm and specification of heart tissue fr

20 nodal homologue, is expressed in the nascent prechordal mesoderm and we provide evidence that Nodal s

21 We identify prechordal mesoderm as the tissue that inhibits NC in th

22 notochord before establishing register with prechordal mesoderm at stage 7.

23 Nearby somitic and prechordal mesoderm becomes recruited into these enlarge

24 We report that notochord and prechordal mesoderm cells are intermingled and share exp

25 Further, prechordal mesoderm cells in which Fgfr3 expression is r

26 terior endoderm-derived TGFbetas may specify prechordal mesoderm character in chick axial mesoderm.

27 oderm as it extends, but is downregulated in prechordal mesoderm coincident with the onset of RDVM ce

28 protein (BMP) and Wnt antagonists located in prechordal mesoderm for head induction, but may be neces

29 onstrate that Shh and Bmp7 from the adjacent prechordal mesoderm govern hypothalamic neural fate, the

30 Anterior endoderm elicits aspects of prechordal mesoderm identity in extending axial mesoderm

31 , targeted electroporation of Fgfr3 siRNA to prechordal mesoderm in vivo results in premature Shh dow

32 Removal of the prechordal mesoderm led to formation of a single retina

33 Exposure of prechordal mesoderm microcultures to Nodal-conditioned m

34 signaling also interferes with migration of prechordal mesoderm on fibronectin.

35 gnals from axial mesoderm (the notochord and prechordal mesoderm) specify the pharyngeal endoderm, co

36 yonic chick, Shh is expressed transiently in prechordal mesoderm, and is governed by unprocessed Noda

37 Removal of prechordal mesoderm, in contrast, caused deficits of ant

38 or plate fate reveals a role for the nascent prechordal mesoderm, indicating that more than one induc

39 enitors of several axial tissues (notochord, prechordal mesoderm, somites, gut endoderm), by characte

40 ein sonic hedgehog (Shh) is expressed in the prechordal mesoderm, where it plays a crucial role in in

41 ebrates, Otx genes are also expressed in the prechordal mesoderm, where they may have a role in cell

42 eral axial structures, such as notochord and prechordal mesoderm, which are thought to induce various

43 rm that gives rise to the notochord, but not prechordal mesoderm, which gives rise to the prechordal

44 er: deep endoderm, which expressed cerberus; prechordal mesoderm, which showed overlapping but non-id

45 e rostralization of ventral midline cells by prechordal mesoderm.

46 and bone morphogenetic protein 7 (BMP7) from prechordal mesoderm.

47 is expressed in the notochord but not in the prechordal mesoderm.

48 se to Sonic Hedgehog (Shh) secreted from the prechordal mesoderm.

49 fects in epiboly and patterning of axial and prechordal mesoderm.

50 nterior endoderm may determine the extent of prechordal mesoderm.

51 ular events that govern the specification of prechordal mesoderm.

52 ick embryo, posterior notochord and anterior prechordal mesoderm.

53 s and a subset of the genes expressed by the prechordal mesoderm.

54 m defects in signaling between the embryonic prechordal plate (consisting of the dorsal foregut endod

55 y the anterior definitive endoderm (ADE) and prechordal plate (PCP) progenitors.

56 h causes an arrest in the development of the prechordal plate (PCP), a structure required for forebra

57 anterior neural ridge (ANR) and Shh from the prechordal plate (PrCP).

58 temporal expression in the anterior endoderm prechordal plate and anterior neural plate can be recapi

59 y expressed after removal of the presumptive prechordal plate and consistently, opl was correctly exp

60 ation anterior axial mesoderm cells form the prechordal plate and express goosecoid (gsc) in wild-typ

61 axes donor tissue contributes to notochord, prechordal plate and floor plate.

62 e-attached and secreted forms of oep rescues prechordal plate and forebrain development in mutant emb

63 We find that prechordal plate and notochord are strongly reduced in m

64 t the blastoderm margin and are required for prechordal plate and notochord formation.

65 sing ShhN, we detected low-level ShhN in the prechordal plate and notochord, consistent with the noti

66 nal tissue, however, leads to a loss of both prechordal plate and notochord.

67 uring the latter half of gastrulation in the prechordal plate and paraxial cephalic mesendoderm, tiss

68 ive interactions dependent on the underlying prechordal plate and signals from the midline of the neu

69 Thus abnormal morphogenesis of the prechordal plate and the notochord is likely a consequen

70 ior axis of the zebrafish gastrula including prechordal plate and ventral diencephalic precursors.

71 ation, organizer cells involute and form the prechordal plate anteriorly and the notochord more poste

72 Thus, the prechordal plate appears as a mesendodermal pivot betwee

73 oncomitantly, cells normally fated to become prechordal plate are transformed into notochord progenit

74 fects in the morphology of the notochord and prechordal plate by the end of gastrulation.

75 ion in zebrafish embryos, we reveal that all prechordal plate cells show the same behavior and rely o

76 In oep mutants the prechordal plate does not form and gsc expression is not

77 end caudally in the ventral midline from the prechordal plate during development of the foregut pocke

78 oderm during late blastula stages and in the prechordal plate during late gastrulation.

79 eyed pinhead (oep) mutant embryos, where the prechordal plate fails to form.

80 axial signaling centers of the notochord and prechordal plate functions as a morphogen in dorsoventra

81 nsion defect, the expression of hedgehog and prechordal plate genes, and the formation of cyclopia in

82 ective anterior migration of the prospective prechordal plate in silberblick (slb)/wnt11 mutant embry

83 g to the loss of shield derivatives, such as prechordal plate in the anterior and notochord in the po

84 periments in chick embryos indicate that the prechordal plate is able to suppress Pax-6 expression.

85 gulated in nehe mutants at the time when the prechordal plate is normally specified.

86 rgely unaffected, suggesting that underlying prechordal plate is not required for anterior-posterior

87 ral plate mesoderm adjacent to the notochord-prechordal plate junction.

88 sors, which reside adjacent to the notochord-prechordal plate junction.

89 ation of the Ca(i)(2+) field by the emerging prechordal plate may permit the independent regulation o

90 ed that the notochord might suppress, or the prechordal plate might enhance, the cardiogenic fate.

91 using cell transplants, we demonstrate that prechordal plate migration is a true collective process,

92 anterior endomesoderm, respectively, and the prechordal plate of gastrula stage embryos.

93 the medial neural plate are regulated by the prechordal plate perhaps through the action of Sonic Hed

94 egion of the field, and demonstrate that the prechordal plate plays a primary signaling role in retin

95 is seen in the anterior midline endoderm and prechordal plate precursor.

96 ed the roles of Mil in anterior migration of prechordal plate progenitor cells and found that, in slb

97 This indicates that prechordal plate progenitor cells can migrate effectivel

98 se results suggest that the net migration of prechordal plate progenitors is determined by different

99 Prechordal plate progenitors reside close to the blastod

100 l signaling at different times suggests that prechordal plate specification requires sustained Nodal

101 their response to injury, suggests that the prechordal plate supports and/or the notochord suppresse

102 g vertebrate gastrulation, cells forming the prechordal plate undergo directed migration as a cohesiv

103 orsal mesendoderm at gastrulation and in the prechordal plate until early somitogenesis.

104 l mesendoderm anterior to the notochord (the prechordal plate) has a central role in induction of the

105 nterior axis (formation of the head process, prechordal plate).

106 its mesendodermal derivatives, including the prechordal plate, an organizing center for rostral devel

107 loss of SHH expression and signaling by the prechordal plate, and a decrease in FGF8 expression and

108 g gastrula stages: in the germ ring, shield, prechordal plate, and notochord.

109 layer of the shield and later in notochord, prechordal plate, and overlying anterior neurectoderm.

110 uring gastrulation in the anterior endoderm, prechordal plate, and the prospective cephalic neural pl

111 sulting in cyclopia and defects in endoderm, prechordal plate, and ventral neuroectoderm formation.

112 the normal progenitors also reside near the prechordal plate, but anterior to the Nkx2.5-expressing

113 severe phenotype characterized by absence of prechordal plate, cardiac mesoderm, endoderm and ventral

114 Prechordal plate, early definitive endoderm, and anterio

115 However, a third head organizer tissue, the prechordal plate, fails to express markers of cell type

116 , axial mesendoderm migrates in a group, the prechordal plate, from the embryonic organizer to the an

117 ly the ventral brain primordium, and not the prechordal plate, is an important Hh source.

118 ls are clustered in a region adjacent to the prechordal plate, just anterior to the notochord tip.

119 lastula stage embryos either the presumptive prechordal plate, marked by goosecoid (gsc) expression,

120 es of the anterior primitive streak, such as prechordal plate, node, notochord and definitive endoder

121 essential to maintain the axial identity of prechordal plate, notochord, floor plate and hypochord p

122 ic structures present at the dorsal midline, prechordal plate, notochord, hypochord and floor plate s

123 ependent midline domain, associated with the prechordal plate, regulates brain asymmetry but is dispe

124 responses to the inductive signals from the prechordal plate, Sonic Hedgehog, the anterior neural ri

125 ed morphogenetic movements that generate the prechordal plate, which is required for normal developme

126 ibutes to the Organizer, head mesenchyme and prechordal plate.

127 is restored upon contact with the endogenous prechordal plate.

128 prechordal mesoderm, which gives rise to the prechordal plate.

129 first detected at bud stage in the anterior prechordal plate.

130 of the ventral neuroectoderm, endoderm, and prechordal plate.

131 We find that the prechordal region does not have neural inducing ability,

132 Here we have investigated whether the prechordal region possesses the lost functions of the or

133 n the initial determination of the anterior (prechordal) region of the embryo.

134 results have suggested that juxtaposition of prechordal (rostral) and epichordal (caudal) neuroepithe

135 ittle is known about how Shh is regulated in prechordal tissue.