ライフサイエンスコーパス: prechordal plate

1 nterior axis (formation of the head process, prechordal plate).

2 prechordal mesoderm, which gives rise to the prechordal plate.

3 is restored upon contact with the endogenous prechordal plate.

4 first detected at bud stage in the anterior prechordal plate.

5 of the ventral neuroectoderm, endoderm, and prechordal plate.

6 ibutes to the Organizer, head mesenchyme and prechordal plate.

7 its mesendodermal derivatives, including the prechordal plate, an organizing center for rostral devel

8 temporal expression in the anterior endoderm prechordal plate and anterior neural plate can be recapi

9 y expressed after removal of the presumptive prechordal plate and consistently, opl was correctly exp

10 ation anterior axial mesoderm cells form the prechordal plate and express goosecoid (gsc) in wild-typ

11 axes donor tissue contributes to notochord, prechordal plate and floor plate.

12 e-attached and secreted forms of oep rescues prechordal plate and forebrain development in mutant emb

13 We find that prechordal plate and notochord are strongly reduced in m

14 t the blastoderm margin and are required for prechordal plate and notochord formation.

15 sing ShhN, we detected low-level ShhN in the prechordal plate and notochord, consistent with the noti

16 nal tissue, however, leads to a loss of both prechordal plate and notochord.

17 uring the latter half of gastrulation in the prechordal plate and paraxial cephalic mesendoderm, tiss

18 ive interactions dependent on the underlying prechordal plate and signals from the midline of the neu

19 Thus abnormal morphogenesis of the prechordal plate and the notochord is likely a consequen

20 ior axis of the zebrafish gastrula including prechordal plate and ventral diencephalic precursors.

21 loss of SHH expression and signaling by the prechordal plate, and a decrease in FGF8 expression and

22 g gastrula stages: in the germ ring, shield, prechordal plate, and notochord.

23 layer of the shield and later in notochord, prechordal plate, and overlying anterior neurectoderm.

24 uring gastrulation in the anterior endoderm, prechordal plate, and the prospective cephalic neural pl

25 sulting in cyclopia and defects in endoderm, prechordal plate, and ventral neuroectoderm formation.

26 ation, organizer cells involute and form the prechordal plate anteriorly and the notochord more poste

27 Thus, the prechordal plate appears as a mesendodermal pivot betwee

28 oncomitantly, cells normally fated to become prechordal plate are transformed into notochord progenit

29 the normal progenitors also reside near the prechordal plate, but anterior to the Nkx2.5-expressing

30 fects in the morphology of the notochord and prechordal plate by the end of gastrulation.

31 severe phenotype characterized by absence of prechordal plate, cardiac mesoderm, endoderm and ventral

32 ion in zebrafish embryos, we reveal that all prechordal plate cells show the same behavior and rely o

33 m defects in signaling between the embryonic prechordal plate (consisting of the dorsal foregut endod

34 In oep mutants the prechordal plate does not form and gsc expression is not

35 end caudally in the ventral midline from the prechordal plate during development of the foregut pocke

36 oderm during late blastula stages and in the prechordal plate during late gastrulation.

37 Prechordal plate, early definitive endoderm, and anterio

38 eyed pinhead (oep) mutant embryos, where the prechordal plate fails to form.

39 However, a third head organizer tissue, the prechordal plate, fails to express markers of cell type

40 , axial mesendoderm migrates in a group, the prechordal plate, from the embryonic organizer to the an

41 axial signaling centers of the notochord and prechordal plate functions as a morphogen in dorsoventra

42 nsion defect, the expression of hedgehog and prechordal plate genes, and the formation of cyclopia in

43 l mesendoderm anterior to the notochord (the prechordal plate) has a central role in induction of the

44 ective anterior migration of the prospective prechordal plate in silberblick (slb)/wnt11 mutant embry

45 g to the loss of shield derivatives, such as prechordal plate in the anterior and notochord in the po

46 periments in chick embryos indicate that the prechordal plate is able to suppress Pax-6 expression.

47 gulated in nehe mutants at the time when the prechordal plate is normally specified.

48 rgely unaffected, suggesting that underlying prechordal plate is not required for anterior-posterior

49 ly the ventral brain primordium, and not the prechordal plate, is an important Hh source.

50 ral plate mesoderm adjacent to the notochord-prechordal plate junction.

51 sors, which reside adjacent to the notochord-prechordal plate junction.

52 ls are clustered in a region adjacent to the prechordal plate, just anterior to the notochord tip.

53 lastula stage embryos either the presumptive prechordal plate, marked by goosecoid (gsc) expression,

54 ation of the Ca(i)(2+) field by the emerging prechordal plate may permit the independent regulation o

55 ed that the notochord might suppress, or the prechordal plate might enhance, the cardiogenic fate.

56 using cell transplants, we demonstrate that prechordal plate migration is a true collective process,

57 es of the anterior primitive streak, such as prechordal plate, node, notochord and definitive endoder

58 essential to maintain the axial identity of prechordal plate, notochord, floor plate and hypochord p

59 ic structures present at the dorsal midline, prechordal plate, notochord, hypochord and floor plate s

60 anterior endomesoderm, respectively, and the prechordal plate of gastrula stage embryos.

61 y the anterior definitive endoderm (ADE) and prechordal plate (PCP) progenitors.

62 h causes an arrest in the development of the prechordal plate (PCP), a structure required for forebra

63 the medial neural plate are regulated by the prechordal plate perhaps through the action of Sonic Hed

64 egion of the field, and demonstrate that the prechordal plate plays a primary signaling role in retin

65 anterior neural ridge (ANR) and Shh from the prechordal plate (PrCP).

66 is seen in the anterior midline endoderm and prechordal plate precursor.

67 ed the roles of Mil in anterior migration of prechordal plate progenitor cells and found that, in slb

68 This indicates that prechordal plate progenitor cells can migrate effectivel

69 se results suggest that the net migration of prechordal plate progenitors is determined by different

70 Prechordal plate progenitors reside close to the blastod

71 ependent midline domain, associated with the prechordal plate, regulates brain asymmetry but is dispe

72 responses to the inductive signals from the prechordal plate, Sonic Hedgehog, the anterior neural ri

73 l signaling at different times suggests that prechordal plate specification requires sustained Nodal

74 their response to injury, suggests that the prechordal plate supports and/or the notochord suppresse

75 g vertebrate gastrulation, cells forming the prechordal plate undergo directed migration as a cohesiv

76 orsal mesendoderm at gastrulation and in the prechordal plate until early somitogenesis.

77 ed morphogenetic movements that generate the prechordal plate, which is required for normal developme