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1 mitochondrial disorders are now at a mature preclinical stage.
2 currently in clinical use or at the advanced preclinical stage.
3 ials have begun to target individuals at the preclinical stage.
4 d with metabolic disturbances already at the preclinical stage.
5 re cognitive symptoms emerge-during the long preclinical stage.
6 ) PIB binding was observed during this early preclinical stage.
7 st clinical episode and, importantly, at the preclinical stage.
8 ndeed evaluating treatments at prodromal and preclinical stages.
9 le the survey of vascular pathologies during preclinical stages.
10 aptic dysfunction can be imaged beginning at preclinical stages.
11 anifestations of CTE, including clinical and preclinical stages.
12 hippocampal atrophy differ based on initial preclinical staging.
13 biomarkers, individuals were classified into preclinical stage 0 (Abeta-/ND-), 1 (Abeta+/ND-), or 2+
14 nt, fully penetrant retinal dystrophy with a preclinical stage, an onset after the age of 30 years, a
15 tial dysbiosis in high-risk individuals at a preclinical stage, and therapeutically target pathogenic
16 ies are being developed and evaluated at the preclinical stage, and will lead to clinical trials in t
19 s, especially if they can be identified in a preclinical stage by the development of antecedent bioma
20 in early childhood, can be identified in the preclinical stages by the detection of catecholamines in
21 arly detection of brain abnormalities at the preclinical stage can be useful for developing preventiv
26 n insulin-resistant individuals at an early, preclinical stage, ie, well before the development of gl
27 g autoaggressive process beneficially at the preclinical stage, if produced at the correct location,
29 ication, for identifying participants at the preclinical stage of AD who may be at risk for cognitive
32 major growth in Abeta burden occurs during a preclinical stage of Alzheimer disease (AD), prior to th
33 appears at the prodromal and possibly at the preclinical stage of Alzheimer's disease, and seems to p
37 e estimates for clinical trials aimed at the preclinical stage of the disorder (HCs with evidence of
38 thus may provide protection against Abeta in preclinical stages of AD and other neurodegenerative pro
39 Conclusions and Relevance: More advanced preclinical stages of AD have greater longitudinal Abeta
43 efects and axonopathy are prominent in early preclinical stages of Alzheimer's disease (AD), often pr
44 -inositol and other metabolites occur in the preclinical stages of Alzheimer's disease associated wit
45 gm can detect metabolic abnormalities in the preclinical stages of Alzheimer's disease despite normal
48 comorbidities and their risk factors in the preclinical stages of chronic obstructive pulmonary dise
49 comorbid diseases were more prevalent in the preclinical stages of COPD and smokers without COPD.
51 NOD female mice representing early and late preclinical stages of disease were treated with mouse an
52 ent in pyramidal neurons of the neocortex at preclinical stages of disease when Alzheimer-like neurop
54 alternative guide for drug therapy at early, preclinical stages of graft rejection and for evaluating
56 eviously found to contribute to the earliest preclinical stages of pancreatic beta cell destruction.
58 shift in functional microglial phenotypes in preclinical stages of superoxide dismutase 1 (SOD1)-muta
59 fective, this therapy should be given in the preclinical stages of the disease, which are assessed mo
60 hypertension, but its role as a biomarker of preclinical stages of this disease has not been investig
61 s the field begins to test the concept of a "preclinical" stage of neurodegenerative disease, when th
62 ly detection of autoimmunity, potentially at preclinical stages, offers a window of opportunity for t
63 beta and their receptors was examined at the preclinical stage, onset, peak, and recovery by RT-PCR a
64 lzheimer disease (AD) pathophysiology at the preclinical stage, prior to the onset of mild cognitive
65 e show that (a) sera from FS patients in the preclinical stage recognized epitopes on the COOH-termin
68 mined cross-sectional associations across AD preclinical stages, those with all biomarkers normal, an
69 drug development pipeline, from 2.0% at the preclinical stage to 8.2% among mechanisms for approved
70 stand their relationship during the earliest preclinical stages, we investigated baseline CSF markers
71 to market involves many steps, including the preclinical stage, where various properties of the drug
72 novel antigens, adjuvants and vectors in the preclinical stage with computational analyses of clinica
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