ライフサイエンスコーパス: preclude

1 ion and deformation behavior have often been precluded.

2 ed tRNA at this position would be sterically precluded.

3 required to have thermal stability have been precluded.

4 Such rearrangements preclude a meaningful analysis of the experimental spect

5 These results do not preclude a normal function for a fully wrapped mode, but

6 dergo complex structural rearrangements that preclude a precise description of the optimal target.

7 le the presence of a BRCA2 mutation does not preclude a response to docetaxel, there is overall a sig

8 on intracranial electrical connectivity has precluded a direct test of this hypothesis in a whole-br

9 between even closely related Solanaceae have precluded a genetic dissection, we captured and compared

10 formational dynamics of 30S IC-bound IF2 has precluded a mechanistic understanding of this process.

11 r subunit d However, insufficient resolution precluded a precise definition of the aNT-d interface.

12 f different proxies in different regions has precluded a unified view of Southern Ocean biogeochemica

13 rea V2, the complexity of the transformation precludes a clear understanding of what specifically thi

14 genome sequence variation on DNA methylation precludes a comprehensive assessment of the consequences

15 paucity of genome-level data for Apocynaceae precludes a deeper understanding of MIA pathway evolutio

16 tly affected by the resistant mutants, which precludes a precise description of fitness from a single

17 This precludes a return to physiological conditions even when

18 variability is poorly constrained, however, precluding a clear link between ridge magmatism and Plei

19 by different techniques in separate animals, precluding a comprehensive and correlative assessment of

20 absorption lines in the X-ray band, thereby precluding a detailed analysis of the accretion flow.

21 Allochromatium vinosum, TsdB is not present, precluding a general and essential role for electron flo

22 ion have predominantly given point estimates precluding a rigorous analysis of the implications of un

23 We believe a reason precluding a wider adoption of TKTD models is that avail

24 lored the regime of weak interactions, which precludes access to correlated many-body states.

25 ver, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis.

26 ssociated with measuring ASL pH in vivo have precluded accurate measurements in humans.

27 diagnosis of non-high-grade DCIS that would preclude active surveillance.

28 ological activity of certain types typically precludes activities of many other types.

29 This conformational change precludes additional chances at membrane targeting for t

30 Postoperatively, his renal function precluded adjuvant cisplatin-based chemotherapy.

31 ations of available technologies have so far precluded adoption of this approach in the clinic.

32 ed genetic heterogeneity of this disease has precluded advances in understanding its pathogenesis and

33 ed in part to sample size issues, which also preclude analysis in potentially vulnerable subgroups.

34 ental arrest associated with cardiomyopathy, precluding analysis of its effects on skeletal muscle de

35 s case, binding of DNA to the second site is precluded and modulation of the Pif1-dependent re-windin

36 sitivity across distant receptive fields and preclude any bias toward local light-intensity fluctuati

37 However, publication biases preclude any definite conclusions for prevention of infe

38 fetimes of the heavy bottom and charm quarks preclude any practical applications of such reactions.

39 dividuals with IVA-associated cardiomyopathy precluded any formal testing.

40 of SCU induced by gBGC in mammalian genomes precludes any optimization of the tRNA pool to the deman

41 ported using a truncated adenylation domain, precluding any insight that might be derived from unders

42 mmunologically silencing microbiota may thus preclude aspects of immune education.

43 emission tomography, where submaximal stress precludes assessing physiological severity of coronary a

44 of decision making has used techniques that preclude assessment of distinct phases of the decision p

45 These inconsistencies preclude assessment of the role of LBR in Xist spreading

46 ke produces neuroadaptations in the DLS that preclude BDNF's ability to gate alcohol self-administrat

47 contacts with HLA-F as well as beta2m, thus precluding binding to HLA-F OCs.

48 The results do not preclude biological constraints favoring integer ratios,

49 in the soil, and is therefore sufficient to preclude boron deficiency.

50 ioinformatic analyses of RNA sequencing have precluded broad assessment of other forms of small-RNAs

51 ulation of Ca(2+) influx in the podocytes is precluded by blocking either AT1 or AT2 receptors (ATRs)

52 across population scale cohorts, however, is precluded by day-to-day nonlinear signal drifts in LC re

53 -containing amino acid, methionine, has been precluded by its intrinsically weaker nucleophilicity.

54 itional behaviors, but causal inferences are precluded by the correlational nature of the data and ge

55 ly invasive procedures, but its use is often precluded by the poor visibility of medical devices.

56 in p-type silicon, but sufficiently high to preclude carrier-lattice coupling associated with small

57 n docked inside the intracellular vestibule, precluding channel opening.

58 t similarity to available protein sequences, precluding classification of this virus and hampering fu

59 side effects and lack of tissue specificity precluded clinical use of first-generation, centrally ac

60 epatoma cells in an experimental design that precluded coevolution of the cells with the virus.

61 he large spatial separation between the RGCs precludes common excitatory inputs from bipolar cells, t

62 aucity of 3'-sequencing data in this species precludes comprehensive assessment of alternative polyad

63 Challenging synthesis protocols have precluded conclusive determination of their crystallogra

64 The paucity of whole Y-chromosome sequences precluded conclusive identification of this ancestor's a

65 Such OH-mediated behaviors presumably preclude concurrent eating, and loss of OH cells produce

66 that 16% of reef-coral habitat </=30 m will preclude coral growth and reef development.

67 tin flow and actomyosin contractility, which precludes cortical microtubule engagement necessary for

68 by introducing modifications in Galphai that preclude coupling to every known major binding partner [

69 ir for HIV-1 in resting CD4(+) T lymphocytes precludes cure.

70 ion of cyclin B1 and its encoding RNA, which precludes cyclin B1/CDK1 complex function, thus preventi

71 etion of cyclin B1 and its encoding RNA that precludes cyclin B1/CDK1 complex functions necessary for

72 ber of studies and significant heterogeneity precludes definitive reassurance about the longer term c

73 n at the ortho-aryl positions of the styrene precludes dehydrogenative homocoupling.

74 re known, the densely packed pore region has precluded delineation of the ion pathway.

75 on, but a lack of structural information has precluded detailed investigations into their functional

76 hewing tobacco in the absence of cigarettes, precluding detailed examinations of dose response and ce

77 tropics, long time-scale oceanic variability precludes determination of how much of a small, but sign

78 The small cohort of malignant lesions precluded determining if these features were independent

79 rotoxicity in preclinical toxicology species precluded development.

80 d peritoneal metastasis are largely unknown, precluding development of more effective targeted therap

81 However, comorbidities or other factors may preclude device removal, thus prompting a nonsurgical ap

82 hat emerge only well below room temperature, precluding device applications.

83 order Due to Another Medical Condition" that preclude diagnosing catatonia in the presence of deliriu

84 suring compartmentalized NAD(+) in cells has precluded direct evidence for this type of regulation.

85 The transient nature of these states has precluded direct observation of their properties.

86 ent during early thymocyte development often precludes direct analysis of potential roles during late

87 xidase correlation, a destructive assay that precludes direct longitudinal study.

88 This precludes discernment of their separate influences on ec

89 deficiencies in diagnosis and access to care preclude disease elimination.

90 s occupy niche space via diversification and preclude dominance of later arrivals, have been observed

91 s, similar studies with proteins are largely precluded due to spectral congestion.

92 g-term oscillations between land states that preclude ecosystem stability; and conservation of the mo

93 ve and are associated with side effects that preclude effective dosing in many patients [8].

94 Lack of structural information has precluded elucidation of the allosteric basis for the de

95 aining Cyclin B1-Cdk1 at the plasma membrane precludes entry to mitosis.

96 renders uS11 susceptible to proteolysis, and precludes eS26 incorporation into the 90S.

97 in the quantification of BK virus (BKV) DNA precludes establishing broadly applicable thresholds for

98 er active positive feedback and replication, precluding establishment of latency.

99 ting methods commonly used in loess deposits preclude exact correlations of paleosol horizons with Gr

100 ile the endangerment of the devil population precludes experimentation on large experimental groups,

101 munogenic/protective T-cell target antigens, precluding extension to PIV3.

102 table validation cohorts are the main factor precluding external validation.

103 ut not the kinase FAK, under conditions that precluded extracellular ligand binding to alphaIIbbeta3.

104 We infer that crystal plasticity precludes failure and can punctuate the viscous-brittle

105 owever, reported outcomes were heterogeneous precluding formal meta-analysis.

106 are inactive in mammalian cells and are thus precluded from genome-editing applications.

107 However, major burn injury is precluded from these studies.

108 ypothesized that constitutive BCR activation precluded functional B-cell maturation in cGVHD.

109 0 degrees C to 75 degrees C), which seems to preclude fungal activity.

110 ), and graft-versus-host disease (GVHD) that precluded further administration of ipilimumab was obser

111 the reduced insular synaptic efficacy, which precluded further LTD induction.

112 ent OCT imaging; 14 (6.1%) had image quality precluding further analysis.

113 angement yielding isomeric diketopiperazines precluding further chemical labeling.

114 o [HR] 0.87, 95% CI 0.63-1.21; p=0.41), thus precluding further formal statistical analysis.

115 e stability at the 5-year time point did not preclude future growth, cross-over to resection, or carc

116 between the introduction and detection often preclude genetic characterization of that crucial phase.

117 tic cause is still unknown in many patients, precluding genetic counselling and better understanding

118 While it is not possible to preclude H2OCl(+) as a chlorinating agent, we were able

119 gh nucleosome occupancy does not necessarily preclude high accessibility, which reveals novel princip

120 are believed to possess MTPJ morphology that precludes high dorsiflexion excursions during terrestria

121 B, in which cases the high CMC of surfactant precludes high monomer concentration within micelles.

122 ution, electron beam induced specimen damage precludes high resolution imaging of sensitive materials

123 uniquely identify individual leukemia clones precludes high-resolution tracing of their clonal dynami

124 ys, but the stochastic nature of the process precludes high-throughput measurement (and sorting) of s

125 ional changes in the alveolar crest that may preclude implant placement.

126 ge size of the factor VIII coding region has precluded improved outcomes with gene therapy in patient

127 n for lyase catalysis in this system that is precluded in the conventional reaction.

128 e of IgA1 and CD89 homologs in the mouse has precluded in vivo proof-of-concept studies of specific t

129 s in part due to loss of miR-33b in rodents, precluding in vivo assessment of the impact of miR-33b u

130 y the use of municipal-aggregate data, which precludes individual-level inference.

131 ing that the high levels of cellular 2OG may preclude inhibition.

132 ve been studied under plasma conditions that preclude insight into their formation mechanism.

133 site of the LPMO and that substrate binding precludes interaction with CDH.

134 thout Ca(2+) these binding sites are closed, precluding interactions with Ax.

135 gical assays involving mutants engineered to preclude intramolecular effects.

136 sumed physiological barriers have heretofore precluded investigation of systemic gene delivery to the

137 tion of eQTLs is their low resolution, which precludes investigation of the causal variants and their

138 urine TLR10 is a disrupted pseudogene, which precludes investigation using classic gene knockout appr

139 due to massive pancreatic acinar cell death, precluding investigation of the effects of SPINK1 defici

140 TP-driven electron delivery from Fe protein, precluding isotope effect measurements on substrate redu

141 reproducibility, and long reaction times may preclude its adoption as a rapid screening method.

142 Traditional criteria for medical catatonia preclude its diagnosis in delirium.

143 istances between proteins in the complex has precluded its 3D characterization.

144 and economic impact of an NDV outbreak have precluded its clinical development.

145 ction, although lack of regioselectivity has precluded its more widespread application.

146 cally been difficult to determine, which has precluded its use in quantitative studies.

147 yynes; however, chemoselectivity issues have precluded its widespread utilization.

148 ational modeling, present-day system designs precludes its adoption by the broader cardiovascular res

149 ciated with systemic administration of IL-12 precludes its clinical application.

150 ange of the tFT toward slower time scales or precludes its use for measurements of protein turnover.

151 e criteria, the site is poorly vascularized, precluding its utility.

152 Microbiologic workup precluded known enteropathogens, but microbiota analysis

153 ctor onto methylmalonyl-CoA mutase (MCM) and precludes loading of inactive cofactor forms.

154 The death of this child precluded long-term evaluations of the clinical conseque

155 is uncertain whether coeliac node metastasis precludes long-term survival in distal oesophageal cance

156 mV dec(-1) at room temperature and therefore precludes lowering of the supply voltage and overall pow

157 Genetic ablation of MsrB1 did not preclude LPS-induced intracellular signaling in macropha

158 iptomes has produced a big data problem that precludes many cancer biologists and oncologists from gl

159 This precludes many higher-risk (acute ischemic and acute str

160 hallenging to detect IBD segments in exomes, precluding many potentially informative downstream analy

161 al nature of Nm still limits sensitivity and precludes mapping in mRNA.

162 Such heterogeneity precludes meaningful comparisons and conclusions at pres

163 development of the infant brain, which would preclude memory consolidation, or to deficits in memory

164 Heterogeneity precluded meta-analysis.

165 This precludes MgO-based cements from providing a large-scale

166 This study is limited by its sample size, precluding more detailed analyses of drivers of the hype

167 replicative human senescent fibroblasts, DDR precluded MYOD-mediated activation of the myogenic progr

168 stained systematic stratigraphic covariance, precluding nonatmospheric explanations.

169 n that resembled the unliganded AR (apo-AR), precluding nuclear localization and DNA binding.

170 Moreover, Fft3 also precludes nucleosome turnover at several euchromatic loc

171 atural labeled sugar substrates that thereby preclude obtaining information as to the specificity of

172 detection schemes are independent and do not preclude one another.

173 ECOG PS 2 or with a comorbidity profile that precludes other regimens; the addition of capecitabine o

174 The safest way to preclude phage infection is to block initial phage adsor

175 nctions of neutrophils under conditions that preclude phagocytosis.

176 However, selective inhibition of TBK1 precludes phosphorylation of IRF3 and subsequent DC acti

177 Heterogeneity of interventions precluded pooling.

178 adaptive change in one species may represent precluded possibilities in other species because of diff

179 occupancy of the PPARgamma regulatory region precludes PPARgamma occupancy of this site, based on the

180 This is long enough to preclude precise calculation of the time or mechanism of

181 n, relatively poor chronological control has precluded precise alignment of ice, atmospheric and mari

182 n emissions of this important greenhouse gas preclude prediction of when and where N2O emissions will

183 n controlling [Formula: see text] production precludes predictions of [Formula: see text] emissions a

184 Clinical heterogeneity precluded primary outcome meta-analysis for Staphylococc

185 0; had to have been randomised in a way that precluded prior knowledge of treatment assignment; and h

186 d in studies, however, lack standardization, precluding quantitative comparison and extrapolation of

187 When anatomic obstacles preclude radiofrequency catheter ablation of idiopathic

188 forward organization of the olfactory system precludes reconstruction using standard compressed sensi

189 onal quenching by the Snail repressor, which precludes recruitment of CBP and prevents histone acetyl

190 erspecific variability in leaf phenology has precluded regional generalizations.

191 e the detrimental signaling environment that precludes remyelination.SIGNIFICANCE STATEMENT As an env

192 marily assessed using destructive histology, precluding repeated investigations of the same animal.

193 uces BRD4 recruitment during reactivation to preclude replication initiation.

194 antation if local invasion and multifocality preclude resection.

195 , a congenital left-sided superior vena cava precluded right-sided capture.

196 Delamination from FN-muprinted PDMS precluded robust detection of myotubes.

197 ough a short life expectancy generally might preclude RT.

198 vertebrates, the shark IgL gene organization precludes secondary rearrangements that delete self-reac

199 aturation indicated this occurs because NAPA precludes selection of novel prion conformations.

200 nockdowns with p120-Kaiso siRNAs since Day 7 precluded senescence mediated by p16(INK4a) by inducing

201 by and Azi1, centrioles fail to form the TZ, precluding sensory cilia assembly, and no ciliary membra

202 ving significant conformational changes that preclude simultaneous substrate and inhibitor binding.

203 +) in the deep CAII active-site cleft, which precludes simultaneous CB[6] binding.

204 ics are limited to cell-permeable drugs that preclude single-cell perturbations.

205 It precludes specific T-cell responses against strong antig

206 of their interactions, these limitations had precluded structural characterization of the PIC.

207 Association of ICP47 precludes substrate binding and prevents nucleotide-bind

208 chanisms occurring in human diseases and may preclude successful clinical translation.

209 iversity within African ancestry populations precludes summarizing risk across different African ethn

210 increased risk of bias, and clinical factors precluded support for exclusive use of either gadoxetate

211 soluble iron concentrations would otherwise preclude survival.

212 ing these contributions met with difficulty, precluding systematic analysis of the energetic basis fo

213 ptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective P

214 tiretroviral treatment programs expand could preclude the 90-90-90 targets adopted by the United Nati

215 rties of the endpoint stiffness and can even preclude the ability to minimize energy.

216 e identity among these available sources may preclude the benefits of screening.

217 the effects of DF properties on appetite and preclude the development of reliable, predictive, struct

218 that current epidemiologic evidence does not preclude the existence of competitive biological interac

219 mpositions could be specifically arranged to preclude the formation of undesirable sequence features.

220 breadth of labeling is generally thought to preclude the higher spatial resolution necessary to inte

221 al DNA methylation; however, such approaches preclude the identification of loci that may alter human

222 laeo-coastline of Phra Thong Island does not preclude the impacts of localised storms in sandsheet em

223 This may not preclude the longer-term effects of fetal exposure to lo

224 hat lack empirical support but inadvertently preclude the observation of hormesis.

225 The kinetic data clearly preclude the operation of classical kinetic versus therm

226 ies require highly specific data inputs that preclude the use of many datasets and databases.

227 multiple modifications on a single ubiquitin preclude the use of standard bottom-up proteomic approac

228 -alloreactive T cell repertoire has thus far precluded the ability to follow these T cells and thereb

229 occurrence in resource-limited settings have precluded the acquisition of extensive clinical and labo

230 d limitations in targeted read coverage have precluded the detection of rare DNA sequence variants by

231 ure of the Ae. tauschii genome has until now precluded the development of a reference-quality genome

232 Such daily problem-solving precluded the development of S-R seeking habits.

233 r, 48.6% believed that eating a healthy diet precluded the need for HCC surveillance, and 34.0% belie

234 nterferon signaling and STAT1 activation, it precluded the nuclear translocation specifically of STAT

235 but the use of pure tones or noise bands has precluded the possibility of dissociating pitch from bri

236 tions presented by this enormous family have precluded the synthesis of many unique members.

237 his cost mount up, as resistance curtails or precludes the activities of some of our most effective d

238 s(326)), known to act as a redox switch that precludes the allosteric activation of bGP by AMP.

239 s disulfide bond acts as a redox switch that precludes the allosteric activation of the enzyme by AMP

240 n cellular transcription, which consequently precludes the cellular antiviral response and/or induces

241 large concentration of free-carriers in GeTe precludes the coupling of external electric field with i

242 hat no two nanoparticles are the same, which precludes the deep understanding of many fundamental pro

243 y p-type materials have been reported, which precludes the development of complementary circuits, and

244 y in seeking behavior, which, by definition, precludes the development of habits.

245 This precludes the direct transfer of the strategies previous

246 nt sequencing methods are error-prone, which precludes the identification of low frequency mutations

247 e of the potential-of-mean-force calculation precludes the inclusion of the conformational change on

248 DraB chaperone, indicating a mechanism that precludes the incorporation of less stable, non-oxidized

249 competing risk is an event whose occurrence precludes the occurrence of the primary event of interes

250 The absence of these capabilities precludes the possibility of comprehensively exploring s

251 nt segmentation of the signal, and virtually precludes the possibility of making comparative studies

252 basis of large tumour size and anatomy that precludes the possibility of safe and radical resection.

253 f the mechanisms driving structure selection precludes the predictive synthesis of polymorphic materi

254 volume, which introduces signal smearing and precludes the scanning of complex structures.

255 horizontal gene transfer (HGT) in bdelloids precludes the sexual transmission of entire haplotypes,

256 the severity of ZIKV infection in these mice precludes the study of foetal (vertical) viral transmiss

257 e and often extended acquisition times which precludes the study of structural dynamics such as defec

258 mphotericin MICs with zone diameters (-0.42) precludes the use of amphotericin B disk diffusion for s

259 es high yields and catalyst reusability, and precludes the use of organic solvents.

260 develop an efficient barcode joining scheme precludes the widespread application of this approach, w

261 f a stable dCas9 effector can be a draw-back precluding the ability to switch rapidly between repress

262 ated transcription factor TIF-IA at Ser-635, precluding the assembly of transcription initiation comp

263 g environmental deoxyribonucleic acid (DNA), precluding the need for pure cultures or screening of re

264 ometry (ICPOES) allows for a quick analysis, precluding the need for time-consuming acid digestion th

265 e stimulus lasted <1 typical whisking cycle, precluding the use of active whisking.

266 that codes for the receptor remains unknown, precluding the use of modern biological methods to study

267 ctors Tsr1, Enp1, Rio2 and Pno1 collectively preclude their final maturation, thereby preventing unti

268 t, and limited availability of strain typing preclude their routine use.

269 sh, or had a cognitive disability that would preclude their understanding of the survey questions.

270 ivity cause on-target side effects that have precluded their further development.

271 following their production, which has so far precluded their optical spectroscopy.

272 complexity of Pol II, TFIID, and TFIIH have precluded their reconstitution from heterologous systems

273 entifying these rare cells by microscopy has precluded their routine use in monitoring or screening f

274 Whereas their featureless ground states have precluded their straightforward experimental identificat

275 cules from the parent indigo dye have so far precluded their use.

276 e micron-sized particles in liver and spleen precludes their clinical use and limits the translationa

277 sity of MTs in the spindle, which presumably precludes their direct observation.

278 s and the fact that their microheterogeneity precludes their isolation in single and pure enough form

279 , and their rapid excited-state deactivation precludes their use as photosensitizers.

280 at they are unstable (DeltaG > 30 kcal/mol), precluding their formation under mild conditions.

281 ontrolling the level of carbon dioxide, thus precluding them from modelling the relationship between

282 t unresolved host-symbiont conflict may have precluded these wild-type symbioses from rising to ecolo

283 ficant risk of cyst hemorrhage and infection precluded this procedure.

284 Inadequate [Mg(2+)] precludes this alleviation, making mgtL translation inef

285 hatidylethanolamine in enveloped virions and precludes TIM1 binding, reduced ZIKV infection in placen

286 iaphragm force is commonly assessed ex vivo, precluding time course studies.

287 major vascular anomalies do not necessarily preclude transplantation in complex pediatric patients a

288 vide sufficient prognostic discrimination to preclude treatment with TAVR.

289 ADP-ribosylation of the Ub carboxyl terminus precludes ubiquitylation.

290 rated iodine (I2 ) as I3 (-) , this approach precludes undesired I2 -mediated decomposition which can

291 tant phenotype, identification of which will preclude use of these agents with their potential side e

292 ctivity with oxygen while their larger sizes preclude use of traditional anion receptors.

293 cal data from longitudinal follow-up studies precludes valid conclusions on possible delayed and adve

294 here are no strong developmental constraints precluding variation in microsporogenesis, and that the

295 s (residues 50 to 60 or residues 110 to 120) precluded viral replication, whereas the truncation of t

296 y across a broad frequency range and further precludes visually induced changes in beta and gamma osc

297 Although m(6)A does not preclude Watson-Crick base pairing, the N(6)-methyl grou

298 been developed, but their limited diffusion precludes whole-body imaging at visceral sites.

299 A-based therapies act systemically, this may preclude widespread clinical use.

300 Our results preclude X-X incompatibilities and instead support an in