ライフサイエンスコーパス: preconditioning

1 ection-conferring episode of brief ischemia (preconditioning).

2 those undergoing short-duration ischemia or preconditioning).

3 mune response, are implicated in gray matter preconditioning.

4 bone fractures after total body irradiation preconditioning.

5 se events were reported with remote ischemic preconditioning.

6 of host immunity often obviates the need for preconditioning.

7 nt of signaling cascades leading to ischemic preconditioning.

8 mediated autophagy in isoflurane and hypoxic preconditioning.

9 usion, a phenomenon known as remote ischemic preconditioning.

10 ion injury, and cardioprotection by ischemic preconditioning.

11 cription and is required for remote ischemic preconditioning.

12 the expected loss was prevented by ischemic preconditioning.

13 improved recovery due to sevoflurane-induced preconditioning.

14 f the cardioprotection conferred by ischemic preconditioning.

15 investigated cell type-specific responses to preconditioning.

16 indeed an important mediator in GTPP-induced preconditioning.

17 verse events were related to remote ischemic preconditioning.

18 roved recovery following sevoflurane-induced preconditioning.

19 fact that antioxidants blocked GTPP-induced preconditioning.

20 that were subjected to stroke without prior preconditioning.

21 suffice to mediate local and remote ischemic preconditioning.

22 entral to the protective effects of exercise preconditioning.

23 ere not given a diagnosis of UTI, or reflect preconditioning.

24 polarization) was assessed immediately after preconditioning.

25 reduced in mice treated with remote ischemic preconditioning.

26 once the therapy can be applied without the preconditioning.

27 proteinases 2 after surgery (remote ischemic preconditioning, 0.36 vs control, 0.97 ng/mL2/1000; diff

28 %], respectively; hazard ratio with ischemic preconditioning, 0.95; 95% confidence interval, 0.79 to

29 Patients received either remote ischemic preconditioning (3 cycles of 5-minute ischemia and 5-min

30 d management, 7 on immunosuppressants, 12 on preconditioning, 34 on preservation fluids, and 21 on pu

31 s significantly reduced with remote ischemic preconditioning (45 of 120 patients [37.5%]) compared wi

32 Amifostine preconditioning activates lung tissue antioxidant cell d

33 osurvival isoenzyme PKCepsilon, resulting in preconditioning against cell death induced by OGD/R.

34 The novel use of chloroquine as a macrophage-preconditioning agent presents a straightforward approac

35 imal studies that isoflurane, when used as a preconditioning agent, has neuroprotective properties, i

36 a paucity of IL-7 in the immune milieu, CTX preconditioning allowed adoptively transferred naive tum

37 Thus, although ischemic preconditioning allowed hepatocytes to better withstand

38 Ischemic preconditioning also induces autophagy, but the contribu

39 comparisons involving xanthine and ischemic preconditioning, although the impact of NAC and xanthine

40 gnaling pathways that contribute to ischemic preconditioning and cardioprotection, high levels of ROS

41 poptosis, and this effect can be enhanced by preconditioning and encapsulation in a fibrin scaffold.

42 he protective responses induced by ischemia, preconditioning and exercise.

43 nhibitors and beneficial actions of ischemic preconditioning and ischemic postconditioning by a mecha

44 nifold biological functions, such as hypoxic preconditioning and neuronal migration.

45 iption factors are required for TLR-mediated preconditioning and neuroprotection.

46 r antigen disparate murine transplant model, preconditioning and postconditioning treatment with AAT

47 ophages are essential mediators of endotoxin preconditioning and required for renal tissue protection

48 an established model for in vitro ischaemic preconditioning and show that Kv2.1 channel modulation i

49 preparation of worms for harsh desiccation (preconditioning) and during the entry of yeast into stat

50 ow for successful reperfusion is extended by preconditioning, and how long the duration of ischemia c

51 hemic preconditioning (IPC), remote ischemic preconditioning, and ischemic postconditioning in 2 rode

52 xanthine, NAC, NaHCO3, NAC+NaHCO3, ischemic preconditioning, and natriuretic peptide may have nephro

53 ine, dopaminergic agent, peripheral ischemic preconditioning, and natriuretic peptide.

54 direct surgical bypass procedures, ischaemic preconditioning, and new anticoagulants (direct thrombin

55 cGMP-degrading phosphodiesterase-5, ischemic preconditioning, and postconditioning regimens.

56 Ischemic preconditioning appears to sustain the beneficial effect

57 Increasing RA clearance efficiency using a preconditioning approach can counteract the increased su

58 te the clinical evidence for remote ischemic preconditioning as a potential strategy to protect the k

59 However, the protective mechanisms of preconditioning at the tissue level in organs such as th

60 Remote ischemic preconditioning before contrast medium use prevents cont

61 schemic preconditioning), or pharmacological preconditioning before transection.

62 ocking mitochondrial K(ATP) channels removed preconditioning benefits of IH, similar to mechanisms in

63 ate that autophagy is involved in isoflurane preconditioning both in vivo and in vitro and that SPK2

64 K2) and autophagy are both involved in brain preconditioning, but whether preconditioning-induced SPK

65 d a similar number of TSPNs, indicating that preconditioning can generate space efficiently for trans

66 Endotoxin preconditioning can thus be used as a discovery platform

67 However, ischemic preconditioning cannot be used to reduce infarct size in

68 ents, with unfractionated GTPP more potently preconditioning cells than EGCG.

69 vivo mouse cerebral focal ischemia models of preconditioning, cellular injury, and neuroprotection.

70 undergoing cardiac surgery, remote ischemic preconditioning compared with no ischemic preconditionin

71 This survival effect was associated with a preconditioning condition that resulted from induction o

72 Here, we show that endotoxin preconditioning confers renal epithelial protection in v

73 ction of anesthesia) or sham remote ischemic preconditioning (control), both via blood pressure cuff

74 emic preconditioning or sham remote ischemic preconditioning (control).

75 However, whether octreotide preconditioning could also reduce acute kidney injury (A

76 Both diabetes mellitus and preconditioning CSCs in high glucose attenuated the proa

77 Preconditioning CSCs with CoPP also induced an increase

78 Further, preconditioning CSCs with CoPP led to a global increase

79 hydrogenase release assays demonstrated that preconditioning CSCs with CoPP markedly enhanced cell su

80 Both regimens comprised preconditioning cytoreduction with hydroxyurea and azath

81 ed significantly with the amount of busulfan preconditioning delivered to patients and to CD34(+) cel

82 Remote ischemic preconditioning did not improve clinical outcomes in pat

83 results from direct interactions between the preconditioning dose of endotoxin and the renal tubules.

84 In immune cells, endotoxin preconditioning downregulates the inflammatory response

85 sis (two studies) showed that ischemic liver preconditioning during harvesting procedures did not ben

86 sized that RIC before shock (remote ischemic preconditioning), during shock (remote ischemic "PER"con

87 he tone and light and eliminated the sensory preconditioning effect.

88 n has been termed both hormesis and exercise preconditioning (EPC).

89 Lack of hepatic preconditioning, extrahepatic extension of resection, an

90 ouse model that does not require irradiation preconditioning for human HSC engraftment and immune sys

91 Despite the potential of ischemic preconditioning for organ protection, long-term effects

92 ts were randomly assigned to remote ischemic preconditioning (four 5-minute inflations and deflations

93 ects of host cytokines and demonstrates that preconditioning freshly isolated islets in culture with

94 years remained lower in the remote ischemic preconditioning group (hazard ratio, 0.58; 95% confidenc

95 rol group and 6 (12%) in the remote ischemic preconditioning group (odds ratio, 0.21; 95% confidence

96 between the patients in the remote ischemic preconditioning group and those in the control group (21

97 benefit in MACCE rate in the remote ischemic preconditioning group was sustained long-term.

98 in the control group and 801 in the ischemic-preconditioning group) at 30 cardiac surgery centers in

99 ably, we found that tubular protection after preconditioning has an absolute requirement for CD14-exp

100 Ischemic preconditioning has been successfully applied to prevent

101 Sensory preconditioning has been used to implicate midbrain dopa

102 The mechanisms of preconditioning have been investigated extensively in is

103 Therefore, we determined whether preconditioning hCSCs with CoPP promotes CSC survival.

104 Thus, preconditioning hCSCs with DETA-NO promotes cell surviva

105 Mice underwent hypoxic preconditioning (HPC) by breathing 10% oxygen for 10 min

106 The Cardiac Remote Ischemic Preconditioning in Coronary Stenting (CRISP Stent) study

107 Volatile anesthetics provide myocardial preconditioning in coronary surgery patients.

108 ditioning and all studies on remote ischemic preconditioning in patients with AMI reported reduced in

109 determined consequences of hepatic ischemic preconditioning in rats, including cell transplantation

110 with preadministration of vehicle, endotoxin preconditioning in the cecal ligation and puncture mouse

111 We found that sevoflurane-induced preconditioning in the rat hippocampal slice enhances th

112 tissue-protective effects of remote ischemic preconditioning in various target organs, including the

113 s study, we demonstrate that remote ischemic preconditioning increases plasma IL-10 levels and decrea

114 Such preconditioning increases the expression of stem cell fa

115 ortical neurons, both isoflurane and hypoxic preconditioning induced autophagy.

116 ls play an important role in remote ischemic preconditioning induced by clamping the femoral artery f

117 Ischemic preconditioning induced persistent alterations; for exam

118 In addition, interleukin 6 preconditioning induced secretion of vascular endothelia

119 Beclin 1 knockdown abolished preconditioning-induced autophagy, and SPK2 inhibitors a

120 vo and in vitro and that SPK2 contributes to preconditioning-induced autophagy, possibly by disruptin

121 4640 and SKI-II) or SPK2 knockdown prevented preconditioning-induced autophagy.

122 Mitigation of ischemic preconditioning-induced DNA damage and deleterious molec

123 volved in brain preconditioning, but whether preconditioning-induced SPK2 up-regulation and autophagy

124 itors (3-methyladenine or KU55933) abolished preconditioning-induced tolerance.

125 onger than previously established windows of preconditioning-induced tolerance.

126 ecause even short periods of ischemia during preconditioning inevitably lead to hypoxia and formation

127 Preconditioning inhibited these changes in p-Bcl-2, Becl

128 We observe that a sublethal ischaemic preconditioning insult also leads to Kv2.1 redistributio

129 t that FK866 acts as a simple and applicable preconditioning intervention to protect against ALF; aut

130 hemic insult, a phenomenon known as ischemic preconditioning (IP).

131 bundle was compared against direct ischemic preconditioning (IPC) and the standard of care intermitt

132 Ischemic preconditioning (IPC) has been studied predominantly in

133 Ischemic preconditioning (IPC) is a robust neuroprotective phenom

134 PURPOSE OF REVIEW: Ischemic preconditioning (IPC) is gaining attention as a novel ne

135 It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC

136 AAR (% of left ventricle) following ischemic preconditioning (IPC) or cyclosporin-A (CsA) treatment.

137 nism similar to what is observed in ischemic preconditioning (IPC) response.

138 size and the protective effects of ischemic preconditioning (IPC), remote ischemic preconditioning,

139 emia and the tolerance conferred by ischemic preconditioning (IPC), would reveal new neuroprotective

140 emic episode, a phenomenon known as ischemic preconditioning (IPC).

141 pisodes of forearm ischemia (remote ischemic preconditioning [IPC]) reduce exercise-induced platelet

142 Inflammatory preconditioning is a mechanism in which exposure to smal

143 Preconditioning is a preventative approach, whereby mini

144 These results show that ALA preconditioning is capable of reducing inflammatory mark

145 ne in the myocardium in response to ischemic preconditioning is NF-kappaB-dependent and necessary for

146 Ischemic preconditioning is the phenomenon whereby brief periods

147 Preconditioning is, therefore, an attractive model to in

148 abrogates the protective effects of ischemic preconditioning, is not associated with ischemia or isch

149 Blocking p42/p44 MAPK activation following preconditioning ischemia with U0126 or using the nonphos

150 One hour following preconditioning ischemia, the binding of Bim to TRIM2 in

151 We delivered a brief in vivo preconditioning ischemic insult (unilateral common carot

152 mportantly, hypoxic response was improved by preconditioning islets to intermittent hypoxia (IH, 1 mi

153 the appropriate intensity of remote ischemic preconditioning, its mechanisms of action, and the role

154 nes in sensory neurons and contribute to the preconditioning lesion effect.

155 however, DLK KO neurons do not respond to a preconditioning lesion with enhanced regeneration in viv

156 ppetitive behavior as this signal returns to preconditioning levels with extended training.

157 ing, but most effects eventually reverted to preconditioning levels.

158 siological effects of metabolic dilation and preconditioning-like mitochondrial ATP-sensitive potassi

159 Remote ischemic preconditioning may offer a novel, noninvasive, and inex

160 Remote ischemic preconditioning may result in reduction in infarct size

161 eperfusion-induced brain injury and ischemic preconditioning-mediated neuroprotection.

162 Together, these findings suggest that VEGF preconditioning might be harnessed for long-term neuroge

163 odel of cisplatin ototoxicity and found that preconditioning mouse inner ears with sound has a robust

164 tandard care with (n=50) or without ischemic preconditioning (n=50; intermittent arm ischemia through

165 A preconditioning nerve injury increases the levels of amp

166 , utilization of natural products capable of preconditioning neuronal cells against ischemia-induced

167 Furthermore, in early preconditioning, NO acts through the canonical cGMP path

168 Anaesthetic preconditioning occurs when a volatile anaesthetic, such

169 Preconditioning of c-kit(+) CSCs via HDAC inhibition wit

170 of the heme complex in myoglobin during the preconditioning of ex vivo cardiomyocytes with pharmacol

171 Engraftment of human HSC requires preconditioning of immunodeficient recipients, usually w

172 We hypothesized that preconditioning of mesenchymal stromal cells with carbon

173 exposure to low-dose DM and MSCs, as well as preconditioning of PBMCs with MSCs, caused refractorines

174 nous mechanisms for myocardial repair or for preconditioning of stem cells before transplantation.

175 This approach requires preconditioning of the host liver to enhance engraftment

176 First, we show that cardiac ischemic preconditioning of the in vivo mouse heart results in de

177 To date, little is known about opioid preconditioning of the intestine.

178 The specific preconditioning of the polymer by alternative exposure t

179 deceleration of the event, was caused by the preconditioning of the upstream solar wind by an earlier

180 Preconditioning of wild-type mice revealed a similar num

181 l to establish the effect of remote ischemic preconditioning on clinical outcomes.

182 was to assess the impact of remote ischemic preconditioning on contrast medium-induced acute kidney

183 was no significant effect of remote ischemic preconditioning on myocardial infarction, stroke, or mor

184 gent mechanism of neuroprotection induced by preconditioning--one that potentially results in reprogr

185 A-expressing gamma-retroviral vector without preconditioning or after 200 cGy or 900 cGy total-body i

186 -ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2-sensing HIF (h

187 Brief periods of ischemia (ischemic preconditioning or IPC) can reduce neuronal death in res

188 e randomized them to receive remote ischemic preconditioning or sham remote ischemic preconditioning

189 ave was blunted or absent in pigs undergoing preconditioning or short-duration ischemia, respectively

190 ry occlusion/reperfusion preceding (ischemic preconditioning) or following (ischemic postconditioning

191 iod of ischemia before transection (ischemic preconditioning), or pharmacological preconditioning bef

192 on ischemia), prolonged ischemia preceded by preconditioning, or prolonged ischemia followed by postc

193 Preconditioning output effects were gradually restored d

194 ion of the brain in the context of ischaemic preconditioning, oxygen sensing and thrombolysis.

195 Here, we evaluate an alternative approach of preconditioning pancreatic islets before transplantation

196 In a sensory preconditioning paradigm, 'indirect' objects were paired

197 Nonetheless, ischemic preconditioning partially protected from toxic liver inj

198 ), whereas it is increased in ischemic brain preconditioning (PC) by hypoxia-inducible factor 1 (HIF-

199 The molecular mechanisms underlying preconditioning (PC), a powerful endogenous neuroprotect

200 verexpressing NCX1 and subjected to ischemic preconditioning (PC+OGD/RX), the neurotoxic effect of p3

201 Silencing RSC neurons during the Preconditioning phase prevented the formation of an asso

202 esented alone on the other trials during the Preconditioning phase.

203 In renal tubules, preconditioning prevented peroxisomal damage and abolish

204 i and control rats were trained in a sensory preconditioning procedure in which a tone and light were

205 Isoflurane and hypoxic preconditioning protected against subsequent oxygen gluc

206 Interleukin 6 preconditioning protected the grafted neural stem cells

207 Minocycline preconditioning protected the grafted NSCs from ischemic

208 nd PKMzeta activity are required to maintain preconditioning protection.

209 These data indicate that sound preconditioning protects against both classes of ototoxi

210 Fewer patients receiving remote ischemic preconditioning received renal replacement therapy (7 [5

211 2.25%-17.75%; P = .01), and remote ischemic preconditioning reduced intensive care unit stay (3 days

212 ent) study demonstrated that remote ischemic preconditioning reduced procedural symptoms, ECG ST-segm

213 Furthermore, endotoxin preconditioning reduced serum levels of proinflammatory

214 Remote ischemic preconditioning reduces the incidence of postprocedural

215 ine a simple, nontoxic, and highly effective preconditioning regimen to enhance the response of epith

216 who received high-dose steroids as part of a preconditioning regimen.

217 s as well as development and optimization of preconditioning regimens for functional engineered tissu

218 be given for the safety of steroids in donor-preconditioning regimens.

219 diating the protective response generated by preconditioning remains unknown.

220 In mice subjected to S/R, remote ischemic preconditioning, remote ischemic "PER"conditioning, and

221 We conclude that preconditioning reprograms macrophages and tubules to ge

222 GTPP-induced preconditioning required the 67-kDa laminin receptor (67

223 er completion of a 2-week repetitive hypoxic preconditioning (RHP) protocol.

224 Remote ischemic preconditioning (RIPC) by brief arm ischemia/reperfusion

225 Remote ischemic preconditioning (RIPC) by repeated brief cycles of limb

226 Remote ischemic preconditioning (RIPC) by repeated brief cycles of limb

227 the renoprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing adult card

228 Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers

229 Additionally, remote ischemic preconditioning (RIPC) may have higher translational val

230 Remote ischemic preconditioning (RIPC) protects against liver ischemia r

231 udy was to determine whether remote ischemic preconditioning (RIPC) protects aged liver against ische

232 Remote ischemic preconditioning (rIPC) with short episodes of ischemia/r

233 Remote ischemic preconditioning (rIPC), defined as transient brief episo

234 In remote ischemic preconditioning (RIPC), ischemia to one organ protects o

235 f myocardial infarct size by remote ischemic preconditioning (RIPC), that is, cycles of ischemia/repe

236 Remote ischemic preconditioning (RIPC), the repetitive transient mechani

237 ar male rats were subjected to either remote preconditioning (RPC) or sham surgery and then subsequen

238 Other modalities of preconditioning should be tested.

239 Remote ischemic preconditioning significantly attenuated the release of

240 between centers and confirmed that ischemic preconditioning significantly reduced infarct size in al

241 ic preconditioning compared with no ischemic preconditioning significantly reduced the rate of acute

242 Following ischemic preconditioning, SNO occupancy increased to an intermedi

243 Interestingly, all three preconditioning stimuli resulted in a reprogrammed respo

244 schemic tolerance can be induced by numerous preconditioning stimuli, including various Toll-like rec

245 aemic tolerance induced by a wide variety of preconditioning stimuli.

246 inutes-hours) or late (days-weeks) after the preconditioning stimulus.

247 or immunoadsorption appeared to be promising preconditioning strategies before ABOi kidney transplant

248 OS-generating system bypassed 67LR to induce preconditioning, suggesting that sublethal levels of ROS

249 may act as a clinical surrogate of ischemic preconditioning that may reduce infarct size and improve

250 t VEGFs and Angs induce a state of 'vascular preconditioning' that may predispose to angioedema attac

251 In late preconditioning, the protection is mediated by peroxynit

252 fficacy and safety of the different types of preconditioning therapies are unclear.

253 ed evidence about the effects of any form of preconditioning therapies in living donor ABOi kidney tr

254 of different types, dosing, and frequency of preconditioning therapies so that this scarce resource c

255 Oi kidney transplantations using any form of preconditioning therapies.

256 th induced by oxidative stress after DETA-NO preconditioning; this cytoprotective effect was abolishe

257 sponse, we found that the ability of thermal preconditioning to limit heat-induced cytoskeletal disru

258 te CAESAR, we tested the ability of ischemic preconditioning to reduce infarct size in 3 species (at

259 dification of the NSG host environment using preconditioning total body irradiation (TBI) was indispe

260 Whether remote ischemic preconditioning (transient ischemia and reperfusion of t

261 in real time, could be used to evaluate the preconditioning treatment of cardiomyocytes and to predi

262 Evaluation of the preconditioning treatment was done at the single-cell le

263 of the NO-donor was completed, where, if the preconditioning treatment was successful, the bands corr

264 on highlights the opportunity for additional preconditioning trials of remote ischemia, gases, opioid

265 Remote ischemic preconditioning, triggered by brief episodes of ischemia

266 Remote ischaemic preconditioning uses brief ischaemia and reperfusion of

267 Remote ischemic preconditioning, using cycles of upper limb ischemia-rep

268 conditioning with these TLR ligands and with preconditioning via exposure to brief ischemia.

269 (V) induced by repetitive depolarizations or preconditioning voltage steps decays within tens of mill

270 We investigated if Naja sputatrix venom preconditioning (VPC) reduces surgical brain injury (SBI

271 Ischemic preconditioning was blocked in rat hearts perfused with

272 ponectin, and secretory leukoprotease during preconditioning was essential to the renoprotective prop

273 PKMzeta and KATP channel activity after the preconditioning was established, we administered 4% sevo

274 Preconditioning was increased by conditional overexpress

275 veral cell signaling molecules after DETA-NO preconditioning was observed by Western blotting, includ

276 The crucial role of PKC in GTPP-induced preconditioning was supported by use of its specific inh

277 Neurogenic enhancement by VEGF preconditioning was, in part, attributed to rescue of ag

278 To elucidate the molecular mechanisms of preconditioning, we compared brain genomic profiles in r

279 Using sensory preconditioning, we show that prediction errors underlyi

280 missive for donor T-cell engraftment without preconditioning, whereas the presence of NK cells is a s

281 roM) on cell migration were alleviated after preconditioning with 10 microM-RS.

282 Preconditioning with a low dose of endotoxin confers unp

283 However, use of preconditioning with alkylating agents is associated wit

284 Ischaemic preconditioning with brief coronary occlusion and reperf

285 Thus, the hypothesis was that preconditioning with C. atrox venom will produce fibrino

286 Ex vivo preconditioning with carbon monoxide allowed mesenchymal

287 The aim of this study was to evaluate preconditioning with Crotalus atrox venom (Cv-PC) as pot

288 0 min of SE was prevented by neuroprotective preconditioning with ECS-evoked seizures.

289 These results indicate that preconditioning with interleukin 6, which reprograms neu

290 The discovery of preconditioning with ischemia is discussed, together wit

291 Additionally, preconditioning with minocycline induced the NSCs to rel

292 Thus, preconditioning with minocycline, which reprograms NSCs

293 actoriness of PBMCs to DM was examined after preconditioning with MSCs and after repeated challenge w

294 Donor preconditioning with NOD leads to better graft function

295 rease in lipid peroxidation was prevented by preconditioning with remifentanil (P < 0.05).

296 Preconditioning with remifentanil attenuates intestinal

297 In this study, we report that preconditioning with the synthetic dsRNA polyinosinic-po

298 mpared brain genomic profiles in response to preconditioning with these TLR ligands and with precondi

299 Pharmacological protection by pretreating ("preconditioning") with opioids attenuates IRI in a numbe

300 or status epilepticus that followed seizure preconditioning, with >90% of the promoters of these gen

301 es of XIAP, combined with mitochondrial XIAP preconditioning, would reduce MOMP signaling.