ライフサイエンスコーパス: precursor B-cell

1 istration rescue anergic Env(+) (non-edited) precursor B cells.

2 the expression of naked IgL on a surface of precursor B cells.

3 e, replenishment must involve replication of precursor B cells.

4 ication artifacts and are unique to leukemic precursor B cells.

5 D86, but not CD80, on follicular, MZ, and MZ precursor B cells.

6 e bnAb induction by activating bnAb germline precursor B cells.

7 ice despite a significant loss of H3K9me2 in precursor B cells.

8 d recombination of Iglambda gene segments in precursor B cells.

9 n from B220+CD43+ progenitor B to B220+CD43- precursor B cells.

10 y and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL).

11 Ikaros (IKZF1) is a hallmark of BCR-ABL1(+) precursor B cell acute lymphoblastic leukemia (pre-B ALL

12 quencies in T-cell acute LL and hyperdiploid precursor B-cell acute LL.

13 The prognosis for adults with precursor B-cell acute lymphoblastic leukemia (B-ALL) re

14 IKAROS function indicates poor prognosis in precursor B-cell acute lymphoblastic leukemia (B-ALL).

15 To test the suitability of targeting CD22 on precursor B-cell acute lymphoblastic leukemia (BCP-ALL),

16 BCR-ABL1(+) precursor B-cell acute lymphoblastic leukemia (BCR-ABL1(

17 d on xenografts from pediatric patients with precursor B-cell acute lymphoblastic leukemia (pre-B ALL

18 Similar results were obtained in human precursor B-cell acute lymphoblastic leukemia lines when

19 As few ETV6-RUNX1 carriers develop precursor B-cell acute lymphocytic leukemia (pB-ALL), th

20 the clonal evolution of a form of childhood precursor-B cell acute lymphoblastic leukemia that is ch

21 ecently been established from a patient with precursor-B-cell acute lymphoblastic leukemia (ALL), whi

22 and TCF3-PBX1 (E2A-PBX1)-frequently found in precursor-B-cell acute lymphoblastic leukemia (preB-ALL)

23 In developing B cells, the IL-7R and precursor B cell Ag receptor (pre-BCR) synergize to indu

24 -consolidation marrows in 2143 children with precursor B-cell ALL (B-ALL).

25 rmed genomic profiling of 1725 patients with precursor B-cell ALL and detailed genomic analysis of 15

26 In patients with precursor B-cell ALL and PGR, survival after relapse was

27 r patients with PGR in the large subgroup of precursor B-cell ALL, dexamethasone especially reduced t

28 ined that LOH of 6q was demonstrated both in precursor-B cell ALLs (15 of 93; 16%) and in T cell ALLs

29 Many of the cell fate decisions in precursor B cells and more mature B cells are controlled

30 caused no change in the cell cycle status of precursor B cells and only modest changes in cycling pro

31 up-regulation of CD86(high) expression on MZ precursor B cells and trafficking of MZ precursor B cell

32 in lentivirus vectors and used to transduce precursor B-cell and myeloid progenitor cell lines.

33 lete loss of marginal zone and marginal zone precursor B cells, and 'preferential' population expansi

34 on of plasmacytoid dendritic cells (DCs), MZ precursor B cells, and CD4 T cells in the spleens of BXD

35 ular mimicry in Graves' disease, where early precursor B cells are expanded by Y. enterocolitica pori

36 ified impaired Ig locus contraction in adult precursor B cells as a likely mechanism by which ID2-med

37 ferentiation into germinal center and memory precursor B cells as well as preplasmablasts that rapidl

38 Precursor B cells assemble a diverse repertoire of immun

39 ings expand the range of NF-kappaB action in precursor B cells beyond Igkappa to include the control

40 ntified on splenic marginal zone (MZ) and MZ precursor B cells, but not on the bulk of newly formed B

41 arily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopoly

42 n IFN receptor-intact BXD2 mouse spleens, MZ precursor B cells clustered at the T cell-B cell border.

43 Notably, the composition of the precursor B cell compartment did not change with age.

44 49F) and IL-7Ralpha(-/-) mice had comparable precursor B cell defects, indicating that signaling from

45 However, MZ precursor B cells demonstrated the highest expression of

46 ed in a blockage of the progenitor B-cell-to-precursor B-cell development in bone marrow (BM) and B-c

47 We studied precursor B-cell development, immunoglobulin and T-cell

48 All patients showed a block in the precursor B-cell development, low B- and T-cell numbers,

49 dependent on sufficient levels of IL-7 than precursor B cell differentiation because the number of B

50 The transcription factor E2A can promote precursor B cell expansion, promote G(1) cell cycle prog

51 se renin-expressing progenitors enriches the precursor B-cell gene programme and constrains lymphocyt

52 How TSAbs arise from early precursor B cells has not been established.

53 rturbs B-cell development, as evidenced by B-precursor/B-cell hyperplasia, and corrupts the regulatio

54 69 and CD86 observed in RBP(+) marginal zone precursor B cells in the spleens of BXD2 mice compared w

55 continue to express markers associated with precursor B cells including RAG gene products.

56 LBL (T-LBL) and six (8%) of 73 patients with precursor B-cell LBL (pB-LBL) suffered from relapse.

57 uption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA

58 Children younger than 6 years of age with precursor B-cell leukemia and no adverse genetic feature

59 with chemotherapy, whereas patients who have precursor B-cell leukemia without other adverse features

60 ed with a favorable outcome in patients with precursor B-cell leukemia.

61 Thus, precursor B-cell leukemias maintain evolution at the IgH

62 nt patient with Epstein-Barr virus-negative, precursor B cell lymphoblastic lymphoma diagnosed 6 mont

63 Precursor B cell lymphoblastic lymphoma has not been pre

64 al of immunosuppression, and a biopsy showed precursor B cell lymphoblastic lymphoma.

65 Leukemic precursor B cells may continue to undergo recombination

66 or (SDF)-1 is a chemoattractant for T cells, precursor B cells, monocytes, and neutrophils.

67 er(fl/fl)/Emicro-myc mice were of very early precursor B-cell origin, a stage of B-cell development p

68 4-year event-free survival (EFS) for the 71 precursor B-cell patients was 70.1% +/- 5.8%.

69 serve to distinguish between the presumed MZ precursor B cell population in the spleen and other IgD-

70 ontrol the progenitor B cell (pro-B cell) to precursor B cell (pre-B cell) transition have not been w

71 ates with GC sensitivity in a panel of human precursor B-cell (pre-B) acute lymphoblastic leukemia (A

72 Precursor B cell production from bone marrow in mice and

73 tive protein as determined by stimulation of precursor B-cell proliferation.

74 a tertiary structure capable of stimulating precursor B-cell proliferation.

75 e critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for r

76 truncated/V(H)-less mouse H chain Dmu forms precursor B cell receptors with the surrogate L chain co

77 expression of Blimp-1 in Abelson-transformed precursor B cells repressed endogenous c-Myc and caused

78 ms behind are still unknown, we studied five precursor B cell subsets (ProB, PreBI, PreBII large, Pre

79 Precursor B cell survival is more dependent on sufficien

80 bs are important vaccine leads because their precursor B cells targeted by an engineered priming immu

81 approximately 10 times fewer virus-specific precursor B cells than normal spleen cells, had no signi

82 n MZ precursor B cells and trafficking of MZ precursor B cells to the T cell-B cell border to provide

83 gH) locus and a block in the progenitor-B-to-precursor-B-cell transition, which was partially rescued

84 to prime specific and exceedingly rare bnAb-precursor B cells within a humanlike repertoire.