ライフサイエンスコーパス: precursor lesion

1 melanoma earlier and through the removal of precursor lesions).

2 e absence of a well-defined, intraepithelial precursor lesion.

3 stage in the sequence of development from a precursor lesion.

4 e to the malignant transformation of gastric precursor lesions.

5 verexpressed in esophageal carcinoma and its precursor lesions.

6 ) in both human colorectal cancers and their precursor lesions.

7 or the prevention of cervical cancer and its precursor lesions.

8 adenomas and flat dysplasias are regarded as precursor lesions.

9 tumor antigens (Nd2 and sialyl Tn) in these precursor lesions.

10 een elucidated in the context of noninvasive precursor lesions.

11 r development but is also observed in benign precursor lesions.

12 is also present in early human atheroma and precursor lesions.

13 ool to examine DPC4 status in these putative precursor lesions.

14 tly decreased the incidence of chest and ear precursor lesions.

15 ing the evolution of an invasive cancer from precursor lesions.

16 bnormalities were detected in the associated precursor lesions.

17 s of 37 primary melanomas and their adjacent precursor lesions.

18 traductal papillary mucinous neoplasm (IPMN) precursor lesions.

19 (ccRCCs) is believed to develop from cystic precursor lesions.

20 venile polyps in CS are bona fide neoplastic precursor lesions.

21 gulated in pancreatic cancers and associated precursor lesions.

22 tiation and maintenance of pancreatic cancer precursor lesions.

23 tenance and progression of pancreatic cancer precursor lesions.

24 in detection of both early cancer and cancer precursor lesions.

25 oma, squamous-cell carcinomas can arise from precursor lesions.

26 revention by detection and removal of cancer precursor lesions.

27 venting the onset of cancers in mice bearing precursor lesions.

28 e-adjusted prevalence and location of cancer precursor lesions.

29 s demonstrating cells exfoliated from cancer precursor lesions.

30 ution of bladder cancer from intraurothelial precursor lesions.

31 d carriers have normal numbers of neoplastic precursor lesions, a relatively low phenotypic penetranc

32 Beginning with precursor lesions, aberrant DNA methylation marks the en

33 s cell carcinoma (SCC) as well as dysplastic precursor lesions, actinic keratoses.

34 the treatment of SCCs and their premalignant precursor lesions, actinic keratoses.

35 is relation is less well established for the precursor lesions, adenomatous polyps.

36 evelop anal invasive cancer or its immediate precursor lesion, anal carcinoma in situ (CIS).

37 By focusing on a cancer precursor lesion and using a variety of methods to asses

38 frequent early event in a distinct subset of precursor lesions and colorectal cancer (CRC) associated

39 Inactivation of KrasG12D in established precursor lesions and during progression to cancer led t

40 een for colorectal cancer (CRC); they detect precursor lesions and early-stage disease.

41 difficulty of early detection, lack of known precursor lesions and high mortality rates.

42 r and it is expressed at high levels in both precursor lesions and invasive cancer.

43 biological response of cells in human cancer precursor lesions and provide strong evidence that TDIS

44 Important precursor lesions and syndromes are stressed.

45 rder to obtain the holistic view of both the precursor lesions and their microenvironment.

46 racterized by palmoplantar keratoderma, oral precursor lesions, and a high lifetime risk of esophagea

47 port their use, ability to detect cancer and precursor lesions, and risk of serious adverse events in

48 nt versions lack high sensitivity for cancer precursor lesions, and tests need to be repeated at regu

49 mRNA and protein were detected in the early precursor lesions, and their expression intensified with

50 ficult to observe human tumor progression as precursor lesions are systematically removed.

51 risks of colorectal cancer and adenoma, the precursor lesion, are believed to be influenced by dieta

52 progression of invasive carcinomas from PIN precursor lesions, as may occur during the development o

53 Nephrogenic rests are precursor lesions associated with about 40% of Wilms' tu

54 for more definitive terminology to describe precursor lesions associated with rupture, now referred

55 mportance: Esophageal adenocarcinoma and its precursor lesion Barrett esophagus have seen a dramatic

56 nterest in strategies that might prevent the precursor lesion Barrett's oesophagus.

57 ween esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly underst

58 as therefore been increasing interest in the precursor lesion, Barrett's esophagus.

59 n world has led to continued interest in its precursor lesion, Barrett's esophagus.

60 f esophageal adenocarcinoma and its presumed precursor lesion, Barrett's esophagus; the pathogenesis

61 increase in the incidence of its recognized precursor lesion, Barrett's metaplasia.

62 ncogene induces apoptosis in cervical cancer precursor lesions but the mechanism is poorly understood

63 f melanomas emerge from clear skin without a precursor lesion, but it is unknown whether these melano

64 rate that multiple and distinct human cancer precursor lesions, but not corresponding malignant cance

65 nal genetic damage that creates a histologic precursor lesion called endometrial intraepithelial neop

66 ought to arise from noninvasive, intraductal precursor lesions called pancreatic intraepithelial neop

67 rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial ca

68 tionary trajectory of the tumour lineage and precursor lesions can be divergent.

69 l tissues from 20 CCs and their accompanying precursor lesions (cervical intraepithelial neoplasia, C

70 es of prostate cancer progression, including precursor lesions, clinically localized disease, and met

71 In a search for possible precursor lesions clonal ERG rearrangements were found b

72 udied to identify and characterize potential precursor lesions containing foci of atypical epithelial

73 otably, even PanIN-1A, the earliest putative precursor lesion, demonstrated a dramatic reduction of t

74 d data exist characterizing the incidence of precursor lesions detected by anal cytology.

75 ming of this model is that clonally expanded precursor lesions do not always belong to the tumour lin

76 heavy-chain immunoglobulin (IgH) and is the precursor lesion for 80% of cases of multiple myeloma.

77 Of the three types of coronary thrombosis, a precursor lesion for acute rupture has been postulated.

78 If, as shown previously, MH is the precursor lesion for melanoma in this model, these resul

79 Similarly, Barrett's metaplasia (a precursor lesion for oesophageal adenocarcinoma) has an

80 ; the evidence that retinoma may represent a precursor lesion for retinoblastoma prior to the acquisi

81 Barrett's esophagus is the presumed precursor lesion for this cancer.

82 Recognized precursor lesions for gastric adenocarcinoma are intesti

83 ary/progenitor markers and frequently act as precursor lesions for HCC.

84 f atypical adenomatous hyperplasia (possible precursor lesions for peripheral adenocarcinomas) were n

85 was very similar suggesting that patches are precursor lesions for SCC, (b) a small number of patches

86 ferative inflammatory atrophy or PIA) may be precursor lesions for the development of prostate cancer

87 uctal metaplasia (ADM) and pancreatic cancer precursor lesion formation by blocking acinar regenerati

88 al alveolar hyperplasia (AAH) is a potential precursor lesion from which lung adenocarcinomas arise a

89 n human MPNSTs and neurofibromas, the benign precursor lesions from which MPNSTs arise.

90 The nomenclature for these precursor lesions has been standardized as pancreatic in

91 ers do not arise de novo, and three distinct precursor lesions have been identified.

92 lasms for which morphologically recognizable precursor lesions have not been identified, so-called de

93 ompanying molecular profiles of PDAC and its precursor lesions have provided the framework for emergi

94 to rapid metastasis without an identifiable precursor lesion (high-grade pathway).

95 at both prostate carcinomas and the presumed precursor lesion (high-grade prostatic intraepithelial n

96 A total of 9 out of 13 MCRs in the putative precursor lesion, high-grade prostatic intraepithelial n

97 tumour, and many forms are derived from the precursor lesions, hydatidiform moles.

98 foci (ACF) are postulated to be the earliest precursor lesion in colorectal carcinogenesis, and CpG i

99 delays the progression of pancreatic cancer precursor lesions in a preclinical animal model.

100 raloxifene, efficiently clear cancer and its precursor lesions in both the cervix and the vagina.

101 foci (ACF) are postulated to be the earliest precursor lesions in colorectal carcinogenesis.

102 nt of pancreatic ductal adenocarcinoma (PDA) precursor lesions in mice expressing a constitutively ac

103 umors and is sufficient to induce neoplastic precursor lesions in mouse models.

104 arrett's esophagus and associated neoplastic precursor lesions in order to optimize decision making w

105 SSA/P were the most frequently observed CRC precursor lesions in patients aged <50.

106 Among colonoscopies yielding CRC precursor lesions in patients under 50 years, SSA/P occu

107 evelopment of oesophageal adenocarcinoma and precursor lesions in people with Barrett's oesophagus--a

108 In this model, noninvasive precursor lesions in the pancreatic ductules accumulate

109 ith an increased frequency of neuroendocrine precursor lesions in young TRAMP mice, detectable at 4 w

110 that can detect both early cancer and cancer precursor lesions include sigmoidoscopy and colonoscopy.

111 Precursor lesions including ductal hyperplasia and hyper

112 CRC precursor lesions (including sessile serrated adenoma/po

113 s displayed a heterogeneous pattern of ccRCC precursor lesions, including cysts, clear cell-type cell

114 reported in a wide range of human and murine precursor lesions, including the pancreas, lung, colon a

115 n-4 is overexpressed in several premalignant precursor lesions, including those of cancers of the bre

116 d with loss of expression in both tumors and precursor lesions indicating that both alleles were func

117 led to a significantly elevated incidence of precursor lesions induced by AOM.

118 kingly, the development of pancreatic cancer precursor lesions induced by either DMBA or mutant Kras

119 at is aberrantly activated in gastric cancer precursor lesions is beta-catenin, and activation of bet

120 and atypical renal cysts that resemble ccRCC precursor lesions is greatly accelerated by the combined

121 reported in gastric cancer, but the role in precursor lesions is not well understood.

122 r regeneration versus the development of PDA precursor lesions is poorly understood.

123 cinoma of the lung develops from noninvasive precursor lesions known as atypical adenomatous hyperpla

124 ough a multistep model comprised of putative precursor lesions known as pancreatic intraepithelial ne

125 ic events defining a clinically undetectable precursor lesion leading to a grade II astrocytoma.

126 The molecular pathology of precursor lesions leading to invasive pancreatic ductal

127 gle dominant tumor surrounded by a region of precursor lesions (low- and high-grade dysplasia) and oc

128 arly phase in CLL development before the CLL precursor lesion monoclonal B cell lymphocytosis.

129 ncluding the first analysis of Wilms' tumour precursor lesions, nephrogenic rests.

130 e to occur, it is important to recognize the precursor lesion of ACS.

131 AT) in subjects with adenomatous polyps, the precursor lesion of colorectal cancer.

132 for Barrett's esophagus (BE), the only known precursor lesion of EAC, is indicated for individuals wi

133 a further supports the concept that PIN is a precursor lesion of invasive carcinoma.

134 Ductal carcinoma in situ (DCIS) is a precursor lesion of invasive ductal carcinoma (IDC) of t

135 epithelial neoplasia (HGPIN) is considered a precursor lesion of prostate cancer (PCa).

136 tic intraepithelial neoplasia, a microscopic precursor lesion of prostate cancer.

137 inomas, we conclude that high-grade PIN is a precursor lesion of prostate carcinoma in this transgeni

138 We will define the precursor lesion of type I endometrioid cancer and the r

139 r UV-induced p53 patches, known to represent precursor lesions of carcinomas, in Xpc(-/-)G1-G3Terc(-/

140 od was expertly reviewed and histopathologic precursor lesions of hepatocellular carcinoma were also

141 neoplasms are increasingly diagnosed cystic precursor lesions of pancreatic cancer.

142 (ADM), as in the case of pancreatitis where precursor lesions of pancreatic ductal adenocarcinoma (P

143 lterations identified to date in noninvasive precursor lesions of the bladder, are detectable in urin

144 cid synthase (FAS) have been found in cancer precursor lesions of the colon, stomach, esophagus, oral

145 lial neoplasia (PanIN) are pancreatic cancer precursor lesions of unclear origin and significance.

146 lineages precede, and are thought to be the precursor lesions of, gastric cancer.

147 tly either from the progression of low grade precursor lesions or rapidly in a de novo fashion and co

148 ciency had little effect on the incidence of precursor lesions, or apoptosis induced by AOM or DSS, o

149 Hh signaling in the formation of PDA and its precursor lesion, pancreatic intraepithelial neoplasia (

150 e and tumour nodal status, while analysis of precursor lesions, pancreatic intraepithelial neoplasias

151 pressed in pancreatic adenocarcinoma and its precursor lesions: pancreatic intraepithelial neoplasia

152 We have analysed the precursor lesions, PanINs, from prophylactic pancreatect

153 llance aids detection of early-stage PDAC or precursor lesions (PRLs) and improves the prognosis.

154 cinogenesis is a multistage process in which precursor lesions progress into early hepatocellular car

155 Washington DC, advances in identification of precursor lesions, progress in disease biomarkers and an

156 ct on the development of the prostate cancer precursor lesions (prostate intraepithelial neoplasia) w

157 pancreatic ductal adenocarcinomas, in which precursor lesions remain unknown.

158 of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific binding by the B

159 papillary serous cancer are that a potential precursor lesion, serous endometrial intraepithelial car

160 erous carcinomas (HGSCs) are associated with precursor lesions (STICs) in the fallopian epithelium in

161 r cell, and granulosa cell carcinomas and in precursor lesions such as inclusion cysts.

162 eatic ductal adenocarcinoma develops through precursor lesions termed pancreatic intraepithelial neop

163 tal adenocarcinoma is believed to arise from precursor lesions termed pancreatic intraepithelial neop

164 ent of squamous anogenital cancers and their precursor lesions, termed "squamous intraepithelial neop

165 model of tumorigenesis, based on analyses of precursor lesions, termed pancreatic intraepithelial neo

166 Monoclonal B-cell lymphocytosis (MBL) is a precursor lesion that can be screened for in apparently

167 of this difference, we sought a surrogate or precursor lesion that leads to hemolysis, and potassium

168 is a prevalent disease with an identifiable precursor lesion that, when treated, favorably alters th

169 nzyme in the subset of human HGPINs or other precursor lesions that are COX-2 positive, as well as in

170 high- and intermediate-grade DCIS, which are precursor lesions that carry a higher risk for transitio

171 ic events in such cancers because of two-hit precursor lesions that have a low probability of maligna

172 ransgenic mice and were found to emerge from precursor lesions that were of two distinct types: dyspl

173 hat may arise from a hitherto underestimated precursor lesion, the proximal hyperplastic polyp-serrat

174 s the inheritance of risk, the nature of the precursor lesions, the challenges involved in the develo

175 mented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represen

176 tive inflammatory atrophy, a prostate cancer precursor lesion, ties inflammatory responses to prostat

177 e (MGUS) is a common disorder of aging and a precursor lesion to full-blown multiple myeloma (MM).

178 erous tubal intraepithelial carcinoma as the precursor lesion to high-grade serous ovarian and perito

179 al carcinoma in situ (DCIS) is a noninvasive precursor lesion to invasive breast carcinoma.

180 ndetermined significance (MGUS) represents a precursor lesion to myeloma (MM).

181 RA biosynthesis in Barrett's oesophagus, the precursor lesion to oesophageal adenocarcinoma.

182 small glandular proliferation, is a putative precursor lesion to prostate cancer, in particular to th

183 neoplasia on needle biopsy--the most common precursor lesion to prostate cancer--is the crucial issu

184 lead to acinar-to-ductal metaplasia (ADM), a precursor lesion to the development of pancreatic ductal

185 Barrett esophagus appears to be a common precursor lesion to this cancer.

186 Precursor lesions to cervical cancer may be effectively

187 As recognized precursor lesions to colorectal cancer, colorectal adeno

188 the number of microadenomas, the presumptive precursor lesions to gross intestinal polyps.

189 intraepithelial neoplasias, the most common precursor lesions to pancreatic cancer, and in the maint

190 a beta-catenin and is sufficient to initiate precursor lesions to prostate cancer in vivo.

191 endocrine cell proliferations believed to be precursor lesions to pulmonary carcinoids.

192 We found that a significant fraction of precursor lesions to some of the most common human cance

193 ethylation change was frequently detected in precursor lesions to the tumors: adenomas, and hyperplas

194 ats 9 months after carcinogen exposure, with precursor lesions (tubular complexes) developing 1 month

195 methylation status of sigma in breast cancer precursor lesions using microdissection for selective ti

196 development of gastritis and gastric cancer precursor lesions, using a variety of experimental infec

197 ated from human subjects with gastric cancer precursor lesions versus persons with gastritis alone.

198 n in the normal colonic mucosa as a possible precursor lesion, we studied 700 bp upstream of MLH1 cov

199 Precursor lesions were initiated by mutations of genes t

200 c intraepithelial neoplasias (PanIN) are the precursor lesions which could be an ideal target for che

201 ation, whereas acinar cells readily form PDA precursor lesions with ductal features.

202 Our comprehensive analysis of precursor lesions without the invasive component provide