ライフサイエンスコーパス: precursor protein

1 n presenilin 1, presenilin 2, or the amyloid precursor protein.

2 secretase of the Alzheimer's disease amyloid precursor protein.

3 esterol for the correct processing of the Hh precursor protein.

4 Hh ligand, generated by autoprocessing of Hh precursor protein.

5 ease-associated mutations within the amyloid precursor protein.

6 ng familial AD-linked forms of human amyloid precursor protein.

7 4 following proteolytic cleavage of pro-NRG1 precursor protein.

8 ed beta-secretase processing of beta-amyloid precursor protein.

9 phosphorylated tau 181, and soluble amyloid precursor protein.

10 bial peptides are derived from nonfunctional precursor proteins.

11 ion involves proteolytic processing of seven precursor proteins.

12 cleaving transport signals off translocated precursor proteins.

13 of plant life and are usually synthesized as precursor proteins.

14 were connected to APP (encoding amyloid beta precursor protein), a major player in Alzheimer's diseas

15 ect recognition test and stained for amyloid precursor protein, a DAI marker.

16 oxycycline (dox) to suppress further amyloid precursor protein/Abeta production, and at the same time

17 sits in Alzheimer disease brain and in Abeta precursor protein (AbetaPP) transgenic mouse models.

18 ervations, anterogradely transported amyloid precursor protein accumulated in ligated sciatic nerves

19 ransmembrane proteins other than the amyloid precursor protein affects the nervous system is only beg

20 Sarm1(-/-) mice developed fewer beta-amyloid precursor protein aggregates in axons of the corpus call

21 ors amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha) and present novel fi

22 ure amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha), analytes central to

23 nce of any changes in the amounts of amyloid precursor protein, amyloid-beta or synaptic proteins.

24 Amyloid precursor protein and endosomal-lysosomal dysfunction in

25 tides deriving from the pro-opiomelanocortin precursor protein and localized a specific area of the p

26 er's disease we used a double mutant amyloid precursor protein and presenilin 1 (APPswe/PSEN1dE9) mou

27 on of human familial AD mutations in amyloid precursor protein and presenilin 1 leads to sensitivity

28 NEDD8 is translated as a precursor protein and proteolytic processing exposes a C

29 s revealed the 3D structure of a macrocyclic precursor protein and provided important mechanistic ins

30 xcision of the internal intein domain from a precursor protein and the concomitant ligation of the fl

31 ates amyloidogenic processing of the amyloid precursor protein and which is a substrate for these pro

32 kines of the IL-1 family, are synthesized as precursor proteins and activated by the inflammasome via

33 play important roles in binding amyloid beta precursor proteins and modulating PS1 catalytic activity

34 pase-3 cleavage site within the amyloid-beta precursor protein, and a caspase-3 cleavage of tau as th

35 teins such as EGF, betacellulin, the amyloid precursor protein, and CD23 from cells.

36 ve diseases such as alpha-synuclein, amyloid precursor protein, and tau.

37 a variety of proteins, including the amyloid precursor protein, and that mediate the assembly of mult

38 are derived from 1 of several amyloidogenic precursor proteins, and the prognosis of the disease is

39 a product of the proteolysis of the amyloid precursor protein APP, is related to Abeta42 by an addit

40 h and Indiana mutations of the human amyloid precursor protein (APP mice) and WT mice.

41 ells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellular mode

42 eimer's disease-causing mutations in amyloid precursor protein (APP(Swe)) and presenilin 1 (PSEN1(M14

43 vious studies have demonstrated that amyloid precursor protein (APP) and Abeta levels can be increase

44 SorLA interacts directly with the amyloid precursor protein (APP) and affects the processing of th

45 roduct of the ubiquitously expressed amyloid precursor protein (APP) and is able to self-associate in

46 We determined that full-length amyloid precursor protein (APP) and its beta-C-terminal fragment

47 Amyloid precursor protein (APP) and its cleavage product amyloid

48 beta-Amyloid precursor protein (APP) and its cleaved products are str

49 Amyloid precursor protein (APP) and its extracellular domain, so

50 rated altered levels of amyloid-beta (Abeta) precursor protein (APP) and its metabolites in FXS and i

51 Amyloid-beta (Abeta) precursor protein (APP) and metabolites are usually asso

52 a-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate beta-amyloid (Abeta

53 cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the amyloid-b

54 The amyloid precursor protein (APP) and the APP-like proteins 1 and

55 to a change in the approximation of amyloid precursor protein (APP) and the beta-site APP cleaving e

56 turn enhances transcription of amyloid-beta precursor protein (APP) and thereby increases amyloid-be

57 er C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrospinal flu

58 rotoxic Abeta fragments derived from amyloid precursor protein (APP) at synapses may be a key contrib

59 Cleavage of amyloid precursor protein (APP) by BACE-1 (beta-site APP cleavin

60 a) peptide, derived from cleavage of amyloid precursor protein (APP) by beta- and gamma-secretases.

61 formed by sequential cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE) and gam

62 enerated by a sequential cleavage of amyloid precursor protein (APP) by beta-secretase 1 (BACE-1) fol

63 ived from sequential cleavage of the amyloid precursor protein (APP) by beta-site APP cleaving enzyme

64 Abeta peptide from the processing of amyloid precursor protein (APP) by clipping enzymes (beta- and g

65 ulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor fo

66 Cleavage of the amyloid precursor protein (APP) by gamma-secretase is a crucial

67 Processing of amyloid-beta (Abeta) precursor protein (APP) by gamma-secretase produces mult

68 sease results from processing of the amyloid precursor protein (APP) by secretases.

69 Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CTFs) by g

70 Alzheimer's disease suggest that the amyloid precursor protein (APP) can cause changes in synaptic pl

71 Prior work suggests that amyloid precursor protein (APP) can function as a proinflammator

72 Tg mice, the critical molecules for amyloid precursor protein (APP) cleavage and signaling pathways

73 beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the

74 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the

75 AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) traffi

76 Amyloid precursor protein (APP) derivative beta-amyloid (Abeta)

77 The two de novo CNVs (an amyloid precursor protein (APP) duplication and a BACE2 intronic

78 y that the Alzheimer-associated beta-amyloid precursor protein (APP) facilitates neuronal iron export

79 Members of the amyloid precursor protein (APP) family participate in many aspec

80 se (AD) brain and the requirement of amyloid precursor protein (APP) for these effects.

81 Mutations in amyloid beta precursor protein (APP) gene alter APP processing, eithe

82 ized by increases in DNA content and amyloid precursor protein (APP) gene copy number.

83 ne synaptic protein belonging to the amyloid precursor protein (APP) gene family.

84 ssense mutations in the amyloid beta (Abeta) precursor protein (APP) gene have been implicated in ear

85 thesis derives from mutations in the amyloid precursor protein (APP) gene.

86 Proteolytic cleavage of the amyloid precursor protein (APP) generates beta-amyloid (Abeta) p

87 The amyloid precursor protein (APP) harbors physiological roles at s

88 proteins.SIGNIFICANCE STATEMENT The amyloid precursor protein (App) has been intensively studied for

89 The amyloid precursor protein (APP) has garnered considerable attent

90 The amyloid precursor protein (APP) has long been appreciated for it

91 The function of the amyloid precursor protein (APP) in brain health remains unclear.

92 ta (Abeta) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosomal compa

93 (BACE1) initiates processing of the amyloid precursor protein (APP) into Abeta peptides, which have

94 s responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-prone am

95 g body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal fragmen

96 Here we report that the amyloid precursor protein (APP) intracellular domain (AICD) down

97 omponent, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage.

98 Amyloid precursor protein (APP) is a key player in Alzheimer's d

99 The amyloid precursor protein (APP) is an ubiquitously expressed cel

100 ted with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by beta-secretase to

101 reveal that the membrane-associated amyloid precursor protein (APP) is highly expressed in macrophag

102 The beta-amyloid precursor protein (APP) is involved in Alzheimer's disea

103 Amyloid precursor protein (APP) is involved in the pathophysiolo

104 umulation of metabolites of the amyloid-beta-precursor protein (APP) is neurotoxic.

105 arlier complications occurring while amyloid precursor protein (APP) is trafficking through the early

106 ations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of longer amy

107 Proteolysis of the amyloid precursor protein (APP) liberates various fragments incl

108 presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), of which

109 Endocytic sorting of amyloid precursor protein (APP) mediated by the vacuolar protein

110 For these cohorts, amyloid precursor protein (APP) metabolism, synaptic markers (SV

111 Amyloid precursor protein (APP) metabolites (amyloid-beta (Abeta

112 retase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (secreted APPbeta, C

113 d replacement mice with mutant human amyloid precursor protein (APP) mice.

114 Amyloid precursor protein (App) plays a crucial role in Alzheime

115 vement of endosomes and lysosomes in amyloid precursor protein (APP) processing and clearance, and th

116 varepsilon3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally increased

117 nfolded protein response and altered amyloid precursor protein (APP) processing.

118 other mutations at this site of amyloid beta precursor protein (APP) reduced C99 generation and decre

119 a42 secretion, and the amount of the amyloid precursor protein (APP) secreted at the cell surface was

120 ompelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD) and

121 pha-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (expressing APP6

122 a pathology and neuroinflammation in amyloid precursor protein (APP) transgenic mice are worsened by

123 Here, we report that cAMP controls amyloid precursor protein (APP) translation and Abeta levels, an

124 Amyloid precursor protein (APP) was originally identified as the

125 es revealed that the dynamics of the amyloid precursor protein (APP) were significantly impaired.

126 scyllo-inositol, in cells expressing amyloid precursor protein (APP) with the Osaka (E693Delta) mutat

127 The amyloid precursor protein (APP), a key player in Alzheimer's dis

128 ouse leads to downregulation of amyloid-beta precursor protein (APP), a known neuronal migration gene

129 cts in the brain, possibly including amyloid precursor protein (APP), a marker of DAI.

130 TN4) or one of its binding partners, amyloid precursor protein (APP), a subset of direction-selective

131 t of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morphology wa

132 esulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofibrillary

133 to an interaction between DISC1 and amyloid precursor protein (APP), and to an association of a sing

134 hrough sequential proteolysis of the amyloid precursor protein (APP), first by the action of beta-sec

135 generation from its precursor, beta-amyloid precursor protein (APP), in a competitive manner.

136 metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in the patho

137 amyloid-beta peptides, derived from amyloid precursor protein (APP), is a neuropathological hallmark

138 linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (PS).

139 rived from proteolytic processing of amyloid precursor protein (APP), play a central role in AD patho

140 The amyloid precursor protein (APP), primarily known as the precurso

141 ndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in both DS

142 ndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in both DS

143 gnation and immunohistochemistry for amyloid precursor protein (APP), respectively.

144 e because of increased processing of amyloid precursor protein (APP), resulting in loss of synapses a

145 that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in DS and i

146 ese conditions may be constituted by amyloid precursor protein (APP), which plays a pivotal role in t

147 tein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggregates t

148 The amyloid precursor protein (APP), whose mutations cause Alzheimer

149 The amyloid precursor protein (APP), whose mutations cause familial

150 The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is req

151 plicate death receptor 6 (DR6) in an amyloid precursor protein (APP)-dependent pathway regulating dev

152 strikingly overlaps with that of the amyloid precursor protein (APP).

153 alpha-secretase cleavage of the Alzheimer's precursor protein (APP).

154 eneration of Abeta-peptides from the amyloid precursor protein (APP).

155 ism of the Alzheimer disease-related amyloid precursor protein (APP).

156 wn for oAbeta, also oTau can bind to amyloid precursor protein (APP).

157 ond strengths in the TM helix of the amyloid precursor protein (APP).

158 Using the amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mo

159 examined the impact of CXCR3 in the amyloid precursor protein (APP)/presenilin 1 (PS1) transgenic mo

160 Here we discovered that, in amyloid precursor protein (APP)/presenilin-1 (PS1) mice (age 3-4

161 ins of Alzheimer's patients and amyloid-beta precursor protein (APP)/PS1 transgenic mice were signifi

162 an Alzheimer's disease mouse model, amyloid precursor protein (APP)/PSEN1dE9(+/-) (PS1) that lacked

163 sion of the membrane-bound beta-site amyloid precursor protein-(APP) cleaving enzyme (BACE1) from the

164 e have previously shown that the fly amyloid precursor protein (APPL) is required for memory in the M

165 D) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1DeltaE9)

166 hat mutations in the gene coding for amyloid precursor protein are responsible for autosomal dominant

167 Approximately 70% of mitochondrial precursor proteins are imported from the cytosol via N-t

168 f functional ASRGL1 and leaving the inactive precursor protein as a destabilized and aggregation-pron

169 of alterations in expression of the amyloid precursor protein, as confirmed by both immunostaining a

170 This protein is generated from the composite precursor protein Atp25 upon internal cleavage by the ma

171 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeutic target in Alzh

172 roblastoma cells expressing the beta-amyloid precursor protein (betaAPP) harboring the familial doubl

173 is expressed in the form of a large Gag-Pol precursor protein by suppression of translational termin

174 nied by a decrease in BACE1-mediated amyloid precursor protein cleavage and amyloid-beta levels.

175 resses the transcription of the beta-amyloid precursor protein cleaving enzyme (BACE1) via binding of

176 nt to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA demethy

177 vative, is a high-affinity beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor cu

178 Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a promisi

179 ses an increase in APP and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) protein, but

180 els reduced translation of beta-site amyloid precursor protein cleaving enzyme 1 and tau, two key pro

181 BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate limitin

182 translation of tau and the beta-site amyloid precursor protein cleaving enzyme 1, a key enzyme in the

183 The beta-site amyloid precursor protein-cleaving enzyme (BACE1) is the rate-li

184 ADE levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), gamma-secr

185 ion of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on Alzheimer

186 bstrate of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)).

187 major target has been the beta-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), with many

188 The transcript encodes a precursor protein comprising a signal peptide and 5 repe

189 therapeutic agents that bind specifically to precursor protein conformations and inhibit amyloid asse

190 LDA is encoded within a 235-amino acid precursor protein containing multiple cleavage sites tha

191 Precursor proteins containing mitochondrial peptide sign

192 Slf is derived from the secreted precursor protein, DfsB, after proteolytic processing.

193 p II mGluR in Dutch APP (Alzheimer's amyloid precursor protein E693Q) transgenic mice that accumulate

194 Although brain amyloid precursor protein expression and amyloid beta production

195 First, POMC mRNA and precursor protein expression in non-neuronal cells varie

196 The amyloid precursor protein family (APP/APLPs) has essential roles

197 a shorter FE65 isoform able to bind amyloid precursor protein family members (APP, APLP1, APLP2), de

198 ense mutations in prodynorphin, encoding the precursor protein for the opioid neuropeptides alpha-neo

199 Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively examine

200 Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a populati

201 Because of an extra copy of the Abeta precursor protein gene on chromosome 21, Down syndrome (

202 xpress the Swedish mutant human beta-amyloid precursor protein gene with G protein-coupled receptor k

203 Ectodomain shedding of transmembrane precursor proteins generates numerous life-essential mol

204 RNA polymerase protein (RdRp), glycoprotein precursor protein, glycoproteins Gn and Gc, as well as p

205 neurons and in mice expressing human amyloid precursor protein (hAPP mice), a model for familial AD t

206 d transgenic mice that express human amyloid precursor protein (hAPP) and patients with mild cognitiv

207 with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels of astr

208 the axon of AD-related mutant human amyloid precursor protein (hAPP) transgenic (Tg) mouse neurons.

209 ity and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which simulate

210 the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice.

211 in transgenic mice expressing human amyloid precursor protein (hAPP).

212 AD (transgenic mice expressing human amyloid precursor protein [hAPP]) and patients in the earlier mi

213 8 (Tg) transgenic mice express human amyloid precursor protein harboring the Swedish and Indiana fami

214 st and human Sde2 are translated as inactive precursor proteins harbouring the ubiquitin-fold domain

215 r, the structural characterization of intact precursor proteins has been limited.

216 sm by which such peptides emerge from linear precursor proteins has received increased attention; how

217 s how FGLK motifs are required for efficient precursor protein import and how these elements may perm

218 in ovalbumin (OVA) were found to release the precursor protein in a slow and steady manner over an ex

219 nkeys, and accompanied by diminished amyloid precursor protein in monkeys.

220 ilarities, strengthening the role of amyloid precursor protein in normal brain function and developme

221 nduced neurons overexpressing mutant amyloid precursor protein in the background of APOE varepsilon3/

222 mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryptic defi

223 s JNK-interacting protein 1 and amyloid beta precursor protein in the brains and spinal cords of MKK7

224 dependent on protease cleavage of the gp160 precursor protein in the Golgi apparatus.

225 Overexpression of human amyloid precursor protein in transgenic mice induces hippocampal

226 Alzheimer's disease-associated beta-amyloid precursor protein in vitro and in human embryonic kidney

227 hment of the GPI anchor to the C terminus of precursor proteins in the endoplasmic reticulum.

228 Purification-tagged Toc159 in the absence of precursor protein, indicating spontaneous and translocat

229 brain regions caused by cleavage of amyloid precursor protein into the pathogenic peptide amyloid-be

230 Two protein translocases transport precursor proteins into or across the inner mitochondria

231 translocases drive the import of beta-barrel precursor proteins into the mitochondrial outer membrane

232 Here we report that the amyloid precursor protein intracellular domain associated-1 prot

233 We report that amyloid precursor protein is crucial for axonal pruning and cont

234 lzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell types an

235 Here we demonstrate that amyloid precursor protein is involved in regulating the phenotyp

236 creatic trypsin inhibitor (BPTI) and amyloid precursor protein Kunitz protease inhibitor (APPI), and

237 overexpressing amyloid beta-peptide (Abeta) precursor protein leads to early cerebral microvascular

238 ization of the resulting products from their precursor protein location.

239 use model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Abeta.

240 Results: Aged mutant amyloid precursor protein mice with established disease showed a

241 and associative memory (P = .02) in amyloid precursor protein mice.

242 The amyloid precursor protein modulates alpha2A-adrenergic receptor

243 Amyloid precursor protein mutations falling within the amyloid-b

244 ve in Drosophila models of Ass42 and amyloid precursor protein neurotoxicity.

245 d with the intracellular accumulation of the precursor protein of Abeta, APP, as a result of the sele

246 ures of the two genes encoding the different precursor proteins of Ms 9a-1 were determined.

247 pending upon the intrinsic properties of the precursor protein/peptide and experimental conditions su

248 Tat precursor proteins possess a conserved twin-arginine (RR

249 We show that BMP4 and BMP7 precursor proteins preferentially or exclusively form he

250 ransgenic mice expressing human amyloid-beta precursor protein, presenilin 1, and tau mutations, and

251 intracerebroventricular infusion in amyloid precursor protein/presenilin 1 (APP/PS1) double-transgen

252 of CLU on Abeta pathology using the amyloid precursor protein/presenilin 1 (APP/PS1) mouse model of

253 of mitochondrial 5-methylcytosine in amyloid precursor protein/presenilin 1 mice along with Alzheimer

254 and boutons distant from plaques in amyloid precursor protein/presenilin 1-GFP (APPPS1-GFP) nor thos

255 se (ILD) due to mutations in the gene of the precursor protein pro-SP-C.

256 hesized in the endoplasmic reticulum, the CD-precursor protein (pro-CD) is transported through endoso

257 s was coupled with reduced levels of amyloid precursor protein processing and Abeta production, compa

258 the latter case, proteins related to amyloid precursor protein processing and secretion are S-nitrosa

259 ransport in regulating amyloidogenic amyloid precursor protein processing and support a model wherein

260 ese swellings contain high levels of amyloid precursor protein processing enzymes (BACE1 and presenil

261 activity without detectably altering amyloid precursor protein processing or extracellular Abeta/beta

262 Increased APP (amyloid precursor protein) processing causes beta-amyloid (Abeta

263 PDYN, which encodes the opioid neuropeptide precursor protein, prodynorphin.

264 ted the expression of Il18 mRNA and inactive precursor protein (proIL-18) in intestinal epithelial ce

265 r, its role in the processing of the amyloid precursor protein remains unknown.

266 cleavage of the inactive SREBP transmembrane precursor protein, RIP of the anchor intermediate by sit

267 we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche signal in t

268 metabolites alpha and beta (soluble amyloid precursor protein (sAPP)alpha, sAPPbeta) and two neuroin

269 -secretase, soluble Abeta42, soluble amyloid precursor protein (sAPP)beta, sAPPalpha, glial-derived n

270 (NFL), alpha-synuclein (alpha-syn), amyloid precursor protein soluble metabolites alpha and beta (so

271 iculum retrograde transport, affects amyloid precursor protein subcellular localization, cell-surface

272 l signs, astrogliosis, deposition of amyloid precursor protein, synaptic loss and neuronal death were

273 Amyloid precursor protein/tetracycline transactivator mice under

274 mice expressing mutated forms of the amyloid precursor protein (Tg2576 mice).

275 Dentin sialophosphoprotein (DSPP) is a precursor protein that is expressed by the connective ti

276 smembrane proteins, most notably the amyloid precursor protein that results in Abeta, a transmembrane

277 mal genes that encode cytosolic proteins and precursor proteins that are synthesized in the cytosol f

278 Such precursor proteins that could be processed into multiple

279 complex involved in the cleavage of amyloid precursor proteins that lead to the formation of amyloid

280 s biological importance, the thyroid hormone precursor protein, thyroglobulin (Tg), has been experime

281 y lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.

282 rom Hh autoprocessing, which converts the Hh precursor protein to the Hh ligand.

283 s noted in untreated HSCs of postnatal Abeta precursor protein transgenic (APP tg) mice, Abeta deposi

284 of brain amyloidosis in amyloid beta (Abeta)-precursor protein transgenic mice (Tg2576).

285 Expression analysis of amyloid precursor protein transgenic mice also revealed high lev

286 RNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell lines.

287 Starting at 5 months of age, tet-off amyloid precursor protein transgenic mice were treated with doxy

288 brain beta-amyloid (Abeta) levels in amyloid precursor protein transgenic mice, but no data are avail

289 In Alzheimer amyloid precursor protein-transgenic mice and SH-SY5Y cell model

290 expectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in decreased,

291 The human systemic amyloid precursor protein transthyretin (TTR) is known to inhibi

292 eta rapidly, with no reactivity to the Abeta precursor protein, transthyretin amyloid aggregates, or

293 he cavity of hexon-the cleaved N terminus of precursor protein VI (pVIn), the cleaved N terminus of p

294 rives from a C-terminal fragment of a larger precursor protein via a caspase-3 mediated cleavage.

295 cellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

296 eased the import competence of mitochondrial precursor proteins via an extramitochondrial coaggregati

297 protein VI (pVIn), the cleaved N terminus of precursor protein VII (pVIIn2), and mature protein VI.

298 resequence translocase (TIM23 complex) sorts precursor proteins with a cleavable presequence either i

299 ributes to the productive interaction of Tat precursor proteins with the TatBC receptor complex.

300 ading ultimately to accumulation of immature precursor proteins within mitochondria.