ライフサイエンスコーパス: prediabetes

1 rough compensation of insulin resistance, to prediabetes.

2 ldren with NAFLD also had type 2 diabetes or prediabetes.

3 undiagnosed diabetes mellitus and 37.5% had prediabetes.

4 of diabetes in individuals with obesity and prediabetes.

5 ith overall diet quality in individuals with prediabetes.

6 parable among smokers and never-smokers with prediabetes.

7 .5% of the patients were women and 61.2% had prediabetes.

8 in UWS of patients with CP with and without prediabetes.

9 levated in patients with CP with and without prediabetes.

10 nd marginal bone loss (MBL) in patients with prediabetes.

11 have not specifically examined subsets with prediabetes.

12 ations, especially in those individuals with prediabetes.

13 flammatory conditions with gutka chewing and prediabetes.

14 ogression of early-stage type 2 diabetes and prediabetes.

15 individuals with prediabetes and 44 without prediabetes.

16 une T1D, whereas nondiabetic BBDP rats mimic prediabetes.

17 with those who consistently met criteria for prediabetes.

18 were positively associated with diabetes and prediabetes.

19 eta-HCH were not associated with diabetes or prediabetes.

20 ng, and diastolic dysfunction, starting from prediabetes.

21 uced diabetes incidence in participants with prediabetes.

22 imated that more than 54 million adults have prediabetes.

23 ing adults who have asymptomatic diabetes or prediabetes.

24 nclear which glucose threshold should define prediabetes.

25 ucose homoeostasis in obese adolescents with prediabetes.

26 lanzapine, were overweight or obese, and had prediabetes.

27 ion and management of diabetes with focus on prediabetes.

28 d with greater IR and a higher likelihood of prediabetes.

29 ffecting multiple organs in individuals with prediabetes.

30 atio was also increased in these donors with prediabetes.

31 networks are affected in type 2 diabetes and prediabetes.

32 was attributable mainly to individuals with prediabetes.

33 point [P < 0.001] in the NHANES III sample), prediabetes (0.26 percentage point [P < 0.001] and 0.30

34 22 (90.9%); diabetes, 15 of 16 (93.8%); and prediabetes, 11 of 11 (100.0%).

35 The most common new diagnoses were prediabetes (28 [6.1%]), vitamin B12 deficiency (20 [4.4

36 omen; 45 with normoglycemia [44.1%], 31 with prediabetes [30.4%], and 26 with type 2 diabetes [25.5%]

37 fetime risk was 48.7% (95% CI 46.2-51.3) for prediabetes, 31.3% (29.3-33.3) for diabetes, and 9.1% (7

38 f HCV RNA(+) 1.1%, of diabetes 10.5%, and of prediabetes 32.8%.

39 e with type 2 diabetes (43.2%) compared with prediabetes (34.2%) or normal glucose (22%) (P < .001).

40 ls to define undiagnosed diabetes (>/=6.5%); prediabetes (5.7% to 6.4%); and, among persons with diag

41 ) for central obesity, 30.5% (30.0-31.0) for prediabetes, 5.1% (4.9-5.3) for diabetes, 16.3% (15.9-16

42 indexes, were similar across groups: 69% had prediabetes, 54% had hypertension (47% were taking antih

43 ts relating to type 2 diabetes in youth (2), prediabetes (69, 166), metabolic syndrome (33, 35), poly

44 In patients with prediabetes, 8-hour nightly CPAP treatment for 2 weeks i

45 nd Jan 1, 2012), 1148 participants developed prediabetes, 828 developed diabetes, and 237 started ins

46 c level was above guideline levels for DM or prediabetes according to the American Diabetes Associati

47 generally emerged later than GADA and IAA in prediabetes, although not in a strict order.

48 The prevalence ratio for prediabetes among participants with moderate/severe vs.

49 identify individuals with undiagnosed DM or prediabetes among patients attending a dental setting fo

50 ratios for diabetes, insulin resistance, and prediabetes among persons with hyperuricemia (serum urat

51 dependent marker for predicting diabetes and prediabetes among young adults in the subsequent 15 year

52 iabetes, and 38.0% (95% CI, 34.7%-41.3%) for prediabetes; among those with diabetes, 36.4% (95% CI, 3

53 ed hs-cTnT were 1.40 (95% CI, 1.08-1.80) for prediabetes and 2.47 (95% CI, 1.78-3.43) for diabetes me

54 fined using HbA1c values (29.2% vs 48.6% for prediabetes and 3.8% vs 7.3% for diabetes in 572 observa

55 th is investigated among 44 individuals with prediabetes and 44 without prediabetes.

56 CI, 1.04-2.40) times greater odds of having prediabetes and 5.0 (95% CI, 2.49-9.98) times greater od

57 Ninety-five males (45 with prediabetes and 50 systemically healthy controls) were i

58 subjects who underwent MRI, 103 subjects had prediabetes and 54 had established diabetes.

59 %) did not have diabetes (of whom 10 344 had prediabetes and 6189 had normoglycaemia).

60 blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m(2)

61 imulated whole saliva (UWS) of patients with prediabetes and chronic periodontitis (CP) remains uninv

62 (USPSTF) recommended targeted screening for prediabetes and diabetes (dysglycemia) in adults who are

63 The substantial lifetime risk of prediabetes and diabetes in lean individuals also suppor

64 diastolic dysfunction among individuals with prediabetes and diabetes mellitus (versus diabetes melli

65 Persons with prediabetes and diabetes mellitus are at high risk for c

66 However, the relationships of prediabetes and diabetes mellitus to the development of

67 Prediabetes and diabetes mellitus were independently ass

68 The prevalence of prediabetes and diabetes was statistically significantly

69 of burn patients who may be at high risk of prediabetes and diabetes.

70 protect against coronary atherosclerosis in prediabetes and early diabetes mellitus among men.

71 vational evidence shows associations between prediabetes and early forms of nephropathy, chronic kidn

72 und of the metabolic environment typical for prediabetes and early type 2 diabetes: combined hypergly

73 T2D-related traits: risk of T2D, presence of prediabetes and homeostatic model of assessment - insuli

74 rovascular dysfunction is already present in prediabetes and is more severe in T2DM.

75 interventions, possible misclassification of prediabetes and metformin use, and inability to define e

76 le grain protects against the development of prediabetes and T2D and tested for modulation by polymor

77 NADPH levels were significantly degraded in prediabetes and T2D but were largely protected when mice

78 independently and inversely associated with prediabetes and T2D in Chinese adults.

79 to coordinate screening for and diagnosis of prediabetes and T2D.

80 es to T2D, and was inversely associated with prediabetes and T2D.

81 ulate are decreased in muscle of people with prediabetes and T2DM.

82 factors that are potentially manageable are prediabetes and the metabolic syndrome, neuropsychiatric

83 ncluding patients with diabetes mellitus and prediabetes and those with high risk of cardiovascular d

84 l blood glucose, particularly in people with prediabetes and type 1 and type 2 diabetes.

85 ss the associations of plasma magnesium with prediabetes and type 2 diabetes (T2D) among Chinese adul

86 were independently associated with incident prediabetes and type 2 diabetes mellitus in obese adults

87 8 in normal glucose metabolism, 3.0+/-2.7 in prediabetes, and 2.3+/-2.6 in T2DM.

88 icipants with diabetes, 47 participants with prediabetes, and 45 control participants underwent detai

89 in normal glucose metabolism, 1109+/-748 in prediabetes, and 937+/-683 in T2DM.

90 hewing alone, chewing among individuals with prediabetes, and chewing among healthy controls did not

91 ars among persons with no diabetes mellitus, prediabetes, and diabetes mellitus were 3.7%, 6.4%, and

92 Normoglycaemia, prediabetes, and diabetes were defined on the basis of W

93 anagement of humans with insulin resistance, prediabetes, and diabetes.

94 Undiagnosed diabetes, prediabetes, and glucose control in persons with diagnos

95 information regarding age, sex, duration of prediabetes, and gutka-chewing habits was collected usin

96 ponents of the metabolic syndrome, including prediabetes, and neuropathy.

97 Diabetes, prediabetes, and obesity are the likely metabolic driver

98 and insulin resistance in healthy controls, prediabetes, and T2D.

99 This resistance may be a stage of prediabetes, and the patients may develop hyperinsulinem

100 uxtamembrane epitopes, which appear early in prediabetes, and those to peptide 853-872 with Abs to an

101 mong subjects with normal glucose tolerance, prediabetes, and type 2 diabetes (P = .980).

102 ters in subjects with insulin resistance and prediabetes, and whether this might be mediated in part

103 munities Study with no diabetes mellitus, or prediabetes, and without cardiovascular disease includin

104 es; group 2: 30 patients with CP and without prediabetes; and group 3: 30 controls.

105 visits (aOR, 1.56; 1.22-1.99), and lifetime prediabetes (aOR, 1.71; 95% CI, 1.19-2.45).

106 Potential living kidney donors with prediabetes are often excluded from donation because of

107 estations of early disease in the context of prediabetes are poorly understood.

108 Among participants without baseline prediabetes, arsenic exposure was associated with incide

109 r fasting plasma glucose (FPG) >/=126 mg/dL, prediabetes as A1C 5.7%-<6.5% or FPG 100-<126 mg/dL, and

110 easures: The presence of type 2 diabetes and prediabetes as determined by American Diabetes Associati

111 en with NAFLD and assess type 2 diabetes and prediabetes as risk factors for nonalcoholic steatohepat

112 oping impaired glucose metabolism, including prediabetes, as are data for the risk of eventual progre

113 (95% CI: 1.18, 2.08) in participants without prediabetes at baseline.

114 lp identification of individuals with DM and prediabetes at early stages of disease, which may preven

115 yses showed a lower arteriolar %-dilation in prediabetes (B=-0.20, 95% confidence interval -0.56 to 0

116 usted analyses showed a lower %-hyperemia in prediabetes (B=-46 [-163 to 72]) with further deteriorat

117 Identification of DM and prediabetes based on a diagnosis of periodontitis yielde

118 mRNA/protein) were higher in AT derived from prediabetes BB rats with destructed pancreatic beta-cell

119 Prior to prediabetes, beta-cell function displays decreased stimu

120 Cytokines are upregulated in prediabetes, but their relationship with Enterovirus (EV

121 that more than 470 million people will have prediabetes by 2030.

122 progression from normal glucose tolerance to prediabetes by mechanisms likely tied to effects on insu

123 rms that individuals with undiagnosed DM and prediabetes can be identified in the dental office by ch

124 tion of amylin is common in individuals with prediabetes, causes amylin deposition and proteotoxicity

125 Odds ratios (ORs) for diabetes and prediabetes, comparing persons with HCV infection to tho

126 g smokers and never-smokers with and without prediabetes (controls).

127 Prediabetes defined using the ADA fasting glucose concen

128 Prediabetes defined using the ADA HbA1c cutoff showed a

129 diovascular outcomes and death compared with prediabetes defined with glucose-based definitions.

130 the risk of future outcomes across different prediabetes definitions based on fasting glucose concent

131 We compared prediabetes definitions based on fasting glucose concent

132 INTERPRETATION: Our results suggest that prediabetes definitions using HbA1c were more specific a

133 Our results suggest that prediabetes definitions using HbA1c were more specific a

134 an inform the comparative value of different prediabetes definitions.

135 etes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.

136 ity, hypertension, hypertension on 2 visits, prediabetes, diabetes, and high cholesterol than eczema

137 Notably, 32% of those with prediabetes/diabetes mellitus at 12 months postpartum ha

138 The prevalence of diabetes and prediabetes did not differ by HCV status.

139 -Western vitamin D-deficient immigrants with prediabetes did not improve insulin sensitivity or beta

140 dontal inflammation than individuals without prediabetes even after controlling for sex and gutka che

141 No consensus on definitions of prediabetes exists among international organisations.

142 A total of 130 non-Western immigrants with prediabetes (fasting glucose concentration >5.5 mmol/L o

143 o three groups: 1) group A: 75 patients with prediabetes (FBGLs = 100 to 125 mg/dL [HbA1c >/=5%]); 2)

144 he network measures of the participants with prediabetes fell between those with diabetes and control

145 A previous study of participants with prediabetes found that hemoglobin A(1c) (HbA(1c)) levels

146 Prediabetes (glucose based, 4.0%; hemoglobin A1c based,

147 ree groups: group 1: 28 patients with CP and prediabetes; group 2: 30 patients with CP and without pr

148 ting glucose (normoglycaemia: </=6.0 mmol/L; prediabetes: >6.0 mmol/L and <7.0 mmol/L; and diabetes >

149 Subjects with prediabetes had an increased risk for carotid plaque and

150 aphic adjustment, HbA1c-based definitions of prediabetes had higher hazard ratios and better risk dis

151 In addition, people with prediabetes had significantly elevated levels of PDFF an

152 exact relationship between periodontitis and prediabetes has not been established.

153 regulation versus those who consistently had prediabetes (hazard ratio [HR] 0.44, 95% CI 0.37-0.55, p

154 glycaemia and diabetes risk in patients with prediabetes (HbA1c 5.7-6.4% [39-46 mmol/mol] or FPG 5.6-

155 was significantly greater among persons with prediabetes (HbA1c level of 5.7% to 6.4%) than among tho

156 cose intolerance was defined as follows: (1) prediabetes: hemoglobin (HbA1c) >/=5.7 and <6.5% and (2)

157 Higher likelihood of prediabetes, higher HOMA-IR, and lower Matsuda index wer

158 HR 1.05, 0.94-1.17), including in those with prediabetes (HR 1.00, 0.89-1.13).

159 confounders (race, body mass index, diabetes/prediabetes, hypertension), adjusted cumulative odd rati

160 f hyperuricemia as a marker for diabetes and prediabetes (impaired fasting glucose) and insulin resis

161 red in 86% (95% CI, 72 to 100), remission of prediabetes in 76% (95% CI, 56 to 97), remission of elev

162 level that approaches that needed to detect prediabetes in a general pediatric population.

163 of these parameters as well as the state of prediabetes in affected individuals.

164 ermine the prevalence of type 2 diabetes and prediabetes in children with NAFLD and assess type 2 dia

165 -perceived oral symptoms among patients with prediabetes in group B and healthy controls.

166 cell compensation and insulin resistance in prediabetes in individuals with periodontitis.

167 valence of undiagnosed diabetes mellitus and prediabetes in patients with community-acquired pneumoni

168 between POP concentrations and diabetes and prediabetes in the general adult population of Catalonia

169 Several measurements were used to test for prediabetes, including fasting plasma glucose, insulin r

170 sex and BMI, the prevalence of diabetes and prediabetes increased in a dose-dependent manner across

171 Diabetes and prediabetes increased risk of conversion from amnestic M

172 h 2001), the incidence rates of diabetes and prediabetes (insulin resistance and impaired fasting glu

173 Prediabetes (intermediate hyperglycaemia) is a high-risk

174 In obese children and adolescents with prediabetes, intramyocellular and intra-abdominal lipid

175 ed mitochondrial capacity is associated with prediabetes, IR, and duration and severity of hyperglyce

176 ere significantly higher in individuals with prediabetes irrespective of gutka-chewing habit (P <0.05

177 INTERPRETATION: We conclude that prediabetes is a high-risk state for diabetes, especiall

178 Prediabetes is associated with the simultaneous presence

179 Identification of individuals with DM and prediabetes is important to reduce DM-related complicati

180 Prevalence of prediabetes is increasing worldwide and experts have pro

181 studies and investigations on the impact on prediabetes is needed.

182 tal inflammatory parameters in patients with prediabetes is unknown.

183 t (type 1) diabetes mellitus, it served as a prediabetes marker, as such autoantibodies were often el

184 nts in intensive lifestyle interventions for prediabetes may not be representative of general prediab

185 T2DM, but also prediabetes, may be risk factors for prefrontal neuroche

186 erm intervention study in 3234 subjects with prediabetes (mean+/-SD age, 64+/-10 years) that showed r

187 a levels of selected miRNAs in subjects with prediabetes (n = 12), type 2 diabetes (T2D, n = 31), lat

188 rmal glucose tolerance (n = 740), those with prediabetes (n = 431), and those with confirmed type 2 d

189 th normal glucose tolerance (NGT) (n = 774), prediabetes (n = 525), or screen-detected type 2 diabete

190 (n = 5), 29% in the obese participants with prediabetes (n = 9), and 34.6% in the obese participants

191 ce test; normal glucose metabolism [n=1269], prediabetes [n=335], or T2DM [n=609]).

192 classified into four groups: normoglycaemia, prediabetes, newly diagnosed diabetes, and known diabete

193 During prediabetes, NOD females displayed a progressive increas

194 Prediabetes (odds ratio, 3.82; 95% CI, 0.95-15.41) was n

195 Currently, the impact of diabetes and prediabetes on cognition and the underlying organization

196 -analysis of the effects of interventions in prediabetes on the incidence of diabetes was performed.

197 e were estimated as the number of years from prediabetes onset and the average oral glucose tolerance

198 eas islet mass continues to increase through prediabetes onset.

199 ine glucose values, the composite outcome of prediabetes or diabetes occurred in 39.1% and was indepe

200 Factors that discriminate prediabetes or diabetes risk within this population have

201 s at baseline, incidence of the composite of prediabetes or diabetes was determined.

202 presence of pancreatic fat is not related to prediabetes or diabetes, which suggests that it has litt

203 rtment were observed in children with either prediabetes or diabetes.

204 of neuropathic dysfunction in patients with prediabetes or impaired glucose tolerance emphasizes the

205 Participants with prediabetes or newly diagnosed diabetes had similar rate

206 enance sessions, risk level of participants (prediabetes or other), and intervention delivery personn

207 lesterol, in overweight or obese people with prediabetes or T2D.

208 risk to deteriorate in glucose tolerance (to prediabetes or T2D; women and men combined).

209 Patients (n = 101) with prediabetes or T2DM and biopsy-proven NASH were recruite

210 tment is safe and effective in patients with prediabetes or T2DM and NASH.

211 onse to an OGTT, and both men and women with prediabetes or type 2 diabetes had 16-21% lower 120-min

212 mpared with individuals with NGT, women with prediabetes or type 2 diabetes had 25% lower GLP-1 respo

213 360 of 20 191 patients who had either prediabetes or type 2 diabetes had congestive heart fail

214 s of nonalcoholic steatohepatitis (NASH) and prediabetes or type 2 diabetes mellitus (T2DM) seem to b

215 5.7% [39 mmol/mol]); (2) diagnosis codes for prediabetes or type 2 diabetes; or (3) antidiabetic medi

216 outcomes (hypertension, composite diabetes [prediabetes or type 2 diabetes], hyperlipidemia, cardiov

217 NASH were significantly higher in those with prediabetes (OR, 1.9; 95% CI, 1.21-2.9) or type 2 diabet

218 es (hypertension, dyslipidaemia, diabetes or prediabetes, or abdominal obesity) to placebo, once-dail

219 f individuals who did not have diabetes, had prediabetes, or had diabetes.

220 groups over time in patients with diabetes, prediabetes, or normoglycaemia.

221 s BP in individuals with insulin resistance, prediabetes, or other noncommunicable chronic diseases.

222 gher among controls than among patients with prediabetes (P <0.05).

223 ls and an improvement in glycemic control in prediabetes patients and in type 2 diabetic patients.

224 control analysis of 4447 867 newly diagnosed prediabetes patients, 1475 newly diagnosed T2D patients

225 on among patients with diabetes mellitus and prediabetes, patients at high risk of cardiovascular dis

226 Associations were significant for prediabetes per se (all, OR: 0.73; 95% CI: 0.56, 0.94; m

227 Among patients with prediabetes, periodontal inflammation and whole salivary

228 Metabolic syndrome and prediabetes predicted all-cause dementia in people with

229 Modified Poisson regression evaluated prediabetes prevalence across bacterial tertiles.

230 association between periodontal bacteria and prediabetes prevalence among diabetes-free adults.

231 dontal microbiota are associated with higher prediabetes prevalence among diabetes-free adults.

232 Prediabetes prevalence was 18%, and 58% of participants

233 Prediabetes prevalence was 42%, and diabetes mellitus pr

234 anagement, people with diabetes mellitus and prediabetes remain at increased coronary heart disease r

235 a and IL-6 in smokers and never-smokers with prediabetes remains uninvestigated.

236 flammation in gutka chewers with and without prediabetes remains unknown.

237 ave undiagnosed type 2 diabetes mellitus and prediabetes, respectively.

238 corresponding to guideline levels for DM and prediabetes, respectively.

239 dicate that myocardial infarction could be a prediabetes risk equivalent.

240 t could enhance population-wide diabetes and prediabetes screening strategies.

241 Thus, subjects with prediabetes show early signs of subclinical disease that

242 with transient insulin resistance during the prediabetes stage and then underwent rapid beta-cell los

243 The prediabetes stage was prolonged in the hemizygous mice,

244 rticipants with normal glucose regulation or prediabetes status during DPP with and without stratific

245 Prediabetes, T2DM, and measures of hyperglycemia are ind

246 o do so, we investigated the associations of prediabetes, T2DM, and measures of hyperglycemia with mi

247 0.05) levels were higher among patients with prediabetes than controls.

248 rameters, and MBL are worse in patients with prediabetes than controls.

249 Levels were also higher in individuals with prediabetes than in subjects without the disorder.

250 function in glucose metabolism in youth with prediabetes, the relationship between adipose tissue ins

251 rs compared to non-chewers; in patients with prediabetes, the severity of periodontal inflammation is

252 In participants with undiagnosed prediabetes, the use of health claims alone, of both lab

253 olerable, evidence-based, and cost-effective prediabetes therapy.

254 -artery dysfunction, which already occurs in prediabetes ("ticking clock hypothesis").

255 ta for the risk of eventual progression from prediabetes to diabetes and for initiation of insulin tr

256 45 years, the lifetime risk to progress from prediabetes to diabetes was 74.0% (95% CI 67.6-80.5), an

257 utic interventions reduce the progression of prediabetes to diabetes, but few data examine the effect

258 imated the lifetime risk of progression from prediabetes to overt diabetes and from diabetes free of

259 of Akt1 in Akt2(-/-) mice, however, converts prediabetes to overt type 2 diabetes, which is also reve

260 Plasma magnesium decreased from NGT to prediabetes to T2D, and was inversely associated with pr

261 to assess the effectiveness of diabetes and prediabetes treatments.

262 e 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of

263 glucose impairments, from normoglycaemia to prediabetes, type 2 diabetes, and eventual insulin use.

264 In conclusion, early in the development of prediabetes/type 2 diabetes in youth, ChREBPbeta express

265 We aimed to determine the prevalence of prediabetes, undiagnosed diabetes mellitus, and risk fac

266 The definition of prediabetes using the ADA fasting glucose concentration

267 nic (445 of 675).The estimated prevalence of prediabetes was 23.4% (95% CI, 20.2%-26.6%), and the est

268 Prediabetes was defined as a hemoglobin A1c level of 5.7

269 Prediabetes was defined as follows: 1) hemoglobin A1c va

270 Prediabetes was defined using the American Diabetes Asso

271 valence of undiagnosed diabetes mellitus and prediabetes was estimated based on hemoglobin A1c measur

272 The prevalence of prediabetes was lower when defined by calibrated HbA1c l

273 G, or 2-hour PG definitions for diabetes and prediabetes) was 14.3% (95% CI, 12.2%-16.8%) for total d

274 etabolism.Among African-American adults with prediabetes, we conducted a double-blinded pilot randomi

275 ng associations between bacterial levels and prediabetes were as follows: A. actinomycetemcomitans, 2

276 Participants with prediabetes were excluded from the logistic regression a

277 All patients with prediabetes were hyperglycemic.

278 Effect estimates for individuals with prediabetes were much larger and highly statistically si

279 periodontal inflammation in individuals with prediabetes were nine times higher than in healthy contr

280 portions of patients with undiagnosed DM and prediabetes were observed in the periodontitis group (32

281 Only 3.7% of patients with prediabetes were prescribed metformin over the 3-year st

282 Individuals with prediabetes were significantly more likely to have perio

283 Twenty-seven controls and 29 patients with prediabetes were smokers.

284 al data from 2654 US adults with undiagnosed prediabetes who participated in the 2005-2010 NHANES cyc

285 evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes.

286 Percentage of health plan enrollees with prediabetes who were prescribed metformin.

287 5-10% of people per year with prediabetes will progress to diabetes, with the same pro

288 ed for possible associations of diabetes and prediabetes with cognitive decline.