ライフサイエンスコーパス: prediagnostic

1 l of the prostate cancer cases (n = 21) with prediagnostic (2-3 years before diagnosis) and diagnosti

2 , n = 267), recent (1995-1999, n = 396), and prediagnostic (2000 and after, n = 770).

3 (tertiles or a priori-defined categories) of prediagnostic 25(OH)D were calculated using conditional

4 ged 50-69 years at baseline, to test whether prediagnostic adiponectin concentrations are associated

5 Prediagnostic alcohol abstaining and heavy drinking were

6 The associations of lifetime and 1-y prediagnostic alcohol consumption with relevant prognost

7 (RR) were estimated for associations between prediagnostic aspirin use and lymph node-positive status

8 Our findings indicate that recent prediagnostic aspirin use is protective against lymph no

9 Prediagnostic aspirin use was associated with lower 5-ye

10 Women with prediagnostic aspirin use were statistically significant

11 % confidence interval [CI], 88 to 100) had a prediagnostic B-cell clone; in 41 patients (91%; 95% CI,

12 ined up to 77 months before a CLL diagnosis, prediagnostic B-cell clones were present in 44 of 45 pat

13 ed the immunoglobulin gene repertoire of the prediagnostic B-cell clones.

14 sample from participants for measurement of prediagnostic biomarkers, assuming that 1 measurement ad

15 assessed by molecular backtracking of paired prediagnostic blood and tumor samples.

16 Prediagnostic blood from these and 218 controls were scr

17 he authors examined the associations between prediagnostic blood levels of micronutrients and prostat

18 he median time between the collection of the prediagnostic blood sample and the subsequent CLL diagno

19 var, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collected on average 3 and

20 entified 170 individuals who had donated two prediagnostic blood samples before B-cell lymphoma diagn

21 Here, we used prediagnostic blood samples from three studies to analyz

22 phoma-free controls who had available stored prediagnostic blood samples.

23 Together with data from prediagnostic blood specimens showing positive associati

24 nal analysis of t(14;18) junctions in paired prediagnostic blood versus tumor samples demonstrated th

25 Compared with survivors with normal prediagnostic BMI (18.5-24.9 kg/m(2)), those who were ov

26 We assessed the effect of prediagnostic BMI and plasma C-peptide concentration (re

27 udies have investigated associations between prediagnostic BMI change and CRC prognosis.

28 The associations of BMI at diagnosis and prediagnostic BMI change with relevant prognostic outcom

29 Compared with stable BMI, a strong prediagnostic BMI decrease of >5 was associated with poo

30 Higher prediagnostic BMI was associated with more advanced stag

31 Higher prediagnostic BMI was associated with statistically sign

32 ls to examine associations between baseline (prediagnostic) BMI and risk of second obesity-associated

33 er, studies have not prospectively evaluated prediagnostic body mass index (BMI) and survival.

34 sociation of non-Hodgkin lymphoma (NHL) with prediagnostic carotenoid levels, a marker for a diet ric

35 t-retest reliability of saccadic measures in prediagnostic carriers of the HD gene expansion (PDHD) a

36 arkedly for recent cases and disappeared for prediagnostic cases.

37 ses but made little difference for recent or prediagnostic cases.

38 1.5 (95% confidence interval: 1.2, 1.9) for prediagnostic cases.

39 mined the association of VDR expression with prediagnostic circulating 25(OH)D and 1,25-dihydroxyvita

40 ncers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were as

41 e was to investigate the association between prediagnostic circulating 25-hydroxyvitamin D [25(OH)D]

42 Heavy smokers defined by prediagnostic circulating cotinine levels had a multivar

43 ve US cohorts, we also evaluated survival by prediagnostic circulating levels of cotinine, a metaboli

44 able (IGHV) genes was determined in 35 of 45 prediagnostic clones (78%).

45 Prediagnostic concentrations of estradiol, estrone, and

46 dition, which often has a long and insidious prediagnostic course, might result in earlier identifica

47 ions; however, findings may be attributed to prediagnostic effects of tumors or recall bias.

48 A range of prediagnostic features can be detected several years bef

49 ease diagnosis, the incidence of all studied prediagnostic features except neck pain or stiffness was

50 iation between first presentation of several prediagnostic features in primary care and a subsequent

51 ons of 6-sulfatoxymelatonin were measured in prediagnostic first-morning urine samples from 251 breas

52 to diagnosis (effect size for the 0-38 weeks prediagnostic group, 1.91; P, 8.3E-05).

53 We investigated the relationship between prediagnostic HDL-C and non-Hodgkin lymphoma (NHL) in th

54 of machine learning models trained to detect prediagnostic heart failure in primary care patients usi

55 These results suggest that prediagnostic hs-CRP and sICAM-1 levels are associated w

56 e observed both in tumor-bearing mice and in prediagnostic human samples.

57 All women reported on prediagnostic intake; a subsample of 4,881 reported on p

58 cant associations for cases with the longest prediagnostic lag (9 to 13 years).

59 n was used to study the associations between prediagnostic levels of high-sensitivity C-reactive prot

60 We evaluated the association between prediagnostic levels of IGF-I and insulin-like growth fa

61 To investigate whether prediagnostic levels of plasma folate are associated wit

62 In two large prospective cohorts, higher prediagnostic levels of plasma folate were not associate

63 In conclusion, higher prediagnostic levels of plasma leptin were associated wi

64 Prediagnostic levels of testosterone, androstenedione, d

65 The association between prediagnostic levels of urinary total NNAL and risk of l

66 an analysis of a third set consisting of 18 prediagnostic lung cancer sera collected as part of the

67 The authors retrieved several prediagnostic mammograms for breast cancer cases and for

68 s study, we investigated the associations of prediagnostic measures of N(epsilon)-(carboxymethyl)-lys

69 Activities of Daily Living Scale), potential prediagnostic motor (hypo- and bradykinesia, tremor, rig

70 e assessed using 16S rRNA gene sequencing in prediagnostic mouthwash samples from n = 81/160 EAC and

71 m metabolite with significant performance in prediagnostic NSCLC and has additive performance with pr

72 ns, kappa/lambda free light chains (FLCs) in prediagnostic obtained up to 9.8 years before CLL diagno

73 dence for an independent association between prediagnostic omentin concentrations and colorectal canc

74 Codes were extracted for a range of possible prediagnostic or early symptoms, comprising motor featur

75 The field of prediagnostic Parkinson's disease (PD) is fast moving wi

76 From 7 years before diagnosis onwards, prediagnostic Parkinson's disease cases more commonly ha

77 In conclusion, in patients with prediagnostic Parkinson's disease, impairments in instru

78 ogical description, and understanding of the prediagnostic, peridiagnostic and immediate postdiagnost

79 types of NSAIDs combined during the 10-year prediagnostic period than did controls (odds ratio (OR)

80 symptoms absent or not considered abnormal); prediagnostic phase (symptoms noticed but diagnosis not

81 20% ("passive"); early diagnosis during the prediagnostic phase at a rate of 10% per year ("enhanced

82 Advances in the understanding of this prediagnostic phase of Parkinson's disease (for which th

83 review, we outline current knowledge of the prediagnostic phase of PD, including an up-to-date revie

84 The prediagnostic phase of the disease offers a window of op

85 We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and l

86 fied risk of prostate cancer associated with prediagnostic plasma antioxidants (P(interaction) > or =

87 ORs and 95% CIs for the association between prediagnostic plasma concentrations of sICAM-1 and cance

88 th early disease, we profiled metabolites in prediagnostic plasma from individuals with pancreatic ca

89 ession to evaluate pancreatic cancer risk by prediagnostic plasma leptin, adjusting for race/ethnicit

90 Mean prediagnostic plasma level of 25(OH)D was 24.6 ng/mL, an

91 ts with pancreatic cancer who had sufficient prediagnostic plasma levels of 25(OH)D.

92 To investigate whether prediagnostic plasma levels of IGFBP-1 are associated wi

93 We investigated the association between prediagnostic plasma omentin concentrations and risk of

94 Prediagnostic plasma samples from patients (collected, o

95 Neither prediagnostic plasma vitamin D levels nor VDR polymorphi

96 Prediagnostic PLCO serum samples were tested for GBV-C R

97 Prediagnostic samples and samples from 2,623 matched con

98 HPV16 E6 seropositivity was present in prediagnostic samples for 34.8% of patients with orophar

99 aphy to measure blood SFA and MUFA levels in prediagnostic samples from 476 incident prostate cancer

100 Prediagnostic samples were analyzed for alpha-carotene,

101 In 30 of 90 patients, 110 prediagnostic samples were available from 2.2 to 15.3 ye

102 and/or structural variant in 91% (63/69) of prediagnostic samples with the mutational spectrum mirro

103 a strong dose-response relationship between prediagnostic sCD30 concentration and NHL risk among 234

104 performed using an independent set of CARET prediagnostic sera from 108 patients with NSCLC and 216

105 plied to identify biomarker candidates using prediagnostic sera from the Beta-Carotene and Retinol Ef

106 very of novel antigens and for validation in prediagnostic sera of autoantibodies to antigens previou

107 ver been determined by laboratory testing on prediagnostic sera.

108 her additional antigens may be identified in prediagnostic sera.

109 h head and neck cancer risk when measured in prediagnostic sera.

110 74 years of age at baseline to test whether prediagnostic serum 25(OH)D concentrations were associat

111 This study showed that prediagnostic serum 25(OH)D concentrations were not asso

112 adequate vitamin D status, as determined by prediagnostic serum 25(OH)D concentrations, was associat

113 Our findings suggest that higher prediagnostic serum 25(OH)D levels may be associated wit

114 Prediagnostic serum concentration of soluble CD30 (sCD30

115 We measured prediagnostic serum concentrations of DDT, its metabolit

116 an (PLCO) Cancer Screening Trial.We examined prediagnostic serum concentrations of diet-related metab

117 d with ER-negative breast cancer (144 cases).Prediagnostic serum concentrations of metabolites relate

118 We examined the associations between prediagnostic serum concentrations of sRAGE or N-(carbox

119 Prediagnostic serum DBP and 25(OH)D were studied in rela

120 y II Nutrition Cohort to investigate whether prediagnostic serum leptin was associated with pancreati

121 authors investigated the association between prediagnostic serum levels of oxidative stress indicator

122 Prediagnostic serum or plasma concentrations of selected

123 ctive cohort studies were able to contribute prediagnostic serum or plasma samples for hormone quanti

124 In conclusion, prediagnostic serum ROM levels were associated with incr

125 To study the relationship of PCBs to TGCT, prediagnostic serum samples from 736 cases and 913 contr

126 e a wide range of metabolites was applied to prediagnostic serum samples from CARET participants (cur

127 e study in whom serially collected (up to 6) prediagnostic serum samples obtained 2 to 9.8 years prio

128 77 469 participants, with serially collected prediagnostic serum samples.

129 Greater prediagnostic serum selenium concentrations were not ass

130 eactive protein, and sCD27] were measured in prediagnostic serum specimens from 297 incident NHL case

131 The presence of HGV RNA in prediagnostic serum was not associated with the risk of

132 uals at high risk of nonfamilial cancer, and prediagnostic signs and symptoms are vague and not limit

133 We assessed the association between prediagnostic smoking and second smoking-associated canc

134 trials being planned for individuals in the prediagnostic stage of HD propose to use delay of diseas

135 be sensitive and specific biomarkers in the prediagnostic stages of Huntington disease (HD).

136 Between December 1993 and August 1994, prediagnostic sTNFp55 concentrations (a marker of excess

137 actors for pancreatic cancer with detectable prediagnostic symptomatology can allow investigators to

138 To examine associations of prediagnostic systemic inflammation with at-diagnosis sa

139 Subsequently, we compared prediagnostic trajectories of daily functioning and othe

140 Prediagnostic urinary 15-F(2t)-IsoP and 15-F(2t)-IsoPM w

141 In this study, we quantified prediagnostic urinary levels of r-1,t-2,3,c-4-tetrahydro

142 ific and all-cause mortality associated with prediagnostic use of 5-ARIs.

143 ined the association between recent (1 year) prediagnostic use of aspirin (COX1/COX2 inhibitor), lymp

144 lity, and considering effect modification by prediagnostic use of statins.

145 ntrary to expectations, subjects with higher prediagnostic vitamin D status had an increased pancreat