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1 tudy aimed to test whether MO epigenetically predisposes adipocyte progenitors in the fat of offsprin
3 show that deleterious maternal environments predispose aging offspring to metabolic disorders and ty
4 te that genetic variation at TCF7L2 does not predispose an individual to type 2 diabetes by altering
5 ypothesis that certain host genetic variants predispose an individual towards microbiome dysbiosis.
6 maintain that this condition is genetically predisposed and is associated with endothelial dysfuncti
7 spital systematically to ascertain baseline, predisposing and precipitating stressors, angiographic f
8 tified specific quantitative trait loci that predispose animals to hypertension-associated albuminuri
9 ium elongation defects in kidney tubules and predisposed animals to cyst development, either in genet
12 mediated by hepatic macrophages, which were predisposed by maternal HBV e antigen (HBeAg) to support
14 found in genes associated with sudden death-predisposing catecholaminergic polymorphic ventricular t
16 sage through the mitosis-G1 transition might predispose cells to diverge in gene expression states.
21 use, and degree of concurrent illness might predispose certain patients presenting with hyperkalemia
22 ile certain ligand physiochemical properties predispose changes in binding mode, particularly those p
24 phisms between low-copy repeats (LCRs) might predispose chromosomes to meiotic non-allelic homologous
27 -competent mice are dispensable in mice with predisposing conditions such as influenza infection.
28 microbiota regulates cancer at the level of predisposing conditions, initiation, genetic instability
29 uggests that (1) genetics play a bigger role predisposing eczema to hay fever and eczema to asthma th
30 alth Services Use were conducted to identify predisposing, enabling, and need variables associated wi
32 Mann-Whitney (continuous) tests to determine predisposing factors and morbidity attributable to resis
33 e of, and to estimate the long-term risk and predisposing factors and the surgical outcomes for, reti
38 CP underscores the importance of identifying predisposing factors for progression of ARP to CP in chi
40 on the incidence, clinical implications, and predisposing factors of transcatheter heart valve (THV)
43 ociations persist after accounting for those predisposing factors, including genetic liability and ea
44 cidence, time course, clinical significance, predisposing factors, optimal imaging modality, and curr
46 d acute threat responding and via that route predispose for affective disorder.SIGNIFICANCE STATEMENT
47 independent well-folded conformation that is predisposed for highly selective and high affinity recog
49 he 3SCC C-termini, whereas the cysteines are predisposed for trigonal planar Hg(II)S3 and 4-coordinat
50 ack the tyrosine phosphatase Ptpn22, a major predisposing gene for autoimmune disease, are resistant
51 tion study indicating that B*08 and B*39 are predisposing genes, the etiologic role of HLA class I in
54 hyosis vulgaris (IV) and represent the major predisposing genetic risk factor for atopic dermatitis (
56 arly for atrophic AMD, the identification of predisposing genetic variations has informed clinical st
58 ns, independent of pathogen replication, may predispose hosts to life-threatening environmental stres
59 rrelated individual characteristics that may predispose individual subjects to exhibit distinct motor
62 dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovari
64 idence suggesting that early-life stress may predispose individuals to increased anxiety and depressi
66 onstraints, mutations in which are likely to predispose individuals to life-threatening disease, as i
67 en chronically or repeatedly activated-might predispose individuals to stress-related psychopathology
68 , we hypothesised that certain genotypes may predispose individuals to these lesions and consequently
69 s, can greatly impact adult behavior and may predispose individuals to various psychopathologies.
71 isk of malignant mesothelioma in genetically predisposed individuals carrying germline BAP1 mutations
73 g as it usually develops in some genetically predisposed individuals with normal cardiac repolarizati
74 llowing repeated use of reinforcing drugs in predisposed individuals, leading to lifelong changes.
79 anism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnor
80 cular degeneration (AMD), and AP dysfunction predisposes individuals to disorders such as paroxysmal
83 ion that behaves as a partial FH deficiency, predisposing individuals to diverse pathologies with dis
87 isruption in the function of the endothelium predisposes it toward formation of atherosclerotic plaqu
88 segment, caesarean scars may heal improperly predisposing it to be a site of improper implantation of
90 I outbreaks often occur among people without predisposing medical conditions and are frequently preci
92 oded by CDH1), inactivation of Cdh1 does not predispose mice to develop mammary tumors, implying that
93 in two independently generated mouse strains predisposed mice to develop obesity, metabolic inflammat
94 ficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malign
95 findings demonstrate that an APOE3 genotype predisposes mice to develop obesity and its metabolic co
96 atory networks of related sets of genes have predisposed miRNAs to become ideal candidates for drug d
97 age 25 years, 16 of 42 patients (38%) had a predisposing mutation to meningioma and 27 of 135 patien
98 of underlying genetic mutation, or lack of a predisposing mutation, was associated with the presentin
99 he known heritable meningioma- or schwannoma-predisposing mutations in children and young adults pres
102 Our data indicate that household smoking may predispose neonates with muco-obstructive lung disease t
103 BB dysfunction in various brain injuries can predispose neural circuitry to the development of chroni
104 that an increase of intracellular Hcy levels predisposes neurons to develop abnormal protein aggregat
106 xposure to dietary refined carbohydrates may predispose offspring to an obese phenotype, indicating a
107 posure to artificial sweeteners in utero may predispose offspring to develop obesity; however, to our
108 t are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, in
109 Maternal obesity and high-fat diet (HFD) predisposes offspring to obesity and metabolic diseases.
110 ecifically, maternal stress during pregnancy predisposes offspring to sex-biased neurodevelopmental d
112 rospectively identify anatomic variants that predispose patients to major surgical complications; how
115 and novel potent off-target sites, which can predispose patients to treatment failure and adverse eff
116 ess, intravenous drug use, and alcohol abuse predisposed patients to emm32.2 iGAS disease; however, n
118 gus is a chronic precancerous condition that predisposes patients to the development of oesophageal a
121 Neutrophils in particular are defective, predisposing patients to life-threatening bacterial infe
123 tial biomass allocation aboveground that (1) predispose plants to hydraulic constraints limiting phot
124 se platelet aggregation, but it is enough to predispose platelets to fully respond to Gi-activating s
125 t triggers biased G-protein agonism and thus predisposes platelets to full activation by other stimul
126 of 19 clinical variables, and the steatosis predisposing PNPLA3 rs738409 single nucleotide polymorph
127 for gene-environment interaction between EoE-predisposing polymorphisms (within TSLP, LOC283710/KLF13
128 e model that disruption of AR's function may predispose prostate cancer to progress to metastatic CRP
130 ar to older-onset type 2 diabetes, the major predisposing risk factors are obesity, family history, a
132 bones might act as a structural constraint, predisposing some articulations to closure, both in norm
133 re-tumor niche establishes a chromatin state predisposing squamous cell carcinomas to undergo EMT and
134 berrations in striatal connectivity that may predispose striatal circuitry to both motor and nonmotor
137 c sleep loss, through microglia priming, may predispose the brain to further damage.SIGNIFICANCE STAT
139 that the droplet state can incubate tau and predispose the protein toward the formation of insoluble
140 , and reveal evolutionary events that likely predisposed the precursor of P. falciparum to colonize h
142 as a bottleneck to bilirubin elimination and predisposes the infant to high total serum bilirubin lev
143 evels of inflammatory cytokines, potentially predisposing the elderly to the subsequent development o
145 CpGs and genomic repetitiveness of the loci predispose their susceptibility to epiallelic switching.
146 CKD have unsuspected genomic disorders that predispose them to organ malformations and neurocognitiv
147 urate levels observed in patients with gout predispose them to the formation of monosodium urate (MS
148 ctions for the control of hand movements and predispose them to undertake different, perhaps somewhat
150 that may be partly established at birth and predisposes them to chronic obstructive pulmonary diseas
151 of MaSC-like properties by luminal cells and predisposes them to development of mammary tumours with
154 radation of wild-type BRCA2 protein, thereby predisposing them to genomic instability and perhaps to
155 ng mice and humans are primed for apoptosis, predisposing them to undergo cell death in response to g
157 lent recessive defects of the myocardium may predispose to acute heart failure presenting as AM, nota
158 ), a key epidermal barrier protein, strongly predispose to AE; however, the precise role of FLG defic
159 ive sleep apnea, and elevated blood pressure predispose to AF, and each factor has been shown to indu
160 ovel traits associated with alleles known to predispose to alcohol and nicotine use, we conducted a p
161 mline pathogenic variants in BRCA1 and BRCA2 predispose to an increased lifetime risk of breast cance
162 decreased and increased copy numbers of NCF1 predispose to and protect against SLE, respectively.
172 prevalence of overweight and obesity, which predispose to chronic disease, highlight the importance
173 ts demonstrate that Csa and Csb deficiencies predispose to cisplatin-induced hearing loss and hair/su
174 ures involved in limbic and memory functions predispose to delirium under the stress of surgery.
175 function as subtherapeutic tacrolimus levels predispose to episodes of acute rejection, whereas supra
176 diseases, such as colitis and pancreatitis, predispose to gastrointestinal (GI) adenocarcinoma by re
177 iated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggest
180 ration, classically has been hypothesized to predispose to irreversible nephron damage, thereby contr
181 1) contributes to ICL repair, FAN1 mutations predispose to karyomegalic interstitial nephritis (KIN)
182 A20-binding inhibitor of NF-kappaB1 (ABIN1) predispose to lupus and other autoimmune diseases in at
183 homeostasis network that have been shown to predispose to obesity and the so-called metabolic syndro
186 rols, even after excluding 13 genes known to predispose to pancreatic cancer (adjusted odds ratio, 1.
187 plex II (succinate dehydrogenase; SDH) genes predispose to paraganglioma tumors that show constitutiv
188 hough functional GLRB gene polymorphisms may predispose to PD by increasing startle response and agor
189 ein transgenics], we show that Gba mutations predispose to PD through a loss-of-function mechanism.
192 chanisms by which SMARCB1 germline mutations predispose to rhabdoid tumors versus schwannomas are sti
193 election pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, m
194 ings of obesity associated changes that help predispose to specific diseases and also identifies nove
195 y suggests that a polymorphism at 7p14.3 may predispose to SPOP mutant prostate cancer subclass throu
196 polymorphic regulatory element at 7p14.3 may predispose to SPOP mutant prostate cancer subclass throu
200 tion and steatohepatitis, have been shown to predispose to the development of hepatocellular carcinom
201 charge from hospital environments, which may predispose to the development of inflammatory and metabo
202 ohort study of patients with conditions that predispose to thoracic aortic aneurysms and dissections,
208 ological mechanisms by which common variants predispose to type 2 diabetes requires large studies wit
212 nset of metabolic dysregulation in offspring predisposed to altered beta-cell function and hyperglyce
213 e found experimentally, model RT neurons are predisposed to an activity-dependent switch from GABA-me
218 3Kgamma inhibition in obese patients who are predisposed to beta-cell failure is not expected to prod
221 rited disease in which affected patients are predisposed to develop benign Schwann cell (SC) tumours
224 saccharide oligomers and polymers, which are predisposed to fold into specific ordered secondary stru
225 ional algorithm for mapping protein surfaces predisposed to HTB1 intermolecular interactions to const
228 tein, with a flexible binding region that is predisposed to ligand binding with the desired geometry.
230 Neurofibromatosis type 1 (NF1) patients are predisposed to neurofibromas but the driver(s) that cont
232 f a progenitor niche in postnatal cerebellum predisposed to oncogenic induction of medulloblastoma.
233 children genetically at risk for obesity are predisposed to represent reward signals more strongly, w
234 Furthermore, people with SRA itself are predisposed to root resorption during orthodontic treatm
235 gly, mice with germline knockout of Lgr6 are predisposed to SCC development, through a mechanism that
236 n during primary Pneumovirus infection alone predisposed to severe bronchiolitis in early life and su
240 er in which affected children and adults are predisposed to the development of benign and malignant n
241 sulin secretion capacity in patients who are predisposed to the failure of pancreatic beta-cell funct
243 r deletion of its I prostanoid receptor also predisposes to accelerated atherogenesis and thrombosis
248 (CS) is an autosomal dominant disorder that predisposes to breast, thyroid, and other epithelial can
249 erase reverse transcriptase (TERT) gene that predisposes to CH (rs34002450; P = 7.4 x 10(-12); odds r
254 tested the hypothesis that CDKN2A deficiency predisposes to increased platelet production, leading to
262 eem to constitute a separate phenomenon that predisposes to postsurgical delirium independent of pres
263 type, mice, suggesting that IL-10 deficiency predisposes to pregnancy disruptive effects of environme
265 ed reactive oxygen species (ROS) production, predisposes to SLE (odds ratio (OR) = 3.47 in Asians (Pm
266 ed with high morbidity and mortality, and it predisposes to the development and progression of CKD.
267 is associated with cardiovascular events and predisposes to the development of clinically important m
268 n that promotes progression to cirrhosis and predisposes to the development of hepatocellular carcino
269 Airway-colonization by Staphylococcus aureus predisposes to the development of ventilator-associated
272 creased brain amyloid accumulation, possibly predisposing to accelerated cognitive impairment or even
274 tricular responses and extracellular changes predisposing to adverse outcomes in this population.
275 skin condition that can occur in early life, predisposing to asthma development in a phenomenon known
276 antly higher costs to the health service and predisposing to Clostridium difficile, methicillin-resis
277 morphine treatment results in a "leaky" gut, predisposing to colonic inflammation that is facilitated
278 ate, a large proportion of genetic variation predisposing to complex disease and traits remains unacc
280 progression of chronic vascular inflammation predisposing to coronary atherosclerosis and to thrombos
286 pathy is an inherited heart muscle disorder, predisposing to sudden cardiac death, particularly in yo
287 resent a stress susceptibility endophenotype predisposing to the development of trauma-related psycho
292 hich indicate that individual susceptibility predisposes towards the expression of different behaviou
294 tin (TBT) throughout pregnancy and lactation predisposes unexposed F4 male descendants to obesity whe
295 V challenges, but their use potentially will predispose vaccinated individuals to infection by the re
297 is studies indicate that amino acid residues predisposing VH1-46 Abs to Dsg3 reactivity reside in CDR
299 ses the latest on how the vaginal microbiota predisposes women to acquisition of STIs and discusses f
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