ライフサイエンスコーパス: predispose @1 to

1 Germline mutations in BRCA1 predispose carriers to a high incidence of breast and ov

2 Mutations within BRCA1 predispose carriers to a high risk of breast and ovarian

3 l groups, yet whether personality traits may predispose individuals to a particular rank remains uncl

4 e of physical restraints/restraining devices predisposed patients to a greater risk of delirium, poin

5 both inflammatory and immunosuppressive and predisposes mice to a defective immune response to a min

6 y injury accompanied by severe inflammation, predisposing patients to a poor prognosis.

7 otine dependence (ND) have disclosed too few predisposing variants to account for the high estimated

8 ses the latest on how the vaginal microbiota predisposes women to acquisition of STIs and discusses f

9 Excessive Ca2+ influx through TRPV4 predisposes RGCs to activation of Ca2+ -dependent proapo

10 ning nine genes at the genomic locus 16p13.1 predispose individuals to acute aortic dissections.

11 Mutation p.N34S in SPINK1 may predispose patients to acute pancreatitis, especially in

12 l squamous epithelium and this process might predispose individuals to adenocarcinoma.

13 is associated with abnormalities that might predispose individuals to adenocarcinoma.

14 ice and humans, and genetic deletion of Dab2 predisposed macrophages to adopt a proinflammatory M1 ph

15 uggest that the deletions of CCL2 and CX3CR1 predispose mice to age- and light-mediated retinal damag

16 AOS predisposes patients to aggressive and widespread cardio

17 e approach to identify genetic variants that predispose individuals to AIH.

18 Knowledge about factors predisposing patients to AL is vital to its early detect

19 r to the neurobehavioral factors which might predispose youth to alcohol misuse.

20 ted with changes in the immune system, which predispose subjects to allergy.

21 Multiple risk factors exist that predispose patients to ALs.

22 Because mutations in VCP predispose humans to amyotrophic lateral sclerosis, fron

23 xposure to dietary refined carbohydrates may predispose offspring to an obese phenotype, indicating a

24 s may elicit a strong inflammatory response, predisposing recipients to an increased risk of cancer a

25 ent, clinical, and surgical factors that may predispose patients to anastomotic leak (AL) after large

26 ly event during cervical carcinogenesis that predisposes cells to aneuploidy.

27 ome had shallow anterior chamber angles that predisposed them to angle-closure glaucoma.

28 bserved during infections, may significantly predispose recipients to antibody-mediated TRALI reactio

29 normalities exist at the molecular level and predispose them to arrhythmias.

30 (GWAS) have discovered genetic variants that predispose individuals to asthma.

31 Genetic factors predispose individuals to attention-deficit/hyperactivit

32 Numerous complement factor H (FH) mutations predispose patients to atypical hemolytic uremic syndrom

33 red hundreds of common genetic variants that predispose humans to autoimmune diseases, opening up unp

34 is initiated by defective host defense that predisposes airways to bacterial infection.

35 segment, caesarean scars may heal improperly predisposing it to be a site of improper implantation of

36 llow us to investigate the factors that both predispose them to become obese and that prevent or enha

37 atory networks of related sets of genes have predisposed miRNAs to become ideal candidates for drug d

38 ost-translational modifications) and thereby predisposing them to become immunogenic.

39 Fuel desulfurization might predispose ULSD to biodeterioration relative to sulfur-r

40 s at two early T cell checkpoints, which may predispose them to both leukemia and autoimmunity.

41 ction with other pathogens, and in doing so, predispose animals to bovine respiratory disease.

42 aim of this study was to identify gene loci predisposing infants to BPD.

43 Mutations in the tumor suppressor BRCA1 predispose women to breast and ovarian cancers.

44 utations in breast cancer 1 (BRCA1) strongly predispose women to breast cancer.

45 the repair of DNA damage, and loss of BRCA2 predisposes carriers to breast and ovarian cancers.

46 d to have a germline mutation in a gene that predisposes women to breast or ovarian cancer, using a p

47 We hypothesized that hyperoxic exposure, a predisposing factor to bronchopulmonary dysplasia, modul

48 rafficking to the central nervous system may predispose patients to C-IRIS.

49 RECENT FINDINGS: Multiple medical factors predispose patients to C. difficile-associated diarrhea.

50 Clindamycin predisposes patients to C. difficile colitis.

51 y genes, in immune and epithelial cells, and predispose GSDs to CAD.

52 wide range of genetic disease syndromes and predispose carriers to cancer.

53 or lost in human tumours and syndromes that predispose individuals to cancer.

54 pathways that control its ubiquitination may predispose one to cancer.

55 s during infection with Helicobacter pylori, predisposing patients to cancer.

56 traceptives and hormonal replacement therapy predispose women to Candida albicans infections.

57 Because pre-eclampsia predisposes mothers to cardiovascular disease later in l

58 ntravascular catheters, forming biofilms and predisposing patients to catheter-associated infection (

59 fect fetal lung development and subsequently predispose children to childhood asthma.

60 esting that the mutation identified here may predispose patients to cholestasis through a delocalizat

61 K8/K18 variants predispose humans to chronic liver disease progression a

62 reduction (MNR) during fetal development may predispose offspring to chronic disease later in life.

63 -related circuitry, white matter connections predisposed patients to chronic pain.

64 that may be partly established at birth and predisposes them to chronic obstructive pulmonary diseas

65 ionate risk factors (diabetes, hypertension) predisposing them to CKD.

66 Long standing IBD predisposes individuals to colitis-associated colorectal

67 lcerative colitis where chronic inflammation predisposes them to colon cancer.

68 dominantly inherited germline mutations that predispose individuals to colorectal, endometrial, ovari

69 germline genetic variation in Mendelian loci predisposes bearers to common cancers, the same loci may

70 mplex pathway to maintain DNA integrity also predispose patients to constitutional defects in growth

71 iated with contact lens cases and lenses can predispose individuals to contact lens-related inflammat

72 th a possible role of psychiatric disease in predisposing patients to critical illness and an increas

73 ium elongation defects in kidney tubules and predisposed animals to cyst development, either in genet

74 ADeltaE, suggesting that the DeltaE mutation predisposes torsinA to defects in the presence of second

75 s that may impede their ability to learn and predispose them to depression.

76 sive interest not only because its mutations predispose carriers to devastating tumors, but also beca

77 gested to be a factor that could potentially predispose humans to develop obesity.

78 ven a single moderate to severe TBI can also predispose individuals to develop a pathologically disti

79 Obesity and associated insulin resistance predispose individuals to develop chronic metabolic dise

80 ence orofacial pain perception and, in turn, predispose individuals to develop fears about pain.

81 e is known about the genetic mechanisms that predispose individuals to develop inguinal hernias.

82 oded by CDH1), inactivation of Cdh1 does not predispose mice to develop mammary tumors, implying that

83 posure to artificial sweeteners in utero may predispose offspring to develop obesity; however, to our

84 nderstand the interplay between factors that predispose patients to develop the disease.

85 experienced an onset of depression; this may predispose them to develop not only MDD but also other a

86 in two independently generated mouse strains predisposed mice to develop obesity, metabolic inflammat

87 findings demonstrate that an APOE3 genotype predisposes mice to develop obesity and its metabolic co

88 that an increase of intracellular Hcy levels predisposes neurons to develop abnormal protein aggregat

89 Low birth weight predisposes one to develop asthma, and excess body mass

90 individuals with the metabolic syndrome and predisposes them to develop type 2 diabetes.

91 attempt to define the age-associated changes predisposing individuals to develop IPF.

92 ess of these risk factors, certain disorders predispose individuals to developing arthritis.

93 lium to metaplastic columnar epithelium that predisposes individuals to developing esophageal adenoca

94 ls cooperate with and/or amplify events that predispose individuals to development of autoimmunity.

95 on of endogenous repair and regeneration and predispose patients to development of future cognitive d

96 of MaSC-like properties by luminal cells and predisposes them to development of mammary tumours with

97 upts rhythmic cycling of Ly6C(hi) monocytes, predisposing mice to development of pathologies associat

98 anism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnor

99 te that increase plasma APOC3 concentrations predispose mice to diet-induced NAFLD and hepatic insuli

100 We further show that loss of Sln predisposes mice to diet-induced obesity, which suggests

101 and knowledge of susceptibility factors that predispose individuals to DILI.

102 Whether having iciHHV-6 predisposes humans to diseases remains undefined.

103 cular degeneration (AMD), and AP dysfunction predisposes individuals to disorders such as paroxysmal

104 rajectories exist in cooperative vertebrates predisposing them to dispersal or philopatry.

105 sage through the mitosis-G1 transition might predispose cells to diverge in gene expression states.

106 ion that behaves as a partial FH deficiency, predisposing individuals to diverse pathologies with dis

107 r early exposure to p,p -DDE correspondingly predisposes women to early-onset breast cancer.

108 hree patients (96%) had at least 1 condition predisposing them to easy bruising.

109 ithelial (NPE) cells have been postulated to predispose cells to EBV infection.

110 letion, and the resulting increases in NAEs, predispose mice to ectopic lipid storage and hepatic ins

111 ess, intravenous drug use, and alcohol abuse predisposed patients to emm32.2 iGAS disease; however, n

112 Mutations in the WFS1 gene predispose cells to endoplasmic reticulum stress-mediate

113 hese data suggest that early life injury may predispose individuals to enhanced sensitivity to painfu

114 13a2 mutants have increased cytotoxicity and predispose cells to ER-stress-induced cell death.

115 as a specific heterochromatin landscape that predisposes it to erosion of X chromosome inactivation (

116 n of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma, a tum

117 These patterns could predispose them to esophagopharyngeal reflux.

118 voltage-dependent activation of I(DR)/Kv2.1, predisposed neurons to excessive K(+) efflux, a vital st

119 uggesting that a history of fat bingeing may predispose individuals to exhibit more robust "addiction

120 of DNA replication through the (CGG)n repeat predisposes it to expansions during intergenerational tr

121 d that heterozygous germline GATA2 mutations predispose carriers to familial myelodysplastic syndrome

122 Thus, their basic biology does not predispose them to favor the recommended low-sugar, low-

123 Chinese because of morphologic findings that predispose whites to femoroacetabular impingement.

124 inflammatory responses that may progress, in predisposed individuals, to fibrosis and cirrhosis.

125 Characteristics that predispose patients to financial hardship during cancer

126 t triggers biased G-protein agonism and thus predisposes platelets to full activation by other stimul

127 se platelet aggregation, but it is enough to predispose platelets to fully respond to Gi-activating s

128 further changes in ecosystem conditions and predispose communities to future disturbances.

129 dies have nominated a number of processes in predisposing PCA to genomic rearrangements, including an

130 radation of wild-type BRCA2 protein, thereby predisposing them to genomic instability and perhaps to

131 We tested whether Myh9 podocyte deletion predisposed mice to glomerulopathy in response to injury

132 ion that increases in frequency with age and predisposes individuals to haematological malignancy.

133 characteristics of prestimulus activity that predisposed participants to hallucinations: overall lowe

134 characteristics of prestimulus activity that predisposed participants to hallucinations: overall lowe

135 y affinity maturation suggests that LypW may predispose individuals to have a diminished capacity to

136 uggests that (1) genetics play a bigger role predisposing eczema to hay fever and eczema to asthma th

137 may adversely influence myocardial function, predisposing individuals to heart failure later in life.

138 Genetic disorders of lymphocyte cytotoxicity predispose patients to hemophagocytic lymphohistiocytosi

139 Genetic variations predispose individuals to hereditary diseases, play impo

140 indicate that haploid insufficiency of SEL1L predispose mice to high fat diet-induced hyperglycemia.

141 dyskinesia, in which mucociliary dysfunction predisposes subjects to high rates of nontuberculous myc

142 Males are less compliant, which in turn may predispose them to higher colonization and infection rat

143 and a source of exposure to the fetus, is a predisposing factor to higher BP in girls but not boys.

144 er CD4 + T cell counts coupled with age were predisposing factors to HIV-related ocular complications

145 and that selection on specific pathways may predispose isolates to human virulence.

146 mimic the high-progesterone luteal phase and predispose women to human immunodeficiency type 1 (HIV-1

147 y contribute to abnormal blood lipid levels, predisposing individuals to human cardiometabolic disord

148 tial biomass allocation aboveground that (1) predispose plants to hydraulic constraints limiting phot

149 tified specific quantitative trait loci that predispose animals to hypertension-associated albuminuri

150 tic defects and/or environmental factors may predispose mammals to immune-mediated diseases triggered

151 allosteric opening of the active site, thus predisposing PBP2a to inactivation by a second beta-lact

152 idence suggesting that early-life stress may predispose individuals to increased anxiety and depressi

153 Some patient characteristics may predispose patients to increased endothelial cell loss d

154 f leptin in lambs born to obese ewes thereby predisposing them to increased appetite and weight gain

155 uced left ventricular ejection fraction (EF) predisposes patients to inducible VT after ST-segment-el

156 depolarizations akin to spreading depression predisposes migraineurs to infarction during mild ischem

157 Reductions in C4 levels may predispose individuals to infection with encapsulated ba

158 function characterized by immune depression, predisposing patients to infections, and immune activati

159 on in various mouse models and is thought to predispose humans to inflammatory bowel disease (IBD).

160 variants of inflammasome components known to predispose individuals to inflammatory disorders have a

161 ic behavioral and neural characteristics may predispose adolescents to initiate and escalate use of a

162 growth, and even mild, episodic stresses can predispose plants to inoculum levels they would otherwis

163 ong evidence that >/= 1 yr of severe drought predisposes pinon to insect attacks and increases mortal

164 To test the hypothesis that drought predisposes trees to insect attacks, we quantified the e

165 Maternal obesity in pregnancy predisposes offspring to insulin resistance and associat

166 Molecular mechanisms predisposing people to insulin resistance are starting t

167 riboswitches have 3b.3n sequences that would predispose them to ion-induced folding, U4 snRNA are str

168 at certain neurons have characteristics that predispose them to join networks with learning.

169 bility that functional mutations in CD36 may predispose individuals to K. pneumoniae syndromes.

170 resented by reduced serum MBL concentration, predisposes individuals to LB.

171 ns, independent of pathogen replication, may predispose hosts to life-threatening environmental stres

172 onstraints, mutations in which are likely to predispose individuals to life-threatening disease, as i

173 Neutrophils in particular are defective, predisposing patients to life-threatening bacterial infe

174 nduces bone marrow (BM) failure in patients, predisposing them to life-threatening infections and ble

175 ver disease, suggesting that genetic factors predispose individuals to liver disease.

176 rotein modification system in CVB3 infection predisposed mice to long-term disease with deposition of

177 abrupt termination of breastfeeding, thereby predisposing infants to long-term health risks.

178 Infection by HIV predisposes individuals to M. tuberculosis infection, an

179 monocytes to chemokine-induced recruitment, predisposing macrophages to M1 polarization, decreased a

180 rospectively identify anatomic variants that predispose patients to major surgical complications; how

181 the Brca1185stop and Brca15382stop mutations predisposed animals to mammary tumors, but Brca1185stop

182 he corresponding mouse allele, Mcm4(Chaos3), predisposes mice to mammary gland tumors.

183 phisms between low-copy repeats (LCRs) might predispose chromosomes to meiotic non-allelic homologous

184 netic mutations and UV irradiation (UVR) can predispose individuals to melanoma.

185 age 25 years, 16 of 42 patients (38%) had a predisposing mutation to meningioma and 27 of 135 patien

186 uld increase MERS-CoV receptor abundance and predispose individuals to MERS morbidity and mortality,

187 mutations in the BAP1 tumor suppressor gene predispose individuals to mesothelioma and other cancers

188 effects of metabolic stress, and its absence predisposes individuals to metabolic dysfunction.

189 Obesity is a major public health problem, predisposing subjects to metabolic syndrome, type 2 diab

190 Efforts to identify genetic aberrations that predispose tumors to metastasis have been mostly unsucce

191 s in a gene encoding a ribosomal protein can predispose individuals to microsatellite-stable colon ca

192 ls mitochondrial morphogenesis and serves to predispose cells to mitochondrial permeability transitio

193 how that the pol gamma mutation R964C, which predisposes patients to mitochondrial toxicity when rece

194 antation, suggesting that lung damage itself predisposed patients to mold infections.

195 ed innate and adaptive immune activation may predispose children to more severe RSV disease.

196 ed childhood genetic diseases and those that predispose individuals to more common complex diseases.

197 uncharacterized NK cell functional deficits predispose individuals to more significant or frequent h

198 Secondary infection predisposes individuals to more severe disease, and B ly

199 mmon complication after severe trauma, which predisposes patients to multiple organ failure.

200 AD STAT1 deficiency selectively predisposes individuals to mycobacterial disease, owing

201 netic and environmental factors are known to predispose individuals to NAFLD.

202 association with NAFLD, genetic factors that predispose liver to NAFLD and molecular mechanisms by wh

203 whether increased expression of APOC3 would predispose mice to NAFLD and hepatic insulin resistance,

204 An SREBF-2 polymorphism predisposes individuals to NAFLD and associated cardiome

205 a large degree of phenotypic plasticity that predisposes them to neoplastic transformation and acquis

206 Genetic factors may also predispose individuals to nephrotoxicity.

207 mong patients with comorbidities reported to predispose them to nephrotoxicity.

208 tically sensitizing locus, Lis1/Pafah1b1, to predispose animals to neurodevelopmental defects.

209 t are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, in

210 Genetic factors that predispose individuals to nonalcoholic fatty liver disea

211 Alterations in immune function can predispose patients to nosocomial infections.

212 ntal disruption of circadian rhythms in mice predisposes animals to OA-like damage.

213 ion is that most mutations in the genes that predispose us to obesity are neutral and have been drift

214 odification, but the mechanisms by which FTO predisposes humans to obesity remain unclear.

215 Maternal obesity and high-fat diet (HFD) predisposes offspring to obesity and metabolic diseases.

216 Maternal obesity (MO) predisposes offspring to obesity and type 2 diabetes des

217 Immunosuppression after measles is known to predispose people to opportunistic infections for a peri

218 CKD have unsuspected genomic disorders that predispose them to organ malformations and neurocognitiv

219 -proliferative phenotype in hPASMCs that may predispose women to PAH.

220 Several surgical and patient risk factors predispose patients to pain following neurosurgery.

221 insulin therapy and to identify factors that predispose patients to pancreatic allograft failure afte

222 VPA does not cause injury on its own, but it predisposes patients to pancreatitis by inhibiting HDACs

223 ial hypoKPP and how mutations of the channel predispose patients to paralysis are unknown.

224 has been suggested that genetic factors may predispose individuals to periodontal diseases.

225 ed in animal models of chronic pain that may predispose patients to persistent neuropathic pain after

226 ests that neglected tropical diseases (NTDs) predispose individuals to poor mental health.

227 determine whether intraoperative hypothermia predisposes patients to postoperative surgical site infe

228 e of membranes (PROM) is a major factor that predisposes women to preterm delivery.

229 nomer-mediated transcriptional effects could predispose individuals to prolonged behavioral and metab

230 c inflammation, regardless of the cause, may predispose men to prostate cancer.

231 leasant information, as measured by the LPP, predispose children to psychiatric symptoms when exposed

232 aberrant brain-wide structural connectivity predisposing individuals to psychosis.

233 Second, these specializations predisposed individuals to pursue different developmenta

234 asions their low-potential biochemistry will predispose them to rapid ROS formation.

235 al inflammation during early HIV-1 infection predisposes women to rapid disease progression.

236 Life on oxygen predisposes cells to reactive oxygen species (ROS) gener

237 mplex repetitive architecture of this region predisposes it to rearrangements, some of which are recu

238 t the varying amplitude of dysrhythmia could predispose patients to recurrent attacks.

239 uring the first 5 years after birth, thereby predisposing individuals to reduced lung function and in

240 clones harboring different sets of mutations predispose patients to relapse or disease progression.

241 by abnormal intravitreal neovascularization predisposing patients to retinal detachment and blindnes

242 ryngeal swallow in chronic cigarette smokers predispose them to risks of aspiration and similarly, ab

243 ative stress may indicate failure to reseal, predisposing membranes to rupture.

244 The single largest risk factor that predisposes people to schizophrenia or bipolar illness i

245 Seasonal and especially pandemic influenza predispose patients to secondary bacterial pneumonias, w

246 sed ATG7 levels and an autophagy defect that predisposes cells to secondary mutations, resulting in t

247 Influenza infection predisposes patients to secondary bacterial pneumonia th

248 he two adult prickle isoforms in neurons can predispose flies to seizures.

249 ganglia reward, circuitries in a manner that predisposes individuals to self-medicating behaviors lik

250 hich oncogenic RAS promotes senescence while predisposing cells to senescence bypass by allowing for

251 The insidious growth of these tumours predisposes patients to serious complications including

252 significant gut bacterial translocation and predisposes patients to serious infections with gut orig

253 Deficient NET formation predisposes humans to severe infection, but, paradoxical

254 ICL predisposes patients to severe opportunistic infections

255 condary infection with a different serotype, predisposing individuals to severe disease.

256 ecifically, maternal stress during pregnancy predisposes offspring to sex-biased neurodevelopmental d

257 Their high hydrophobicity predisposes them to signal-amyloid interactions, but spe

258 composition of the cutaneous microbiota may predispose individuals to skin abscesses.

259 ne proteins can affect receptor function and predispose individuals to specific autoinflammatory diso

260 lts demonstrate how genes and processes that predispose organs to specific diseases can be identified

261 The presence of comorbid conditions may predispose patients to specific complications or forms o

262 hat neural-specific knockout of nucleostemin predisposes embryos to spontaneous DNA damage that leads

263 a complete lack of TGF-beta signaling in DCs predisposes mice to spontaneous autoimmunity and to veri

264 prion diseases, support that mutations might predispose PrP to spontaneously misfold.

265 egy to screen for genes that upon repression predispose mice to squamous cell carcinomas (SCCs).

266 en chronically or repeatedly activated-might predispose individuals to stress-related psychopathology

267 rs generate an abundance of micronuclei that predispose chromosomes to subsequent catastrophic pulver

268 perative sinus CT with a focus on those that predispose patients to surgical complications.

269 Loss of this function predisposes animals to systemic insulin resistance, over

270 n, suggesting that they precede and possibly predispose chromosomes to the translocation.

271 e or bacterial microbiota have been shown to predispose individuals to the development of opportunist

272 in dopamine neurons during normal aging may predispose individuals to the development of PD.

273 bulbar manifestations, or low lung volumes, predispose patients to the development of obstructive ev

274 rations of myocardial diastolic function may predispose patients to the development of POAF.

275 urate levels observed in patients with gout predispose them to the formation of monosodium urate (MS

276 Neurofibromatosis type 1 (NF1) predisposes individuals to the development of juvenile m

277 Acute kidney injury predisposes patients to the development of both chronic

278 ronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal ca

279 Autonomic dysfunction predisposes patients to the development of critical illn

280 gus is a chronic precancerous condition that predisposes patients to the development of oesophageal a

281 of nonalcoholic fatty liver disease (NAFLD), predisposes patients to the risk of developing hepatocel

282 ational loss of the skin barrier protein FLG predisposes subjects to the development of atopic dermat

283 , we hypothesised that certain genotypes may predispose individuals to these lesions and consequently

284 nd suggest that impaired liver tolerance may predispose patients to this disease.

285 action within the adult Leydig cell lineage predisposes individuals to this late-onset degeneration

286 used for identification of additional genes predisposing individuals to this condition.

287 Evidence that these variants predispose individuals to thoracic aortic aneurysms and

288 nclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease.

289 they remain sufficiently severe at birth to predispose newborns to thrombocytopenia.

290 nduced other phenotypic alterations that may predispose cells to transformation.

291 and novel potent off-target sites, which can predispose patients to treatment failure and adverse eff

292 acterium tuberculosis (Mtb) infection, which predisposes individuals to tuberculosis disease.

293 ptional activation domain, and loss of TAp73 predisposes mice to tumor development.

294 genomic stability and how its deficiency may predispose cells to tumorigenesis.

295 ces a rapid down-regulation of p21(Cip1) and predisposes cells to undergo p53-mediated apoptosis, whi

296 ng mice and humans are primed for apoptosis, predisposing them to undergo cell death in response to g

297 ctions for the control of hand movements and predispose them to undertake different, perhaps somewhat

298 f the BRCA1-associated protein-1 gene (BAP1) predispose carriers to uveal melanoma.

299 s, can greatly impact adult behavior and may predispose individuals to various psychopathologies.

300 prognoses.We investigated factors that might predispose patients to wound complications.