ライフサイエンスコーパス: predisposition

1 sted to cause genomic instability and cancer predisposition.

2 nic germline mutation associated with cancer predisposition.

3 3 patients (29%) had an identifiable genetic predisposition.

4 childhood, yet little is known about BCP-ALL predisposition.

5 ergic reactions (NARs) influenced by genetic predisposition.

6 thway lead to genomic instability and cancer predisposition.

7 erapy discontinuation, suggesting epigenetic predisposition.

8 skin inflammatory syndromes and skin cancer predisposition.

9 phenotypes of genome instability and cancer predisposition.

10 ger genomic instability and result in cancer predisposition.

11 its expression levels may influence melanoma predisposition.

12 in genetic risk SNPs associated with cancer predisposition.

13 effects of an exogenous trigger and genetic predisposition.

14 was done to identify causal variants for ALL predisposition.

15 mutation) is an accepted mechanism of cancer predisposition.

16 ay be better suited for the study of disease predisposition.

17 tical workflow and therefore minimizes error predisposition.

18 associated with premature ageing and cancer predisposition.

19 hologues, implicating immune processes in AD predisposition.

20 on that is likely to be moderated by genetic predisposition.

21 n of young CRC cases associated with genetic predisposition.

22 hondrial topoisomerases and potential cancer predisposition.

23 lity, progressive marrow failure, and cancer predisposition.

24 ck of exercise, but it also involves genetic predisposition.

25 ificant role in the genetic component of T2D predisposition.

26 e genetic heterogeneity of pancreatic cancer predisposition.

27 AMD9L mutations represent a new class of MDS predisposition.

28 progressive bone marrow failure, and cancer predisposition.

29 portive environment based upon their genetic predispositions.

30 r between individuals with different genetic predispositions.

31 dentified additional genome-wide significant predisposition alleles associated with CHEK2, ATM, PINT,

32 e association study (GWAS) to identify novel predisposition alleles associated with Philadelphia chro

33 LAPTM5(c403t) and HCLS1(g496a) may represent predisposition alleles in patients with familial WM.

34 s the presence of 2 or more inherited cancer predisposition alleles in the same individual.

35 ty, predict it, are reflective of biological predisposition and are potential drug targets) brought t

36 itically contribute to the heightened cancer predisposition and bone marrow failure of individuals wi

37 atrial fibrillation (AF) considering genetic predisposition and clinical risk factor burden is unknow

38 al causal pathways, including common genetic predisposition and environmental factors, and increased

39 ase that arises on the background of genetic predisposition and environmental risk factors, such as e

40 are limited due to the possible confounds of predisposition and other factors affecting musicians and

41 an important path in TP53-associated cancer predisposition and represents a therapeutically actionab

42 ric disorders, as a mechanism for biological predisposition and vulnerability.

43 4-RNAi directly or indirectly altered poplar predisposition and/or response to changes in soil water

44 ived from aged patients with HF with genetic predispositions and comorbidities of chronic diseases ex

45 a is curable, but survivors with a heritable predisposition are at high risk for second malignancies.

46 Preorganization and predisposition are important molecular recognition conce

47 Smoking, drinking alcohol, and genetic predisposition are the major risk factors for chronic ca

48 Confirmation of genetic predisposition, as defined by reproducibility and prospe

49 driving epithelial dysfunction and allergic predisposition at various barrier sites.

50 Neurodegeneration and cancer predisposition, both hallmarks of A-T, are likely to eme

51 bind to the neurotoxin with a high degree of predisposition but with low affinities.

52 ies have transformed our understanding of MM predisposition, but individual studies have had limited

53 al autoimmunity usually reflects a polygenic predisposition, but rare cases result from monogenic aut

54 Fraumeni syndrome (LFS), a remarkable cancer predisposition characterized by extensive clinical heter

55 i-Fraumeni syndrome, a multiple-organ cancer predisposition condition, are limited.

56 ann syndrome (BWS), an overgrowth and cancer predisposition condition.

57 noma (RCC) have been identified, yet genetic predisposition contributes significantly to this maligna

58 ese factors act on a substrate of individual predisposition derived from the composite effects of inh

59 ical and social opportunities) or intrinsic (predispositions) differences explain this contrast by co

60 Li-Fraumeni syndrome (LFS) is a cancer predisposition disorder caused by germline mutations in

61 ofibromatosis type 1 (NF1) is a common tumor-predisposition disorder due to germline mutations in the

62 ciency causes the premature aging and cancer predisposition disorder Ruijs-Aalfs syndrome.

63 ectable in a yeast model of the human cancer predisposition disorder, Bloom's syndrome.

64 the patient newly diagnosed with a leukemia predisposition disorder.

65 er, some rare families with apparent MTC/CCH predisposition do not have a detectable RET mutation.

66 ar, although studies have implicated genetic predispositions, environmental risk factors, and materna

67 e ideal to investigate the effect of genetic predisposition, epigenetics, and environmental exposures

68 genesis is multifactorial, involving genetic predisposition, epithelial barrier defects, dysregulated

69 g the number of genes known to contribute to predisposition for ALS.

70 ait anxiety form a non-clinical group with a predisposition for an anxiety-related bias in emotional

71 iated with the individual variability in the predisposition for antipsychotic-associated weight gain.

72 upus erythematosus, and the etiology of this predisposition for cutaneous inflammation is unknown.

73 ders, particularly in patients whose greater predisposition for disease is not explained by tradition

74 All grain boundaries are not equal in their predisposition for fracture due to the complex coupling

75 implies primary basal NHE3 malfunction as a predisposition for IBD in a subset of patients.

76 s with neurofibromatosis type 1 (NF1) have a predisposition for premature and severe arterial stenosi

77 lly when accompanied by a heightened genetic predisposition for response to physical exercise.

78 canonical autophagy and LAP, as markers of a predisposition for SLE.

79 spontaneous brain activity contributes to a predisposition for social behavior and how this is modul

80 nts suggest a differential effect of genetic predisposition for SZ versus BD on the developmental for

81 ous brain activity and personality provide a predisposition for the processing of environmental deman

82 , suggesting a potentially different genetic predisposition for VR-PAH.

83 field variations in subjects with different predispositions for head movement.

84 New research has identified innate predispositions for structuring vocal sequences in cultu

85 rdiometabolic and liver disease, but disease predisposition from developmental exposures remains uncl

86 E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting clinical

87 Application of this strategy to the cancer predisposition gene NTHL1, which encodes a base excision

88 FANCM gene has been suggested as a novel BC predisposition gene, while the analysis of the entire co

89 nt evidence for NTHL1 to be considered a CRC predisposition gene-members of 3 unrelated Dutch familie

90 id not carry mutations in an established CRC predisposition gene.

91 onstitutional mutation in a known meningioma predisposition gene.

92 10.8%) and 71 with mutations in other cancer predisposition genes (5.6%; 95% CI, 4.4%-7.1%).

93 thogenic variants in non-BRCA1 and non-BRCA2 predisposition genes and breast cancer risk were estimat

94 Although mutations in other predisposition genes are observed among patients with TN

95 nts) and 4.6% in other breast/ovarian cancer predisposition genes including CHEK2 (n = 10), ATM (n =

96 To identify novel MTC/CCH predisposition genes we undertook exome resequencing stu

97 Deleterious mutations in 15 other predisposition genes were detected in 3.7% of patients,

98 receiving germline genetic testing of cancer predisposition genes with hereditary cancer multigene pa

99 n and characterization of novel BC and/or OC predisposition genes, a total of 2047 well-characterized

100 We assessed the frequency of mutations in 17 predisposition genes, including BRCA1 and BRCA2, in a la

101 ncy and predictors of mutations in 25 cancer predisposition genes, including BRCA1/2, in a sequential

102 thogenic variants in non-BRCA1 and non-BRCA2 predisposition genes.

103 edicted for mutations in other breast cancer predisposition genes.

104 ng for mutations in additional breast cancer predisposition genes.

105 reast or ovarian cancer, using a panel of 25 predisposition genes.

106 tations in BRCA1, BRCA2, and 16 other cancer predisposition genes.

107 cologists for germline analysis of 76 cancer predisposition genes.

108 associated with germline variants in cancer predisposition genes.

109 As the importance of genetic predisposition has been firmly established in these illn

110 are a common skin aging feature, but genetic predisposition has yet to be thoroughly investigated.

111 actors for AF include age, male sex, genetic predisposition, hypertension, diabetes mellitus, sleep a

112 he rarity of such associations and of such a predisposition if it exists.

113 Here we studied genetic predisposition in a family with six affected individuals

114 aluate the role of germline CNVs in melanoma predisposition in high-risk melanoma families.

115 owever, no universal mechanism of malignancy predisposition in patients with PIDs has been determined

116 orts, we conclude that a large part of tumor predisposition in patients with PIDs is derived from the

117 or understanding ANS dysfunction and disease predisposition in premature and postnatal humans.

118 FpEF presentations in the abscissa and HFpEF predispositions in the ordinate.

119 ell as disease progression such as germ line predisposition, inflammation, and aging.

120 Thus, there is a genetic predisposition inherent in B-1 development generating re

121 mortality (p < 0.005), for the level of the Predisposition Insult Response of Organ failure (p < 0.0

122 nd indicate that regional variation in tumor predisposition is dictated by microenvironmental cues ra

123 While IR predisposition is heritable, the genetic basis remains l

124 rostate cancer who are unselected for family predisposition is insufficient to warrant routine testin

125 The effect of predisposition is more prominent early in the life cours

126 n DNA MMR genes are causative for the cancer predisposition Lynch syndrome (LS).

127 Genetic predisposition mainly arises from mutations on the skele

128 relation to genetic coronary artery disease predisposition may merit further evaluation in patients

129 tivity signature of a cognitive or affective predisposition may similarly vary across different ages

130 nction is disrupted by, for example, genetic predisposition, mechanical damage, or the enzymatic acti

131 ecirculate available water (through rainfall predisposition mechanisms).

132 ary meningioma or schwannoma had a causative predisposition mutation.

133 germ line variants endow individuals with a predisposition not only to MPN, but also to JAK2 V617F c

134 theoretical kinetic model is used to examine predisposition of different alloys to AM induced composi

135 essed two questions, (1) whether the genetic predisposition of nicotine dependence influence COPD ris

136 We found the genetic predisposition of nicotine dependence was associated wit

137 The predisposition of patients with Hepatitis C virus (HCV)

138 Conformational predisposition of the anthranilamide starting material b

139 ed secretory phenotype, indicating a genetic predisposition of these mice to increased carcinogen-ind

140 k-billed' hadrosaurid dinosaurs confirms the predisposition of this clade towards neoplasia pathologi

141 Therefore, USF3 may be involved in the predisposition of thyroid cancer.

142 re account of the perceptual and behavioural predispositions of infants and parents that allow young

143 ity associated with AUD arises both from the predispositions of the person who develops AUD and the d

144 e likely to influence differences in disease predisposition, onset, and progression at the individual

145 This may reflect an underlying familial predisposition or persistent damage caused by the hypert

146 mutant cancers arising from primary (genetic predisposition) or secondary MMRD.

147 e endocrinopathies can result from polygenic predisposition, or more rarely, may present as part of a

148 th a cranial schwannoma had a constitutional predisposition (P < .001).

149 h later AF onset after adjusting for genetic predisposition (P<0.001).

150 n of nontruncating RAD51D variants to cancer predisposition remains uncertain.

151 d significantly between children with atopic predisposition (RR 0.84 (0.74-0.95)) and children withou

152 .84 (0.74-0.95)) and children without atopic predisposition (RR 1.09 [0.88-1.37]) (test of no interac

153 (GRSs) were constructed: a complete genetic predisposition score including all 50 single nucleotide

154 otide polymorphisms (GRSComplete), a genetic predisposition score including BMI-associated single nuc

155 leotide polymorphisms (GRSWC), and a genetic predisposition score including the waist-to-hip ratio ad

156 nucleotide polymorphisms (GRSBMI), a genetic predisposition score including waist circumference-assoc

157 ed for BMI (WHRBMI), the following 4 genetic predisposition scores (GRSs) were constructed: a complet

158 Genetic predispositions strongly contribute to the development o

159 me project, has been linked to Cowden cancer-predisposition syndrome (CS) in PTEN wild-type cases.

160 indicating the possible presence of a cancer predisposition syndrome and translocations suggesting a

161 n with neurofibromatosis type 1 (NF1) cancer predisposition syndrome are prone to the development of

162 ni syndrome (LFS), a highly penetrant cancer predisposition syndrome associated with germline mutatio

163 ed polyposis syndrome is a rare colon cancer predisposition syndrome caused by a duplication of a non

164 ndau (VHL) disease is a rare familial cancer predisposition syndrome caused by a loss or mutation in

165 Neurofibromatosis type 2 (NF2) is a tumor predisposition syndrome characterized by bilateral vesti

166 Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypers

167 in a pathway that is defective in the cancer predisposition syndrome Fanconi anemia (FA).

168 Examining the cancer predisposition syndrome Fanconi anemia in depth revealed

169 ydratase, which underlie the familial cancer predisposition syndrome hereditary leiomyomatosis and re

170 BAP1 cutaneous melanoma (CM)/ocular melanoma predisposition syndrome suggests a tumor suppressor func

171 mach (GAPPS) is an autosomal-dominant cancer-predisposition syndrome with a significant risk of gastr

172 germline DICER1 mutations result in a cancer predisposition syndrome, associated with an increased ri

173 two distinct tumor syndromes: rhabdoid tumor predisposition syndrome, with malignant pediatric tumors

174 BAP1 cancer predisposition syndrome-related cancers were present in

175 ni syndrome, a rare, highly penetrant cancer predisposition syndrome.

176 een described in an autosomal dominant tumor predisposition syndrome.

177 trum of cancers linked to various hereditary predisposition syndromes and can be leveraged to improve

178 recognition of sarcomas occurring in cancer predisposition syndromes is critical, with implications

179 s for both sporadic cancer as well as cancer predisposition syndromes with similar mechanisms.

180 ld more effective therapies for these cancer predisposition syndromes.

181 es associated with autosomal dominant cancer-predisposition syndromes.

182 toward salient goals linked to power roles, predispositions, tasks, and opportunities.

183 platelet function-related CpG-SNP, a genetic predisposition that reinforces PEAR1 enhancer activity t

184 Among children with atopic predisposition, the number-needed-to-treat with BCG to p

185 This polymorphism leads to HCC predisposition through modifying c-Myc-mediated transcri

186 ses of the DeltaWCBMI CONCLUSIONS: A genetic predisposition to a high WC may attenuate the associatio

187 y multiple clinical manifestations including predisposition to a wide spectrum of cancers.

188 r WHR adjusted for BMI, a measure of genetic predisposition to abdominal adiposity, was constructed w

189 These results suggest that genetic predisposition to acrophobia in this genetic isolate is

190 Possible predisposition to an inflammatory component was suggeste

191 The association of TSG101 with ALIX prevents predisposition to apoptosis, whereas ALIX-ALG-2 interact

192 contribute to individual differences in our predisposition to approach the animate world.

193 ctions and that in the presence of a genetic predisposition to ASD, diet can make a large difference

194 The mechanism is unknown, and genetic predisposition to asparaginase-induced pancreatitis has

195 iption of potential molecular substrates for predisposition to atrial fibrillation (AF) is incomplete

196 ed lymphocyte apoptosis, autoantibodies, and predisposition to autoimmunity.

197 genetic instability, growth deficiency, and predisposition to cancer.

198 sive bone marrow failure (BMF), and a strong predisposition to cancer.

199 la virus (EBOV) is highly pathogenic, with a predisposition to cause outbreaks in human populations a

200 HLA-DQ8 molecules, present in people with a predisposition to celiac disease.

201 and VDR polymorphisms may contribute to the predisposition to childhood asthma.

202 w genetic factors contribute to sex-specific predisposition to childhood-onset asthma.

203 CKGROUND & AIMS: Although there is a genetic predisposition to colorectal cancer (CRC), few of the ge

204 anges in colon mucosa associated with WD and predisposition to colorectal cancer.

205 e associated germline mutations in BRF1 with predisposition to CRC.

206 We demonstrate that primary predisposition to cutaneous NVP HSR, seen across ancestr

207 at cause AF in patients, including a genetic predisposition to develop AF.

208 that the CNS plays a fundamental role in the predisposition to develop different forms of headache.

209 ariants in this region seem to confer a high predisposition to develop malignancies compared with the

210 X1), and MYD88 (-938C>A) are associated with predisposition to development of chronic Q fever.

211 A variable individual predisposition to development of metabolic disturbances

212 g the role of beta cell fragility in genetic predisposition to diabetes.

213 fetal naive CD4(+) T cells exhibit a strong predisposition to differentiate into Tregs when stimulat

214 embryonic development influences ageing and predisposition to disease in adults.

215 ute to different stages of oncogenesis, from predisposition to disease manifestation and evolution.

216 e of infectious stimuli in modifying genetic predisposition to disease.Insight into the genetic influ

217 tifying markers and underlying mechanisms of predisposition to diseases and treatment responsiveness

218 hing the neural mechanisms that underlie the predisposition to drug addiction from effects of drugs i

219 e neural substrate underlying the biological predisposition to EDs.

220 Genetic predisposition to elevated triglyceride levels was assoc

221 authors sought to evaluate whether a genetic predisposition to elevations in plasma lipids is associa

222 A genetic predisposition to enhanced nitric oxide signaling is ass

223 e seek to understand the impact of a genetic predisposition to enhanced nitric oxide signaling on ris

224 A genetic predisposition to enhanced nitric oxide signaling was as

225 tentially novel contributors for the genetic predisposition to familial WM and indicate that LAPTM5(c

226 in 1, type 1, E-cadherin gene (CDH1) cause a predisposition to gastric cancer.

227 ypical symptoms or those who lack an obvious predisposition to GERD (eg, central obesity, large hiata

228 Inherited predisposition to glioma has been consistently observed

229 As individuals with germ line predisposition to hematologic malignancies are diagnosed

230 Some are associated with predisposition to hematologic malignancies.

231 Diagnosis of an inherited predisposition to hematologic malignancy informs choice

232 sis and management of patients with germline predisposition to hematology malignancies and will consi

233 genetic modifiers that provide resistance or predisposition to hepatocyte death.

234 A genetic predisposition to high BMI as well as a genetic predispo

235 disposition to high BMI as well as a genetic predisposition to high BMI, WC, and WHRBMI combined may

236 ages and disadvantages of disclosing genetic predisposition to high BP for risk stratification needs

237 nic environment, to evaluate whether genetic predisposition to higher BMI has a larger magnitude of a

238 A genetic predisposition to higher serum calcium levels was associ

239 AUD treatment for individuals with a genetic predisposition to higher synaptic DA tone.

240 A genetic predisposition to higher waist-to-hip ratio adjusted for

241 hways, and dysfunctional Tregs may influence predisposition to hypersensitivity.

242 Genetic predisposition to increased WHR adjusted for BMI.

243 h gonadal, adrenal, and bone marrow failure, predisposition to infections, and high mortality.

244 g in C57BL/6J male mice on their offspring's predisposition to insulin resistance.

245 ging and can be considered a neurobiological predisposition to later-life cognitive disorders.

246 ilial platelet disorders are associated with predisposition to leukemia, myelodysplastic syndrome (MD

247 pulation and is considered to be a metabolic predisposition to liver cancer.

248 e risk only in women with the lowest genetic predisposition to low BMD.

249 Our understanding of familial predisposition to lymphoma (collectively defined as non-

250 ataxia, variable hematologic cytopenias, and predisposition to marrow failure and myeloid leukemia, s

251 ncy, variable neurological presentation, and predisposition to MDS with -7/del(7q), whereas hematopoi

252 We studied 2 families with cytopenia, predisposition to MDS with chromosome 7 aberrations, imm

253 glycoproteins like mucins, exhibit a higher predisposition to metastasize, but the role of mucins in

254 of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypo

255 sequencing studies in a family with apparent predisposition to MTC/CCH and no identifiable RET mutati

256 The genetic predisposition to multiple sclerosis (MS) is most strong

257 egrative study improves our understanding of predisposition to nevi and their potential contribution

258 Rgamma) genotype as a measure of the genetic predisposition to obesity were investigated.

259 Independent of a genetic predisposition to obesity, maternal intake of DHA-rich f

260 his association may be modified by a genetic predisposition to obesity.

261 utside the brain are involved in the genetic predisposition to PD.

262 ent, emerged in only a subset of rats with a predisposition to prefer and drink alcohol, and was main

263 hat may connect early-life BPA to later-life predisposition to prostate carcinogenesis.

264 the purinergic system in the development and predisposition to psychiatric disorders, with a focus on

265 YH9, and the coding gene FOXE1 underlies the predisposition to PTC triggered by rs965513.

266 A genetic predisposition to RA, such as HLA-DR4 positivity, indica

267 These data suggest that a genetic predisposition to raised plasma isoleucine levels is pos

268 ecause they participate fundamentally in the predisposition to SAM, they have increasingly been repai

269 osis, increasing inflammation, and enhancing predisposition to secondary bacterial infections.

270 onnectivity and the underlying physiological predisposition to seizures is unclear.

271 on and the potential effect of these GBPs on predisposition to sepsis and other infectious or inflamm

272 sis infection and of patients with Mendelian predisposition to severe tuberculosis have started to re

273 mechanism in individuals with and without a predisposition to skin barrier impairment.

274 Predisposition to sporadic Alzheimer's disease (SAD) inv

275 A genetic predisposition to Staphylococcus aureus bacteremia has b

276 ening the effect of the I148M variant on the predisposition to steatosis and liver damage.

277 Biomechanical assessment revealed a high predisposition to stretch-induced damage in fiber bundle

278 es indeed evidence such an intergenerational predisposition to surgical delivery.

279 gration, suggesting a potential mechanism of predisposition to TB.

280 Although there is evidence of genetic predisposition to the disease, most of the genetic risk

281 oding RNAs, including microRNAs (miRNAs), in predisposition to the disease.

282 These findings link colorectal cancer predisposition to the Fanconi anemia DNA repair pathway,

283 We investigated genetic predisposition to the response to steroid treatment of a

284 A genetic predisposition to thoracic aortic aneurysm has been esta

285 rolled trial of 230 infants with HLA-defined predisposition to type 1 diabetes and at least 1 family

286 Finally, we demonstrate that genetic predisposition to type 2 diabetes associates with increa

287 ower-frequency variants have a major role in predisposition to type 2 diabetes.

288 the interactions between a molecular genetic predisposition to various aspects of obesity and the con

289 th wild-type MYD88, mutated ARID1A, familial predisposition to WM, chr6q deletions, chr3q amplificati

290 Of all inherited predispositions to breast cancer in the NYBCS, 73.8% (10

291 Identification of genetic predispositions to IA could have important implications

292 lty by studying for the very first time, the predispositions to pay attention to social stimuli in ne

293 isorders that increases oxidative stress and predisposition toward apoptosis.

294 Early predispositions toward prosociality are thought to arise

295 a compositional signature that indicates the predisposition towards an early development of metabolic

296 s study were to comprehensively identify ALL predisposition variants in ETV6 and to determine the ext

297 ow genome sequence variation affects disease predisposition via gene regulatory mechanisms and identi

298 te-risk CMM genes may influence familial CMM predisposition, warranting further investigation of both

299 germline events involved in prostate cancer predisposition, we develop a computational approach to n

300 f multicomponent assemblies against entropic predisposition, we present the rational assembly of a he