ライフサイエンスコーパス: preexist

1 cally novel GII.4 strain VLP correlated with preexisting Ab titer to an ancestral strain Epitope A.

2 experience new-onset or severe worsening of preexisting abnormalities of liver tests, including seve

3 A28gamma and PA200 but rather recruitment of preexisting activators to 20S and 26S proteasome complex

4 nal change versus selective stabilization of preexisting active conformations.

5 Preexisting Ad26- or Ad35-neutralizing antibody titers h

6 Higher titers (>/=320) of preexisting ADCC-Abs were associated with lower virus re

7 ite adipose tissue (WAT) from hypertrophy of preexisting adipocytes and enhancement of precursor diff

8 ence of a "double-hit" phenomenon because of preexisting alterations in cortical function in nonstrok

9 for the presence of two distinct LD pools, a preexisting and a dynamic LD pool.

10 on of recrudescent viruses and selection for preexisting and emerging antibody neutralization-resista

11 astral microtubule organization between the preexisting and new SPBs.

12 port the hypothesis that identification of a preexisting and stable adaptive immune response as defin

13 disease is highest within a narrow range of preexisting anti-DENV antibody titers.

14 rejection (ABMR) can occur in patients with preexisting anti-HLA donor-specific antibodies (DSA) or

15 sport use increased risk of infection, while preexisting antibodies against the same subtype (odds ra

16 lorus agglutinin glycans recognized by human preexisting antibodies in humans.

17 es or using COBRA HA based vaccines to boost preexisting antibodies induced by wild-type H1N1 viruses

18 diabetic patients have substantial levels of preexisting antibodies of the 3 specificities, before in

19 Therefore, this study investigated how preexisting antibodies to historical influenza viruses i

20 e examined the possible inhibitory effect of preexisting antirotavirus antibodies on immunogenicity o

21 S architecture was created by diversifying a preexisting appended domain.

22 ndi Event were determined by the size of the preexisting Archean siderite reservoir, which was consum

23 Preexisting asthma was associated with EV-D68 infection

24 entricity can occur and persist even without preexisting asymmetric cues, such as spindle placement o

25 d these effects are greater for smokers with preexisting attention problems, such as attention defici

26 this is the largest series of patients with preexisting autoimmune disease treated with immune check

27 icacy of ipilimumab therapy in patients with preexisting autoimmune disorders is not known.

28 eview of patients with advanced melanoma and preexisting autoimmune disorders who received ipilimumab

29 pocampal synapse loss and completely rescues preexisting behavioral deficits by 17 months.

30 hite adipocytes in maintaining properties of preexisting beige adipocytes.

31 dness of an outcome and the uncertainty of a preexisting belief-on learning rate.

32 ion of the brain parenchyma, including along preexisting blood vessels, is a leading cause of therape

33 ministration of RT53 inhibited the growth of preexisting BRAF wild-type and V600E mutant melanoma xen

34 We hypothesized that preexisting brain microvascular disease in patients with

35 women aged 40 years or older who do not have preexisting breast cancer or a previously diagnosed high

36 Sports SCA cases presented with known preexisting cardiac disease in 16% and >/=1 cardiovascul

37 col for patients of advanced age and/or with preexisting cardiac disease.

38 .0 years; 6.8% and 39.4% of participants had preexisting cardiovascular and microvascular disease, re

39 e Cox regression to model the association of preexisting cardiovascular conditions on subsequent HF.

40 e, population-based cohort of NHL survivors, preexisting cardiovascular conditions were associated wi

41 dic surgery, cardiac surgery, and those with preexisting cardiovascular disease (strong recommendatio

42 ypertension, dyslipidemia, and diabetes) and preexisting cardiovascular disease were ascertained.

43 lar complications, and without hypertension, preexisting cardiovascular disease, or other potentially

44 antially differ after further adjustment for preexisting cardiovascular disease.

45 individuals (n = 1094; 21%), and those with preexisting cardiovascular events (n = 1620; 35%).

46 Among survivors only, preexisting cardiovascular factors (hypertension, dyslip

47 th drugs such as trastuzumab is predicted by preexisting cardiovascular risk factors and disease, pos

48 We aimed to understand the contribution of preexisting cardiovascular risk factors to HF risk among

49 BCP-ALL may be a result of the selection of preexisting CD19(-) malignant progenitor cells.

50 progressive heart failure, or combination of preexisting cerebrovascular disease and mild cognitive i

51 in state was achieved by specific erasure of preexisting chromatin marks in the precursor cell or by

52 ding transcription by Pol V is controlled by preexisting chromatin modifications located within the t

53 maintained by insertion of nucleosomes into preexisting chromatin, both on newly synthesized DNA at

54 s of death, age, sex, location of death, and preexisting chronic and acute conditions from the previo

55 Progression of preexisting chronic arthropathy in one participant was t

56 -12,542; p < 0.001), and lower in those with preexisting chronic disease than without (2,989 [95% CI,

57 Thus, preexisting CKD aggravates the cardiac dysfunction cause

58 Here, we investigated the effect of preexisting CKD on cardiac function in mice with sepsis

59 Despite preexisting CKD or a lower ejection fraction, pLVAD supp

60 ass II DSA, and 5 subjects showed persistent preexisting class II DSA.

61 transition to MM involves altered growth of preexisting clones.

62 murine injury models, PLT/uPA-T did not lyse preexisting clots, even when administration was delayed

63 eptors recruited to the plasma membrane from preexisting clusters, consistent with vesicular recruitm

64 inked to multiple risk factors, such as age, preexisting cognitive impairment, and use of sedatives;

65 ic withdrawal syndrome included younger age, preexisting cognitive impairment, higher preweaning mean

66 7; 47%) were younger and more likely to have preexisting cognitive or functional impairment.

67 CCO2R on driving pressure and mortality in a preexisting cohort of patients with ARDS.

68 riggered by increasing fluid shear stress in preexisting collateral arteries.

69 e conferred without disturbing the desirable preexisting commensal colonization of the nasopharynx.

70 ty (after adjustment for age, PSI score, and preexisting comorbid conditions).

71 d similar acute physiology scores, but fewer preexisting comorbidities among elderly patients (p = 0.

72 ses of death, urban and rural residence, and preexisting comorbidities.

73 rmed an analysis stratified by the degree of preexisting comorbidity.

74 d health insurance are mainly because of the preexisting condition, even in the presence of protectiv

75 and pediatric patients and the influence of preexisting conditions (PECs) on chymase levels.

76 py-related complications and exacerbation of preexisting conditions are important and largely unanswe

77 This suggests that pAg binding disrupts a preexisting conformation of the BTN3A1 intracellular dom

78 work for biased agonism based on alternative preexisting conformations that bind more strongly, but n

79 Preexisting coordinated regulation of symbiosis traits b

80 Toric IOLs may correct for preexisting corneal astigmatism at the time of surgery.

81 itation from hemorrhagic shock in swine with preexisting coronary artery disease reduced renal dysfun

82 itation from hemorrhagic shock in swine with preexisting coronary artery disease.

83 Nineteen hypercholesterolemic pigs with preexisting coronary artery disease.

84 Preexisting cross-reactive T cells to genetically divers

85 tudy shows proof of concept that LAIVs boost preexisting, cross-reactive T cells in children to genet

86 loop prevented CSC induction and sensitized preexisting CSCs to chemotherapy.

87 Treatment of preexisting CSCs with a genotoxic drug combination (5-fl

88 ing the nuclear translocation of NFkappaB in preexisting CSCs.

89 Children are devoid of preexisting CVD and provide unique insight into specific

90 patients, respectively, mostly in those with preexisting cytopenias.

91 mechanisms driving programmed elimination of preexisting cytosolic proteins are unclear.

92 3 randomized clinical trial, a low level of preexisting cytotoxic sTILs predicted the most benefit f

93 cs, as defined in this review, is the use of preexisting data sets to address questions in ecology.

94 0.81; P < .001), the reduction was due to a preexisting declining trend in mortality.

95 th of hospital stay less than 2 days, or had preexisting deep vein thrombosis.

96 NiCo) and 50%Ni50%Fe (NiFe) without apparent preexisting defect sinks were employed to study defect d

97 Patients with preexisting dementia and ICU admission within 3 years of

98 Recent studies reveal that preexisting dengue antibodies may have opposite effects

99 and address the critical question of whether preexisting dengue virus (DENV) T cell immunity modulate

100 ntial ZIKV and DENV cross-reactivity and how preexisting DENV T cell immunity modulates Zika T cell r

101 at both 3 and 12 months (P < 0.001), as was preexisting depression (P < 0.03), but veteran status wa

102 ucose target in critically ill patients with preexisting diabetes and chronic hyperglycemia is unknow

103 s irrespective of the presence or absence of preexisting diabetes by a mechanism unrelated to exagger

104 nts with acute stroke, even in those without preexisting diabetes, and denotes a bad outcome.

105 o the asymmetric transfer of VPL depended on preexisting differences between the reliability of near-

106 observed variation was tied to stochastic or preexisting differences in the epigenome occurring at re

107 ost of these were conducted in patients with preexisting diseases that dispose to CKD.

108 We quantified the 28-day mortality effect of preexisting do-not-resuscitate orders in ICUs.

109 study, we determined the association between preexisting donor hypertension and glomerular number and

110 ransplantation into sensitized patients with preexisting donor-specific antibodies (DSA) is very chal

111 Preexisting, donor-specific antibodies (DSAs) are culpri

112 sorbed dose estimates for common organs in a preexisting dosimetry tool (OLINDA/EXM).

113 tatistically significant acceleration in the preexisting downward trend for firearm suicide (ratio of

114 There was also significant change in the preexisting downward trends for rates of total firearm d

115 Droplets grew by the fusion of preexisting droplets, with no restriction on the size of

116 istribution to define the cutoff to identify preexisting drug resistance mutations at low abundance i

117 The preexisting DSA ABMR had superior graft survival compare

118 Compared with patients with preexisting DSA ABMR, patients with de novo DSA ABMR dis

119 expression of AKI transcripts compared with preexisting DSA ABMR.

120 ABMR (hazard ratio [HR], 1.82 compared with preexisting DSA ABMR; 95% confidence interval [95% CI],

121 Overall, 103 (50%) patients had preexisting DSA and 102 (50%) had de novo DSA.

122 However, neuronal sequences may also reflect preexisting dynamics.

123 oendocrine axis dysfunction in patients with preexisting dysfunction in at least 1 axis at baseline w

124 However, the preexisting elevation in TNFalpha expression rendered VH

125 raditional" NSQIP method, this approach uses preexisting equations, built on historical data, which p

126 sducing T cells with a transgenic TCR is the preexisting expression of TCRs in the recipient cells.

127 However, the impact of preexisting flavivirus immunity on ZIKV pathogenesis, th

128 t from scratch, but rather form by co-opting preexisting gene networks.

129 e the possibility of adding new functions to preexisting genes, we considered a framework of riboregu

130 mental and dietary factors are acting upon a preexisting genetic background.

131 sis is further potentiated in embryos with a preexisting genetic defect of RA metabolism.

132 leen and bone marrow while also obliterating preexisting germinal centers.

133 Before surgery, 62 patients had either preexisting glaucoma (n = 39) or high IOP (>/=22 mm Hg)

134 ber 2009, we observed 25420 patients with no preexisting glaucoma and quantified exposure to statins

135 Preexisting glaucoma was present in 72.9% (35 of 48 eyes

136 ontrols were identified and matched for age, preexisting glaucoma, calendar time, and follow-up time.

137 colony-stimulating factor in exacerbation of preexisting GN.

138 ference manual toothbrush (MT) on mid-buccal preexisting GR (PreGR) during 12 months.

139 ESCRT-III/Snf7 promotes direct engulfment of preexisting Grh1 containing vesicles and tubules into a

140 Animals were depleted of their preexisting gut microbiota and then inoculated with alte

141 s model can simulate HbS polymerization with preexisting HbS nuclei.

142 respectively), age (HR, 1.02, P = .001), and preexisting heart failure (HR, 1.85, P < .001) independe

143 hepatobiliary function but does not reduce (preexisting) hepatobiliary injury in ECD livers.

144 Preexisting HF was defined by any HF encounter during th

145 Within this cohort, 518 223 patients had preexisting HF, and 349 826 had a new diagnosis of HF du

146 ntinuously generated, and integrate into the preexisting hippocampal network in the adult brain.

147 to induce posttranslational modifications in preexisting HLA-DP2-peptide complexes, resulting in the

148 st intricate symbiotic arrangements and that preexisting horizontally transferred genes can remain st

149 on efficiency and the detrimental effects of preexisting host antibodies.

150 chimpanzee adenoviruses is overlapping, and preexisting humoral and cellular immunity to both are ex

151 ith hemorrhage, gestational hypertension, or preexisting hypertension identified women with a 4- to 7

152 glomerulopenia in living kidney donors with preexisting hypertension justifies the need for long-ter

153 The effect of preexisting hypertension on living donor nephron number

154 We found that, in donors ages >50 years old, preexisting hypertension was associated with a reduction

155 Preexisting hypertension was associated with a twofold (

156 he main risk factor even in patients without preexisting hyponatremia; however, isolated hypernatremi

157 ithout requiring cognitive preadaptations or preexisting iconic communication schemes as previously c

158 es interact in distinct ways with cells in a preexisting IFN-induced antiviral state.

159 genes, (2) the composition and activity of a preexisting immune infiltrate, and (3) mechanisms of tum

160 previous proposals that they derive from the preexisting immune repertoire in the absence of antigeni

161 ng HIV-1 latency, it remains unclear whether preexisting immune responses within HIV-1(+) individuals

162 Immunization of pregnant women could boost preexisting immune responses, providing passive protecti

163 onary adaptation, reducing the efficiency of preexisting immune responses.

164 Age and preexisting immunity affected virus-specific plasmablast

165 Transplantation of a preexisting immunity and cross-reactivity with ubiquitou

166 However, the impact of preexisting immunity and ICPs on the risk of malignant t

167 ue to the continual evolution of escape from preexisting immunity and the potential for zoonotic emer

168 ch as CD80/CTLA-4 and PD-1/PD1-L, amplifying preexisting immunity and thereby evoking antitumor immun

169 ggest that humans are likely to have limited preexisting immunity to CIV-H3N2 and that CIV-H3N2 x pdm

170 Subjects with no preexisting immunity to DENV developed neutralizing anti

171 Taken together, these findings suggest that preexisting immunity to DENV may impact protective immun

172 When subjects with preexisting immunity to DENV were vaccinated, they devel

173 n transplanted and whether the recipient has preexisting immunity to EBV but can be as high as 20%.

174 Paradoxically, patients who already had high preexisting immunity to HER2-ICD did not respond to ther

175 uenza immune responses; however, humans have preexisting immunity to influenza viral antigens, partic

176 ss of vaccine candidates in humans that have preexisting immunity to influenza.

177 data support the concept that stimulation of preexisting immunological memory to Pneumocystis with a

178 sely, CTCF binding sites in NPCs are largely preexisting in pluripotent stem cells.

179 In contrast, prevalent (preexisting + incident) HF increased during our study pe

180 ry 2000 and December 2011 who did not have a preexisting indication for implantable cardioverter defi

181 Thus, preexisting indole levels in the gut join the oocyst dos

182 ociated with reinfection or recrudescence of preexisting infection.

183 location was without tumor in the absence of preexisting inflammation at that location.

184 isruption and injury, even in the absence of preexisting inflammation.

185 EH) is characterized by viral infection of a preexisting inflammatory dermatosis and is associated wi

186 All factors, except preexisting kidney disease and failed ventilator liberat

187 , vasopressor requirement, thrombocytopenia, preexisting kidney disease, failed ventilator liberation

188 Genomic discovery that is agnostic to preexisting knowledge has uncovered dozens of loci that

189 ning durable knowledge that is associated to preexisting knowledge, but they do so at the cost of mem

190 e Northeast U.S. (LAGOS-NE), a collection of preexisting lake data mostly from state agencies.

191 after liver transplantation in patients with preexisting LAM resistance HBV.

192 obulin for chronic hepatitis B patients with preexisting lamivudine (LAM) resistance (LAM-R) undergoi

193 ams by fluorescein staining from underlying, preexisting laser scars.

194 echanisms of neutral lipid metabolism in the preexisting LD pool.

195 Preexisting levels of cells indicating either T-cell exh

196 10 seasonal vaccine also demonstrated higher preexisting levels of interferon gamma-secreting CD4(+)C

197 ollowing TAVR in patients with severe AS and preexisting LF.

198 (odds ratio [OR], 1.80; 95% CI, 1.19-2.71), preexisting liver disease (OR, 2.28; 95% CI, 1.23-4.24),

199 BCVA unchanged in 3 eyes due to preexisting macular scar and advanced glaucoma.

200 examination should be performed to rule out preexisting maculopathy.

201 Preexisting maternal antibody inhibited infant antibody

202 ssion is highly dependent on the presence of preexisting maternal immunity, with the lowest rates obs

203 o distinguish acutely induced cells from the preexisting MBC pool.

204 survival of patients with breast cancer with preexisting mental illness, and elderly women are of spe

205 ary tumor can also favor the rapid growth of preexisting metastatic lesions.

206 rials that were previously inaccessible with preexisting methods.

207 wn a striking spread of melanoma cells along preexisting microvascular channels and features of both

208 ing PDX passaging, often due to selection of preexisting minor clones.

209 failure to form these structures exacerbates preexisting mitochondrial dysfunction, suggesting that t

210 Preexisting morbidity and functional ability at hospital

211 Independent of agent or regimen, preexisting morphologic features of the retina at baseli

212 to differentiate nascent transcription from preexisting mRNAs are desired.

213 tly, it was uncovered that MTs nucleate from preexisting MTs within the mitotic spindle, which requir

214 hese structural observations help to explain preexisting mutational data and provide insights into se

215 s cell membranes, typically by utilizing the preexisting Na(+) gradient.

216 rs regulatory T cells and thereby, unleashes preexisting nephritogenic responses.

217 The interaction of this preexisting network structure with patent growth in upst

218 gnificant proportion of patients with IE and preexisting neurological complications either undergo de

219 AND were aged </=4 years; less than half had preexisting neurological disease or other risk factors f

220 Adult ICU patients without preexisting neuromuscular abnormalities and a discharge

221 Preexisting neutralizing antibodies (NAbs) against adeno

222 tood, and effective solutions for overcoming preexisting neutralizing antibodies are still lacking.

223 induced later during adulthood in quiescent preexisting oligodendrocytes, after active myelination i

224 duce myelination by the larger population of preexisting OLs carries the potential for enhanced remye

225 Although preexisting OLs do not normally contribute to remyelinat

226 signal-regulated kinases 1 and 2 (ERK1/2) in preexisting OLs of adult mice is sufficient to drive inc

227 myelin in the adult CNS, the contribution of preexisting OLs to functional myelin remodeling is not k

228 erest remains in additionally driving mature preexisting OLs to make myelin.

229 sly after being imprinted and do not disrupt preexisting ones.

230 new cellular traces and the modification of preexisting ones.

231 two models of C3 glomerulopathy with either preexisting or triggered C3 deposition along the GBM.

232 a specific process of care was implemented, preexisting, or never implemented.

233 at differentiating stem cells integrate into preexisting ordered spatial units of the epidermis.

234 ase to form SOA is thought to be enhanced by preexisting organic particles.

235 Most important, 16% of all patients had no preexisting pain condition and now experience chronic IC

236 mor, arises from the epithelial component of preexisting parotid Warthin tumors (WT).

237 larger set of features decorated by smaller preexisting patterns, indicating a structural "memory."

238 ctive than HAPMIX at inferring ancestry when preexisting phased reference data are unavailable and ge

239 An open question is whether there are preexisting plexin dimers that could act as autoinhibito

240 is involved in the degradation of a specific preexisting pool of LDs and that inhibition of this path

241 e of Chol, MA preferentially interacted with preexisting POPS-rich clusters formed by nonideal lipid

242 Thus tumor transformation amplified preexisting population heterogeneity and led some cells

243 with the Sup35 or Rnq1 aggregates; without a preexisting prion, however, such colocalizations are rar

244 nting for first-time prostate biopsy without preexisting prostate cancer: 516 eligible participants f

245 t pathway resulted from the repurposing of a preexisting protein import apparatus.

246 Selective removal of preexisting proteins is achieved by sorting into a mitoc

247 Natural recombination combines pieces of preexisting proteins to create new tertiary structures a

248 Conversely, the preexisting proteome of proteins performing basic cellul

249 We also show that preexisting [PSI(+) ] or [PIN(+) ] (prion form of Rnq1),

250 Preexisting psychiatric difficulties, the initial trauma

251 After classifying those with/without preexisting PTSD (i.e., PTSD before hospitalization), we

252 Preexisting PTSD and depression were strongly associated

253 In the multivariable regression, preexisting PTSD was independently associated with ICU-r

254 This finding suggests that preexisting pulmonary disease could increase MERS-CoV re

255 tion in embryonic MBs evolved by hijacking a preexisting regulatory landscape that was already at wor

256 cedures requiring cardiopulmonary bypass, no preexisting renal dysfunction.

257 dules on treatment efficacy in patients with preexisting resistance.

258 tibiotic use selects for clonal expansion of preexisting resistant bacterial strains.

259 Our results suggest that preexisting responses elicited by a previous DENV3 infec

260 t differ significantly between patients with preexisting (RR, 1.12; 95% CI, 0.86-1.44) or newly diagn

261 onsecutive chronic hepatitis B patients with preexisting rt204 LAM-R mutations or virological load re

262 The preexisting SADS diagnosis was the major reason reported

263 phosphomimetic, competes for a lysine from a preexisting salt bridge, initiating a partial unfolding

264 Despite moderately high levels of preexisting serum antibody, 34 (56%) became infected, of

265 High levels of preexisting serum IgG, including transplacentally acquir

266 Results Nearly 3% of patients had preexisting severe mental illness.

267 These experiments demonstrate that multiple preexisting SMCs give rise to excess aortic SMCs in elas

268 al decisions, thus emphasizing the impact of preexisting social bonds on decision-making.

269 s an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradie

270 s type of transport was taking place through preexisting spaces in the nasal cavity that were orders

271 2013 was driven mainly by the persistence of preexisting strains rather than through de novo adaptati

272 shifts, it was found that urea redistributes preexisting structural microstates, stabilizing a substr

273 The presence of strong, preexisting T-cell responses, including those induced by

274 Thus, the presence of strong, preexisting T-cell responses, including those induced by

275 ntrolled the proliferative response of human preexisting Tfh cells more efficiently than belatacept.

276 agent that selectively targets nascent over preexisting thrombi.

277 After controlling for preexisting time trends, we observed that between April

278 ctions may be demarcated in development by a preexisting topological framework created by constitutiv

279 form of passive diffusion that is driven by preexisting transepithelial electrochemical gradients.

280 es have shown that resistance mutations that preexist treatment can be detected in a substantial numb

281 dinal, fixed-effects model that adjusted for preexisting trends to test whether the observed post-tax

282 P = .03), neither of which were explained by preexisting trends.

283 ration of NAC was not effective in resolving preexisting TTP signs; thrombocytopenia, hemolytic anemi

284 were diagnosed as having ASD (115 exposed to preexisting type 2 diabetes, 130 exposed to GDM at </=26

285 extubation leak pressure, poor sedation, and preexisting UAO (P < 0.04) for cuffed ETTs; and age (ran

286 dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of in

287 ate complication of Q fever in patients with preexisting valvular heart disease (VHD).

288 Forty-five patients (52.9%) had a preexisting valvulopathy.

289 We assessed the association between preexisting variant-specific antibody titers and subsequ

290 ral novel mutations that most likely reflect preexisting variation in circulating HSV-2.

291 ary elevations of LDL-C >/=190 mg/dL without preexisting vascular disease at baseline.

292 HF (HR, 2.71; 95% CI, 1.15 to 6.36), whereas preexisting vascular disease had no association with HF

293 work in concert to form new vessels from the preexisting vasculature, there remains a lack of insight

294 n (88 minutes implementers versus 89 minutes preexisting versus 98 minutes nonimplementers; P<0.001 f

295 'Bright Yellow-2' cells: massive delivery of preexisting vesicles to a disk-shaped region at the equa

296 ut a reconciliation of this perspective with preexisting views of transcriptional regulation is lacki

297 Lack of sensitivity can occur due to preexisting virus that uses the CXCR4 coreceptor, while

298 g, interventions may benefit from addressing preexisting vulnerabilities and focus on resilience.

299 m genetic and environmental confounding (eg, preexisting vulnerabilities).

300 ullying may partly be viewed as a symptom of preexisting vulnerabilities.