ライフサイエンスコーパス: preexisting

1 cally novel GII.4 strain VLP correlated with preexisting Ab titer to an ancestral strain Epitope A.

2 experience new-onset or severe worsening of preexisting abnormalities of liver tests, including seve

3 A28gamma and PA200 but rather recruitment of preexisting activators to 20S and 26S proteasome complex

4 nal change versus selective stabilization of preexisting active conformations.

5 Preexisting Ad26- or Ad35-neutralizing antibody titers h

6 Higher titers (>/=320) of preexisting ADCC-Abs were associated with lower virus re

7 ite adipose tissue (WAT) from hypertrophy of preexisting adipocytes and enhancement of precursor diff

8 ence of a "double-hit" phenomenon because of preexisting alterations in cortical function in nonstrok

9 for the presence of two distinct LD pools, a preexisting and a dynamic LD pool.

10 on of recrudescent viruses and selection for preexisting and emerging antibody neutralization-resista

11 astral microtubule organization between the preexisting and new SPBs.

12 stood, but recent evidence implies that both preexisting and pain-related variations in the structure

13 port the hypothesis that identification of a preexisting and stable adaptive immune response as defin

14 disease is highest within a narrow range of preexisting anti-DENV antibody titers.

15 rejection (ABMR) can occur in patients with preexisting anti-HLA donor-specific antibodies (DSA) or

16 sport use increased risk of infection, while preexisting antibodies against the same subtype (odds ra

17 lorus agglutinin glycans recognized by human preexisting antibodies in humans.

18 es or using COBRA HA based vaccines to boost preexisting antibodies induced by wild-type H1N1 viruses

19 diabetic patients have substantial levels of preexisting antibodies of the 3 specificities, before in

20 Therefore, this study investigated how preexisting antibodies to historical influenza viruses i

21 e examined the possible inhibitory effect of preexisting antirotavirus antibodies on immunogenicity o

22 S architecture was created by diversifying a preexisting appended domain.

23 ndi Event were determined by the size of the preexisting Archean siderite reservoir, which was consum

24 Preexisting asthma was associated with EV-D68 infection

25 entricity can occur and persist even without preexisting asymmetric cues, such as spindle placement o

26 d these effects are greater for smokers with preexisting attention problems, such as attention defici

27 this is the largest series of patients with preexisting autoimmune disease treated with immune check

28 icacy of ipilimumab therapy in patients with preexisting autoimmune disorders is not known.

29 eview of patients with advanced melanoma and preexisting autoimmune disorders who received ipilimumab

30 pocampal synapse loss and completely rescues preexisting behavioral deficits by 17 months.

31 hite adipocytes in maintaining properties of preexisting beige adipocytes.

32 dness of an outcome and the uncertainty of a preexisting belief-on learning rate.

33 ion of the brain parenchyma, including along preexisting blood vessels, is a leading cause of therape

34 ministration of RT53 inhibited the growth of preexisting BRAF wild-type and V600E mutant melanoma xen

35 We hypothesized that preexisting brain microvascular disease in patients with

36 women aged 40 years or older who do not have preexisting breast cancer or a previously diagnosed high

37 Sports SCA cases presented with known preexisting cardiac disease in 16% and >/=1 cardiovascul

38 col for patients of advanced age and/or with preexisting cardiac disease.

39 .0 years; 6.8% and 39.4% of participants had preexisting cardiovascular and microvascular disease, re

40 e Cox regression to model the association of preexisting cardiovascular conditions on subsequent HF.

41 e, population-based cohort of NHL survivors, preexisting cardiovascular conditions were associated wi

42 dic surgery, cardiac surgery, and those with preexisting cardiovascular disease (strong recommendatio

43 ypertension, dyslipidemia, and diabetes) and preexisting cardiovascular disease were ascertained.

44 lar complications, and without hypertension, preexisting cardiovascular disease, or other potentially

45 antially differ after further adjustment for preexisting cardiovascular disease.

46 individuals (n = 1094; 21%), and those with preexisting cardiovascular events (n = 1620; 35%).

47 Among survivors only, preexisting cardiovascular factors (hypertension, dyslip

48 th drugs such as trastuzumab is predicted by preexisting cardiovascular risk factors and disease, pos

49 We aimed to understand the contribution of preexisting cardiovascular risk factors to HF risk among

50 BCP-ALL may be a result of the selection of preexisting CD19(-) malignant progenitor cells.

51 progressive heart failure, or combination of preexisting cerebrovascular disease and mild cognitive i

52 in state was achieved by specific erasure of preexisting chromatin marks in the precursor cell or by

53 ding transcription by Pol V is controlled by preexisting chromatin modifications located within the t

54 maintained by insertion of nucleosomes into preexisting chromatin, both on newly synthesized DNA at

55 s of death, age, sex, location of death, and preexisting chronic and acute conditions from the previo

56 Progression of preexisting chronic arthropathy in one participant was t

57 -12,542; p < 0.001), and lower in those with preexisting chronic disease than without (2,989 [95% CI,

58 Thus, preexisting CKD aggravates the cardiac dysfunction cause

59 Here, we investigated the effect of preexisting CKD on cardiac function in mice with sepsis

60 Despite preexisting CKD or a lower ejection fraction, pLVAD supp

61 ass II DSA, and 5 subjects showed persistent preexisting class II DSA.

62 transition to MM involves altered growth of preexisting clones.

63 murine injury models, PLT/uPA-T did not lyse preexisting clots, even when administration was delayed

64 eptors recruited to the plasma membrane from preexisting clusters, consistent with vesicular recruitm

65 inked to multiple risk factors, such as age, preexisting cognitive impairment, and use of sedatives;

66 ic withdrawal syndrome included younger age, preexisting cognitive impairment, higher preweaning mean

67 7; 47%) were younger and more likely to have preexisting cognitive or functional impairment.

68 CCO2R on driving pressure and mortality in a preexisting cohort of patients with ARDS.

69 riggered by increasing fluid shear stress in preexisting collateral arteries.

70 e conferred without disturbing the desirable preexisting commensal colonization of the nasopharynx.

71 ty (after adjustment for age, PSI score, and preexisting comorbid conditions).

72 d similar acute physiology scores, but fewer preexisting comorbidities among elderly patients (p = 0.

73 ses of death, urban and rural residence, and preexisting comorbidities.

74 rmed an analysis stratified by the degree of preexisting comorbidity.

75 d health insurance are mainly because of the preexisting condition, even in the presence of protectiv

76 and pediatric patients and the influence of preexisting conditions (PECs) on chymase levels.

77 py-related complications and exacerbation of preexisting conditions are important and largely unanswe

78 This suggests that pAg binding disrupts a preexisting conformation of the BTN3A1 intracellular dom

79 work for biased agonism based on alternative preexisting conformations that bind more strongly, but n

80 Preexisting coordinated regulation of symbiosis traits b

81 Toric IOLs may correct for preexisting corneal astigmatism at the time of surgery.

82 itation from hemorrhagic shock in swine with preexisting coronary artery disease reduced renal dysfun

83 itation from hemorrhagic shock in swine with preexisting coronary artery disease.

84 Nineteen hypercholesterolemic pigs with preexisting coronary artery disease.

85 Preexisting cross-reactive T cells to genetically divers

86 tudy shows proof of concept that LAIVs boost preexisting, cross-reactive T cells in children to genet

87 loop prevented CSC induction and sensitized preexisting CSCs to chemotherapy.

88 Treatment of preexisting CSCs with a genotoxic drug combination (5-fl

89 ing the nuclear translocation of NFkappaB in preexisting CSCs.

90 Children are devoid of preexisting CVD and provide unique insight into specific

91 patients, respectively, mostly in those with preexisting cytopenias.

92 mechanisms driving programmed elimination of preexisting cytosolic proteins are unclear.

93 3 randomized clinical trial, a low level of preexisting cytotoxic sTILs predicted the most benefit f

94 cs, as defined in this review, is the use of preexisting data sets to address questions in ecology.

95 0.81; P < .001), the reduction was due to a preexisting declining trend in mortality.

96 th of hospital stay less than 2 days, or had preexisting deep vein thrombosis.

97 NiCo) and 50%Ni50%Fe (NiFe) without apparent preexisting defect sinks were employed to study defect d

98 Patients with preexisting dementia and ICU admission within 3 years of

99 Recent studies reveal that preexisting dengue antibodies may have opposite effects

100 and address the critical question of whether preexisting dengue virus (DENV) T cell immunity modulate

101 ntial ZIKV and DENV cross-reactivity and how preexisting DENV T cell immunity modulates Zika T cell r

102 at both 3 and 12 months (P < 0.001), as was preexisting depression (P < 0.03), but veteran status wa

103 ucose target in critically ill patients with preexisting diabetes and chronic hyperglycemia is unknow

104 s irrespective of the presence or absence of preexisting diabetes by a mechanism unrelated to exagger

105 nts with acute stroke, even in those without preexisting diabetes, and denotes a bad outcome.

106 o the asymmetric transfer of VPL depended on preexisting differences between the reliability of near-

107 observed variation was tied to stochastic or preexisting differences in the epigenome occurring at re

108 ost of these were conducted in patients with preexisting diseases that dispose to CKD.

109 We quantified the 28-day mortality effect of preexisting do-not-resuscitate orders in ICUs.

110 study, we determined the association between preexisting donor hypertension and glomerular number and

111 ransplantation into sensitized patients with preexisting donor-specific antibodies (DSA) is very chal

112 Preexisting, donor-specific antibodies (DSAs) are culpri

113 sorbed dose estimates for common organs in a preexisting dosimetry tool (OLINDA/EXM).

114 tatistically significant acceleration in the preexisting downward trend for firearm suicide (ratio of

115 There was also significant change in the preexisting downward trends for rates of total firearm d

116 Droplets grew by the fusion of preexisting droplets, with no restriction on the size of

117 istribution to define the cutoff to identify preexisting drug resistance mutations at low abundance i

118 The preexisting DSA ABMR had superior graft survival compare

119 Compared with patients with preexisting DSA ABMR, patients with de novo DSA ABMR dis

120 expression of AKI transcripts compared with preexisting DSA ABMR.

121 ABMR (hazard ratio [HR], 1.82 compared with preexisting DSA ABMR; 95% confidence interval [95% CI],

122 Overall, 103 (50%) patients had preexisting DSA and 102 (50%) had de novo DSA.

123 However, neuronal sequences may also reflect preexisting dynamics.

124 oendocrine axis dysfunction in patients with preexisting dysfunction in at least 1 axis at baseline w

125 However, the preexisting elevation in TNFalpha expression rendered VH

126 raditional" NSQIP method, this approach uses preexisting equations, built on historical data, which p

127 sducing T cells with a transgenic TCR is the preexisting expression of TCRs in the recipient cells.

128 However, the impact of preexisting flavivirus immunity on ZIKV pathogenesis, th

129 t from scratch, but rather form by co-opting preexisting gene networks.

130 e the possibility of adding new functions to preexisting genes, we considered a framework of riboregu

131 mental and dietary factors are acting upon a preexisting genetic background.

132 sis is further potentiated in embryos with a preexisting genetic defect of RA metabolism.

133 leen and bone marrow while also obliterating preexisting germinal centers.

134 Before surgery, 62 patients had either preexisting glaucoma (n = 39) or high IOP (>/=22 mm Hg)

135 ber 2009, we observed 25420 patients with no preexisting glaucoma and quantified exposure to statins

136 Preexisting glaucoma was present in 72.9% (35 of 48 eyes

137 ontrols were identified and matched for age, preexisting glaucoma, calendar time, and follow-up time.

138 colony-stimulating factor in exacerbation of preexisting GN.

139 ference manual toothbrush (MT) on mid-buccal preexisting GR (PreGR) during 12 months.

140 ESCRT-III/Snf7 promotes direct engulfment of preexisting Grh1 containing vesicles and tubules into a

141 Animals were depleted of their preexisting gut microbiota and then inoculated with alte

142 s model can simulate HbS polymerization with preexisting HbS nuclei.

143 respectively), age (HR, 1.02, P = .001), and preexisting heart failure (HR, 1.85, P < .001) independe

144 hepatobiliary function but does not reduce (preexisting) hepatobiliary injury in ECD livers.

145 Preexisting HF was defined by any HF encounter during th

146 Within this cohort, 518 223 patients had preexisting HF, and 349 826 had a new diagnosis of HF du

147 ntinuously generated, and integrate into the preexisting hippocampal network in the adult brain.

148 to induce posttranslational modifications in preexisting HLA-DP2-peptide complexes, resulting in the

149 st intricate symbiotic arrangements and that preexisting horizontally transferred genes can remain st

150 on efficiency and the detrimental effects of preexisting host antibodies.

151 chimpanzee adenoviruses is overlapping, and preexisting humoral and cellular immunity to both are ex

152 ith hemorrhage, gestational hypertension, or preexisting hypertension identified women with a 4- to 7

153 glomerulopenia in living kidney donors with preexisting hypertension justifies the need for long-ter

154 The effect of preexisting hypertension on living donor nephron number

155 We found that, in donors ages >50 years old, preexisting hypertension was associated with a reduction

156 Preexisting hypertension was associated with a twofold (

157 he main risk factor even in patients without preexisting hyponatremia; however, isolated hypernatremi

158 ithout requiring cognitive preadaptations or preexisting iconic communication schemes as previously c

159 es interact in distinct ways with cells in a preexisting IFN-induced antiviral state.

160 genes, (2) the composition and activity of a preexisting immune infiltrate, and (3) mechanisms of tum

161 previous proposals that they derive from the preexisting immune repertoire in the absence of antigeni

162 ng HIV-1 latency, it remains unclear whether preexisting immune responses within HIV-1(+) individuals

163 Immunization of pregnant women could boost preexisting immune responses, providing passive protecti

164 onary adaptation, reducing the efficiency of preexisting immune responses.

165 Age and preexisting immunity affected virus-specific plasmablast

166 Transplantation of a preexisting immunity and cross-reactivity with ubiquitou

167 However, the impact of preexisting immunity and ICPs on the risk of malignant t

168 ue to the continual evolution of escape from preexisting immunity and the potential for zoonotic emer

169 ch as CD80/CTLA-4 and PD-1/PD1-L, amplifying preexisting immunity and thereby evoking antitumor immun

170 ggest that humans are likely to have limited preexisting immunity to CIV-H3N2 and that CIV-H3N2 x pdm

171 Subjects with no preexisting immunity to DENV developed neutralizing anti

172 Taken together, these findings suggest that preexisting immunity to DENV may impact protective immun

173 When subjects with preexisting immunity to DENV were vaccinated, they devel

174 n transplanted and whether the recipient has preexisting immunity to EBV but can be as high as 20%.

175 Paradoxically, patients who already had high preexisting immunity to HER2-ICD did not respond to ther

176 uenza immune responses; however, humans have preexisting immunity to influenza viral antigens, partic

177 ss of vaccine candidates in humans that have preexisting immunity to influenza.

178 data support the concept that stimulation of preexisting immunological memory to Pneumocystis with a

179 sely, CTCF binding sites in NPCs are largely preexisting in pluripotent stem cells.

180 In contrast, prevalent (preexisting + incident) HF increased during our study pe

181 ry 2000 and December 2011 who did not have a preexisting indication for implantable cardioverter defi

182 Thus, preexisting indole levels in the gut join the oocyst dos

183 ociated with reinfection or recrudescence of preexisting infection.

184 location was without tumor in the absence of preexisting inflammation at that location.

185 isruption and injury, even in the absence of preexisting inflammation.

186 EH) is characterized by viral infection of a preexisting inflammatory dermatosis and is associated wi

187 All factors, except preexisting kidney disease and failed ventilator liberat

188 , vasopressor requirement, thrombocytopenia, preexisting kidney disease, failed ventilator liberation

189 Genomic discovery that is agnostic to preexisting knowledge has uncovered dozens of loci that

190 ning durable knowledge that is associated to preexisting knowledge, but they do so at the cost of mem

191 e Northeast U.S. (LAGOS-NE), a collection of preexisting lake data mostly from state agencies.

192 after liver transplantation in patients with preexisting LAM resistance HBV.

193 obulin for chronic hepatitis B patients with preexisting lamivudine (LAM) resistance (LAM-R) undergoi

194 ams by fluorescein staining from underlying, preexisting laser scars.

195 echanisms of neutral lipid metabolism in the preexisting LD pool.

196 Preexisting levels of cells indicating either T-cell exh

197 10 seasonal vaccine also demonstrated higher preexisting levels of interferon gamma-secreting CD4(+)C

198 ollowing TAVR in patients with severe AS and preexisting LF.

199 (odds ratio [OR], 1.80; 95% CI, 1.19-2.71), preexisting liver disease (OR, 2.28; 95% CI, 1.23-4.24),

200 BCVA unchanged in 3 eyes due to preexisting macular scar and advanced glaucoma.

201 examination should be performed to rule out preexisting maculopathy.

202 Preexisting maternal antibody inhibited infant antibody

203 ssion is highly dependent on the presence of preexisting maternal immunity, with the lowest rates obs

204 o distinguish acutely induced cells from the preexisting MBC pool.

205 survival of patients with breast cancer with preexisting mental illness, and elderly women are of spe

206 ary tumor can also favor the rapid growth of preexisting metastatic lesions.

207 rials that were previously inaccessible with preexisting methods.

208 wn a striking spread of melanoma cells along preexisting microvascular channels and features of both

209 ing PDX passaging, often due to selection of preexisting minor clones.

210 failure to form these structures exacerbates preexisting mitochondrial dysfunction, suggesting that t

211 Preexisting morbidity and functional ability at hospital

212 Independent of agent or regimen, preexisting morphologic features of the retina at baseli

213 to differentiate nascent transcription from preexisting mRNAs are desired.

214 tly, it was uncovered that MTs nucleate from preexisting MTs within the mitotic spindle, which requir

215 hese structural observations help to explain preexisting mutational data and provide insights into se

216 s cell membranes, typically by utilizing the preexisting Na(+) gradient.

217 rs regulatory T cells and thereby, unleashes preexisting nephritogenic responses.

218 The interaction of this preexisting network structure with patent growth in upst

219 gnificant proportion of patients with IE and preexisting neurological complications either undergo de

220 AND were aged </=4 years; less than half had preexisting neurological disease or other risk factors f

221 Adult ICU patients without preexisting neuromuscular abnormalities and a discharge

222 Preexisting neutralizing antibodies (NAbs) against adeno

223 tood, and effective solutions for overcoming preexisting neutralizing antibodies are still lacking.

224 induced later during adulthood in quiescent preexisting oligodendrocytes, after active myelination i

225 duce myelination by the larger population of preexisting OLs carries the potential for enhanced remye

226 Although preexisting OLs do not normally contribute to remyelinat

227 signal-regulated kinases 1 and 2 (ERK1/2) in preexisting OLs of adult mice is sufficient to drive inc

228 myelin in the adult CNS, the contribution of preexisting OLs to functional myelin remodeling is not k

229 erest remains in additionally driving mature preexisting OLs to make myelin.

230 sly after being imprinted and do not disrupt preexisting ones.

231 new cellular traces and the modification of preexisting ones.

232 two models of C3 glomerulopathy with either preexisting or triggered C3 deposition along the GBM.

233 a specific process of care was implemented, preexisting, or never implemented.

234 at differentiating stem cells integrate into preexisting ordered spatial units of the epidermis.

235 ase to form SOA is thought to be enhanced by preexisting organic particles.

236 Most important, 16% of all patients had no preexisting pain condition and now experience chronic IC

237 mor, arises from the epithelial component of preexisting parotid Warthin tumors (WT).

238 larger set of features decorated by smaller preexisting patterns, indicating a structural "memory."

239 ctive than HAPMIX at inferring ancestry when preexisting phased reference data are unavailable and ge

240 An open question is whether there are preexisting plexin dimers that could act as autoinhibito

241 is involved in the degradation of a specific preexisting pool of LDs and that inhibition of this path

242 e of Chol, MA preferentially interacted with preexisting POPS-rich clusters formed by nonideal lipid

243 Thus tumor transformation amplified preexisting population heterogeneity and led some cells

244 with the Sup35 or Rnq1 aggregates; without a preexisting prion, however, such colocalizations are rar

245 nting for first-time prostate biopsy without preexisting prostate cancer: 516 eligible participants f

246 t pathway resulted from the repurposing of a preexisting protein import apparatus.

247 Selective removal of preexisting proteins is achieved by sorting into a mitoc

248 Natural recombination combines pieces of preexisting proteins to create new tertiary structures a

249 Conversely, the preexisting proteome of proteins performing basic cellul

250 We also show that preexisting [PSI(+) ] or [PIN(+) ] (prion form of Rnq1),

251 Preexisting psychiatric difficulties, the initial trauma

252 After classifying those with/without preexisting PTSD (i.e., PTSD before hospitalization), we

253 Preexisting PTSD and depression were strongly associated

254 In the multivariable regression, preexisting PTSD was independently associated with ICU-r

255 This finding suggests that preexisting pulmonary disease could increase MERS-CoV re

256 tion in embryonic MBs evolved by hijacking a preexisting regulatory landscape that was already at wor

257 cedures requiring cardiopulmonary bypass, no preexisting renal dysfunction.

258 dules on treatment efficacy in patients with preexisting resistance.

259 tibiotic use selects for clonal expansion of preexisting resistant bacterial strains.

260 Our results suggest that preexisting responses elicited by a previous DENV3 infec

261 t differ significantly between patients with preexisting (RR, 1.12; 95% CI, 0.86-1.44) or newly diagn

262 onsecutive chronic hepatitis B patients with preexisting rt204 LAM-R mutations or virological load re

263 The preexisting SADS diagnosis was the major reason reported

264 phosphomimetic, competes for a lysine from a preexisting salt bridge, initiating a partial unfolding

265 Despite moderately high levels of preexisting serum antibody, 34 (56%) became infected, of

266 High levels of preexisting serum IgG, including transplacentally acquir

267 Results Nearly 3% of patients had preexisting severe mental illness.

268 These experiments demonstrate that multiple preexisting SMCs give rise to excess aortic SMCs in elas

269 al decisions, thus emphasizing the impact of preexisting social bonds on decision-making.

270 s an integral membrane protein that exploits preexisting sodium-, chloride-, and potassium ion gradie

271 s type of transport was taking place through preexisting spaces in the nasal cavity that were orders

272 2013 was driven mainly by the persistence of preexisting strains rather than through de novo adaptati

273 shifts, it was found that urea redistributes preexisting structural microstates, stabilizing a substr

274 The presence of strong, preexisting T-cell responses, including those induced by

275 Thus, the presence of strong, preexisting T-cell responses, including those induced by

276 ntrolled the proliferative response of human preexisting Tfh cells more efficiently than belatacept.

277 agent that selectively targets nascent over preexisting thrombi.

278 After controlling for preexisting time trends, we observed that between April

279 ctions may be demarcated in development by a preexisting topological framework created by constitutiv

280 form of passive diffusion that is driven by preexisting transepithelial electrochemical gradients.

281 dinal, fixed-effects model that adjusted for preexisting trends to test whether the observed post-tax

282 P = .03), neither of which were explained by preexisting trends.

283 ration of NAC was not effective in resolving preexisting TTP signs; thrombocytopenia, hemolytic anemi

284 were diagnosed as having ASD (115 exposed to preexisting type 2 diabetes, 130 exposed to GDM at </=26

285 extubation leak pressure, poor sedation, and preexisting UAO (P < 0.04) for cuffed ETTs; and age (ran

286 dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of in

287 ate complication of Q fever in patients with preexisting valvular heart disease (VHD).

288 Forty-five patients (52.9%) had a preexisting valvulopathy.

289 We assessed the association between preexisting variant-specific antibody titers and subsequ

290 ral novel mutations that most likely reflect preexisting variation in circulating HSV-2.

291 ary elevations of LDL-C >/=190 mg/dL without preexisting vascular disease at baseline.

292 HF (HR, 2.71; 95% CI, 1.15 to 6.36), whereas preexisting vascular disease had no association with HF

293 work in concert to form new vessels from the preexisting vasculature, there remains a lack of insight

294 n (88 minutes implementers versus 89 minutes preexisting versus 98 minutes nonimplementers; P<0.001 f

295 'Bright Yellow-2' cells: massive delivery of preexisting vesicles to a disk-shaped region at the equa

296 ut a reconciliation of this perspective with preexisting views of transcriptional regulation is lacki

297 Lack of sensitivity can occur due to preexisting virus that uses the CXCR4 coreceptor, while

298 g, interventions may benefit from addressing preexisting vulnerabilities and focus on resilience.

299 m genetic and environmental confounding (eg, preexisting vulnerabilities).

300 ullying may partly be viewed as a symptom of preexisting vulnerabilities.