ライフサイエンスコーパス: pregnane X receptor

1 (CXD2), as well as induction by rifampicin (pregnane X receptor).

2 involve the glucocorticoid receptor and the pregnane X receptor.

3 ling modulates the phosphorylation status of pregnane x receptor.

4 loss of the nuclear xenobiotic receptor PXR (pregnane X receptor), a regulator of enterohepatic drug

5 genes can be targeted for regulation by the pregnane X receptor activator pregnenolone-16alpha-carbo

6 Cotreatment with the prototypical pregnane X receptor activator, rifampicin, significantly

7 sults identify a novel mode of regulation of pregnane x receptor activity and highlight prominent fun

8 protein kinase-mediated repression of human pregnane x receptor activity.

9 y, is a potent ligand (K(i) = 27 nM) for the pregnane X receptor, an orphan nuclear receptor that reg

10 ation of the intestinal xenobiotic receptors pregnane X receptor and constitutive androstane receptor

11 ng pathway, which is a critical regulator of pregnane X receptor and hepatocyte nuclear factor 1alpha

12 ic AMP-dependent protein kinase signaling on pregnane x receptor and provide a molecular explanation

13 to determine whether the interaction between pregnane x receptor and these key biochemical pathways i

14 xenobiotic-activated nuclear receptors PXR (pregnane X receptor) and CAR (constitutive androstane re

15 ncoding P-glycoprotein), NR1I2 (encoding the pregnane X receptor), and PPIA (encoding cyclophilin).

16 the nuclear receptors farsenoid X receptor, pregnane X receptor, and constitutive androstane recepto

17 ative binding sites for retinoid X receptor, pregnane X receptor, and estrogen receptor.

18 receptors constitutive androstane receptor, pregnane X receptor, and peroxisome proliferator-activat

19 including constitutive androstane receptor, pregnane X receptor, and retinoid X receptor (RXR), modu

20 s: farnesoid X receptor, vitamin D receptor, pregnane X receptor, and TGR5.

21 as enhanced in mice lacking the SXR ortholog pregnane X receptor, and treatment of humans with the SX

22 ity is opposite to the sensitizing effect of pregnane X receptor, constitutive androstane receptor, a

23 ilirubinemia can be reduced by activation of pregnane X receptor, constitutive androstane receptor, o

24 h the ability of these compounds to activate pregnane X receptor-dependent pathways in vivo.

25 of the protein in vivo indicates that human pregnane x receptor exists as a phosphoprotein and that

26 The human nuclear pregnane X receptor (hPXR) activates cytochrome P450-3A

27 rapeutic tool.The xenobiotic-activated human pregnane X receptor (hPXR) regulates drug metabolism.

28 The human pregnane X receptor (hPXR) regulates the expression of c

29 Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizi

30 ed off-target activities, most notably human pregnane X receptor (hPXR) transactivation, and led to s

31 Human pregnane X receptor (hPXR), an orphan nuclear receptor k

32 bound to RNA polymerase (RNAP) and the human pregnane X receptor (hPXR), representative examples (2b-

33 role of the nuclear xenobiotic receptor PXR (pregnane X receptor) in this process.

34 Pregnane x receptor is a ligand-activated transcription

35 We also report that pregnane X receptor is essential to maintain robust in v

36 The mouse pregnane X receptor is highly similar to the human ortho

37 The nuclear receptor PXR (pregnane X receptor) is a broad-specificity sensor that

38 These findings suggest that treatment with pregnane X receptor ligands may be useful clinically in

39 ein kinase signaling pathway synergizes with pregnane x receptor-mediated gene activation in mouse he

40 inase signaling has a repressive effect upon pregnane x receptor-mediated gene activation in rat and

41 Both constitutive and pregnane X receptor-mediated inducible activities were m

42 Furthermore, IL-6 attenuated pregnane X receptor-mediated transcription of the CYP3A2

43 The effect of IL-6 on pregnane X receptor-mediated transcription of the rat CY

44 n at 24 hrs, potentially via IL-6 effects on pregnane X receptor-mediated transcription.

45 tutive androstane receptor) (NR1I3) and PXR (pregnane X receptor) (NR1I2) was generated to study thei

46 f CYP3a13 by dexamethasone occurring only in pregnane X receptor null mice.

47 RDelta8 did not repress the nuclear receptor pregnane X receptor or estrogen receptor alpha but did r

48 HNSCC and focused on the role of the nuclear pregnane X receptor (or NR1I2) and epigenetic mechanisms

49 These data demonstrate an impact of pregnane X receptor polymorphisms on tacrolimus pharmaco

50 The nuclear receptor PXR (pregnane X receptor) protects the body from hepatotoxici

51 We show that the human pregnane x receptor protein can serve as an effective su

52 sistance 1 (MDR1 C3435T) P-glycoprotein, and pregnane X receptor (PXR C-25385T, C8055T, and A7635G).

53 mes and drug export pumps, but only one, the pregnane X receptor (PXR in rodents, SXR in humans), reg

54 ehyde-O-(3,4-dichlorobenz yl)oxime (CITCO)], pregnane X receptor (PXR) [rifampicin], and peroxisome p

55 Ketoconazole binds to and antagonizes pregnane X receptor (PXR) activation.

56 Upon treatment with the pregnane X receptor (PXR) activator rifampicin (RIF), hu

57 The pregnane X receptor (PXR) acts as a receptor to induce g

58 sm by which the nuclear xenobiotic receptors pregnane X receptor (PXR) and constitutive active/andros

59 The orphan nuclear receptors pregnane X receptor (PXR) and constitutive androstane re

60 The nuclear pregnane X receptor (PXR) and constitutive androstane re

61 dicates that xenobiotic sensors, such as the pregnane X receptor (PXR) and constitutive androstane re

62 The nuclear receptors pregnane X receptor (PXR) and constitutive androstane re

63 Statins utilize pregnane X receptor (PXR) and serum/glucocorticoid regul

64 , a by-product of intestinal flora, activate pregnane X receptor (PXR) and subsequent CYP3A4 and CYP2

65 The pregnane X receptor (PXR) and the constitutive androstan

66 s constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are involved in the transcript

67 Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that en

68 The steroid and xenobiotic-responsive human pregnane X receptor (PXR) binds a broad range of structu

69 The pregnane X receptor (PXR) detects the presence of a wide

70 investigated whether the xenobiotic receptor pregnane X receptor (PXR) has a role in pathogenesis of

71 Ralpha) as well as its heterodimeric partner pregnane X receptor (PXR) in mice.

72 CYP3A4, hepatocyte nuclear factor-4alpha, or pregnane X receptor (PXR) in PHHs.

73 Here we show that the pregnane X receptor (PXR) interacts more strongly with S

74 The pregnane X receptor (PXR) is a key regulator of xenobiot

75 Pregnane X receptor (PXR) is a ligand-dependent transcri

76 The pregnane X receptor (PXR) is a master regulator of xenob

77 The pregnane X receptor (PXR) is a master regulator of xenob

78 Pregnane X receptor (PXR) is a nuclear receptor consider

79 The pregnane X receptor (PXR) is a nuclear receptor signific

80 The human pregnane X receptor (PXR) is a promiscuous nuclear recep

81 Pregnane X receptor (PXR) is a xenobiotic receptor that

82 The nuclear receptor pregnane X receptor (PXR) is activated by a range of xen

83 The pregnane X receptor (PXR) is an important transcriptiona

84 The pregnane X receptor (PXR) is an orphan nuclear receptor

85 Pregnane X receptor (PXR) is known to function as a xeno

86 The nuclear xenobiotic receptor pregnane X receptor (PXR) is promiscuously activated by

87 The pregnane X receptor (PXR) is the molecular target for ca

88 Pregnane X receptor (PXR) mediates xenobiotic and endobi

89 GSTA2 and expression plasmids for either GR, pregnane X receptor (PXR) or a combination of both.

90 The nuclear pregnane X receptor (PXR) plays a central role in regula

91 In mammals the pregnane X receptor (PXR) plays a key role in the regula

92 Pregnane X receptor (PXR) plays an important role in det

93 The pregnane X receptor (PXR) plays an important role in the

94 constitutive androstane receptor (CAR), and pregnane X receptor (PXR) regulate and alter the metabol

95 The human pregnane X receptor (PXR) regulates genes involved in dr

96 Upon drug activation, the nuclear pregnane X receptor (PXR) regulates not only hepatic dru

97 The pregnane X receptor (PXR) regulates the metabolism and e

98 By employing a pregnane X receptor (PXR) reporter gene assay to priorit

99 The human nuclear receptor pregnane X receptor (PXR) responds to a wide variety of

100 man hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in cell-based tr

101 iosgenin increased the expression of several pregnane X receptor (PXR) target genes and the cholereti

102 nduced by the farnesoid X receptor (FXR) and pregnane X receptor (PXR) through the same IR0.

103 The pregnane X receptor (PXR) was isolated as a xenosensor r

104 Pregnane X receptor (PXR) was originally characterized a

105 ells had reduced nuclear localization of the pregnane X receptor (PXR), a key transcriptional regulat

106 Pregnane X receptor (PXR), a member of the NR1I nuclear

107 In contrast, expression levels of the pregnane X receptor (PXR), a nuclear receptor most simil

108 cluding BPA, have been shown to activate the pregnane X receptor (PXR), a nuclear receptor that funct

109 Pregnane X receptor (PXR), a previously known "xenobioti

110 Recent reports suggest that pregnane X receptor (PXR), a xenobiotic nuclear receptor

111 in was transcriptionally up-regulated by the pregnane X receptor (PXR), a xenobiotic-activated nuclea

112 Pregnane X receptor (PXR), acting as a xenobiotic-activa

113 ydrocarbon receptor (AhR), activation of the pregnane X receptor (PXR), activation of the estrogen re

114 The pregnane X receptor (PXR), along with its sister recepto

115 The human pregnane X receptor (PXR), also known as steroid and xen

116 eptors including farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive active/andro

117 tream promoter-transcription factor COUP-TF, pregnane X receptor (PXR), and hepatocyte nuclear factor

118 ar receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining

119 cells and hepatoma cells overexpressing the pregnane X receptor (PXR), but not in hepatoma cells in

120 al regulation by nuclear factors such as the pregnane X receptor (PXR), constitutive androstane recep

121 f CYP2B6 and CYP3A4, targets of hCAR and the pregnane X receptor (PXR), in HPH, HepaRG, and PXR-knock

122 e investigated the role of nuclear receptor, pregnane X receptor (PXR), in M. tuberculosis infection

123 s constitutive androstane receptor (CAR) and pregnane X receptor (PXR), respectively.

124 -carbonitrile (PCN), a ligand for the rodent pregnane X receptor (PXR), significantly enhances the ra

125 uman (h) orphan nuclear receptor, termed the pregnane X receptor (PXR), that binds to a response elem

126 a novel orphan nuclear receptor, termed the pregnane X receptor (PXR), that is activated by naturall

127 y increased in mice lacking the SXR ortholog pregnane X receptor (PXR), thereby demonstrating a direc

128 promoter element has been shown to bind the pregnane X receptor (PXR), this receptor does not mediat

129 to the hCAR: PK1195 strongly activated human pregnane X receptor (PXR), whereas it did not alter the

130 mplicated in activating the nuclear receptor pregnane X receptor (PXR), which acts as a xenobiotic se

131 expression is transcriptionally regulated by pregnane X receptor (PXR), which is a ligand-dependent t

132 Here, using a pregnane X receptor (PXR)-humanized mouse model, we foun

133 id, antimineralocorticoid, progestogenic and pregnane X receptor (PXR)-like activities (mug standard-

134 olished in hepatocyte cultures prepared from pregnane X receptor (PXR)-null mice, and cotransfection

135 n CYP3A4-null animals, suggesting that other pregnane X receptor (PXR)-regulated pathways may contrib

136 multiple mechanisms, including activation of pregnane X receptor (PXR).

137 hift assays showed that CAR-RE binds CAR and pregnane X receptor (PXR).

138 s regulated by nuclear receptors such as the pregnane X receptor (PXR).

139 e constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

140 rier function through the xenobiotic sensor, pregnane X receptor (PXR).

141 ted during confluence in a process involving pregnane X receptor (PXR).

142 n of constitutive androstane receptor and/or pregnane X receptor (PXR).

143 tagonists have been identified for the human pregnane X receptor (PXR).

144 vated the human nuclear xenobiotic receptor, pregnane X receptor (PXR).

145 nuclear receptors, including the xenobiotic pregnane X receptor (PXR); (c) the ability to induce hum

146 own that MRP2 expression is regulated by the pregnane X receptor (PXR, NR1I2) and constitutive andros

147 The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing

148 Ligand-mediated activation of the pregnane X receptor (PXR, NR1I2) is postulated to affect

149 Pregnane X receptor (PXR, NR1I2), a member of the superf

150 Recently, the pregnane X receptor (PXR, NR1I2), initially characterize

151 that the ligand-activated nuclear receptors pregnane X receptor (PXR; NR1I2) and constitutive andros

152 ers of the nuclear receptor superfamily, the pregnane X receptor (PXR; NR1I2) and constitutive andros

153 ptor (CAR; NR1I3) and to a lesser extent the pregnane X receptor (PXR; NR1I2) are responsible for med

154 itutive androstane receptor (CAR; NR1I3) and pregnane X receptor (PXR; NR1I2), respectively.

155 ted with rifampicin in order to identify new pregnane-X receptor (PXR) target genes.

156 Genes encoding CYP3A6, in addition to the pregnane-X-receptor (PXR) and P-glycoprotein (P-gp) were

157 arbonitrile to activate the nuclear receptor pregnane X receptor restores P-glycoprotein expression a

158 pathways and biological functions, including pregnane X receptor/retinoic acid receptor activation as

159 biotic receptor) and its rodent homolog PXR (pregnane X receptor) serve as functional bile acid recep

160 e acids as CYP3A4 inducers and activators of pregnane X receptor/steroid and xenobiotic receptor (PXR

161 Expression of other pregnane X receptor target enzymes and transporter genes

162 that topotecan and etoposide are ligands of pregnane X receptor that induce CYP3A4 transcription.

163 ptors, constitutive androstane receptor, and pregnane X receptor, these results suggest that decrease

164 signaling also modulates the interactions of pregnane x receptor with protein cofactors.