ライフサイエンスコーパス: pregnenolone sulfate

1 ally, testosterone antagonized the effect of pregnenolone sulfate.

2 t postulated for the inhibitory neurosteroid pregnenolone sulfate.

3 fected the negative allosteric modulation by pregnenolone sulfate.

4 omers of dehydroepiandrosterone sulfate (1), pregnenolone sulfate (2), and (3alpha,5beta)-3-hydroxypr

5 teric potentiation of NMDA receptor pores by pregnenolone sulfate, 24(S)-hydroxycholesterol, and doco

6 The ability of pregnenolone sulfate (a positive modulator) and epipregn

7 The steroid pregnenolone sulfate activates the transcription factor

8 iously shown that the sulfated neurosteroids pregnenolone sulfate and 3alpha-hydroxy-5beta-pregnan-20

9 Sig-1R agonists such as pregnenolone sulfate and cocaine caused the dissociation

10 loreclezole, had different IC(50) values for pregnenolone sulfate and lanthanum, and were insensitive

11 sure alters the actions of the neurosteroids pregnenolone sulfate and pregnenolone hemisuccinate, whi

12 oth compounds competed with progesterone and pregnenolone sulfate and significantly reduced CatSper a

13 bserve enantioselectivity for the actions of pregnenolone sulfate and steroid sulfate 3 indicates tha

14 hermore, the GluN2A/B-selective potentiator (pregnenolone sulfate) and the GluN2C/D-selective potenti

15 s steroids allopregnanolone (3alpha5alphaP), pregnenolone sulfate, and beta-estradiol in the absence

16 tsynaptic neuron depolarization, and an anti-pregnenolone sulfate antibody scavenger blocked this eff

17 The neurosteroids alphaxalone and pregnenolone sulfate appropriately modulated GABAR curre

18 ulfated and unsulfated neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DH

19 l CatSper currents, whereas the neurosteroid pregnenolone sulfate exerted similar effects as progeste

20 ectrophysiological techniques, we found that pregnenolone sulfate increases the frequency of AMPA-med

21 c-Jun-specific short hairpin RNA attenuated pregnenolone sulfate-induced AP-1 activation.

22 We conclude that pregnenolone sulfate-induced TRPM3 channel activation ch

23 report here that the excitatory neurosteroid pregnenolone sulfate induces a long-lasting strengthenin

24 Pregnenolone sulfate inhibited GABA-evoked currents with

25 The mechanism of action of pregnenolone sulfate involved a short-term increase in t

26 This finding indicates that a pregnenolone sulfate-like neurosteroid is a previously u

27 Moreover, the actions of pregnenolone sulfate on type A gamma-aminobutyric acid a

28 modulation by 3alpha5alphaP but not that by pregnenolone sulfate or beta-estradiol.

29 sure to the steroids cortisol, pregnenolone, pregnenolone sulfate, or progesterone.

30 ne mediating the effects of the neurosteroid pregnenolone sulfate, or the allosteric regulatory site

31 roid pregnenolone (PREG) and its metabolites pregnenolone sulfate (PregS) and allopregnanolone in ser

32 TRPM3 can be activated by the neurosteroid pregnenolone sulfate (PregS) and heat.

33 Pregnenolone sulfate (PREGS), one of the most abundantly

34 h models of the GABA-inhibitory neurosteroid pregnenolone sulfate (PREGS), suggesting common mechanis

35 ates serum levels of the neuroactive steroid pregnenolone sulfate (PregS).

36 ted by heat and chemical agonists, including pregnenolone sulfate (PS) and nifedipine (Nif).

37 Sulfated steroids like pregnenolone sulfate (PS) are found endogenously in the

38 Pregnenolone sulfate (PS) is a sulfated neurosteroid whi

39 Pregnenolone sulfate (PS) is an abundant neurosteroid th

40 Pregnenolone sulfate (PS) is an abundant neurosteroid th

41 Pregnenolone sulfate (PS) is an endogenous neurosteroid

42 The endogenous neurosteroid pregnenolone sulfate (PS) is known to enhance memory and

43 We examined the effects of the neurosteroid pregnenolone sulfate (PS) on GABA(A) receptor-mediated s

44 Here, we report that pregnenolone sulfate (PS) uses a unique mechanism for en

45 The effects of the neurosteroid pregnenolone sulfate (PS) were studied in 3- to 9-week-o

46 One of these neurosteroid, pregnenolone sulfate (PS), depends on six identified M1

47 Pregnenolone sulfate (PS), one of the most commonly occu

48 exceeds that of the canonical TRPM3 agonist, pregnenolone sulfate (PS).

49 These results indicate that (i) pregnenolone sulfate together with progesterone are the

50 Neurosteroids, such as pregnenolone sulfate, were previously shown to modulate