ライフサイエンスコーパス: preimplantation

1 ks of genes that play important roles during preimplantation.

2 We assayed 712 genes for requirements during preimplantation.

3 This study analyzed preimplantation, 3 and 24 months protocol biopsies and a

4 Independent factors associated with preimplantation and 3-month HRQOL scores, and with the l

5 cessful TAVR or surgical AVR (SAVR) obtained preimplantation and at 7 days, 1 and 6 months, and 1, 2,

6 how developmental abnormalities in both late preimplantation and early postimplantation development.

7 ntification of novel phenotypes during mouse preimplantation and facilitates functional annotation of

8 Extensive preimplantation and outcome data were collected on all p

9 ome inactivation (XCI) was performed in both preimplantation and postimplantation nuclear transfer em

10 artificial insemination (AI) at day (d) 18 (preimplantation) and d 34 (postimplantation) of gestatio

11 preservation, its various modes (continuous, preimplantation) and temperatures (hypo-, sub, or normot

12 Preimplantation aortic regurgitation >/=mild was associa

13 nzyme-catalyzed process, loss of 5hmC during preimplantation appears to be a DNA replication-dependen

14 expression) than would be predicted by their preimplantation baseline scores (5.4; 95% CI, 4.1-6.7, c

15 with real-time polymerase chain reaction, in preimplantation biopsies (n=89) and first day posttransp

16 Preimplantation biopsies and related scores have been us

17 Preimplantation biopsy analysis is associated with accep

18 ted from DCD donors over 70 years old, using preimplantation biopsy Remuzzi grading to inform implant

19 ue of the Kidney Donor Profile Index policy, preimplantation biopsy, dual KT, machine perfusion and s

20 Embryonic stem (ES) cells derived from preimplantation blastocysts and induced pluripotent stem

21 However, the inner cell mass (ICM) of mouse preimplantation blastocysts and their in vitro counterpa

22 g through the emergence of epiblast cells in preimplantation blastocysts, and ceasing during human em

23 in 116 single blastomeres comprising entire preimplantation bovine embryos (n = 23) following in vit

24 Although preimplantation clinical status was associated with outc

25 reprogramming and apoptotic status of bovine preimplantation cloned embryos.

26 Preimplantation coronary angiography with simultaneous t

27 duction or various methods of ART, including preimplantation culture, embryo transfer, in vitro ferti

28 and methylation were examined after in vitro preimplantation culture.

29 associated with Fe-S protein instability and preimplantation death of mice in which Mms19 has been kn

30 al low protein diet exclusively during mouse preimplantation development (Emb-LPD) is sufficient to c

31 protein, is correlated with a faster rate of preimplantation development (Ped fast phenotype) in mice

32 t genome-scale DNA methylation maps of human preimplantation development and embryonic stem cell deri

33 s directly involved in genome defense during preimplantation development and in PGCs at the time of g

34 GA), begins during the 2-cell stage in mouse preimplantation development and marks a vital transition

35 ally suppressed during oocyte maturation and preimplantation development and that endo-siRNAs, rather

36 es exhibiting differential expression during preimplantation development are of unknown identity and/

37 highlights significant differences in human preimplantation development compared with mouse and prov

38 Preimplantation development culminates with the emergenc

39 However, the roles of PADI1 in preimplantation development have not been addressed.

40 iling the expression of microRNAs throughout preimplantation development identified several candidate

41 ion using methyl-beta-cyclodextrin inhibited preimplantation development in culture.

42 ed during oocyte growth and persists through preimplantation development in mice.

43 of DNA methylation patterns during mammalian preimplantation development involves the concurrent main

44 me-wide DNA methylation reprogramming during preimplantation development is a dynamic balance between

45 Preimplantation development is a period of dynamic epige

46 are present in the blastocyst, each stage of preimplantation development is characterized by a differ

47 While Oct-4's role during preimplantation development is to maintain embryonic cel

48 tially packaged sperm and egg genomes during preimplantation development is unknown.

49 Our findings show that the dynamics during preimplantation development of gene inactivation and acq

50 tivation of the FGF signaling pathway during preimplantation development of the mouse embryo is known

51 ttranslational modification is essential for preimplantation development of the mouse embryo.

52 ic primitive endoderm (PrE) formation during preimplantation development of the rabbit.

53 ucture of chromatin and its reprogramming in preimplantation development remain poorly understood.

54 vation, the full range of their functions in preimplantation development remains largely unknown.

55 ingle-cell gene-expression analysis in human preimplantation development to instruct human stem cell

56 rnal LPD treatment during post-fertilization preimplantation development which may reflect the relati

57 horylated Akt was detected throughout murine preimplantation development, and its presence at the pla

58 evelopment to blastocyst, the final stage of preimplantation development, and promoted mitochondrial

59 tage-specific expression in ICM cells during preimplantation development, and show that Mbd3 is requi

60 is a prolonged process that extends through preimplantation development, as characterized by slow co

61 are not only expressed in oocytes and during preimplantation development, but also display distinct s

62 e methylation acquired in the oocyte through preimplantation development, but become fully methylated

63 We focus on how imprinted XCI occurs during preimplantation development, including a brief discussio

64 nal and zygotic Dgcr8 alleles did not impair preimplantation development, including the determination

65 Although it is essential for mammalian preimplantation development, its role remains unclear.

66 During germ cell and preimplantation development, mammalian cells undergo nea

67 he single-cell transcriptional data of mouse preimplantation development, our algorithm outperforms c

68 duction of HDAC2 has no noticeable effect on preimplantation development, suggesting that individual

69 During mouse preimplantation development, the generation of the inner

70 omplex and hybrid N-glycans in oogenesis and preimplantation development, the Mgat1 gene in oocytes w

71 During preimplantation development, the number of cellular MTOC

72 It has been suggested that during mouse preimplantation development, the zygotically expressed t

73 During preimplantation development, there is passive DNA demeth

74 nt, maternal HDAC3 protein was stable during preimplantation development, thereby preventing an exami

75 powerful tool for the study of fertilization/preimplantation development, vertical viral gene transmi

76 tional regulation during human oogenesis and preimplantation development, we defined stage-specific t

77 neage restriction and cell commitment during preimplantation development.

78 s, DNA methylation is globally erased during preimplantation development.

79 ole in maintaining energy homeostasis during preimplantation development.

80 ly disrupts oocyte chromatin methylation and preimplantation development.

81 nd the inner cell mass (ICM) lineages during preimplantation development.

82 Ctr9 and Rtf1, are required during mammalian preimplantation development.

83 tic reprogramming is required for successful preimplantation development.

84 l genome in zygotes is gradually lost during preimplantation development.

85 developing intestinal epithelium and during preimplantation development.

86 ed proteins and multi-component complexes in preimplantation development.

87 e function and chromosome segregation during preimplantation development.

88 ividual HDACs have distinct functions during preimplantation development.

89 the acetylation state of histone H4K5 during preimplantation development.

90 ylases (HDAC) HDAC1, HDAC2, and HDAC3 during preimplantation development.

91 l roles during oogenesis, fertilization, and preimplantation development.

92 Zscan4 thus seems to be essential for preimplantation development.

93 ether PI3K is intrinsically activated during preimplantation development.

94 the question whether they play any roles in preimplantation development.

95 TP production to survive and proceed through preimplantation development.

96 h notable differences between species during preimplantation development.

97 ing oocyte growth and is required for normal preimplantation development.

98 re present in oocytes and persist throughout preimplantation development.

99 contents are required for fertilization and preimplantation development.

100 failed fertilization or embryo arrest during preimplantation development.

101 eres comprising a single embryo during human preimplantation development.

102 uct function in supporting fertilization and preimplantation development.

103 os segregate three different lineages during preimplantation development: trophoblast, epiblast and h

104 lication is therefore a major cause of human preimplantation developmental arrest in vitro.

105 ally positioned to a play a critical role in preimplantation developmental events.

106 Procedural guidance includes preimplantation device selection, intraprocedural guidan

107 in preimplantation embryos suggest that the preimplantation DNMT1-dependent maintenance mechanism sp

108 slightly between FCRx samples and the paired preimplantation donor organ samples, but most of the fun

109 imprinted, which occurs in all cells of the preimplantation embryo and in the extraembryonic lineage

110 DNA methylation patterns in the preimplantation embryo are dependent on the oocyte-speci

111 ed methylation to maintain in the zygote and preimplantation embryo at a time when much of the remain

112 that appeared to match only ovary, egg, and preimplantation embryo cDNAs.

113 In conclusion, TSPO was found necessary for preimplantation embryo development and ACTH-stimulated s

114 ocannabinoid signaling is critical to normal preimplantation embryo development and migration of trop

115 Synchronized preimplantation embryo development and passage through t

116 Human preimplantation embryo development involves complex cell

117 cate that HPAT2, HPAT3 and HPAT5 function in preimplantation embryo development to modulate the acqui

118 epletion of maternal stores of Filia impairs preimplantation embryo development with a high incidence

119 elta9-tetrahydrocannabinol] levels constrain preimplantation embryo development with aberrant express

120 The Ped (preimplantation embryo development) gene, whose product

121 idence of an association between the rate of preimplantation embryo development, postnatal growth and

122 fects in several pregnancy events, including preimplantation embryo development.

123 ived mRNAs during mammalian oocyte and early preimplantation embryo development.

124 -cell through the blastocyst stage of murine preimplantation embryo development.

125 signaling is required for fertilization and preimplantation embryo development.

126 The preimplantation embryo floats freely within the oviduct

127 analysed global remethylation from the mouse preimplantation embryo into the early epiblast and extra

128 is not associated with the majority of human preimplantation embryo loss.

129 In conclusion, the preimplantation embryo possesses a functional WNT signal

130 e critical importance of the PI3K pathway in preimplantation embryo survival and pregnancy outcome an

131 GRK2 deletion in the preimplantation embryo with EIIa-Cre (germline null) res

132 pression changes in the germ line and in the preimplantation embryo would greatly enhance the underst

133 Each protein persists in cells of the preimplantation embryo, but the continuous cell-cell con

134 anonical WNT signaling in development of the preimplantation embryo.

135 ys essential for the continued growth of the preimplantation embryo.

136 enerated from the inner cell mass of a human preimplantation embryo.

137 econd, to resist global demethylation in the preimplantation embryo.

138 sis is common in the blastomere stage of the preimplantation embryo.

139 expressed by pluripotent cells in the human preimplantation embryo.

140 hromosome status resembles that of the human preimplantation embryo.

141 on of endogenous retroelements active in the preimplantation embryo.

142 derm (PrE) fate that occurs in the mammalian preimplantation embryo.

143 a mouse model of transient DNMT1 loss in the preimplantation embryo.

144 lipid formation in cultured cells and during preimplantation embryogenesis.

145 nscriptome data of human, macaque, and mouse preimplantation embryogenesis.

146 Mammalian preimplantation embryonic development (PED) is thought t

147 ome activation and comparatively accelerated preimplantation embryonic development program observed i

148 transcripts frequently results in failure of preimplantation embryonic development, but their functio

149 y have any function during fertilization and preimplantation embryonic development.

150 ablation of geminin in the mouse results in preimplantation embryonic lethality because pluripotent

151 BRG1 depletion in preimplantation embryos and Cdx2-inducible embryonic ste

152 and corresponding nascent RNA transcripts in preimplantation embryos and during spermatogenesis.

153 Imprinted XCI, normally found in preimplantation embryos and extraembryonic tissues, was

154 fication phenotypes, similar to FGF4-treated preimplantation embryos and Fgf4 KO embryos, respectivel

155 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from i

156 ngle-cell DNA methylome sequencing for human preimplantation embryos and found that tens of thousands

157 HDAC1 is likely a major deacetylase in preimplantation embryos and its expression inversely cor

158 mammalian genomes can be global, as seen in preimplantation embryos and primordial germ cells (PGCs)

159 enhances both the developmental potential of preimplantation embryos and the live birth rate, it migh

160 ses similar changes in downstream targets in preimplantation embryos and trophoblast stem cells.

161 Mouse oocytes and preimplantation embryos apparently lack this response, a

162 Preimplantation embryos are formed, yet abnormalities in

163 inally, we show that chromatin compaction in preimplantation embryos can partially proceed in the abs

164 A decrease of the cleavage rate in 4n preimplantation embryos compared to diploid (2n) embryos

165 Here, we show that mouse preimplantation embryos contain endogenous betaine; Bhmt

166 Mammalian preimplantation embryos develop in the oviduct as indivi

167 ylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of ce

168 f DNase I-hypersensitive site (DHS) of mouse preimplantation embryos from 1-cell to morula stage.

169 High quality preimplantation embryos from individual cows were pooled

170 how that Kcnq1ot1 is paternally expressed in preimplantation embryos from the two-cell stage, and tha

171 iologic importance of this pathway in murine preimplantation embryos is beginning to emerge.

172 Optimal development of fertilized eggs into preimplantation embryos is essential for reproduction.

173 We further demonstrate L1 RNA in preimplantation embryos lacking the L1 transgene and L1

174 and support the notion that discarded human preimplantation embryos may be useful recipients for the

175 ablation of the geminin gene (Gmnn) in mouse preimplantation embryos resulted in apoptosis, suggestin

176 liMAB-seq analysis of preimplantation embryos reveals the oxidation of 5mC to

177 ments of non-DMD, but not DMD methylation in preimplantation embryos suggest that the preimplantation

178 unostaining of mitotic chromosome spreads of preimplantation embryos that the 5hmC associated with th

179 does not adversely affect the development of preimplantation embryos to blastocysts and uterine prepa

180 plex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulate

181 Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming

182 perm protection but also indirect effects on preimplantation embryos via oviduct expression of embryo

183 ontribute to the regulation of cavitation in preimplantation embryos via target proteins including Na

184 essential cytoplasmic complex in oocytes and preimplantation embryos with poorly understood function,

185 of the heterozygous MYBPC3 mutation in human preimplantation embryos with precise CRISPR-Cas9-based t

186 In some developmental contexts (e.g., preimplantation embryos) DNA is hypomethylated but repet

187 allele-specific CpG methylation 5' of H19 in preimplantation embryos, although this methylation is no

188 gly, these genes are paternally expressed in preimplantation embryos, and ectopic removal of H3K27me3

189 ression of repetitive parasitic sequences in preimplantation embryos, and thereby contributes to pres

190 rs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and bi

191 ced in ES cell lines isolated from 3-day-old preimplantation embryos, consistent with the hypothesis

192 ation and oxidative stress were increased in preimplantation embryos, fetuses, and newborns of Wester

193 factor in determining methylation status in preimplantation embryos, suggesting a need to reassess m

194 ethod that facilitates chromatin analysis of preimplantation embryos, that H3K9me3 is enriched at the

195 s critical functions for spindle assembly in preimplantation embryos.

196 pplementation on the transcriptome of bovine preimplantation embryos.

197 f the H3K27me3 decrease normally observed in preimplantation embryos.

198 ning the role of kinesin 5 in mouse eggs and preimplantation embryos.

199 essential role for CTCF in mouse oocytes and preimplantation embryos.

200 ne lipid rafts in mouse oocytes and cleaving preimplantation embryos.

201 at PI3K is constitutively activated in mouse preimplantation embryos.

202 th dividing and postmitotic cells, including preimplantation embryos.

203 peripheral organs including sperm, eggs, and preimplantation embryos.

204 r function of the PI3K/Akt pathway in murine preimplantation embryos.

205 ote the in vitro development of zygotes into preimplantation embryos.

206 ntial for successful oocyte development into preimplantation embryos.

207 unction of the PI3K/Akt pathway in mammalian preimplantation embryos.

208 uring the oocyte to embryo transition and in preimplantation embryos.

209 maternal Xist expression and maternal XCI in preimplantation embryos.

210 the first time, a knockdown screen in mouse preimplantation embryos.

211 ingle-cell RNA-sequencing of human and mouse preimplantation embryos.

212 preservation of human and animal oocytes and preimplantation embryos.

213 in naive pluripotent stem cells (PSCs) with preimplantation embryos.

214 be reset in primordial germ cells (PGCs) and preimplantation embryos.

215 use embryonic stem cells (ESCs) resemble the preimplantation epiblast and efficiently contribute to c

216 how the naive state is inherently linked to preimplantation epiblast identity in the embryo.

217 , a pre-requisite for rapid progression from preimplantation epiblast to gastrulation in rodents.

218 e transcriptional circuitry operative in the preimplantation epiblast.

219 Mettl3 knockout preimplantation epiblasts and naive embryonic stem cells

220 Therefore, DMAP1 mediates distinct preimplantation epigenetic reprogramming processes: TIP6

221 of this compensation, we found that reduced preimplantation estrogen secretion from ovarian HB-EGF d

222 regulating on-site anandamide tone to direct preimplantation events that determine the fate of pregna

223 estions: are the cells that show such early, preimplantation expression of this AVE marker the real p

224 To describe the first case of preimplantation genetic diagnosis (PGD) and in vitro fer

225 pplication, success rates and limitations of preimplantation genetic diagnosis (PGD) for haematologic

226 Currently, the methods available for preimplantation genetic diagnosis (PGD) of in vitro fert

227 ite markers is the current gold standard for preimplantation genetic diagnosis (PGD) of single-gene d

228 Among these reproductive options, preimplantation genetic diagnosis (PGD) offers the oppor

229 a single-cell biopsy similar to that used in preimplantation genetic diagnosis (PGD), which does not

230 The technology of preimplantation genetic diagnosis and genetic testing in

231 in genetic counseling, prenatal testing, and preimplantation genetic diagnosis in extended families a

232 Preimplantation genetic diagnosis of leukocyte adhesion

233 ethod can be applied as a generic method for preimplantation genetic diagnosis on single cells biopsi

234 fate may be of practical importance, because preimplantation genetic diagnosis requires removal of bl

235 mutations in human embryos by complementing preimplantation genetic diagnosis.

236 for prenatal and presymptomatic testing and preimplantation genetic diagnosis.

237 in vitro fertilization and subsequently used preimplantation genetic diagnosis; 3 months ago she deli

238 s using whole genome amplification (WGA) and preimplantation genetic haplotyping (PGH) of embryos.

239 The MALBAC-based preimplantation genomic screening in in vitro fertilizat

240 cytes are important for meiosis research and preimplantation genomic screening.

241 This is the first known experience of preimplantation HLA typing performed without PGD for a c

242 the ability to spontaneously assimilate into preimplantation host morula via diploid aggregation, uni

243 We report studies of preimplantation human embryo development that correlate

244 age-specific transcription factors in staged preimplantation human embryos from the zygote until the

245 ant insight into developmental patterning of preimplantation human embryos with potential consequence

246 ion promoted a stable acquisition of a human preimplantation ICM-like ground state via modulation of

247 60-p400 complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1(+/+) and Dnmt1(V)(/)(V) ba

248 PSC) lines could be reverted to stable human preimplantation inner cell mass (ICM)-like naive states

249 icroarrays in 34 graft biopsies collected at preimplantation (L1) and at 90 min postreperfusion (L2)

250 Geminin knockout mouse embryos are preimplantation lethal by the 32-cell stage, precluding

251 blation of the mouse Tead4 gene results in a preimplantation lethal phenotype, and TEAD4 is one of tw

252 blation of the single murine Sac1 results in preimplantation lethality in the mouse and that Sac1 ins

253 for a disrupted Mcm4 allele (Mcm4(-)) caused preimplantation lethality, Mcm(Chaos3/-) embryos died la

254 The preimplantation mammalian embryo is a paradigm of tissue

255 Naive pluripotency is manifest in the preimplantation mammalian embryo.

256 Intriguingly, the trophectoderm (TE) in preimplantation monkey blastocysts also expressed X-link

257 ion methods to assess gene expression during preimplantation mouse development indicate that changes

258 proaches, and small molecule analyses during preimplantation mouse development to probe the mechanism

259 at Xist RNA functions relatively late during preimplantation mouse development.

260 y and high-quality cell cycle progression in preimplantation mouse development.

261 tomeres compact to form polarized morulae in preimplantation mouse development.

262 ization may reflect the regulative nature of preimplantation mouse development.

263 re activated during genome activation in the preimplantation mouse embryo, and both sense and antisen

264 In the preimplantation mouse embryo, TEAD4 is critical to estab

265 ombine to determine distinct lineages of the preimplantation mouse embryo.

266 r development beyond the 2-cell stage in the preimplantation mouse embryo.

267 gain of EED along with depletion of KDM6B in preimplantation mouse embryos abrogates CDX2 and GATA3 e

268 sed on activation of the embryonic genome in preimplantation mouse embryos is the formation of a chro

269 (mESCs) are clonal populations derived from preimplantation mouse embryos that can be propagated in

270 We show that Usp36 depletion is lethal in preimplantation mouse embryos, where it blocks the trans

271 Perturbation of BMP signaling in preimplantation mouse embryos, whether by treatment with

272 lopment and is required for cell cleavage in preimplantation mouse embryos.

273 ding cells in the C. elegans germline and in preimplantation mouse embryos.

274 ta-2-spectrin co-localize with E-cadherin in preimplantation mouse embryos.

275 otent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established thro

276 Blastocysts derived from preimplantation msin3A null embryos and mouse embryo fib

277 Preimplantation necrosis (n = 7) was initially managed c

278 defers on-time implantation without altering preimplantation ovarian estrogen secretion.

279 e to dams prior to conception and during the preimplantation period can modulate gene expression in b

280 PR was decreased during decidualization and preimplantation period in Stat3(d/d) mice, and PR target

281 pha accumulation in stromal cells during the preimplantation period.

282 nto adjacent tissue layers by the end of the preimplantation period.

283 ICD shock and the patient's preimplantation personality disposition were equally imp

284 d the association of shock and the patient's preimplantation personality with health status, using a

285 maternal Xist (Xm-Xist) is repressed during preimplantation phases to establish imprinted X-chromoso

286 of genetic discoveries on stigma, abortion, preimplantation procedures, and population screening for

287 what we believe to be a novel regulation of preimplantation processes, which could be clinically rel

288 THODS AND INTERMACS patients (n=3248) with a preimplantation profile of 1 (critical cardiogenic shock

289 d the apoptosis executor enzyme caspase-3 in preimplantation renal biopsies (PIB) as markers for dela

290 learning than would be predicted from their preimplantation scores.

291 n gonads at 12.5 dpc, these findings suggest preimplantation selection of embryos.

292 is revealed transient and early induction of preimplantation-specific genes in a Zscan4-dependent man

293 the frequency at which unspecified cells in preimplantation stage embryos express lineage markers pr

294 mitosis progresses gradually throughout the preimplantation stage in the mouse embryo, thus providin

295 sults show that multiple signaling inputs at preimplantation stages specify the first embryonic linea

296 undant at the blastocyst stage but not other preimplantation stages, and BHMT activity is similarly d

297 nce of histone H3 lysine 9 trimethylation in preimplantation stem cells.

298 genes at postreperfusion time compared with preimplantation time.

299 We have examined the preimplantation transcriptome of 112 kidney transplant r

300 The results demonstrate that the preimplantation uterus relies on Notch signaling to inhi