ライフサイエンスコーパス: preimplantation embryo

1 sis is common in the blastomere stage of the preimplantation embryo.

2 expressed by pluripotent cells in the human preimplantation embryo.

3 lucose transporter of the fertilized egg and preimplantation embryo.

4 in the gametes is recognized already in the preimplantation embryo.

5 hromosome status resembles that of the human preimplantation embryo.

6 on of endogenous retroelements active in the preimplantation embryo.

7 derm (PrE) fate that occurs in the mammalian preimplantation embryo.

8 a mouse model of transient DNMT1 loss in the preimplantation embryo.

9 anonical WNT signaling in development of the preimplantation embryo.

10 ys essential for the continued growth of the preimplantation embryo.

11 enerated from the inner cell mass of a human preimplantation embryo.

12 econd, to resist global demethylation in the preimplantation embryo.

13 s critical functions for spindle assembly in preimplantation embryos.

14 to treat human infertility entail culture of preimplantation embryos.

15 maternal Xist expression and maternal XCI in preimplantation embryos.

16 ) facilitative glucose transporter 49-66% in preimplantation embryos.

17 accumulates in oocyte nuclei and persists in preimplantation embryos.

18 y for gene transfer into murine ES cells and preimplantation embryos.

19 r by immunocytochemical staining in wildtype preimplantation embryos.

20 f in vitro fertilization (IVF)-derived human preimplantation embryos.

21 (ES) cells and a shorter form in oocytes and preimplantation embryos.

22 iated serine protease expressed by mammalian preimplantation embryos.

23 not detected by RT-PCR in either oocytes or preimplantation embryos.

24 tors influence cellular growth in very early preimplantation embryos.

25 ounds the growing oocytes, ovulated eggs and preimplantation embryos.

26 the first time, a knockdown screen in mouse preimplantation embryos.

27 ingle-cell RNA-sequencing of human and mouse preimplantation embryos.

28 preservation of human and animal oocytes and preimplantation embryos.

29 in naive pluripotent stem cells (PSCs) with preimplantation embryos.

30 be reset in primordial germ cells (PGCs) and preimplantation embryos.

31 pplementation on the transcriptome of bovine preimplantation embryos.

32 f the H3K27me3 decrease normally observed in preimplantation embryos.

33 ning the role of kinesin 5 in mouse eggs and preimplantation embryos.

34 essential role for CTCF in mouse oocytes and preimplantation embryos.

35 ne lipid rafts in mouse oocytes and cleaving preimplantation embryos.

36 at PI3K is constitutively activated in mouse preimplantation embryos.

37 th dividing and postmitotic cells, including preimplantation embryos.

38 peripheral organs including sperm, eggs, and preimplantation embryos.

39 r function of the PI3K/Akt pathway in murine preimplantation embryos.

40 ote the in vitro development of zygotes into preimplantation embryos.

41 ntial for successful oocyte development into preimplantation embryos.

42 unction of the PI3K/Akt pathway in mammalian preimplantation embryos.

43 uring the oocyte to embryo transition and in preimplantation embryos.

44 allele-specific CpG methylation 5' of H19 in preimplantation embryos, although this methylation is no

45 nd motor deficiencies that produce aneuploid preimplantation embryos, among other anomalies including

46 Pem is normally expressed in the preimplantation embryo and expressed in a lineage-restri

47 imprinted, which occurs in all cells of the preimplantation embryo and in the extraembryonic lineage

48 d with 5'-coding sequences from single human preimplantation embryos and a 10 week old whole foetus.

49 ow that AP-2gamma is present in all cells of preimplantation embryos and becomes restricted to the ex

50 BRG1 depletion in preimplantation embryos and Cdx2-inducible embryonic ste

51 and corresponding nascent RNA transcripts in preimplantation embryos and during spermatogenesis.

52 slands, were coordinately expressed in mouse preimplantation embryos and embryonic stem (ES) cells bu

53 Imprinted XCI, normally found in preimplantation embryos and extraembryonic tissues, was

54 fication phenotypes, similar to FGF4-treated preimplantation embryos and Fgf4 KO embryos, respectivel

55 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from i

56 ngle-cell DNA methylome sequencing for human preimplantation embryos and found that tens of thousands

57 prepare amplified cDNA from human individual preimplantation embryos and isolate embryo-specific sequ

58 HDAC1 is likely a major deacetylase in preimplantation embryos and its expression inversely cor

59 adotropins, and produced a reduced number of preimplantation embryos and less progeny than controls.

60 mammalian genomes can be global, as seen in preimplantation embryos and primordial germ cells (PGCs)

61 enhances both the developmental potential of preimplantation embryos and the live birth rate, it migh

62 ses similar changes in downstream targets in preimplantation embryos and trophoblast stem cells.

63 that Dnmt1 protein is also expressed in the preimplantation embryo, and may account for maintenance

64 gly, these genes are paternally expressed in preimplantation embryos, and ectopic removal of H3K27me3

65 expressed in primordial germ cells, oocytes, preimplantation embryos, and pluripotent cells.

66 ression of repetitive parasitic sequences in preimplantation embryos, and thereby contributes to pres

67 Mouse oocytes and preimplantation embryos apparently lack this response, a

68 DNA methylation patterns in the preimplantation embryo are dependent on the oocyte-speci

69 Preimplantation embryos are formed, yet abnormalities in

70 hat are accessible to viral DNA insertion in preimplantation embryos are incompatible with expression

71 ed methylation to maintain in the zygote and preimplantation embryo at a time when much of the remain

72 Infection of murine preimplantation embryos at morula stage with lentiviral

73 pplication of CGH to single cells from human preimplantation embryos (blastomeres) and to single fibr

74 Each protein persists in cells of the preimplantation embryo, but the continuous cell-cell con

75 rs in mouse primordial germ cells (PGCs) and preimplantation embryos, but the precise dynamics and bi

76 inally, we show that chromatin compaction in preimplantation embryos can partially proceed in the abs

77 that appeared to match only ovary, egg, and preimplantation embryo cDNAs.

78 Preimplantation embryos collected from dams after 0-4.25

79 A decrease of the cleavage rate in 4n preimplantation embryos compared to diploid (2n) embryos

80 ced in ES cell lines isolated from 3-day-old preimplantation embryos, consistent with the hypothesis

81 Here, we show that mouse preimplantation embryos contain endogenous betaine; Bhmt

82 Mammalian preimplantation embryos develop in the oviduct as indivi

83 In conclusion, TSPO was found necessary for preimplantation embryo development and ACTH-stimulated s

84 ocannabinoid signaling is critical to normal preimplantation embryo development and migration of trop

85 Synchronized preimplantation embryo development and passage through t

86 We show in this study that preimplantation embryo development became asynchronous i

87 Human preimplantation embryo development involves complex cell

88 cate that HPAT2, HPAT3 and HPAT5 function in preimplantation embryo development to modulate the acqui

89 epletion of maternal stores of Filia impairs preimplantation embryo development with a high incidence

90 elta9-tetrahydrocannabinol] levels constrain preimplantation embryo development with aberrant express

91 The Ped (preimplantation embryo development) gene, whose product

92 idence of an association between the rate of preimplantation embryo development, postnatal growth and

93 males have fertility defects owing to failed preimplantation embryo development.

94 wever, it reduced the competence to complete preimplantation embryo development.

95 signaling is required for fertilization and preimplantation embryo development.

96 fects in several pregnancy events, including preimplantation embryo development.

97 ived mRNAs during mammalian oocyte and early preimplantation embryo development.

98 -cell through the blastocyst stage of murine preimplantation embryo development.

99 These cells, when reintroduced into preimplantation embryos, differentiated into derivatives

100 In some developmental contexts (e.g., preimplantation embryos) DNA is hypomethylated but repet

101 Human preimplantation embryos exhibit high levels of apoptotic

102 ation and oxidative stress were increased in preimplantation embryos, fetuses, and newborns of Wester

103 ylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of ce

104 The preimplantation embryo floats freely within the oviduct

105 of single cells biopsied from human eggs and preimplantation embryos following in vitro fertilization

106 f DNase I-hypersensitive site (DHS) of mouse preimplantation embryos from 1-cell to morula stage.

107 High quality preimplantation embryos from individual cows were pooled

108 Transfer of preimplantation embryos from mutant Hmx3 uterine horns t

109 ssion of the human homologue, XIST, in human preimplantation embryos from the 5- to 10-cell stage onw

110 how that Kcnq1ot1 is paternally expressed in preimplantation embryos from the two-cell stage, and tha

111 transfer into rhesus monkey (Macaca mulatta) preimplantation embryos gives rise to transgenic placent

112 The mouse preimplantation embryo has been used to investigate the

113 severe disturbance in the development of the preimplantation embryo in a majority of pregnancies, as

114 t (i) protocols optimized in humans generate preimplantation embryos in nonhuman primates; (ii) some,

115 o developmental periods-in germ cells and in preimplantation embryos-in which methylation patterns ar

116 analysed global remethylation from the mouse preimplantation embryo into the early epiblast and extra

117 iologic importance of this pathway in murine preimplantation embryos is beginning to emerge.

118 Optimal development of fertilized eggs into preimplantation embryos is essential for reproduction.

119 Mouse oocytes and preimplantation embryos lack Dnmt1 but express a variant

120 We further demonstrate L1 RNA in preimplantation embryos lacking the L1 transgene and L1

121 ely linked to the Om locus that controls the preimplantation embryo-lethal phenotype known as the "DD

122 is not associated with the majority of human preimplantation embryo loss.

123 and support the notion that discarded human preimplantation embryos may be useful recipients for the

124 In preimplantation embryos, Nanog is restricted to founder

125 Two populations of preimplantation embryos obtained from GT1AS x GT1AS hete

126 In conclusion, the preimplantation embryo possesses a functional WNT signal

127 Pluripotent stem cells derived from preimplantation embryos, primordial germ cells or terato

128 us and the coordinate expression of CR-1a by preimplantation embryos regulates blastocyst differentia

129 ablation of the geminin gene (Gmnn) in mouse preimplantation embryos resulted in apoptosis, suggestin

130 liMAB-seq analysis of preimplantation embryos reveals the oxidation of 5mC to

131 ments of non-DMD, but not DMD methylation in preimplantation embryos suggest that the preimplantation

132 factor in determining methylation status in preimplantation embryos, suggesting a need to reassess m

133 Transcripts encoding Dnmt1 are present in preimplantation embryos, suggesting that Dnmt1 protein i

134 e critical importance of the PI3K pathway in preimplantation embryo survival and pregnancy outcome an

135 obtained from animal model systems and human preimplantation embryos that provide the scientific basi

136 unostaining of mitotic chromosome spreads of preimplantation embryos that the 5hmC associated with th

137 ethod that facilitates chromatin analysis of preimplantation embryos, that H3K9me3 is enriched at the

138 are known to happen during X inactivation in preimplantation embryos, the accumulation of macroH2A1 a

139 does not adversely affect the development of preimplantation embryos to blastocysts and uterine prepa

140 plex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulate

141 ughout early embryo development from zygote, preimplantation embryos, to post-implantation embryos.

142 ovide the first global analysis of the human preimplantation embryo transcriptome, and demonstrate th

143 Primordial germ cells (PGCs) and preimplantation embryos undergo epigenetic reprogramming

144 perm protection but also indirect effects on preimplantation embryos via oviduct expression of embryo

145 ontribute to the regulation of cavitation in preimplantation embryos via target proteins including Na

146 GRK2 deletion in the preimplantation embryo with EIIa-Cre (germline null) res

147 essential cytoplasmic complex in oocytes and preimplantation embryos with poorly understood function,

148 of the heterozygous MYBPC3 mutation in human preimplantation embryos with precise CRISPR-Cas9-based t

149 pression changes in the germ line and in the preimplantation embryo would greatly enhance the underst