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1 irements for retrograde transport of the MLV preintegration complex.
2 f the karyophilic MA into the viral core and preintegration complex.
3 involved in the nuclear translocation of the preintegration complex.
4 infected cells as part of the nucleoprotein/preintegration complex.
5 y gain access to viral proteins of the HIV-1 preintegration complex.
6 n gain access to viral proteins of the HIV-1 preintegration complex.
7 y, and shares properties associated with the preintegration complex.
8 ient to account for its association with the preintegration complex.
9 ransient intermediate within the cytoplasmic preintegration complex.
10 process of nuclear translocation of the HIV preintegration complex.
11 ing infectivity for nuclear targeting of the preintegration complex.
12 plays a role in nuclear import of the viral preintegration complex.
13 ecessary for efficient nuclear import of the preintegration complex.
14 estigate the nuclear import of the HIV-2/SIV preintegration complex.
15 of Vpx in nuclear translocation of the viral preintegration complex.
16 intasome to distinguish it from the greater preintegration complex.
17 ive intasome structure detected in wild-type preintegration complexes.
18 rganization of Moloney murine leukemia virus preintegration complexes.
19 tegrase and the viral DNA ends in functional preintegration complexes.
20 for such inhibitors in assays using isolated preintegration complexes.
21 diated blockade of productive infection from preintegration complexes.
22 ed in the nuclear localization of retroviral preintegration complexes.
23 icate that HMG I(Y) is associated with MoMLV preintegration complexes.
24 human immunodeficiency virus type I (HIV-I) preintegration complexes.
25 grase (IN) is the catalytic component of the preintegration complex, a large nucleoprotein assembly c
26 etroviral DNA integration is mediated by the preintegration complex, a large nucleoprotein complex de
27 RK1 and -2 appear to phosphorylate the HIV-1 preintegration complex, a step necessary for nuclear tra
28 1 has been implicated in import of the viral preintegration complex across the nuclear pore complex (
29 ulted in a decrease in nuclear import of the preintegration complex and attenuated replication in mac
30 would facilitate nuclear import of the viral preintegration complex and transduction of quiescent cel
31 pecific antigen (Gag) is associated with the preintegration complex, and mutants of p12 (PM14) show d
33 tion and subcellular trafficking of subviral preintegration complexes are reported to vary among the
35 ssociation of BAF from retroviral DNA within preintegration complexes as monitored by functional assa
37 inhibits nuclear targeting of HIV-1-derived preintegration complexes by inactivating the nuclear loc
38 ested HeLa cells, indicating that the mutant preintegration complexes can enter the nuclei of both di
39 alization, participation in transport of the preintegration complex, cation channel activity, oligome
40 itate the study of the roles of IN and other preintegration complex components in preintegration phas
41 r DCTN2/p50/dynamitin interacts with the MLV preintegration complex early in infection, suggesting a
44 of sufficient quantities of the cytoplasmic preintegration complexes for biochemical and biophysical
45 , which is equivalent to isolated retrovirus preintegration complexes for full-site integration activ
46 -1) replication is the movement of the viral preintegration complex from the cytoplasm into the nucle
48 Vpr regulates nuclear transport of the viral preintegration complex, G(2) cell cycle arrest, and tran
49 ocess by which the avian sarcoma virus (ASV) preintegration complex gains access to target chromatin
51 mbrane, envelope incorporation into virions, preintegration complex import into the nucleus, and nucl
52 port cargoes, the driving force behind HIV-1 preintegration complex import is likely a gradient of th
53 rticipates in nuclear targeting of the viral preintegration complex in nondividing cells and induces
54 py allow three-dimensional analysis of HIV-1 preintegration complexes in the nuclei of infected cells
56 tations demonstrate that in vivo, within the preintegration complex, IN performs a central role in co
58 peat, participation in the nuclear import of preintegration complexes, induction of G2 arrest, and in
60 rmitting the translocation of the retroviral preintegration complex into the nucleus and enabling int
61 ription, DNA synthesis, and translocation of preintegration complex into the nucleus in cord and adul
63 A model in which TRN-SR2 imports the viral preintegration complex into the nucleus is supported by
67 cells such as macrophages because the viral preintegration complex is able to actively traverse the
68 and GLFG Nups and that nuclear entry of the preintegration complex is further promoted by nuclear lo
69 that the impairment of nuclear transport of preintegration complexes is responsible for the restrict
70 lex in retrovirus-infected cells, termed the preintegration complex, is responsible for the concerted
71 us to analyze the structure and function of preintegration complexes isolated from cells infected wi
72 Previous transposon-mediated footprinting of preintegration complexes isolated from infected cells re
73 outhern blotting of S1 nuclease-digested FIV preintegration complexes isolated from infected cells, w
74 tions between a gypsy provirus and the gypsy preintegration complex may also participate in the proce
75 NA flap does not play a major role in either preintegration complex nuclear import or HIV-1 replicati
77 These ruptures are sufficient to enable the preintegration complexes of invading virions to enter th
78 reverse transcription, nuclear import of the preintegration complex, or viral DNA integration, sugges
79 ne breakdown during cell division, the HIV-1 preintegration complex (PIC) enters the nucleus by trave
81 human immunodeficiency virus type 1 (HIV-1) preintegration complex (PIC) is essential for the produc
83 reverse transcription is a component of the preintegration complex (PIC) that also contains the vira
84 ion, the retroviral genome is contained in a preintegration complex (PIC) that mediates its integrati
85 LV) p12, encoded within Gag, binds the viral preintegration complex (PIC) to the mitotic chromatin.
86 gate the role of Vpr in docking of the HIV-1 preintegration complex (PIC) to the nuclear pore complex
88 rse transcription complex and later with the preintegration complex (PIC), allowing it to reach and e
89 kemia virus (MLV) Gag is associated with the preintegration complex (PIC), and mutants of p12 (PM14)
97 ion, it is possible to lyse cells and obtain preintegration complexes (PICs) capable of integrating t
98 etroviral integration in vivo is mediated by preintegration complexes (PICs) derived from infectious
99 r of viral factors that are present in HIV-1 preintegration complexes (PICs) have been assigned funct
103 arly reduced the efficiency with which HIV-1 preintegration complexes (PICs) integrated into a target
104 are actively dividing, and nuclear import of preintegration complexes (PICs) is not required for infe
105 A nonspecifically and is a host component of preintegration complexes (PICs) isolated from cells infe
106 rted that HMG I(Y) cofractionates with HIV-1 preintegration complexes (PICs) isolated from freshly in
107 vitro on purified integrase and on subviral preintegration complexes (PICs) isolated from lymphoid c
109 ave established an assay for the function of preintegration complexes (PICs) of human immunodeficienc
112 and U5 ends of viral cDNA or by using viral preintegration complexes (PICs) that form during virus i
113 t factors to facilitate the passage of their preintegration complexes (PICs) through nuclear pore com
114 growth factor (LEDGF/p75) tethers lentiviral preintegration complexes (PICs) to chromatin and is esse
115 Retroviral integration is mediated by viral preintegration complexes (PICs), and human immunodeficie
116 human immunodeficiency virus type 1 (HIV-1) preintegration complexes (PICs), the large nucleoprotein
118 ll cycle arrest, apoptosis, translocation of preintegration complex, potentiation of glucocorticoid a
119 ns in mitotic nuclear reassembly, retroviral preintegration complex stability, and transcriptional re
120 s with the ability to mature into functional preintegration complexes that can proceed to provirus es
122 rocess of nuclear translocation of the viral preintegration complex, thus facilitating HIV-1 replicat
123 and LEDGF/p75 in the targeting of the viral preintegration complex to gene-dense regions of chromati
125 gnal that promotes localization of the viral preintegration complex to the nucleus of non-dividing ce
128 g that binds HIV-1 capsid and connects HIV-1 preintegration complexes to intranuclear trafficking pat
129 ey molecular interactions that specify HIV-1 preintegration complex trafficking to active chromatin.
130 Cell fractionation showed that the viral preintegration complex was present in a form that could
131 reverse transcription and nuclear import of preintegration complexes, we found that memory, but not
133 rase-binding domain interacts with the viral preintegration complex, whereas the N-terminal PWWP doma
134 chromosome, can suffice to connect the HIV-1 preintegration complex with the cell nuclear import mach
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