ライフサイエンスコーパス: preinvasive

1 lung, 29 normal bronchial epithelium, and 20 preinvasive and 36 invasive lung tumor tissue samples fr

2 accumulate, the clinical characteristics of preinvasive and early invasive glandular cervical neopla

3 athway as a potential therapeutic target for preinvasive and invasive breast carcinoma treatment.

4 ia, NKX3.1 expression levels were similar in preinvasive and invasive cancer cells and significantly

5 st of genes differentially expressed between preinvasive and invasive cells.

6 Further studies of gene expression in preinvasive and invasive cervical cancers should assist

7 entive and therapeutic roles of retinoids in preinvasive and invasive cervical neoplasia.

8 luding human papillomavirus (HPV)-associated preinvasive and invasive genital squamous lesions.

9 ogression genes using gene array analysis of preinvasive and invasive tumors from mice, which were th

10 and their accompanying normal epithelium and preinvasive and metastatic lesions.

11 Abnormal mucosal cells surrounding preinvasive and microinvasive lesions shared common gene

12 sion in invasive human cancers compared with preinvasive and normal samples.

13 pattern of TN isoform expression in benign, preinvasive, and invasive breast lesions using reverse t

14 l predictive accuracy of over 90% of normal, preinvasive, and invasive lung tissues.

15 to classify this independent set of normal, preinvasive, and invasive lung tissues.

16 ene expression profiles of the premalignant, preinvasive, and invasive stages of human breast cancer.

17 Preinvasive breast cancer accounts for approximately one

18 tromal and myoepithelial microenvironment of preinvasive breast cancer actively participates in the t

19 reast tissue, and they strongly suggest that preinvasive breast cancer develops and evolves along two

20 ma, 1 astrocytoma, 1 low-grade glioma, and 2 preinvasive breast cancers [ductal carcinoma in situ]);

21 w tool for dissection of mechanisms by which preinvasive breast cells could acquire invasiveness in a

22 d alveolar tissue with normal histology from preinvasive bronchial lesions and from invasive lung can

23 There was a lower detection rate of preinvasive cancer in the 65-year-old and older patients

24 Genes that distinguish invasive from preinvasive cells were then hierarchically clustered wit

25 diagnosis and treatment of more problematic preinvasive cervical lesions.

26 severity of histopathological preneoplastic/preinvasive changes.

27 have recently exposed the high prevalence of preinvasive colorectal neoplasia in the adult U.S. popul

28 Early detection of preinvasive (curative cancers) is significantly less tha

29 HGF/c-Met signaling between fibroblasts and preinvasive DCIS cells enhances the transition to invasi

30 rop6(DN) plants exhibited enhanced preinvasive defense responses to a host-adapted virulent

31 t powdery mildew fungus but were impaired in preinvasive defenses upon inoculation with a nonadapted

32 ductal adenocarcinoma from the inception of preinvasive disease to invasive cancer.

33 The ability to screen and treat women for preinvasive disease, cervical dysplasia, is the key fact

34 continue screening efforts and treatment of preinvasive disease.

35 The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive

36 hown that myoepithelial cells in a subset of preinvasive ductal carcinoma in situ (DCIS) upregulate e

37 breast cancers and at higher frequencies in preinvasive ductal carcinoma in situ (DCIS).

38 the uterine cervix are thought to arise from preinvasive dysplastic lesions, termed cervical intraepi

39 However, LC risk in patients with preinvasive endobronchial lesions is unclear.

40 microdissected SV40 TAg-expressing cells in preinvasive foci and invasive tumors.

41 ental allele lost comparing 42 preneoplastic/preinvasive foci with those lost in the lung cancer in t

42 invasive PDAs and accelerates progression of preinvasive foci.

43 ation at the site of attack is essential for preinvasive immunity; in postinvasive immunity, the enca

44 We found PLK1 to be also highly expressed in preinvasive in situ carcinomas of the breast.

45 ek2 protein is significantly up-regulated in preinvasive in situ ductal carcinomas of the breast as w

46 ied six susceptibility loci that affect mean preinvasive lesion multiplicity.

47 LCs occur both at preinvasive lesion sites and elsewhere in the bronchial

48 allow the progression from a precancerous or preinvasive lesion to a malignant tumor.

49 The progression from preinvasive lesion to invasive carcinoma is a critical s

50 of 30 mo, range 4-152) of 164 subjects with preinvasive lesions (80 high grade and 84 low grade at i

51 even lesions of the head and neck, including preinvasive lesions and benign lesions associated with c

52 lung cancers, 70% of normal or preneoplastic/preinvasive lesions associated with lung cancer, and 49%

53 0% of all EL-Kras/Tgfbr1(+/-) mice developed preinvasive lesions compared with 100% of EL-Kras (wild-

54 mors because the molecular phenotypes of the preinvasive lesions differed at various sites.

55 47 normal, mildly abnormal, or preneoplastic/preinvasive lesions found in smokers without lung cancer

56 We found a significant increase in CN in preinvasive lesions graded severe dysplasia or higher.

57 1%) of the adenocarcinomas and preneoplastic/preinvasive lesions had smaller chromosome areas of 3p a

58 mas and the frequency of PIK3CA mutations in preinvasive lesions has not been explored.

59 n individual tumors; occurs in preneoplastic/preinvasive lesions in smokers with and without lung can

60 We asked whether we could classify preinvasive lesions of airway epithelium according to th

61 (c) address the interpretation of benign and preinvasive lesions of the mouse lung.

62 lleles of Nkx3.1 leads to the development of preinvasive lesions that resemble PIN.

63 rs can become lethal when they progress from preinvasive lesions to invasive carcinomas.

64 ell populations from prostate cancer and its preinvasive lesions using laser capture microdissection,

65 xpression levels in invasive lesions than in preinvasive lesions using samples obtained by laser capt

66 iary care referral center, 164 subjects with preinvasive lesions were monitored up to 12.5 years by r

67 In preinvasive lesions, amplification of the PIK3CA and ove

68 ic infiltration even around the lowest grade preinvasive lesions, but immunosuppressive cells, includ

69 creasing molecular characterisation of these preinvasive lesions, data will be available for how fact

70 Presence of preinvasive lesions, especially high-grade lesions, may

71 Effector T cells, however, were scarce in preinvasive lesions, found in only a subset of advanced

72 94% of human breast carcinomas and in 95% of preinvasive lesions, such as ductal and lobular carcinom

73 wth appear to occur after the development of preinvasive lesions, suggesting that these agents inhibi

74 lung cancers and in 78% of the preneoplastic/preinvasive lesions.

75 g cancer types (30 of 40; 75%) but not in 10 preinvasive lesions.

76 mutagenesis in both prostate cancer and its preinvasive lesions.

77 immunohistochemistry in 242 invasive and 43 preinvasive lung cancers and correlated our findings wit

78 hosphorylated Akt expression in invasive and preinvasive lung cancers.

79 ctal carcinoma in situ is considered to be a preinvasive malignant lesion.

80 No significant differences in the numbers of preinvasive mammary intraepithelial neoplasia lesions (h

81 t ERK1/2 can promote noninvasive motility in preinvasive mammary tumors.

82 llular localization changes from nuclear, in preinvasive melanomas (melanomas in situ), to nuclear an

83 d pressure transducer provides a convenient, preinvasive method to measure and study IOP in unrestrai

84 In this study a preinvasive method was developed for determining the cam

85 udies on 97 lung cancer and 54 preneoplastic/preinvasive microdissected respiratory epithelial sample

86 Among the neoplastic disorders, preinvasive, microinvasive, and poorly differentiated ne

87 ryngeal carcinoma (NPC) and all EBV-infected preinvasive nasopharyngeal lesions.

88 Preinvasive neoplasias of the mouse prostate were recogn

89 DNA methylation studies profiling epithelial preinvasive neoplasias.

90 a2 dysregulation and identify new markers of preinvasive neoplastic change during progression to SCC.

91 ressor genes (TSGs) in sporadic invasive and preinvasive non-small-cell lung cancer (NSCLC) genomes,

92 one of the screen-detected malignancies were preinvasive or subcentimeter node-negative breast cancer

93 eficiency in eNOS limited the development of preinvasive pancreatic lesions and trended toward an ext

94 c cancer cell lines, we investigated whether preinvasive pancreatic neoplasia contains a subpopulatio

95 t promotes the initiation and progression of preinvasive pancreatic neoplasia.

96 ult mice in two surviving lineages displayed preinvasive pancreatic neoplastic lesions with ductal mo

97 rophages from radiation treated invasive and preinvasive pancreatic tumors had an immune-suppressive,

98 ylation defects were present in superficial, preinvasive, papillary tumors.

99 losses of the p53 gene were mapped to early preinvasive phases of urothelial neoplasia.

100 allelic losses of chromosome 17 in the early preinvasive phases of urothelial neoplasia.

101 raepithelial neoplasia (HGPIN) is a putative preinvasive precursor of prostatic adenocarcinoma, the m

102 ade the surprising finding that PDAC and its preinvasive precursors, pancreatic intraepithelial neopl

103 ed in regions of inflammatory atrophy and in preinvasive prostate cancer.

104 l as detection of molecular abnormalities in preinvasive respiratory lesions, have recently come into

105 analyzed p63 CN and protein expression in 41 preinvasive squamous lesions.

106 Such a high frequency of LOH at a preinvasive stage of breast cancer suggests that a candi

107 ndostatin (Ad-mEndo) administered during the preinvasive stage of mammary tumor development in C3(1)/

108 HG-DCIS lesions, in spite of representing a preinvasive stage of tumor progression, displayed molecu

109 asia at a surgically curative and preferably preinvasive stage, i.e., dysplasia.

110 ny breast cancers to be detected at an early preinvasive stage.

111 iated disease rapidly progresses through the preinvasive stages of neoplasia.

112 r invasive growth are already present in the preinvasive stages.

113 mproved understanding of the transition from preinvasive to invasive breast cancer will pave the way

114 elial compartment during the transition from preinvasive to invasive disease, distinct molecular alte

115 actively participates in the transition from preinvasive to invasive disease.

116 tatively correlated with the transition from preinvasive to invasive growth.

117 culture models to study the transition from preinvasive to invasive phenotype as it may occur "spont

118 nally significant changes in transition from preinvasive to invasive phenotype, we performed attribut

119 hysterectomy as an exposure, and evidence of preinvasive vaginal disease or vaginal carcinoma outcome

120 we found that S100A7 is highly expressed in preinvasive, well-differentiated and early staged human