ライフサイエンスコーパス: prelimbic

1 xtensive striatal projection fields from the prelimbic and anterior cingulate areas, which partly ove

2 e midfrontal cortex in humans and within the prelimbic and anterior cingulate regions of the MFC in r

3 eactivity in all layers, particularly in the prelimbic and anterior cingulate subregions.

4 ist challenge, which was most significant in prelimbic and anterior cingulate subregions.

5 L) directly into the dorsomedial PFC (dorsal prelimbic and dorsal anterior cingulate cortex), the ven

6 Single neuron activity was recorded from the prelimbic and infralimbic areas of the medial prefrontal

7 Stereological analyses of the ventral mPFC (prelimbic and infralimbic areas) and the BLN were perfor

8 er V-VI pyramidal neurons in slices of mouse prelimbic and infralimbic cortex were studied.

9 These data indicate a role for mPFC (prelimbic and infralimbic cortex) in the formation of a

10 neuronal activity in homolog regions (i.e., prelimbic and infralimbic cortices) changes during fear

11 sus ventral aspects of mPFC, centered in the prelimbic and infralimbic fields, respectively, on acute

12 tion in response to the exposed music in the prelimbic and infralimbic medial prefrontal cortex only

13 , a GABA agonist, was used to inactivate the prelimbic and infralimbic mPFC subdivisions (400 ng in 2

14 number of Fos-ir(+) and Fos-ir(-) neurons in prelimbic and infralimbic mPFC.

15 sed expression of a plasticity marker in the prelimbic and infralimbic prefrontal cortices, the orbit

16 labelled neurons were exclusively located in prelimbic and infralimbic regions in layers V and VI, af

17 ters spontaneous single-unit activity in the prelimbic and infralimbic subdivisions of the mPFC in be

18 redominantly inhibitory and emanate from the prelimbic and/or dorsal anterior cingulate cortical fiel

19 on and reward processing, i.e., infralimbic, prelimbic, and anterior cingulate cortices, amygdala, an

20 n the medial prefrontal cortex (infralimbic, prelimbic, and cingulate cortex) and dorsolateral striat

21 ith dorsal (encompassing anterior cingulate, prelimbic, and infralimbic cortices) or ventral (encompa

22 ivisions of the mPFC, i.e., the infralimbic, prelimbic, anterior cingulate and medial agranular corti

23 We showed that (1) the infralimbic, prelimbic, anterior cingulate cortices distribute heavil

24 ial prefrontal cortex (mPFC) centered on the prelimbic area (Brodmann's area 32), at five different i

25 fast spiking interneurons (PV+ FSIs) in the prelimbic area (PrL) of the mPFC in mice.

26 a 25 and area 32pl, which corresponds to the prelimbic area 32 in Brodmann's monkey brain map, caudal

27 The prelimbic area and the rostral part of the anterior cing

28 In the medial prefrontal cortex, the prelimbic area is emerging as a major modulator of fear

29 Pyramidal neurons in the prelimbic area of medial prefrontal cortex were selected

30 of pyramidal neuron apical dendrites in the prelimbic area of the medial prefrontal cortex (mPFC).

31 Pyramidal neurons in the prelimbic area of the mPFC were selected for intracellul

32 r area of the prefrontal cortex (PFC) or the prelimbic area of the PFC.

33 visually-guided version was dependent on the prelimbic area.

34 ne inactivation of the agranular insular and prelimbic areas.

35 orhinal) and medial prefrontal (infralimbic, prelimbic) areas and the hippocampal formation.

36 These data indicate that prelimbic BDNF is critical for consolidation of learned

37 he medial prefrontal cortex (infralimbic and prelimbic) but not the anterior cingulate and M1 motor c

38 In this immunocytochemical study of rat prelimbic cortex (area 32), a gradient of CN immunolabel

39 mPFC lesions of prelimbic cortex (Brodmann's Area 32) retarded EB condit

40 bgenual anterior cingulate in the human), or prelimbic cortex (midventral anterior cingulate).

41 l hippocampal (VH) neurons projecting to the prelimbic cortex (PL) and basal amygdala (BA) after the

42 In rats, inactivation of the prelimbic cortex (PL) attenuates renewal.

43 Prelimbic cortex (PL) projections to nucleus accumbens c

44 statement of cocaine- and sucrose-seeking in prelimbic cortex (PL), infralimbic cortex (IL), BLA, and

45 muscimol to pharmacologically inactivate the prelimbic cortex (PL), infralimbic cortex (IL), ventral

46 ttenuation of inhibitory transmission in the prelimbic cortex (PL).

47 Although the prelimbic cortex (PL, part of medial prefrontal cortex)

48 strongly activated neuronal ensembles in rat prelimbic cortex (PLC) and assess altered intrinsic exci

49 DAT blockade induced pMeCP2 in the prelimbic cortex (PLC) and nucleus accumbens (NAc), wher

50 Fos-expressing layer V pyramidal neurons in prelimbic cortex (PLC) of FosGFP-transgenic rats, we fou

51 e observed as the oscillations in the dorsal prelimbic cortex (PrL) were smaller in magnitude than th

52 ocorticolimbic system: that is, the VTA, the prelimbic cortex (PrL), and infralimbic cortex of medial

53 HT receptors, in layer II/III neurons of the prelimbic cortex (PrL), as well as depression-like behav

54 ediate early genes (IEGs; e.g. c-fos) in the prelimbic cortex (PrL), basolateral amygdala complex (BL

55 and dopaminergic abnormalities in the adult prelimbic cortex (PrL-C).

56 naling in layer 5/6 pyramidal neurons of the prelimbic cortex (PrLC) and involved a D(1)/(5) dopamine

57 Theta and low-gamma synchrony in the prelimbic cortex (PrlC) is impaired in Disc1 mice and in

58 c-fos mRNA was injected into the infralimbic/prelimbic cortex 12 or 72 hr before the acquisition sess

59 cal field potential pattern generated in the prelimbic cortex and associated with goal-directed behav

60 cted to specific forebrain areas such as the prelimbic cortex and the accumbens nucleus.

61 ted drug seeking by depending on activity in prelimbic cortex and the basolateral amygdala.

62 sion group) or vehicle (sham group) into the prelimbic cortex and were later tested for acquisition,

63 naling in layer 5/6 pyramidal neurons of the prelimbic cortex appears to represent an early adaptatio

64 Our findings show that the prelimbic cortex can generate oscillatory patterns that

65 ons in S1, but normal infralimbic cortex and prelimbic cortex dendritic arborization.

66 on of a protein synthesis inhibitor into the prelimbic cortex did not affect any measure of acquisiti

67 isition, showing that during acquisition the prelimbic cortex does not mediate postsession consolidat

68 Our results show a marked reduction in prelimbic cortex excitability in compulsive cocaine-seek

69 Finally, inhibition of the prelimbic cortex immediately after unreinforced lever pr

70 l and central nuclei of the amygdala and the prelimbic cortex in both the Paired and Pavlovian groups

71 vestigating the potential involvement of the prelimbic cortex in instrumental acquisition, in which t

72 discussed in the context of the role of the prelimbic cortex in processing temporal information duri

73 However, inactivation of the prelimbic cortex increased responding, suggesting that t

74 pulsive cocaine seeking, whereas optogenetic prelimbic cortex inhibition significantly increased comp

75 The prelimbic cortex is implicated in goal-directed learning

76 This finding suggests that the prelimbic cortex is involved in the incentive motivation

77 To determine whether the prelimbic cortex is necessary for cocaine-reinstated CPP

78 10 mg/kg, i.p.) was attenuated in rats with prelimbic cortex lesions relative to sham controls.

79 ex increased responding, suggesting that the prelimbic cortex mediates a form of inhibitory response

80 Furthermore, compensating for hypoactive prelimbic cortex neurons with in vivo optogenetic prelim

81 he spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo

82 ) reported that single cells recorded in the prelimbic cortex of rats during the acquisition of trace

83 The potential role of the prelimbic cortex of the rat in the acquisition of instru

84 al application of guanfacine into either the prelimbic cortex or the ventral tegmental area did not p

85 xtran amine deposits centered in the ventral prelimbic cortex revealed that, during this period, the

86 e-seeking rats, and that in vivo optogenetic prelimbic cortex stimulation decreased compulsive drug-s

87 mbic cortex neurons with in vivo optogenetic prelimbic cortex stimulation significantly prevented com

88 ojections from anterior cingulate cortex and prelimbic cortex to infralimbic cortex may be important

89 ent of the glutamatergic projection from the prelimbic cortex to NAcore is necessary to initiate the

90 olved and suggests that ketamine acts at the prelimbic cortex to sensitize neurons that project to an

91 f the D1 receptor agonist SKF-38393 into the prelimbic cortex was found to modulate incongruent trial

92 sine hydroxylase in adjacent sections of the prelimbic cortex was localized to both varicosities and

93 However, DAT-labeled processes in the prelimbic cortex were almost exclusively intervaricose a

94 jections in the dorsal mPFC (centered in the prelimbic cortex) attenuated increments in restraint-ind

95 onist eticlopride into the NAcc (but not the prelimbic cortex) blocked the formation of a partner pre

96 t not the anterior cingulate cortex (ACC) or prelimbic cortex), reduced IL single-unit firing and bur

97 lpha and BDNF in the hypothalamus, amygdala, prelimbic cortex, and ventral hippocampus.

98 In some sites, e.g., prelimbic cortex, anterior cingulate cortex, and seconda

99 rimary motor cortex, orbital frontal cortex, prelimbic cortex, dorsal lateral striatum, medial dorsal

100 fusions of NaB into the infralimbic, but not prelimbic cortex, induced extinction enhancements.

101 x, but had no effect on the dorsal striatum, prelimbic cortex, or ventral pallidum.

102 g correlates with dendritic spine density in prelimbic cortex, suggesting that new action-outcome lea

103 ly assumed that infralimbic cortex (ILC) and prelimbic cortex, two adjacent areas of the medial prefr

104 ic brain areas (nucleus accumbens, amygdala, prelimbic cortex, ventral hippocampus, and ventral tegme

105 of GABAergic chandelier cells (ChCs) in the prelimbic cortex, which innervate PCs at spike initiatio

106 ility of deep-layer pyramidal neurons in the prelimbic cortex, which was significantly more pronounce

107 Cs as opposed to BLAPCs and BLA neurons (the prelimbic cortex-BLA network).

108 No similar effect was seen in the prelimbic cortex.

109 nce following infusion of SKF-38393 into the prelimbic cortex.

110 oss in layer II/III pyramidal neurons of rat prelimbic cortex.

111 utamatergic afferents to the NAcore from the prelimbic cortex.

112 ation and its potential interaction with the prelimbic cortex.

113 s, whereas c-fos expression was decreased in prelimbic cortex.

114 ociated increase in dopamine turnover in the prelimbic cortex.

115 re and shell, anterior cingulate cortex, and prelimbic cortex.

116 ction of candles was observed in the ventral prelimbic cortex.

117 areas we explored, including prefrontal and prelimbic cortex.

118 uted only sparsely to the deep layers of the prelimbic cortex.

119 or inhibition of CB1 transmission within the prelimbic cortical (PLC) division of the mPFC bidirectio

120 ses (EPSPs/EPSCs) elicited by stimulation of prelimbic cortical afferents.

121 Fasudil transiently reduces prelimbic cortical dendritic spine densities during a pe

122 on selection by augmenting the plasticity of prelimbic cortical dendritic spines during the formation

123 suggest that CN is differentially present in prelimbic cortical neurones--this may reflect possible d

124 neocortical knockout mouse, virally mediated prelimbic cortical-specific gene deletion, and pharmacol

125 rised of two subregions: the infralimbic and prelimbic cortices (ilPFC and plPFC).

126 t, lesions restricted to the infralimbic and prelimbic cortices have no effect on CAL but impair perf

127 ing the anterior cingulate, infralimbic, and prelimbic cortices impair CAL because of increased inter

128 cortex, including the anterior cingulate and prelimbic cortices, and the temporal cortex show robust

129 al cortex, which consists of infralimbic and prelimbic cortices, blocks recall of fear extinction, in

130 ry nuclear groups, including the insular and prelimbic cortices, paraventricular hypothalamic nucleus

131 ex projected to the dysgranular anterior and prelimbic cortices.

132 These include the infralimbic, prelimbic, dorsal agranular insular, and entorhinal cort

133 In contrast, prelimbic inactivation caused an apparent improvement in

134 sults contrast with findings indicating that prelimbic inactivation impairs behavioral flexibility du

135 gic pyramidal neurons of layer V/VI frontal (prelimbic, infralimbic) cortex (FC).

136 rat OFC (lateral and medial) and medial PFC (prelimbic, infralimbic, and anterior cingulate) on proba

137 f rat medial frontal cortex (MFC) (including prelimbic, infralimbic, and cingulate cortices) in effor

138 " pathway provides disynaptic input from the prelimbic, infralimbic, and orbital cortex to the ventra

139 urth, the BSTju provides light inputs to the prelimbic, infralimbic, and ventral CA1 cortical areas;

140 ial and ventral orbital, anterior cingulate, prelimbic, infralimbic, insular, perirhinal, and entorhi

141 This includes prelimbic, infralimbic, medial, ventrolateral and latera

142 Overall, these results suggest that the prelimbic-infralimbic areas are important for behavioral

143 These findings suggest that the prelimbic-infralimbic areas are involved in switching to

144 Infusions of 2% tetracaine into the prelimbic-infralimbic areas did not impair acquisition o

145 ved in the odor-place tests suggest that the prelimbic-infralimbic areas enable behavioral flexibilit

146 ent experiments investigated the role of the prelimbic-infralimbic areas in behavioral flexibility us

147 To investigate the role of the prelimbic-infralimbic areas in intramodal shifts (revers

148 To examine the role of the prelimbic-infralimbic areas in shifting strategies, rats

149 t study examined whether inactivation of the prelimbic-infralimbic areas or the dorsal anterior cingu

150 However, inactivation of the prelimbic-infralimbic areas, but not the dorsal anterior

151 ved a bilateral cannula implant aimed at the prelimbic-infralimbic areas.

152 Prelimbic-infralimbic cortex (PL-IL) and orbitofrontal c

153 regions [anterior cingulate cortex (ACC) and prelimbic-infralimbic cortex (PL-IL)] play in such decis

154 lesions of the dorsal anterior cingulate and prelimbic-infralimbic cortices on spatial working memory

155 These findings suggest that the prelimbic-infralimbic cortices, but not the anterior cin

156 Prelimbic-infralimbic inactivation did impair learning w

157 Prelimbic-infralimbic inactivation did not impair acquis

158 Prelimbic-infralimbic inactivation did not impair place

159 The experiments examined the effects of prelimbic-infralimbic inactivation in rats on the acquis

160 Prelimbic-infralimbic lesions impaired spatial working m

161 Infusions of 2% tetracaine into the prelimbic-infralimbic or dorsal anterior cingulate areas

162 mplantation of a cannula aimed at either the prelimbic-infralimbic or dorsal anterior cingulate areas

163 originated from stimulation sites in ventral prelimbic/infralimbic cortex, and were significantly mor

164 memory in rats with bilateral mPFC lesions (prelimbic/infralimbic regions; ibotenic acid) using a va

165 was associated with greater hippocampal and prelimbic inputs.

166 dendritic arborization and spine density of prelimbic layer III neurons in prenatally stressed and c

167 In adults, the prelimbic medial prefrontal cortex (mPFC) appears to be

168 Persistent IG occurs in rat prelimbic medial prefrontal cortex (mPFC), a crucial sit

169 The prelimbic medial prefrontal cortex (PL-mPFC) and basolat

170 of abuse cause dendritic spine plasticity in prelimbic medial prefrontal cortex (PL-mPFC) pyramidal n

171 Methylphenidate administration into the prelimbic, medial/ventral orbitofrontal, and ventrolater

172 ic synapses within both infralimbic (IL) and prelimbic mPFC (PrL) to NAc projections, measured after

173 d local field potentials (LFP) directly from prelimbic mPFC and examined the influence of tone-shock

174 venile rats infused with picrotoxin into the prelimbic mPFC and exposed to a threatening stimulus fro

175 ed and allowed a small meal, c-Fos counts in prelimbic mPFC and NAcc core were positively correlated,

176 In juveniles, the prelimbic mPFC became responsive in processing aversive

177 function localized to the anterior cingulate/prelimbic mPFC or dorsal CA3 hippocampus differentially

178 induced plasticity is impaired by removal of prelimbic mPFC PNNs and that PNNs may be a therapeutic t

179 Pre rats showed increased Egr-1 mRNA in the prelimbic mPFC relative to Alt-Pre rats.

180 lly, during adolescence, inactivation of the prelimbic mPFC significantly attenuated freezing and dec

181 levated numbers of Fos-positive cells in the prelimbic mPFC, the medial amygdala, and ventral PAG.

182 site was true of animals 36 h deprived, with prelimbic mPFC/NAcc core and infralimbic mPFC/NAcc shell

183 between mean c-Fos counts were found, though prelimbic mPFC/NAcc core and mPFC/NAcc shell were positi

184 short hairpin RNA targeting the GR into the prelimbic (n = 44) or infralimbic (n = 52) cortices.

185 A subset of prelimbic neurons exhibited sustained increases in activ

186 Prelimbic neurons showed learning-related increases in a

187 discrete lesions of the infralimbic but not prelimbic or cingulate cortex made before but not after

188 croinjected into the anterior cingulate, and prelimbic or infralimbic cortices before cocaine reinsta

189 red impulsive behavior when infused into the prelimbic or infralimbic cortices.

190 to show significant neural activation in the prelimbic or infralimbic mPFC during the heroin-seeking

191 tal area into ventral striatum, infralimbic, prelimbic, orbitofrontal and anterior cingulate cortex.

192 tal-ventral striatal areas, and infralimbic, prelimbic, orbitofrontal, cingulate, entorhinal and insu

193 ilver labeling for SERT (SERT-ir) in the rat prelimbic PFC and to describe its ultrastructural spatia

194 Knockdown of GR in the neighboring prelimbic PFC increased hypothalamic-pituitary-adrenocor

195 e extracellular diffusion of dopamine in the prelimbic PFC may result, at least in part, from a pauci

196 populations of SERT profiles within the rat prelimbic PFC that may arise from different raphe nuclei

197 ween presumed NE and DA axons within the rat prelimbic PFC, we combined immunogold-silver localizatio

198 ed on increased neuronal activity within the prelimbic PFC, which is considered the rodent functional

199 bserved after apamin microinfusions into the prelimbic PFC.

200 neous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recognit

201 Prelimbic (PL) and infralimbic (IL) neuronal activity ch

202 ced adaptations in intrinsic excitability of prelimbic (PL) and infralimbic (IL) pyramidal neurons; a

203 is heterogeneity in the contributions of the prelimbic (PL) and infralimbic (IL) regions of the media

204 The prelimbic (PL) and infralimbic (IL) regions of the rat p

205 ormed tetrode recordings simultaneously from prelimbic (PL) and rostral (rACC) and caudal (cACC) ante

206 irect projections from dorsal hippocampus to prelimbic (PL) cortex and activation of critical PL mole

207 ampus (vHPC) inputs to fear signaling in the prelimbic (PL) cortex, a PFC region critical for the exp

208 ly, the ventral tegmental area (VTA) and the prelimbic (PL) cortex.

209 f pyramidal cell apical dendrites in the rat prelimbic (PL) cortex.

210 med by projections from infralimbic (IL) and prelimbic (PL) cortices.

211 In rodents, the dorsal/prelimbic (PL) medial PFC (mPFC) is frequently considere

212 asolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implic

213 Plasticity in the prelimbic (PL) medial prefrontal cortex is critical to t

214 ntaining a working memory buffer, neurons in prelimbic (PL) mPFC may selectively contribute to learni

215 input from the ventral hippocampus (VH) and prelimbic (PL) prefrontal cortex and may integrate VH an

216 on and stimulation studies suggests that the prelimbic (PL) prefrontal cortex is necessary for expres

217 reduced the excitability of regular spiking prelimbic (PL) projection neurons, through a learning-re

218 By contrast, the neighboring prelimbic (PL) pyramidal neurons, which normally inhibit

219 Inactivation of the prelimbic (PL) region of the medial prefrontal cortex by

220 Microinjection of ketamine into the prelimbic (PL) region of the medial prefrontal cortex du

221 yramidal neurons in the infralimbic (IL) and prelimbic (PL) regions of the mPFC in mice.

222 ll mPFC subregions, anterior cingulate (AC), prelimbic (PL), and infralimbic (IL) but enhanced CRF-in

223 cute stress, notably from medial prefrontal [prelimbic (PL)] and hippocampal [ventral subiculum (vSUB

224 The areas studied were the prelimbic (PL, area 32) and infralimbic (IL, area 25) co

225 dividual layers of infralimbic (IL; area 25) prelimbic (PL; area 32), and dorsal anterior cingulate (

226 or infusions of memantine directly into the prelimbic (PLmPFC) or infralimbic medial PFC (ILmPFC).

227 itioned locomotion and Fos activation in the prelimbic portion of prefrontal cortex and the nucleus a

228 SST-IRES-Cre mice were injected in FC (prelimbic/precingulate) with CRE-dependent adeno-associa

229 sociative memories, neuron firing in the rat prelimbic prefrontal cortex (mPFC) became less selective

230 nstatement are glutamatergic inputs from the prelimbic prefrontal cortex (PL) and dopamine from the v

231 The prelimbic prefrontal cortex (PL) has consistently been f

232 The prelimbic prefrontal cortex (PL) is a brain region integ

233 tinct layers and neuronal populations of the prelimbic prefrontal cortex (PL).

234 5-min pretreatment) acts directly within the prelimbic prefrontal cortex (PrL-PFC) to potentiate rein

235 The rat prelimbic prefrontal cortex and nucleus accumbens core a

236 This included connectivity between the prelimbic prefrontal cortex and other areas of the front

237 The prelimbic prefrontal cortex is necessary for associating

238 h and decreased complexity of neurons in the prelimbic prefrontal cortex, a brain region important in

239 mmunoreactivity in axon terminals within the prelimbic prefrontal cortex, consistent with postulates

240 s, secondary motor cortex, gustatory cortex, prelimbic prefrontal cortex, orbital cortex, and the ant

241 amygdala, dorsal hippocampus, infralimbic or prelimbic prefrontal cortex.

242 structures, specifically the infralimbic and prelimbic prefrontal cortices, is required for compensat

243 actor DeltaFosB in mPFC, specifically in the prelimbic (PrL) area, mediates susceptibility to stress.

244 The prelimbic (PrL) cortex constitutes one of the highest le

245 Dysregulation of the pathway from the prelimbic (PrL) cortex to the nucleus accumbens is impli

246 tex, but had no effect when infused into the prelimbic (PrL) cortex.

247 Oscillations were elicited in the prelimbic (PrL), infralimbic (IL) and the dorsopeduncula

248 C sub-regions have been proposed to promote (prelimbic, PRL) or inhibit (infralimbic, IL) these behav

249 esions were made in the mPFC centered on the prelimbic region (Brodmann's area 32) or the cingulate c

250 The prelimbic region (PL) of the medial prefrontal cortex (m

251 of the orbital prefrontal cortex (PFo), the prelimbic region of the medial prefrontal cortex (PL), a

252 p-regulation of immediate early genes in the prelimbic region of the medial prefrontal cortex, and th

253 ound that removal of PNNs primarily from the prelimbic region of the mPFC of adult, male, Sprague Daw

254 upon principal neurons within layer V of the prelimbic region of the mPFC.

255 the outflow of the principal neurons of the prelimbic region to contribute to termination of the str

256 ase onto principal neurons in layer V of the prelimbic region, when examined 1 h later, which was pre

257 in 0.5 mul/side) in infralimbic (IL) versus prelimbic regions of rat mPFC, in appetitive trace and l

258 Here we find that the infralimbic and prelimbic regions of the ventral medial prefrontal corte

259 of areas 4 and 6) as well as prefrontal and prelimbic regions.

260 These sustained prelimbic responses may provide a bridging code that all

261 onal ensemble in the infralimbic but not the prelimbic subregion induced excessive alcohol seeking.

262 Previous research suggests that the prelimbic subregion of the medial prefrontal cortex (mPF

263 0 microinfused into the infralimbic, but not prelimbic, subregion of the mPFC-reduced binge-like eati