ライフサイエンスコーパス: premalignant

1 epatocytes, not just hepatocytes that appear premalignant.

2 The tumor was benign (52%), premalignant (18%), or malignant (30%).

3 ctice, conjunctival tumors are benign (52%), premalignant (18%), or malignant (30%).

4 y UV radiation and to reduce the rate of new premalignant actinic keratoses.

5 here was a reduction in PTEN levels in human premalignant actinic keratosis and malignant SCCs, suppo

6 rge carcinomas in all AhR-/- mice but mostly premalignant adenomas in less than half of AhR+/+ mice.

7 doscopic surveillance is essential to remove premalignant adenomas.

8 as it localized in the cytoplasm in prostate premalignant and cancer tissues.

9 e increasingly been used in the treatment of premalignant and early oesophageal tumours.

10 Plasma cells from premalignant and early stages of myeloma were characteri

11 The most consistent dietary risk factor for premalignant and invasive breast cancer is alcohol, whet

12 ependent apoptosis pathways, which eliminate premalignant and malignant cells and thus delay overt tu

13 and carcinogenesis have been investigated in premalignant and malignant JB6 mouse epidermal cells sti

14 Premalignant and malignant lesions from the gastric muco

15 lerated the development of H. pylori-induced premalignant and malignant lesions in a cagA-dependent m

16 ace, thereby facilitating the development of premalignant and malignant lesions in the stomach.

17 idenced by increased levels of expression in premalignant and malignant lesions of the pancreas.

18 replication stress, and induced formation of premalignant and malignant lesions.

19 diagnostic methods cannot robustly identify premalignant and malignant pancreatic cystic lesions.

20 ude in studies to further define the risk of premalignant and malignant pancreatic neoplasms and pote

21 In sun-associated premalignant and malignant skin neoplasia, E-cadherin is

22 was discovered in approximately one-third of premalignant and malignant skin tumors.

23 etic resonance imaging (MRI), the anatomy of premalignant and malignant stages of cervical carcinogen

24 g qualitative epigenetic differences between premalignant and malignant stages.

25 e, and could prove useful for distinguishing premalignant and malignant tissues from biopsies or with

26 h levels in inflammatory lesions and in many premalignant and malignant tumors.

27 nd that elevated MCT1 levels are manifest in premalignant and neoplastic Emu-Myc transgenic B cells a

28 wnregulated as melanocytes progressed to the premalignant and then the malignant and metastatic state

29 not known whether MM is always preceded by a premalignant asymptomatic MGUS stage.

30 ore, splenic and thymic T cells derived from premalignant Atm(-/-)Casp2(-/-) mice also showed increas

31 in the lungs and reduced the development of premalignant atypical adenomatous hyperplasia lesions at

32 (miRNAs), can compensate for lack of IL-6 in premalignant B cell activation.

33 The gradual progression from premalignant Barrett's esophagus to esophageal adenocarc

34 on of liver progenitor cells, development of premalignant biliary lesions, and progression to metasta

35 he development of stroma-rich tumors and the premalignant biliary lesions, intraductal papillary bili

36 amental rethinking and deep understanding of premalignant biology.

37 ErbB2 is frequently highly expressed in premalignant breast cancers, including ductal carcinoma

38 nsition at residue 303 (K303R) in ERalpha in premalignant breast lesions and invasive breast cancers,

39 GF)-A is overexpressed in most malignant and premalignant breast lesions.

40 romes as prognostic markers, particularly in premalignant breast lesions.

41 gest that bFGF regulates ERK oscillations in premalignant but not malignant JB6 cells.

42 ) exhibit a cyclin D1-dependent expansion of premalignant CD24(+) CD29(low) luminal progenitors with

43 Premalignant CD4(+)CD8(+) T cells show persistent catena

44 ends, we found that initiating mutations and premalignant cell kinetics can explain the primary featu

45 e results suggest that stiffness exacerbates premalignant cell line of MCF10A.

46 ary to expectations, preventing apoptosis of premalignant cells abrogated transformation to AML.

47 found that mCXCL1 blocks differentiation of premalignant cells and activates quiescence in tumor-ini

48 levels of HPV16 E6/E7 oncogene expression in premalignant cells are regulated epigenetically.

49 TGF-beta) functions as a tumor suppressor in premalignant cells but as a metastasis promoter in cance

50 ion likely constitutes one mechanism whereby premalignant cells can circumvent this DNA damage respon

51 uggesting that decreased miRNA expression in premalignant cells contributes to their tumorigenic phen

52 eterogeneous population of non-proliferating premalignant cells in the pancreas, and the concomitant

53 strates that gaining a survival advantage of premalignant cells may delay or prevent leukemic progres

54 r-ductal metaplasia (ADM) can transform into premalignant cells that can eventually become cancerous.

55 rscored by evidence that autophagy can allow premalignant cells to escape the genotoxic stress and in

56 protein-dependent checkpoint override allows premalignant cells to evade oncogene stress barriers, pr

57 ired the proliferation of both malignant and premalignant cells with early-stage oncogenic lesions.

58 L and RAc induces apoptosis in APC-deficient premalignant cells without affecting normal cells in vit

59 ion, we show that hMENA(11a) is expressed in premalignant cells, whereas hMENADeltav6 expression is r

60 e suppresses cancer by halting the growth of premalignant cells, yet the accumulation of senescent ce

61 nd was cytotoxic to normal cells, but not to premalignant cells.

62 ting that the effects of Mdm2 loss extend to premalignant cells.

63 ng M2-state and enhance the proliferation of premalignant cells.

64 g mutations occur before clonal expansion of premalignant cells.

65 beta also functions as a tumor suppressor in premalignant cells.

66 ration and/or altered telomere regulation in premalignant cells.

67 e expression, and induction of senescence in premalignant cells.

68 may provide a selective growth advantage to premalignant cells.

69 ention regimens targeting the vasculature in premalignant cervical dysplasia.

70 While editing of HPV genomes in benign and premalignant cervical lesions has been demonstrated, it

71 lysis of RDEB patient samples suggested that premalignant changes to the dermal microenvironment driv

72 Measuring these premalignant changes using microultrasound provides a po

73 oxin- or ethanol-induced injury and manifest premalignant changes within weeks.

74 MR imaging cannot depict premalignant changes; therefore, the standard of care fo

75 about hidden processes of tumor initiation, premalignant clonal expansion, and malignant transformat

76 the age of 60 years that are associated with premalignant clonal expansion.

77 en in their 50s, suggesting that potentially premalignant clones are ubiquitous.

78 epertoire selection and counter-selection of premalignant clones for leukemia suppression.

79 ntribute critically to persistence of covert premalignant clones in children.

80 ed information on the mean sojourn times for premalignant clones until occurrence of either the first

81 ain the differential rates of progression of premalignant colonic lesions and differences in behaviou

82 There were 73 premalignant colonic lesions diagnosed in 56 cases (tubu

83 nts with premalignant or benign tumors had a premalignant condition (cryptochydism in two and Peutz-J

84 Multiple myeloma (MM) evolves from a premalignant condition known as monoclonal gammopathy of

85 evalence of monoclonal B cell lymphocytosis, premalignant condition poorly described in KT recipients

86 MM is preceded by an age-progressive premalignant condition termed monoclonal gammopathy of u

87 nflammatory disease, behaves as a well-known premalignant condition that contributes to PDAC developm

88 ndetermined significance, a highly prevalent premalignant condition.

89 ng sensitivity of endoscopic surveillance of premalignant conditions in the gastrointestinal tract.

90 iple myeloma (MM), is one of the most common premalignant conditions in the general population.

91 Gastric premalignant conditions, atrophic gastritis (AG) and int

92 nown about their role in the pathogenesis of premalignant conditions.

93 importance of PRL signaling in malignant and premalignant conditions.

94 r progression, but its potential role during premalignant development has not been studied.

95 Barrett's esophagus (BE) is a highly premalignant disease that predisposes to the development

96 ithelial tissues that might be used to study premalignant disease.

97 that may improve diagnosis and prevention in premalignant diseases and in screening of high-risk indi

98 Myelodysplastic syndromes are premalignant diseases characterized by cytopenias, myelo

99 MGUS is a premalignant disorder frequently encountered in KT recip

100 pathy of undetermined significance (a mostly premalignant disorder) and active multiple myeloma (MM).

101 egnancy-related disorders, consisting of the premalignant disorders of complete and partial hydatidif

102 on did not affect the onset of inflammation, premalignant dKO livers showed reduced liver damage and

103 DCE)-MRI was used to quantify leakage across premalignant dysplastic microvasculature.

104 ene expression and cellular function between premalignant (dysplastic) epithelial cells and their nor

105 The presence of immature or premalignant elements may influence therapy and long-ter

106 In premalignant Emu-Myc transgenic mice deficient in Smchd1

107 Increased HAND2 methylation was a feature of premalignant endometrial lesions and was seen to paralle

108 g an important role of liver fibrosis in the premalignant environment (PME) of the liver.

109 The residual tumor was composed only of premalignant epithelial cells and inflammatory cells.

110 ntercellular interactions between normal and premalignant epithelial cells and their functional relev

111 , and metastasis, the response of normal and premalignant epithelial cells to cytokines present in a

112 tegrin signaling repressed the invasion of a premalignant epithelium into a stiffened, crosslinked EC

113 I3K signaling, and induced the invasion of a premalignant epithelium.

114 ide study of GR transcriptional targets in a premalignant ER(-) cell line model of early breast cance

115 fy with a CD24(med)CD49f(hi) population from premalignant ErbB2-expressing mammary glands.

116 Additionally, the premalignant events taking place between initial mutatio

117 years) contain mutations that may represent premalignant events that cause clonal hematopoietic expa

118 eduction in ROS generation endows cells with premalignant features, including rapid growth, resistanc

119 Premalignant foci were detected in three patients, two w

120 gastropathy resembling Menetrier disease, a premalignant gastric disorder with epithelial hyperplasi

121 ic strategy for preventing transformation of premalignant gliomas.

122 ike receptor (TLR) activation contributes to premalignant hematologic conditions, such as myelodyspla

123 LR pathways during an immune response and in premalignant hematologic diseases, such as MDS.

124 pecific c-Fos expression leads to reversible premalignant hepatocyte transformation and enhanced DEN-

125 ammary glands lacking ErbB3, thus inhibiting premalignant HER2-induced hyperplasia.

126 ng COX-2 oncogene prevent the development of premalignant human colon adenomas.

127 ry revealed that alone, Pik3caH1047R induced premalignant hyperplasia of the ovarian surface epitheli

128 g radiation exposure but are dispensable for premalignant hyperproliferation.

129 C and possibly other epithelial cancers with premalignant immune involvement.

130 Primary diagnosis of malignant or premalignant, infectious, and inflammatory disease.

131 In premalignant JB6 cells, bFGF stimulation (1) increases c

132 sity-dependent repression of gamma2, whereas premalignant keratinocytes and SCC cells overexpressed g

133 ons, suggesting the prevalent existence of a premalignant landscape in women without clinical evidenc

134 eports over the past year have redefined the premalignant landscape remarkably identifying tiny clone

135 be present within the cells of a polyclonal premalignant lesion and the features that underpin clona

136 ated H3K79 in testicular seminoma and in the premalignant lesion in situ carcinoma.

137 ic gastroesophageal reflux and constitutes a premalignant lesion leading to a 30- to 60-fold increase

138 te clones, derived from cells of a low-grade premalignant lesion naturally infected with the major HR

139 on characterizes the clinical emergence of a premalignant lesion which is carried forward to carcinom

140 e possibility of reducing gastric atrophy, a premalignant lesion, using micronutrient-antioxidant sup

141 ting that FTH may have the potential to be a premalignant lesion.

142 prostatic intraepithelial neoplasia (PIN), a premalignant lesion.

143 ing tested in clinical trials, to treat oral premalignant lesions (OPLs) and prevent oral cancers.

144 ral cancer development in patients with oral premalignant lesions (OPLs) are lacking.

145 However, it was never established that premalignant lesions actually contain tumor progenitors

146 Premalignant lesions and early stage tumors contain immu

147 overexpression in the mammary gland leads to premalignant lesions and eventually mammary tumors.

148 nificant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK

149 ditions, normal repair, aberrant repair with premalignant lesions and lung cancer, and their correlat

150 Pdx1 progenitors induced the development of premalignant lesions and malignant transformation in old

151 e data suggest that retinomas represent true premalignant lesions and not regressed retinoblastoma tu

152 ption factor required for the development of premalignant lesions and their progression into pancreat

153 nduced gastric injury and the development of premalignant lesions by suppressing M1 macrophage polari

154 Whereas regression of lesions was shown for premalignant lesions caused by HPV, clinical benefit in

155 We show that formation of acinar-derived premalignant lesions depends on ectopic induction of the

156 Several studies have shown premalignant lesions gastric atrophy (GA) and intestinal

157 tern of [18 F]FDG uptake, 98 % of those with premalignant lesions had focal [18 F]FDG uptake.

158 nducible factors (HIF) in the progression of premalignant lesions has not been critically examined.

159 auses of cancer-related death, develops from premalignant lesions in chronically damaged livers.

160 eloping malignancy postulated to evolve from premalignant lesions in chronically damaged livers.

161 indicate that CagA variants are linked with premalignant lesions in distinct populations and that ep

162 estigated the bacteria's potential to induce premalignant lesions in mice and studied the kinetics of

163 depletion in IKTA mice reduced the number of premalignant lesions in the lungs in association with an

164 hisms have been linked to the development of premalignant lesions in the stomach.

165 the different steps of the transformation of premalignant lesions into HCC on cirrhosis.

166 ew biomarker predictive of transformation of premalignant lesions into HCC.

167 However, surveillance of these premalignant lesions is recommended by some of the leadi

168 Progression of premalignant lesions is restrained by oncogene-induced s

169 Here, we report that early premalignant lesions of nasopharyngeal epithelium overex

170 uptake is highly sensitive for malignant and premalignant lesions of the GIT.

171 Especially in premalignant lesions of the skin and colon, rapid progre

172 Radiotherapy is often used to treat early premalignant lesions regardless of ErbB2 status.

173 The presence of p53 mutations in premalignant lesions suggests that they represent early

174 reatest chance (42 %) of being malignant and premalignant lesions than in any other area.

175 granulosa cells results in the formation of premalignant lesions that develop into granulosa cell tu

176 on of caveolin-1 expression to progress from premalignant lesions to cancer.

177 extract against the progression of prostate premalignant lesions to malignant tumors.

178 high endometrial HAND2 methylation in their premalignant lesions were less likely to respond to prog

179 s in traditional serrated adenomas, sporadic premalignant lesions with a hitherto unknown pathogenesi

180 ed that Pten deficiency initiated widespread premalignant lesions, and a low tumor incidence that was

181 of breast and ovarian cancers but is high in premalignant lesions, ARHI-induced autophagy could be ma

182 two-stage model allows for greater yield of premalignant lesions, as well as separation of the initi

183 rce for the surveillance of gastrointestinal premalignant lesions, focusing on the scientific article

184 d alterations, including a discrimination of premalignant lesions, represents a major challenge in la

185 process characterized by the development of premalignant lesions, such as low- or high-grade dysplas

186 conjunction with samples from patients with premalignant lesions, to define the effects of a carcino

187 In 81 patients with oral premalignant lesions, we found that Ebp1 expression is s

188 stages of disease, including normal tissue, premalignant lesions, well-differentiated cancer, and po

189 te of gastric cancer for patients with these premalignant lesions.

190 ariation in annual incidence rate of GC from premalignant lesions.

191 enign, Sertoli adenomas can sometimes harbor premalignant lesions.

192 gland level, the smallest unit of colorectal premalignant lesions.

193 thelium, resulting in increased formation of premalignant lesions.

194 ncogenic Kras, Sox9 accelerates formation of premalignant lesions.

195 th main-duct and branch-duct IPMNs represent premalignant lesions.

196 of the development and progression of these premalignant lesions.

197 ells in the airway epithelium in potentially premalignant lesions.

198 months postinfection (mpi) for gastritis and premalignant lesions.

199 after pancreaticoduodenectomy for benign and premalignant lesions.

200 scence stimuli, as well as in senescent skin premalignant lesions.

201 of HPX and CFH may serve as an indicator of premalignant liver disease.

202 or and signaling protein that accumulates in premalignant liver diseases and most hepatocellular carc

203 into highly metastatic liver cancer cells in premalignant liver tissue.

204 We previously established a model of premalignant lung cancer wherein we treated human bronch

205 nitiation to promote the clonal expansion of premalignant lung epithelial cells.

206 iloprost reduces endobronchial dysplasia, a premalignant lung lesion.

207 in-5AC and mucin-2, which could discriminate premalignant/malignant lesions from benign with an accur

208 -3-3zeta destabilizes p53, a Smad partner in premalignant mammary epithelial cells, by downregulating

209 -Myc or K-Ras(G12D), it was detected only in premalignant mammary lesions expressing K-Ras(G12D).

210 , and Wnt/beta-catenin signaling pathways in premalignant mammary tissues.

211 hypothesizes overexpression of ERBB2 in the premalignant MCF10A cell lines at a stiffness value that

212 CD138(+) cells from 56 subjects representing premalignant (monoclonal gammopathy of uncertain signifi

213 irements for early cellular invasion using a premalignant mouse model of pancreatic cancer with condi

214 ity to reliably discriminate between SCA and premalignant mucinous cysts (intraductal papillary mucin

215 provide a potential mechanism through which premalignant mutations accrue in HSCs.

216 We show that in mice, premalignant myeloid cells harboring a Kras(G12D) allele

217 o address whether this event is critical for premalignant myeloid disorders and leukemia development,

218 by methylation in acute myeloid leukemia and premalignant myeloid disorders.

219 ding to activation of cyclin D1 signaling in premalignant nasopharyngeal epithelial (NPE) cells have

220 e is a relative paucity of such knowledge in premalignant neoplasia, which inherently limits the pote

221 m for tumor-suppressive senescent cells in a premalignant neoplasm.

222 hRNA-mediated knockdown of A2BP1 or Myt1L in premalignant neural stem cells compromised neuronal line

223 Five (83%) of six patients with premalignant or benign tumors had a premalignant conditi

224 sons with ulcerative colitis with or without premalignant or malignant changes.

225 The premalignant organoids also displayed significant downre

226 anced cell proliferation and survival in the premalignant organoids in a manner that recapitulated th

227 l and pancreatic tumor tissues as well as in premalignant pancreatic cyst fluids.

228 The GSI inhibited the growth of premalignant pancreatic duct-derived cells in a Notch-de

229 receptor tyrosine kinase is overexpressed in premalignant pancreatic intraepithelial neoplasia (PanIN

230 Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (Pan

231 ia, a process associated with development of premalignant pancreatic intraepithelial neoplasia lesion

232 are upregulated in human PDAC tissues and in premalignant pancreatic intraepithelial neoplasia tissue

233 fibroblasts and promotes the development of premalignant pancreatic intraepithelial neoplasias (PanI

234 The premalignant pancreatic lesions that developed in KPC an

235 e possible to design immunotherapies against premalignant pancreatic lesions to slow or prevent progr

236 required for the development of the earliest premalignant pancreatic lesions, acinar-to-ductal metapl

237 along with 14-3-3 sigma was observed within premalignant PanIN lesions that arise in the mouse model

238 tress, frequently prompting cells to enter a premalignant period during which they mount a defense ag

239 ar defense against transformation during the premalignant period.

240 l for KSHV-associated B-cell malignancies or premalignant persistence in B cells.

241 SNAIL1 gene deletion either during the premalignant phase or after primary tumors have reached

242 , we then tracked these cells throughout the premalignant phase, which revealed a dynamic multistep t

243 Some patients progress rapidly through a premalignant phase.

244 nition, prevalence, and progression of these premalignant phases of light-chain multiple myeloma have

245 mined significance (MGUS) is an asymptomatic premalignant plasma cell disorder.

246 us stimuli, they are also largely present in premalignant plasma cell dyscrasia such as monoclonal ga

247 thy of undetermined significance (MGUS) is a premalignant plasma-cell proliferative disorder associat

248 Since the original polyp studies, premalignant potential of sessile serrated adenomas has

249 ding suggests a scenario in which the common premalignant precursor had acquired shared transforming

250 effective in the treatment of SCCs and their premalignant precursor lesions, actinic keratoses.

251 Claudin-4 is overexpressed in several premalignant precursor lesions, including those of cance

252 Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma.

253 Development of CM from premalignant precursors is concurrent with the outgrowth

254 evelopment of multiple colonic adenomas, the premalignant precursors of colorectal cancer (CRC), freq

255 Induction of TGFbeta1 in premalignant primary keratinocytes elevated the expressi

256 have elucidated genetic processes underlying premalignant progression and preventive targets.

257 n to repeated episodes of acute hypoxia in a premalignant progression model.

258 w show that the restoration of p53 in murine premalignant proliferating pineal lesions resulted in ce

259 gical changes associated with development of premalignant prostate intraepithelial neoplasia (PIN) le

260 est phases of prostate carcinogenesis and in premalignant regions of the prostate gland.

261 the SELECT supplements on benign (primary), premalignant ( RWPE-1) and malignant (LNCaP) prostate ep

262 f a signaling molecule, Pak1, in sun-induced premalignant skin lesions and indicates that increased P

263 high in clinical samples of sunlight-induced premalignant skin lesions assessed by immunohistochemist

264 tinic keratosis, are generally considered as premalignant skin lesions that can progress into squamou

265 ways that promote the progression of certain premalignant skin lesions to malignant lesions will perm

266 s of ceramides may underlie inflammatory and premalignant skin.

267 transgenic mouse to overexpress TGFbeta1 in premalignant squamous lesions.

268 ncy of the bone marrow, which evolves from a premalignant stage called monoclonal gammopathy of undet

269 -suppressive role of DDR activity during the premalignant stage has been studied, and strong evidence

270 At a premalignant stage of tumorigenesis, we documented a def

271 Furthermore, at the premalignant stage we observed disturbance of cell adhes

272 At the premalignant stage, hemizygous deletion of Bif-1 resulte

273 these changes are ultimately proven to be a premalignant stage, this method may prove useful in scre

274 MYC, increases p27(kip1) expression during a premalignant stage.

275 -beta functions as a tumor suppressor in the premalignant stages of tumorigenesis, paradoxically, it

276 be timely pondered to allow tissue repair at premalignant stages or to reduce aggressiveness at the t

277 s, and highlight the importance of analyzing premalignant stages to identify the cancer cell of origi

278 chanism that restrains cancer progression at premalignant stages, in part by causing telomere dysfunc

279 that expression of oncogenic Kras induced a premalignant state accompanied with an arrest in T-cell

280 Our work identifies a distinct premalignant state and multiple tumorigenic pathways cau

281 plasma cell neoplasm that proceeds through a premalignant state of monoclonal gammopathy of unknown s

282 our strategies for correctly managing B-cell premalignant states.

283 LEF-1 was aberrantly upregulated in premalignant Tcf7(-/-) early thymocytes and lymphoma cel

284 le-cell-targeted sequencing of wild-type and premalignant Tet2(-/-) Lin(-)c-Kit(+) cells shows higher

285 everal microRNAs upregulated specifically in premalignant thymocytes, including miR-146a, miR-146b, a

286 mmunoglobulin-containing immune complexes in premalignant tissue and Fcgamma receptor-dependent activ

287 h different H. pylori infection statuses and premalignant tissue changes.

288 Tumors and premalignant tissue from Fbx4(+/-) and Fbx4(-/-) mice ex

289 ffinity ligands with preferential binding to premalignant tissue.

290 t differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE),

291 suppressor effects during progression from a premalignant to a malignant state in our mouse model of

292 their functional relevance in the context of premalignant to malignant progression in Barrett's esoph

293 rsion of Ras-expressing keratinocytes from a premalignant to malignant state induced by decreasing E-

294 pendent and IL-17-independent changes in the premalignant tumor inflammatory microenvironment.

295 normal cells to create and interact with the premalignant tumor microenvironment to promote oncogenes

296 cells, and its development is preceded by a premalignant tumor with which it shares genetic abnormal

297 to identify patients harboring malignant or premalignant tumors by interrogating easily accessible t

298 Loxl2 levels in premalignant tumors negatively correlate with expression

299 revention approach that specifically targets premalignant tumour cells for apoptosis.

300 of the p53 pathway has different effects in premalignant versus invasive pineal tumors, and that p53