ライフサイエンスコーパス: premature death

1 factor for cardiovascular disease (CVD) and premature death.

2 , blindness, motor and cognitive decline and premature death.

3 a strong predictor of subsequent suicide and premature death.

4 tios for cardiomyopathy by family history of premature death.

5 ion, Purkinje cell death, lipid storage, and premature death.

6 l infarction, heart failure, and stroke, and premature death.

7 ncluding severe neurological impairments and premature death.

8 an adults have extraordinarily high rates of premature death.

9 n, impairment of mobility, and in some cases premature death.

10 Rap1b induced massive glomerulosclerosis and premature death.

11 vors (CCSs) are at high risk for illness and premature death.

12 t lead to muscle wasting and, in most cases, premature death.

13 en living in adverse contexts are at risk of premature death.

14 g neuropathy, failed muscle regeneration and premature death.

15 ized by progressive neuronal dysfunction and premature death.

16 s to loss of abdominal fat, infertility, and premature death.

17 ing,respiratory and cardiac impairments, and premature death.

18 rs may have greater risk for poor health and premature death.

19 s in neurons, severe locomotion defects, and premature death.

20 late-onset lymphoid cancer development, and premature death.

21 are generalized skeletal muscle weakness and premature death.

22 rupted skin and hair development, and caused premature death.

23 , blindness, motor and cognitive decline and premature death.

24 e phenotype with impaired liver function and premature death.

25 is and fibrosis, dilated cardiomyopathy, and premature death.

26 tributed to myocyte loss, heart failure, and premature death.

27 O2 suggest that traffic pollution relates to premature death.

28 multiorgan disease that ultimately leads to premature death.

29 th comorbidities of cognitive impairment and premature death.

30 behavioral abnormalities, and prevention of premature death.

31 l lung disease, ulcerative skin lesions, and premature death.

32 ysfunction leads to spontaneous seizures and premature death.

33 y, motor dysfunction, cognitive decline, and premature death.

34 sis, also led to breathing abnormalities and premature death.

35 uorescent lipopigment, neurodegeneration and premature death.

36 too late to avoid significant disability and premature death.

37 ople who self-harm have an increased risk of premature death.

38 rophin causes progressive muscle wasting and premature death.

39 reventable cause of disease, disability, and premature death.

40 ss to fibrosis and cirrhosis contributing to premature death.

41 nd adults and that, if untreated, results in premature death.

42 leads to a profound loss of life quality and premature death.

43 ted fibro-adiposis, cardiac dysfunction, and premature death.

44 ical symptoms, including severe epilepsy and premature death.

45 dilated cardiomyopathy in humans, leading to premature death.

46 muscle causes hypertension, hypertrophy, and premature death.

47 with no indications of cardiac pathology or premature death.

48 Smoking is a major cause for premature death.

49 ized by progressive muscle wasting and often premature death.

50 pread central nervous system dysfunction and premature death.

51 ople with epilepsy have an increased risk of premature death.

52 ological dysfunction, neurodegeneration, and premature death.

53 od pressure and cholesterol levels predicted premature death.

54 of Bcl2 failed to ameliorate CR-Csn8KO mouse premature death.

55 specific extracutaneous complications and/or premature death.

56 hich rapidly progressed to heart failure and premature death.

57 weakness, heart and respiratory failure and premature death.

58 ness, atrophy and, in the majority of cases, premature death.

59 ect quality of life and increase the risk of premature death.

60 -cell loss, lymphatic tissue destruction and premature death.

61 heart failure, reduced quality of life, and premature death.

62 emonstrates poor coordination, seizures, and premature death.

63 d leads to ESRD, cardiovascular disease, and premature death.

64 ical degeneration that causes disability and premature death.

65 mia, T cell cytopenia, skin ulcerations, and premature death.

66 r risk factor for stroke, heart failure, and premature death.

67 lead to a considerable change in the risk of premature death.

68 n leading to abnormal foetal development and premature death.

69 ociated with cardiovascular disease risk and premature death.

70 r risk factor for cardiovascular disease and premature death.

71 ations, severe cardiovascular pathology, and premature death.

72 progressive cognitive and motor decline, and premature death.

73 ing disease leading to severe disability and premature death.

74 sis that increase the risk of arrhythmia and premature death.

75 use progressive neurologic deterioration and premature death.

76 d cardiac ventricular hypertrophy leading to premature death.

77 factor for ESRD, cardiovascular disease, and premature death.

78 istance, right ventricular (RV) failure, and premature death.

79 pread sickling and tissue damage, leading to premature death.

80 e dementia, movement disorders, seizures and premature death.

81 pathy that leads to hind limb spasticity and premature death.

82 n of morbidity and are at increased risk for premature death.

83 cardiomyopathy, myocardial infarctions, and premature death.

84 hy (DCM), a major cause of heart failure and premature death.

85 2.5) is a causal factor in over 5% of global premature deaths.

86 in treatment, monitor DST results, and avoid premature deaths.

87 erdose in this population in order to reduce premature deaths.

88 strategy for preventing chronic diseases and premature deaths.

89 epilepsy being one of the leading causes of premature deaths.

90 6) total deaths and 1.08 million (1.00-1.15) premature deaths.

91 c health response is needed to avert further premature deaths.

92 global population, cause 3.9 million annual premature deaths.

93 ockade of embryogenesis, adult sterility and premature death 18-24 months post-treatment.

94 0.1-1.6 mug/m(3)), avoiding an estimated 290 premature deaths, 180 hospital admissions for respirator

95 Rather than undergoing premature death, a large subpopulation of these neurons

96 A third scenario assumed a 40% reduction in premature deaths across all ages and causes.

97 ires cause poor air quality and thousands of premature deaths across densely populated regions in Equ

98 We ascertained family history of premature death (age <60 years) in all individuals born

99 c fatty liver disease (NAFLD) contributes to premature death along with obesity, diabetes, and cardio

100 Risk of premature death among patients with lifetime anorexia ne

101 h is needed to help decision makers to avoid premature deaths among patients already in hospitals and

102 Herein, we demonstrate premature death and acceleration of age-related patholog

103 Premature death and cardiac abnormalities are described

104 In 2008, the worldwide cost of cancer due to premature death and disability (not including direct med

105 Since 1990, premature death and disability caused by communicable, n

106 ic heart disease (RHD) is a leading cause of premature death and disability in low-income countries;

107 the impact of tobacco smoking on the risk of premature death and its contribution to the excess morta

108 Type 2 diabetes leads to premature death and reduced quality of life for 8% of Am

109 et syndrome, including spontaneous seizures, premature death and seizures triggered by hyperthermia.

110 nary atherosclerosis, vulnerable plaque, and premature death and that these effect could be attenuate

111 ulation) would accrue 81.8% of reductions in premature deaths and 87.1% of gains in terms of quality-

112 to be associated with avoidance of 8 million premature deaths and an estimated extended mean life spa

113 Tobacco taxation reduces smoking-related premature deaths and increases government revenues, but

114 al causes of death, resulting in 5.8 million premature deaths and millions more with disability.

115 and has the potential to avoid a few million premature deaths and related morbidity from CVD at low c

116 spastic paraplegia, developmental delay with premature death, and autism spectrum disorder with intel

117 nts (ie, informal care), lost earnings after premature death, and costs associated with individuals w

118 vision loss, cognitive and motor regression, premature death, and prominent NCL-type storage material

119 deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architect

120 dmissions from exposure to SO2, and up to 30 premature deaths annually due to ECA emission controls.

121 e workplace are responsible for over 370,000 premature deaths annually.

122 l combustion is associated with four million premature deaths annually; contributes to forest degrada

123 Premature deaths are generally more common among patient

124 The increased risk of premature death associated with mental disorder is not c

125 early-onset spontaneous seizures leading to premature death at 2-3 weeks of age.

126 henotype with mental retardation, leading to premature death at age 36 years in one of them.

127 sive motor weakness from 100 days of age and premature death at around 135 days of age.

128 and tissue eosinophilia, tissue injury, and premature death at around 25-30 wk of age.

129 egy for the poorest populations that targets premature death at younger ages, addresses environmental

130 r quality improvements decreased the risk of premature death attributable to PM2.5 sulfate in NC by a

131 We calculated the numbers of total and premature deaths attributable to blood pressure using po

132 eme Court) could substantially decrease U.S. premature deaths attributable to coal-fired power plant

133 Although studies have provided estimates of premature deaths attributable to either heat or cold in

134 ne across Europe will increase the number of premature deaths attributable to ozone pollution each ye

135 Number of premature deaths avoided and years of life saved were pr

136 exhibit spontaneous generalized seizures and premature death between P16 and P26, whereas Scn1a(RH/+)

137 sible for averting 180,000 (117,000-389,000) premature deaths between 1990 and 2012.

138 ted all mice by weaning age and led to their premature death by 3-5 wk of age.

139 ron degeneration, severe muscle wasting, and premature death by 6 mo of age.

140 spholamban (PLB) triggers cardiomyopathy and premature death by altering regulation of sarco/endoplas

141 eractivation, progression to dilatation, and premature death by approximately 1 year of age.

142 Adjusted odds ratios (AORs) of premature death by external causes in patients with TBI

143 ion, seizures, uncontrollable movements, and premature death by postnatal week 9-10.

144 ssive skeletal muscle dysfunction leading to premature death by the third decade of life.

145 n lower-middle-income countries would reduce premature deaths by an estimated 4.2 million per year.

146 to examine the effect of a family history of premature death, cardiovascular death in particular, on

147 Of an estimated 1.10 million premature deaths caused by PM2.5 pollution throughout Ch

148 nevitability of death (patients), preventing premature death (clinicians), and ensuring safety (regul

149 ted severe growth retardation, kyphosis, and premature death, closely resembling the phenotype of sys

150 us erythematosus (SLE) have a higher rate of premature death compared to the general population, sugg

151 T2 from the brain, resulting in epilepsy and premature death, confirming the importance of EAAT2 for

152 stigate the impact of smoking on the risk of premature death, controlling for confounders.

153 More premature deaths could be averted in southern states (60

154 million-2.0 million) out of 9 million future premature deaths could be averted.

155 Occurrence of premature death (death prior to scheduled euthanasia) wa

156 es and rescued the mutants from epilepsy and premature death, despite prenatal onset of Tsc1 loss and

157 degenerative disease can be fatal, including premature death due to respiratory dysfunction.

158 ombin (Serpinc1) or protein C (Proc) display premature death due to thrombosis-related coagulopathy,

159 of cause-specific outcomes examined, risk of premature death during the first year after discharge wa

160 regions could avoid several hundred thousand premature deaths each year.

161 they still account for tens of thousands of premature deaths every year.

162 The burden of premature death for men (2.04 million years of potential

163 Physical activity can reduce the risk of premature death from a range of conditions.

164 ned the relation between body mass index and premature death from all causes, cardiovascular disease

165 in older mice and led to overt diabetes and premature death from approximately 14 months of age.

166 ies could substantially reduce suffering and premature death from cancer before 2030, with even great

167 pertension was significantly associated with premature death from endogenous causes (incidence-rate r

168 strongly associated with increased rates of premature death from endogenous causes in this populatio

169 cholesterolemia was not a major predictor of premature death from endogenous causes.

170 th of President Franklin D Roosevelt and his premature death from hypertensive heart disease and stro

171 entral Asia, face particularly high rates of premature death from ischemic heart disease.

172 In contrast, a family history of premature death from other cardiac or noncardiac conditi

173 riated muscle wasting disorder that leads to premature death from respiratory and/or cardiac failure.

174 We estimated the burden of premature death from SCD and compared it with other dise

175 r) results in neurological abnormalities and premature death from vascular complications.

176 program was predicted to annually prevent 90 premature deaths from AAA and to gain 577 quality-adjust

177 desh contributes to the largest reduction of premature deaths from ambient air pollution, preventing

178 The majority of premature deaths from CRC in southern states and half th

179 0 (142000-172000) and 182000 (163000-197000) premature deaths from heating and cooking emissions, res

180 ted with significant short-term increases in premature deaths from intentional violence, while reduci

181 culosis, HIV, and malaria deaths; a third of premature deaths from non-communicable diseases (NCDs);

182 is strategy avoids 0.7 to 4.7 million annual premature deaths from outdoor air pollution and increase

183 d with about 38,000 PM2.5- and ozone-related premature deaths globally in 2015, including about 10 pe

184 d avoid 0.6-4.4 and 0.04-0.52 million annual premature deaths globally in 2030.

185 ct cause of hyperexcitability, epilepsy, and premature death has remained unresolved.

186 ulting in stroke, device-exchange surgery or premature death) has been increasing dramatically, which

187 a and neurodegenerative phenotype leading to premature death in 36% of the population.

188 on and developed early-onset GCTs leading to premature death in a manner similar to the Ctnnb1;Pten-m

189 ive therapies for this disease, which causes premature death in adolescence.

190 Acute loss of Sel1L leads to premature death in adult mice within 3 wk with profound

191 sed risk of developing diabetes, obesity and premature death in adult offspring.

192 record of CHD was calculated, factoring out premature death in both cohorts.

193 ajor contributor to morbidity, mortality and premature death in cystic fibrosis.

194 cessary and sufficient to cause epilepsy and premature death in DS.

195 ibitory neurons is the cause of epilepsy and premature death in DS.

196 this study was to investigate cause-specific premature death in individuals who self-harm, including

197 ecognized site and mechanism contributing to premature death in individuals with leaky RYR2 mutations

198 ciency exacerbated aortic disease and caused premature death in MFS mice.

199 e hypothyroidism leads to growth defects and premature death in mice, we assayed for changes in thyro

200 atrophy, loss of goblet and Paneth cells and premature death in mice.

201 nal calcification, renal tubular injury, and premature death in multiple animal models.

202 ls rapidly led to severe organ pathology and premature death in Noxa-deficient mice.

203 continue to cause unnecessary disability and premature death in older people.

204 alled early afterdepolarizations (EADs), and premature death in paced adult rabbit ventricular myocyt

205 pected death in epilepsy is a major cause of premature death in people with epilepsy.

206 dering these postmitotic cells vulnerable to premature death in retinal degenerative disorders.

207 t vodka is a major cause of the high risk of premature death in Russian adults.

208 We studied the mechanism of premature death in Scn1a heterozygous KO mice and condit

209 h parents and by AUD, drug abuse, crime, and premature death in stepparents.

210 rate ratios (IRRs) reflecting the effect of premature death in the family on early cardiovascular di

211 death (SCD) are among the leading causes of premature death in the general population, the origins r

212 allucinations, loss of circadian rhythm, and premature death in the late-twenties to early-thirties.

213 Smoking is the leading preventable cause of premature death in the United States.

214 ease and stroke remain the leading causes of premature death in the world; however, there is wide reg

215 y mass index (weight (kg)/height (m)(2)) and premature death in young adulthood is very limited, espe

216 tely 174,000 global PM2.5- and ozone-related premature deaths in 2040.

217 Contributory factors to premature deaths in a subset of people with intellectual

218 000 (306000-370000; 95% confidence interval) premature deaths in China are attributable to residentia

219 e and the USA is linked to more than 108,600 premature deaths in China.

220 ardiomyopathy increased 100-fold; given >/=2 premature deaths in first-degree relatives, the rate inc

221 Around 2045 (1665) avoided premature deaths in greater Dhaka (City Corporation) can

222 China in 2007 is linked to more than 64,800 premature deaths in regions other than China, including

223 rosis followed by myocardial infarctions and premature deaths in response to high-fat, high-cholester

224 uding about 10 per cent of all ozone-related premature deaths in the 28 European Union member states.

225 lan, we sought to quantify the illnesses and premature deaths in the UAE attributable to 14 environme

226 bustion emissions cause approximately 13,000 premature deaths in the UK per year, while an additional

227 about contributory factors to avoidable and premature deaths in this population.

228 other than China, including more than 3,100 premature deaths in western Europe and the USA; on the o

229 Epilepsy may cause premature death indirectly through co-morbid conditions.

230 Understanding the causes of premature death is a prerequisite for improving long-ter

231 supplements in preventing chronic disease or premature death is unclear.

232 Shp1, result in widespread inflammation and premature death, known as the motheaten (me) phenotype.

233 2 in adipocytes, mediated by aP2-Cre, led to premature death, lack of white fat, low blood pressure,

234 progressive cognitive and motor decline and premature death (late teens to 20s).

235 risk of cardiomyopathy by family history of premature death (<60 years) from cardiomyopathy.

236 announced its goal of reducing the number of premature deaths (<70 years) due to noncommunicable chro

237 ubertal nadir androgen condition resulted in premature death, maintenance of androgen levels extended

238 ate identification of people at high risk of premature death may assist in the targeting of preventiv

239 , glucose intolerant, and on a trajectory to premature death may confound data interpretation and out

240 Consequently, a family history of premature death may indicate a familial cardiac frailty

241 ged 25-49 years, an estimated 111 000 excess premature deaths occurred in white individuals and 6600

242 To counter premature death of a virus-infected cell, poxviruses use

243 ve muscle weakness, paralysis and eventually premature death of afflicted individuals.

244 ture of the photoreceptors that leads to the premature death of both rod and cone photoreceptors.

245 s an important survival factor that inhibits premature death of bursCCAP neurons.

246 at 16 weeks of age significantly delayed the premature death of CryAB(R120G) TG mice, with a median l

247 ellular retention of mutant COMP protein and premature death of growth-plate chondrocytes.

248 umulations trigger the neurodegeneration and premature death of LD patients.

249 on inhibited IEC apoptosis and prevented the premature death of mice with IEC-specific RIPK1 knockout

250 leading to a severe skin barrier defect and premature death of newborn animals.

251 it did not prevent the eventual decline and premature death of Npc1(-/-) mice.

252 ay explores the consequences of the imagined premature death of Oswald Avery, who in 1944 provided ev

253 n the anterior palate of Hand2(LoxP/-) mice, premature death of periderm cells and a down-regulation

254 steps of neuronal differentiation but causes premature death of postmitotic neurons.

255 ints induced Rett-like phenotypes and caused premature death of the animals.

256 ia activates a brainstorm, which accelerates premature death of the heart and the brain.

257 ediated inhibition of PARP, thereby avoiding premature death of the infected cell.

258 ors are highly significantly associated with premature death of the patient (Wilcoxon statistics, P <

259 tion followed by either clonal exhaustion or premature death of the T cell.

260 for Brazil, the model assesses the effect on premature deaths of cigarette taxes, smoke-free air laws

261 The Confidential Inquiry into premature deaths of people with intellectual disabilitie

262 ns cause ODs shows that a majority result in premature death or are lethal in the orthologous mouse g

263 eads to cardiac conduction abnormalities and premature death owing to arrhythmia.

264 matter (PM) pollution is a leading cause of premature death, particularly in those with pre-existing

265 cent confidence interval 1.61-4.81) million premature deaths per year worldwide, predominantly in As

266 olid fuels used for cooking cause ~4 million premature deaths per year.

267 sis and vascular calcification that leads to premature death, predominantly of myocardial infarction

268 (PM2.5) amount to approximately 22.5 million premature deaths prevented between 2000 and 2100.

269 ion in these mice, consequently leading to a premature death rate of 40% within 2 weeks of treatment,

270 al fibrosis, leading to kidney failure and a premature death rate of 67% by 9 weeks of age.

271 ossible explanation for a modest increase in premature death rate.

272 We find that, of the 3.45 million premature deaths related to PM2.5 pollution in 2007 worl

273 The risk of premature death remains significantly elevated at 20-25

274 extent to which these factors contribute to premature death resulting from CRC nationwide and by sta

275 We also calculated the proportion of premature death resulting from CRC that could potentiall

276 Overall, half the premature deaths resulting from CRC that occurred nation

277 n of autonomic and respiratory deficits with premature death suggests that Mecp2 is critical within a

278 in neurons exhibited growth retardation and premature death that are characterized by abnormal intra

279 harboring constitutively active MalT undergo premature death that involves increased expression of th

280 ques but profoundly reduced the incidence of premature deaths, the number of thrombi (7 in 249 plaque

281 vere hepatomegaly and steatosis resulting in premature death, thereby limiting studies of the role of

282 odelling, decline of cardiac performance and premature death, thereby limiting the use of betaAR agon

283 idney disease among NCD targets for reducing premature death throughout the world.

284 ulted in a reduction of risk with respect to premature death to 20.6% compared with the control group

285 icable to non-communicable diseases and from premature death to years lived with disability.

286 ing from progressive infantile paralysis and premature death (type I) to limited motor neuron loss an

287 health target, "Avoid in each country 40% of premature deaths (under-70 deaths that would be seen in

288 the number needed to operate on to prevent 1 premature death were 667 and 1.5, respectively.

289 e inflammation in lung, skin, and liver with premature death, whereas the intestine remains uninflame

290 require 2 major advancements: (1) minimizing premature death with a functioning graft in the patients

291 riction, CPT1b(+/-) mice were susceptible to premature death with congestive heart failure.

292 d that deletion of the p44/WDR77 gene caused premature death with dramatic astrogliosis in mouse brai

293 ial fatty acid oxidation, bioenergetics, and premature death with lipotoxic cardiomyopathy.

294 of the ten leading causes of disability and premature death worldwide are psychiatric conditions.

295 rtension is the leading preventable cause of premature death worldwide.

296 olid fuels is associated with over 4 million premature deaths worldwide every year including half a m

297 g risk factor for cardiovascular disease and premature deaths worldwide.

298 40% fewer premature deaths would be important in all countries, bu

299 that annual numbers of avoided ozone-related premature deaths would have ranged from 1,410 to 2,480 a

300 ion people, causing severe complications and premature death, yet the underlying molecular mechanisms