ライフサイエンスコーパス: prematurely

1 ents photocaged DHEA from activating neurons prematurely.

2 on in which one or more cranial sutures fuse prematurely.

3 tients never started IFN-alpha-2b or stopped prematurely.

4 rogressive neuromuscular dysfunction and die prematurely.

5 17 who received 2400 mg/d of CoQ10) withdrew prematurely.

6 treatment and those who did not or recurred prematurely.

7 evious Swedish cohorts of children born less prematurely.

8 ive in the placebo group withdrew from study prematurely.

9 he molar tooth bud, both processes terminate prematurely.

10 is not sustained, and HF downgrowth arrests prematurely.

11 troke and ischemic retinopathy, and 48% died prematurely.

12 bitor 5-azacytidine and find that they ripen prematurely.

13 small peptides, some substrates are released prematurely.

14 were not blinded, and the trial was stopped prematurely.

15 c follow-up of children and adults born very prematurely.

16 terminate the breastfeeding of their infants prematurely.

17 immune disease where platelets are destroyed prematurely.

18 ory deficits seen in children born extremely prematurely.

19 unscheduled SOCS7 expression stops migration prematurely.

20 pport, 2 women died, and 6 infants were born prematurely.

21 hospitalizations when the trial was stopped prematurely.

22 ctivation, causes the DTCs to stop migration prematurely.

23 rticipants were randomized; 29 (9%) withdrew prematurely.

24 conclude that these neurons ceased migration prematurely.

25 y, but displayed growth retardation and died prematurely.

26 rogressive neuromuscular dysfunction and die prematurely.

27 to follow-up; 19% discontinued their regimen prematurely.

28 d, cell size increased, and nephrocytes died prematurely.

29 vation after Gram-negative infection and die prematurely.

30 s can dissociate replisomes from chromosomes prematurely.

31 pended dual antiplatelet therapy, in 6 cases prematurely.

32 n of patients who experience relapse and die prematurely.

33 152 singleton infants, 22 (14.5%) were born prematurely.

34 white men enrolled in the study; 2 withdrew prematurely, 1 because of a non-drug-related serious adv

35 Four subjects died and 2 discontinued prematurely; 117 of 123 (95%) completed 104 weeks.

36 Seven patients stopped treatment prematurely (12%).

37 months of treatment, 3 patients discontinued prematurely, 2 patients died, 7 patients were hospitaliz

38 Six patients (8%) stopped HCV therapy prematurely: 2 due to HCV breakthrough, 4 to adverse eve

39 The corresponding HRs in subjects born very prematurely (28-31 weeks) were 4.32 (95% CI, 2.70-6.90)

40 la pt4 mutant in which arbuscules degenerate prematurely [4], we identified arbuscule degeneration-as

41 The trial was stopped prematurely (445 randomized patients) because of a low g

42 erotic coronary artery disease (CAD) and die prematurely (50% mortality at 42 d of age).

43 055 otherwise healthy children who were born prematurely, 583 received a diagnosis of strabismus late

44 articipants withdrew consent or discontinued prematurely, 6 owing to adverse events attributed to X-8

45 The study was discontinued prematurely (645 patients; 299 SREs) after the corporate

46 We investigated prediction in infants born prematurely, a leading cause of neuro-cognitive impairme

47 " reactions that recognize the structures of prematurely abandoned replication forks and mediate repl

48 Those that do grow prematurely acquire lipid synthesis enzymes and undergo

49 uRD-deficient lymphoid progenitors therefore prematurely activate a B cell transcriptional program an

50 acinar damage caused by the accumulation of prematurely activated trypsin.

51 We hypothesize that prematurely activated virions are less fit for receptor

52 cle stem cells of Foxp1 null mice from being prematurely activated.

53 not in close proximity, and these genes were prematurely activated.

54 se sperm will go astray, invading the ovary, prematurely activating oocytes, and sometimes crossing b

55 ese cells, both APC(Cdc20) and APC(Ama1) are prematurely active, and meiosis I and meiosis II events

56 ic progenitors do not die, but differentiate prematurely adjacent to the somite.

57 st transform new inputs into outputs without prematurely affecting downstream circuits while still ma

58 (DCT-/-) develop cardiac hypertrophy and die prematurely after E15.

59 Recruitment was halted prematurely after enrollment of 1220 patients (888 who u

60 Study was terminated prematurely after interim analysis, which showed no diff

61 The trial was terminated prematurely after the enrollment of 252 patients because

62 irological breakthrough and one discontinued prematurely after the first day of treatment.

63 The trial was stopped prematurely after the second interim efficacy analysis.

64 is a distinctive disorder characterized by a prematurely aged appearance with lipoatrophy, epidermal

65 thymectomy and may also explain in part the prematurely aged phenotype of the naive T cell pool in i

66 ounds associated with the flavor of aged and prematurely aged red wines.

67 yte cause aggravation of aging phenotypes in prematurely aging mtDNA mutator (PolgA(mut/mut)) mice.

68 atg mutants, ATG11-deficient plants senesce prematurely and are hypersensitive to nitrogen and fixed

69 raise concern that this cohort may be aging prematurely and at risk for substantial medical and cogn

70 Although the trial closed prematurely and definitive statements regarding the effi

71 ABCG5/G8 knockout mice died prematurely and developed a phenotype that included high

72 and did not proliferate but rearranged Tcra prematurely and differentiated rapidly.

73 ications, are at a higher risk of delivering prematurely and giving birth to SGA newborns.

74 nia and related serious mental illnesses die prematurely and have significantly higher medical co-mor

75 The Class I mutant secretes translocators prematurely and is specifically defective in IpaD secret

76 ased cardiovascular risk in individuals born prematurely and open perspectives for therapeutic strate

77 herin causes RGCs to lose apical attachments prematurely and rescues retraction in slit1b morphants.

78 mtpt4 mutants arbuscule degeneration occurs prematurely and symbiosis fails.

79 nial region of the Wolffian duct degenerated prematurely and the cranial mesonephric tubules were mis

80 three patients had to discontinue treatment prematurely and the third required dose reduction.

81 0-4h E(z)(Trm) embryos, H3K27me3 accumulates prematurely and to high levels and does so at the expens

82 ic or substance abuse comorbidity (3.8% died prematurely) and those with solely substance abuse (6.2%

83 , preventing the cells from entering mitosis prematurely, and efficient activation of the CHK1 and G2

84 EFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signat

85 gland cells overproliferated, differentiated prematurely, and often adopted a mixed lineage fate.

86 hus protecting unprimed vesicles from fusing prematurely, and redirecting them to refill the readily

87 usible, that co-divergence has been rejected prematurely, and that long-term evolutionary rates are v

88 ic Pi transport fails, arbuscules degenerate prematurely, and the symbiosis is not maintained.

89 ll, exposed colonies were more likely to die prematurely, and those that survived reached a lower fin

90 ogical deficits observed in individuals born prematurely are not completely understood.

91 less, the Mgp(-/-);Tgm2(-/-) mice still died prematurely as compared with wild-type and retained the

92 ch of age-dependent cell death was turned on prematurely, as indicated by the accumulation of ORE1 tr

93 inal extension for initiation and terminated prematurely at an internal cis-acting element.

94 Robo2 in mice caused axons to defasciculate prematurely at muscle targets.

95 essful because metal precursors precipitated prematurely at the pH and temperatures required for MFI

96 Further, ubp3 sir2 mutants age prematurely at the same rate as sir2 mutants.

97 ed the ledipasvir and sofosbuvir combination prematurely because of adverse events; 10 patients died,

98 ur patients discontinued the trial treatment prematurely because of adverse events; three of these pa

99 e mouse Thr2605 phosphorylation cluster, die prematurely because of congenital bone marrow failure.

100 The study was halted prematurely because of difficulty with patient recruitme

101 an AZT/3TC/NVP; a third study was terminated prematurely because of early virological failure.

102 The 1600-IU/d dosage was discontinued prematurely because of elevated plasma 25(OH)D concentra

103 Recruitment was halted prematurely because of excess toxicity; 8 patients died

104 The study was stopped prematurely because of excess treatment-related mortalit

105 Cohort A was closed prematurely because of poor accrual and is not reported.

106 e absence of Hey1 and Hey2 but differentiate prematurely because of precocious upregulation of the pr

107 Hydration treatment was terminated prematurely because of shortness of breath in three pati

108 The study was terminated prematurely because of unacceptable rates of AR (4 of 14

109 Enrollment was closed prematurely because preliminary results indicated failur

110 t least 2.284 million people might have died prematurely because RRT could not be accessed.

111 uted to HIV/AIDS, and 94% of deaths occurred prematurely (before age 65).

112 d this question in 40 infants born extremely prematurely (between 25- and 32-wk gestation) in the fir

113 00 of 165 low-birth-weight survivors (60.6%) prematurely born between January 1, 1977, and December 3

114 One-third of the extremely prematurely born children in this study had some kind of

115 pothesized that cBF integrity is impaired in prematurely born individuals and mediates adult cognitiv

116 Prematurely born individuals have an increased risk for

117 Three hundred thirty-five fundus images of prematurely born infants were obtained by neonatal inten

118 mportant diagnostic problem in both term and prematurely born neonates.

119 Most of the neonates were prematurely born: 19 (70.4%) were born at gestational ag

120 hout functional FAK initiate differentiation prematurely, both in vivo and in vitro.

121 re infants >38 weeks postmenstrual age (born prematurely but chronologically past term, n=4) resulted

122 treatment (group 2), patients who were born prematurely but who had no history of ROP (group 3), and

123 eumatoid arthritis (RA), T cell aging occurs prematurely, but the mechanisms involved and their contr

124 of axon regenerative capacity was triggered prematurely by early exposure of mouse PCs to T(3), wher

125 or recovery from hearing loss is also closed prematurely by early eyelid opening and extended by dela

126 uire the Cdk1 mitotic kinase and be promoted prematurely by ectopic expression of the NIMA kinase.

127 The trial was interrupted prematurely by the Data Safety and Monitoring Board beca

128 atural age-dependent process that is induced prematurely by various environmental stresses.

129 ailed to gain weight, were smaller, and died prematurely (by approximately 6-8 weeks of age).

130 immature physiologic functions, infants born prematurely cannot be expected to readily feed by mouth

131 tex can thereby prepare the movement without prematurely causing it.

132 ition, ICP27 induced expression of pre-mRNAs prematurely cleaved and polyadenylated from cryptic poly

133 These previously undescribed prematurely cleaved and polyadenylated pre-mRNAs, some o

134 )I-BZA2 sensitivity, this clinical trial was prematurely closed after 87 patients had been included.

135 Results The study was prematurely closed after the random assignment of 270 pa

136 pared with 16 weeks or older; and being born prematurely compared with full-term (1.41 [1.22-1.62]).

137 to 0.5 mg semaglutide discontinued treatment prematurely, compared with 55 (15%) assigned to 1.0 mg s

138 function is lacking, resulting in cells that prematurely condense their chromosomes during mid G2-pha

139 oduction in vitro reveals that FlnA-null MKs prematurely convert their cytoplasm into large CD61(+) p

140 the primary response, FDC-less GC dissipated prematurely, correlating with impaired affinity maturati

141 significantly higher density in live versus prematurely deceased females indicating a potentially mu

142 Although the epiblast prematurely decreases in size, we did not detect evidenc

143 enome and IN from ALLINI-treated virions are prematurely degraded in target cells, whereas reverse tr

144 RNA genome and IN in eccentric particles are prematurely degraded, whereas reverse transcriptase rema

145 ized by the ER quality-control machinery and prematurely degraded, whereas the secretable LGI1(S473L)

146 , which has residual channel activity but is prematurely degraded.

147 Imp1-deficient neural stem cells were prematurely depleted in the dorsal telencephalon due to

148 not receive adequate medical attention, were prematurely detached from the health system, or held unr

149 ing compartment, cortical interstitial cells prematurely differentiate.

150 acodes and dermal condensates that result in prematurely differentiated enlarged hair follicles.

151 1 null in which misexpressed DCN produced by prematurely differentiated interstitial cells accumulate

152 rt one had reached post-treatment week 12 or prematurely discontinued from the study.

153 Treatment was prematurely discontinued in four patients.

154 Sixteen patients (12.3%) prematurely discontinued therapy or were lost to follow-

155 articipants (14.5%) in the rifapentine group prematurely discontinued treatment (P=.79).

156 in alanine aminotransferase and no patients prematurely discontinued treatment because of adverse ev

157 from the first 104 patients who completed or prematurely discontinued treatment by January 1, 2014 ar

158 Eight patients prematurely discontinued treatment due to ECMPS gastroin

159 However, more patients prematurely discontinued treatment with ticagrelor than

160 germ cell divisions within the niche, but by prematurely displacing proliferating cells from their no

161 domization to TAC Elimination was terminated prematurely due to a higher rate of treated biopsy-prove

162 lence of cardiovascular diseases was stopped prematurely due to adverse cardiovascular events raising

163 ents (2%) discontinued ledipasvir-sofosbuvir prematurely due to adverse events.

164 es may not be averted when DAA therapy fails prematurely due to emergence of resistant HCV variants.

165 Everolimus 3.0 mg was terminated prematurely due to higher mortality.

166 Recruitment was closed prematurely due to poor accrual after 89 of 200 planned

167 enrollment was 200, but the trial was halted prematurely due to slow accrual.

168 ice with T cell-specific Stim1 deletion died prematurely during the chronic phase of infection and ha

169 found that dendritic spine synapses develop prematurely during the early postnatal period.

170 Over 15 million babies are born prematurely each year with approximately 1 million of th

171 re responsible for almost 500,000 lives lost prematurely each year.

172 cell-programming transcription factors from prematurely enacting lineage commitment.

173 olar masses) indicates that the outburst was prematurely ended when a sizeable fraction of the outer

174 tion, preventing the incomplete subunit from prematurely engaging in translation.

175 in FSHD myoblasts, which nonetheless did not prematurely enter myogenic differentiation.

176 ockout (KO) and in thalamus-specific KO mice prematurely entered the cortical plate, eventually inner

177 thaliana plants in which starch reserves are prematurely exhausted.

178 y active until neurula, Nanos1-depleted PGCs prematurely exhibit a hyperphosphorylated RNA polymerase

179 utants in Arabidopsis (Arabidopsis thaliana) prematurely exit embryogenesis and enter seedling develo

180 Drosophila neuroblasts upregulate Cyclin E, prematurely exit quiescence, and overproliferate to gene

181 eumophila replication and causes bacteria to prematurely exit the host cell.

182 In seven cases, two meshes were prematurely exposed (within 4 to 6 weeks), and five were

183 Remarkably, fall migrants prematurely exposed to overwintering-like coldness rever

184 d with the undifferentiated state and do not prematurely express genes characteristic of more differe

185 ases with chronological age, but in AD it is prematurely expressed as if some of the subjects were 14

186 re affected and 47 pollen-related genes were prematurely expressed at a higher level.

187 stimulated by retinoic acid 8 (Stra8), were prematurely expressed in teratoma-susceptible germ cells

188 isions when the alphabeta-TCR heterodimer is prematurely expressed, but not the process of negative s

189 ct KEAP1, the major suppressor of Nrf2, from prematurely extracting the transcription factor off of a

190 Moreover, we caution against prematurely focusing on redistricting as the only method

191 ch that cells lacking both inhibitors divide prematurely following DNA damage, with lethal consequenc

192 Mice with this deletion died prematurely following generalized tonic-clonic seizures,

193 The study was stopped prematurely for futility because of a lower than expecte

194 an sPLA2 inhibitor (varespladib) was stopped prematurely for lack of efficacy.

195 The study was stopped prematurely for safety reasons after 16 patients (61+/-8

196 of the placebo before the trial was stopped prematurely for safety reasons.

197 Moreover, the prematurely formed cyclodehydrogenation products during

198 The enteral feeding tube was withdrawn prematurely from 48.5% of patients, and serious adverse

199 lobal cellular proliferative defects and die prematurely from complete bone marrow failure due to the

200 t study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascul

201 iption from all coding exons, to remove REST prematurely from neural progenitors.

202 orn at the expected Mendelian ratio, but die prematurely from spontaneous cardiovascular disease.

203 nt trends continue, the probability of dying prematurely from the four main NCDs is projected to incr

204 rgos driven by a few motors tended to unbind prematurely from the microtubule, whereas cargos driven

205 Analysis of a recent prematurely halted vaccine trial revealed increased mort

206 Among the 188 852 subjects born prematurely (i.e., at <37 weeks of gestation), there wer

207 Eco1 degradation also occurs prematurely if Mcm complex loading at origins is prevent

208 This process is arrested prematurely in albinism.

209 ation was increased, while meiosis commenced prematurely in both single and double knockouts.

210 c changes that occur with normal aging occur prematurely in Ercc1(-/Delta) mice, we systematically co

211 Furthermore, the CMG complex assembles prematurely in G1 in mutant cells, but not wild-type cel

212 importance of not terminating resuscitation prematurely in gasping patients and the need to routinel

213 ited closer together and the PLLp terminates prematurely in lef1-deficient zebrafish embryos.

214 We find that expressing Ttk69 prematurely in R7s collapses their growth cones and disr

215 uring that telomere cohesion is not resolved prematurely in S phase.

216 matids of the unpaired X chromosome separate prematurely, in meiosis I.

217 r, misexpression of miR-14 was sufficient to prematurely induce autophagy in salivary glands, but not

218 In contrast, early triggering prematurely induced by energy poisons resulted in many f

219 herin silencing inhibited hair shaft growth, prematurely induced HF regression (catagen), and inhibit

220 d at the onset of fiber differentiation were prematurely induced in the Spry mutant lens epithelial c

221 s accumulated dysfunctional mitochondria and prematurely induced p53 and proliferative arrest, which

222 Some CD4mc have been shown to trigger Env prematurely, initially activating Env function, followed

223 ically for gene deletions that advance cells prematurely into mitosis.

224 progenitors in lsd1 or CoRest heterozygotes prematurely lose epigenetic plasticity, undergo the Notc

225 Thus, mitochondria are prematurely lost in bdh2-inactivated erythrocytes.

226 lems in one-third of children born extremely prematurely (<27 weeks' gestation).

227 Forty-eight patients discontinued the study prematurely, mainly because of relaparotomy (control, n=

228 People born prematurely may have defects in epithelial innate immuni

229 ence, and 3.3% of men and 2.0% of women died prematurely of any cause).

230 Isolation and identification of extended but prematurely offloaded shunt products suggested that the

231 l temperatures, and these cones appear to be prematurely opening owing to increasingly hot summer con

232 their smaller craniofacial skeletons, and by prematurely over-expressing Runx2 in chick embryos we re

233 were at increased risk of dying and of dying prematurely, particularly from conditions associated wit

234 oid of >4 consecutive AAA codons, sensing of prematurely placed polyA tails by a specialized RNA-bind

235 ed neurites, accumulated synuclein, and died prematurely, recapitulating key features of PD.

236 hat did not initially activate or which have prematurely recovered from refractoriness might release

237 e awareness if the inspired concentration is prematurely reduced.

238 ADAM within premigratory neural crest cells prematurely reduces or maintains Cad6B, respectively.

239 Thus, the ability of TE2 to prematurely release fatty acids from FASN parallels the

240 er, the findings indicate that FlnA-null MKs prematurely release large and fragile platelets that are

241 ng, and the adenylylated DNA intermediate is prematurely released into solution.

242 s finding as PD could lead to patients being prematurely removed from a treatment from which they act

243 y 9 months of age, at which time they became prematurely reproductively senescent.

244 never starting IFN-alpha-2b and for stopping prematurely, respectively.

245 tion from the fovea was delayed and arrested prematurely, resulting in a significantly thicker centra

246 phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations.

247 age difficulties are common in children born prematurely, robust neuroanatomical correlates of these

248 Prematurely slowing MCM loading in pluripotent cells not

249 mic abilities in a group of adolescents born prematurely, some of whom had evidence of brain injury a

250 By contrast, k-MTs are prematurely stabilized in cyclin-A-deficient cells.

251 urora phosphorylation of the tail results in prematurely stable attachments that restrain spindle elo

252 malformation formed when neocortical neurons prematurely stop their migration in the white matter, fo

253 eveloped a systemic drug eruption, or had to prematurely stop triple therapy secondary to a cutaneous

254 frequently started in older patients and was prematurely stopped in a higher proportion of that popul

255 interact with the transcription machinery to prematurely terminate transcription.

256 The study was prematurely terminated after the first interim analysis

257 Due to lack of efficacy, the study was prematurely terminated at the end of the treatment phase

258 The trial was prematurely terminated due to recruitment problems, leav

259 The study was prematurely terminated for futility.

260 teral photostimulation targeting the preBotC prematurely terminated inspiration, whereas expiratory-p

261 d to close, and short arcs are suggestive of prematurely terminated LH1 complex assembly.

262 Although prematurely terminated MHC-TCR/CD4 interaction in transg

263 ycin as a means to experimentally manipulate prematurely terminated polypeptide production in human c

264 ace MHC I-peptide complexes, indicating that prematurely terminated polypeptides can be processed for

265 for the metabolism and immunosurveillance of prematurely terminated polypeptides that are, by their n

266 A SF2 DNA helicase, which governs restart of prematurely terminated replication processes in bacteria

267 ted in accumulation of two types of lncRNAs: prematurely terminated RNAs (ptRNAs) and upstream antise

268 ry efficacy analysis at 12 weeks, but it was prematurely terminated when another study found that epr

269 Mc1r(e/e)J mice, in which endogenous MC1R is prematurely terminated, expressing Mc1r RHC variants, we

270 diminished and extension of the body axis is prematurely terminated.

271 In Drosophila, loss of Notch prematurely terminates the self-renewal of larval type I

272 This rearrangement prematurely terminates translation of the full-length pr

273 CKD are five to ten times more likely to die prematurely than they are to progress to end stage kidne

274 volving children who had been born extremely prematurely, those who had undergone HFOV, as compared w

275 A nonphosphorylatable Nsk1 mutant binds prematurely to kinetochores and spindle, cementing impro

276 etrial adenocarcinoma, and instead succumbed prematurely to multi-organ failure.

277 Compared with infants born prematurely to untreated women with and without preeclam

278 s to ensure that dormant transcripts are not prematurely translated: a transcript with a short poly(A

279 s effectively remove saccadic inhibition and prematurely trigger impending saccades in reaction time

280 Prematurely truncated transcripts also occur at Polr1a,

281 The um18 mutation prematurely truncated Vegfc, blocking its secretion and

282 rdiac SCN5A mRNA splice variants that encode prematurely truncated, nonfunctional Na(+) channels.

283 rs Ca(2+) too early in the cardiac cycle and prematurely truncates sarcomere shortening in the facili

284 eoside reverse transcriptase inhibitors were prematurely unblinded in the high viral load stratum; an

285 e might reduce crop yield when it is induced prematurely under adverse environmental conditions.

286 Females who enter menopause prematurely via bilateral ovariectomy (surgical menopaus

287 y of each craniofacial articulation to close prematurely, we used a network model of the skull to qua

288 Without Ndj1, meiotic SPBs lost cohesion prematurely, whereas overproduction of Ndj1 delayed SPB

289 g the mismatched base or switching templates prematurely, while AZT(R) RT primarily misaligned the pr

290 AZ levels are reduced, shedding takes place prematurely, while if they are enhanced, organ loss is d

291 mino-terminal EF-hands activates proteolysis prematurely, while residues in cytoplasmic loops connect

292 Children born prematurely who develop retinopathy of prematurity (ROP)

293 luded 38,055 otherwise healthy children born prematurely who were enrolled for more than 6 months in

294 The patient was born prematurely with a gestation age of 27 weeks and a body

295 hat in UGT1-deficient cells, CD1d associates prematurely with beta2-microglobulin (beta2m) and is abl

296 cophenolate mofetil than on cyclophosphamide prematurely withdrew from study drug (20 vs 32) or met p

297 the activation signal; mutant sperm activate prematurely without an activation signal in males, and m

298 Impulsivity is the tendency to act prematurely without foresight.

299 A randomized phase III trial ended prematurely, without a definitive conclusion regarding T

300 cer have been underpowered and/or terminated prematurely, yielding inconsistent results and creating