ライフサイエンスコーパス: premorbid

1 was significantly predicted by high verbal (premorbid) abilities (beta = 0.40; hazard ratio [HR], 1.

2 The results suggest that higher levels of premorbid ability are associated with greater pathophysi

3 se to test the effect of differing levels of premorbid ability on neurophysiological dysfunction.

4 It has been hypothesized that premorbid ability, as measured by educational experience

5 lications were assessed without knowledge of premorbid abnormalities and were compared in the patient

6 otic drug use showed that patients with poor premorbid adaptation to school and premorbid social with

7 is (t=-0.86, p=0.031, CI -1.65 to -0.08) and premorbid adjustment (t=-2.26, p=0.017, CI -4.11 to -0.4

8 dinal cohort assessed premorbid delinquency (premorbid adjustment adaptation subscale across childhoo

9 ems, physical disorders in infancy, and poor premorbid adjustment in childhood and adolescence appear

10 he authors examined the relationship between premorbid adjustment in schizophrenia and event-related

11 Worse premorbid adjustment in the schizophrenic patients was s

12 Premorbid adjustment may predict the severity of specifi

13 Worse Premorbid Adjustment Scale scores were significantly ass

14 nterview for DSM-III-R--Patient Version, the Premorbid Adjustment Scale, and a semistructured intervi

15 ed from inpatients with schizophrenia on the Premorbid Adjustment Scale.

16 and objective data to score the Cannon-Spoor Premorbid Adjustment Scale.

17 Specifically, gender, premorbid adjustment, and clinical symptoms were examine

18 a high rate of birth complications and poor premorbid adjustment, appear to be associated with funct

19 iods of untreated psychosis and prodrome and premorbid adjustment.

20 between DUP and outcome was not explained by premorbid adjustment.

21 Of 653 consecutive eligible patients, premorbid and acute-phase blood pressure readings were a

22 E is complicated by the presence of multiple premorbid and comorbid factors affecting cognitive reser

23 lthy control subjects to examine patterns of premorbid and current intellect (measured by means of re

24 of schizophrenia have been defined based on premorbid and current IQ, but little is known about the

25 rential relationships of these measures with premorbid and present function and with clinical course

26 both prepsychotic developmental abnormality (Premorbid Assessment Scale, P = .06) and Brief Psychiatr

27 These included the known (premorbid) B(m) (WD(2)), a proposed correction for unkno

28 ed admission glycated hemoglobin to estimate premorbid baseline blood glucose concentration.

29 asurement of plasma Abeta may be useful as a premorbid biomarker for AD.

30 Premorbid blood pressure (total readings 13,244) had bee

31 ral haemorrhage, we compared acute-phase and premorbid blood pressure levels in these two disorders.

32 Premorbid blood pressure was higher in patients with typ

33 However, the role of premorbid BMI in the development of ALS and survival aft

34 Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range f

35 f independent positive associations of a low premorbid body mass index and a high fat intake together

36 s transgenic for SOD1 and earlier reports on premorbid body mass index support a role for increased r

37 In this study we investigated the impact of premorbid brain microstructural integrity, as measured b

38 nistering in vivo neutralizing Ab to PD-1 to premorbid BWF(1) and healthy control mice.

39 Premorbid, clinical, prenatal, perinatal, and magnetic r

40 the time of the event, after adjustment for premorbid cognition but MI hospitalization was not.

41 neural substrate for the association between premorbid cognition, as measured by general cognitive pe

42 How do joint measures of premorbid cognitive ability and familial cognitive aptit

43 l-Hill Vocabulary Scale was used to estimate premorbid cognitive ability.

44 Do all premorbid cognitive deficits follow the same course?

45 Premorbid cognitive deficits in schizophrenia are well d

46 Are premorbid cognitive deficits specific to schizophrenia o

47 s associated with prenatal brain insults and premorbid cognitive deficits, we tested the a priori hyp

48 e following three unresolved questions about premorbid cognitive deficits: What is their developmenta

49 as to investigate the longitudinal course of premorbid cognitive functioning in individuals with schi

50 nding variables, such as estimated levels of premorbid cognitive functioning, and for use of alcohol

51 Studies suggest the presence of premorbid cognitive impairment in patients with schizoph

52 These two premorbid cognitive patterns were not observed in childr

53 mechanical ventilation and supportive care, premorbid condition is the most important determinant of

54 the esophagoscope confirmed that GERD was a premorbid condition.

55 ome 32 days later with a status close to his premorbid condition.

56 Patients with premorbid conditions (eg, previous head injury, learning

57 istic regression was performed to adjust for premorbid conditions and presentation physiology.

58 To evaluate premorbid conditions and sociodemographic characteristic

59 nd critical illnesses is strongly related to premorbid conditions: the strength of the mucosal barrie

60 itories and multiple treatable risk factors, premorbid control is poor.

61 bjects with schizophrenia showed significant premorbid deficits on all intellectual and behavioral me

62 e concerning issues of intellectual decline, premorbid deficits, a modal deficit pattern, and preserv

63 Midlands) Study longitudinal cohort assessed premorbid delinquency (premorbid adjustment adaptation s

64 Stable high premorbid delinquency from childhood onwards appears to

65 d high (odds ratio, 3.53; 95% CI, 1.85-6.73) premorbid delinquency trajectories increased the risk fo

66 Group trajectories of premorbid delinquency were estimated using latent class

67 Four groups of premorbid delinquency were identified: stable low, adole

68 e view of schizophrenic men as having poorer premorbid development, earlier age at onset, and worse o

69 Premorbid developmental impairments are common in childh

70 Lower performance IQ and more pronounced premorbid developmental impairments were seen in this su

71 n areas 9 and 46) from 19 individuals with a premorbid diagnosis of SZ and 33 control individuals.

72 and unique potential drug targets, determine premorbid diagnosis, predict drug responsiveness for ind

73 ral sclerosis (ALS), the association between premorbid dietary intake and the risk of sporadic ALS wi

74 zations by demographics, comorbidity burden, premorbid disability, hospitalization length, and intens

75 were developed controlling for education and premorbid disability.

76 related significantly and independently with premorbid educational achievement, cognitive symptoms, g

77 dherence) and time-invariant (eg, genetic or premorbid environment) unobserved confounders revealed t

78 d with frequency-matched control subjects on premorbid factors in the immediate (0-6 months), interme

79 Our findings indicate that treatment of premorbid female NZB/NZW mice with DMPA reduces mortalit

80 he MMN deficits are independently related to premorbid function and illness duration, suggesting inde

81 aluate the incidence and time to recovery of premorbid function within 6 months of a critical illness

82 Premorbid function, symptom, and global outcome measures

83 Low socioeconomic status, poor premorbid function, treatment noncompliance, and substan

84 ciated with functional recovery, as was good premorbid function.

85 ferentially reduced in individuals with poor premorbid function.

86 grades, provides evidence for deteriorating premorbid functional adjustment in schizophrenia.

87 Marital status, premorbid functional status, clinical service (neurology

88 n individual domains and clinical variables (premorbid functioning and negative domain; absence of re

89 ms, but GM volume was associated with better premorbid functioning in women (r, 0.36-0.51).

90 The premorbid functioning of these subjects was compared to

91 roke (n=432) and MI (n=450), controlling for premorbid functioning using fixed-effects regression.

92 Remission may reflect a return to premorbid functioning, consistent with neurodevelopmenta

93 izophrenia versus schizoaffective disorder), premorbid functioning, duration of psychotic symptoms pr

94 l volume in women was associated with poorer premorbid functioning, more severe negative symptoms, an

95 rked improvement in symptoms and a return to premorbid functioning, now more than 2.5 and 4.5 years a

96 erences are small relative to differences in premorbid functioning, particularly those associated wit

97 ted problems, physical disorders in infancy, premorbid functioning, presence of mixed episodes and ra

98 n samples with first-episode psychosis, poor premorbid functioning, stable negative symptoms and impa

99 een untreated initial psychosis duration and premorbid functioning.

100 Transcriptome analysis of premorbid genetic risk identified the enrichment terms m

101 uated whether ESLD death was associated with premorbid HCV RNA level or specific HCV protein antibodi

102 come are factors such advanced age; impaired premorbid health status, especially diabetes and high bo

103 Older age at injury, a premorbid history of brain illness or physical disabilit

104 eimer's disease (the majority of whom had no premorbid history of major depression), common emergence

105 Activation of macrophages from premorbid HLA-B27 transgenic rats with IFN-gamma increas

106 In multivariate analysis, patients with premorbid HTN had a higher risk of in-hospital aneurysm

107 Premorbid HTN is associated with increased severity of t

108 We aimed to assess the impact of premorbid HTN on the severity of initial bleeding and th

109 Patients with premorbid HTN presented more frequently as Hunt-Hess Gra

110 consecutive patients with SAH; 643 (49%) had premorbid HTN.

111 of intracerebral haemorrhage associated with premorbid hypertension (blood pressure >or=160/100 mm Hg

112 case fatality, but also the association with premorbid hypertension.

113 Premorbid illness, neurological features, treatment with

114 hrenia, including (1) genetic, prenatal, and premorbid immune risk factors and (2) immune markers acr

115 rate of gray matter reduction was related to premorbid impairment and baseline severity of clinical s

116 The rate of reduction was related to premorbid impairment and baseline symptom severity, but

117 caine addicts may, in part, be determined by premorbid influences.

118 We studied the premorbid intake of nutrients in association with the ri

119 lues reported as odds ratio (95% CI), higher premorbid intake of total fat (1.14; 1.07-1.23; P < .001

120 tients (23%) with consistently low estimated premorbid intellect and current intellectual levels who

121 Premorbid intellectual ability was assessed by a demogra

122 ics and dementia severity, both estimates of premorbid intellectual ability were inversely correlated

123 ession of dementia in Alzheimer's disease is premorbid intellectual ability.

124 vestigated the relation between estimates of premorbid intellectual function and cerebral glucose met

125 tients (25%) who displayed average estimated premorbid intellectual levels did not show IQ decline an

126 The premorbid intellectual, language, and behavioral functio

127 There was no association between premorbid intelligence and treatment preferences.

128 , it is not clear whether this below-average premorbid intelligence is stable or progressive.

129 a group of controls (matched on age, sex and premorbid intelligence quotient), the patients showed de

130 se), and baseline demographics and estimated premorbid intelligence quotient, non-HIV-related comorbi

131 mines the influence of cognitive impairment, premorbid intelligence, and decision-making capacity to

132 differences in a measure thought to reflect premorbid intelligence, Wide Range Achievement Test 3 re

133 parental socioeconomic status, and estimated premorbid intelligence.

134 education, occupational level, and estimated premorbid intelligence.

135 However, tests of the association between premorbid IQ and adult mental disorders other than schiz

136 compared with nonalcoholics, despite similar premorbid IQ and education.

137 cluster analysis on the basis of current and premorbid IQ differences.

138 w was to provide an updated meta-analysis of premorbid IQ in individuals who later develop schizophre

139 ast quantitative review of the literature on premorbid IQ in schizophrenia was published more than tw

140 There was no association between premorbid IQ score and risk of bipolar disorder.

141 or population-based, longitudinal studies of premorbid IQ score and risk of developing severe depress

142 Despite within-normal-range premorbid IQ scores, apparently healthy adolescents who

143 After adjustment for age, age at onset, and premorbid IQ, male chronic patients performed worse than

144 rated a reliable, medium-sized impairment in premorbid IQ.

145 nt of psychotic symptoms and (iii) decreased premorbid IQ.

146 ctive studies are needed to evaluate whether premorbid iron levels are increased in individuals who d

147 Premorbid language, motor, and social impairments were a

148 6-2.6) or in the number of ADLs recovered to premorbid level (difference, 0.09 ADL; 95% CI, -0.27-0.4

149 gher premorbid level of openness and a lower premorbid level of agreeableness.

150 n relative to men and in those with a higher premorbid level of openness and a lower premorbid level

151 0 mm Hg higher, on average, than the maximum premorbid level whereas that after ischaemic stroke was

152 vels (increase of 10.6 mm Hg vs 10-year mean premorbid level), and decreased only slightly during the

153 e is much closer to the accustomed long-term premorbid level, providing a potential explanation for w

154 Hg [37.4], p<0.0001), was little higher than premorbid levels (increase of 10.6 mm Hg vs 10-year mean

155 al haemorrhage was substantially higher than premorbid levels (mean increase of 40.7 mm Hg, p<0.0001)

156 is substantially raised compared with usual premorbid levels after intracerebral haemorrhage, wherea

157 cline of 10 points or greater from estimated premorbid levels also exhibited deficits of executive fu

158 e versus no impairment after controlling for premorbid levels of cognitive ability.

159 Premorbid lower limb dysfunction was associated with inc

160 Particularly in infants with premorbid lung function and inflammation, air pollution

161 10 mug/m(3) PM10 levels) and in infants with premorbid lung function.

162 Using premorbid magnetic resonance images, brain regions from

163 sis suggest that childhood enuresis may be a premorbid marker for neurodevelopmental abnormalities re

164 re is comparatively little information about premorbid maturational brain abnormalities in schizophre

165 m cognitive impairment but have not included premorbid measures of cognitive functioning and have not

166 ce and evaluate associations with a range of premorbid medical conditions for chronic rhinosinusitis

167 s, together with associated risk factors and premorbid medications.

168 All athletes reported no premorbid mood disorders, anxiety disorders, substance a

169 The boys had more premorbid motor abnormalities, but early language and so

170 Within this context, premorbid movement abnormalities are of particular inter

171 Scale score, history of atrial fibrillation, premorbid mRS score, and stroke parent artery status, th

172 teral activations basically overlapping with premorbid naming networks observed in healthy subjects.

173 As both premorbid neurodevelopmental impairments and familial ri

174 Few studies have addressed the premorbid neuropsychological alterations in subjects at

175 the observation of minor physical anomalies, premorbid neuropsychological and social deficits, obstet

176 ies of childhood sexual abuse (36.4%, n=12), premorbid non-dissociative mental illness (81.1%, n=27)

177 ematous weight loss of more than 7.5% of the premorbid normal weight occurs over a time period of mor

178 le score </=8), and functional (regaining of premorbid occupational and residential status).

179 were initial mood-congruent psychosis, lower premorbid occupational status, and initial manic present

180 The 6-OPRI group had lower premorbid optimal levels of functioning (assessed on the

181 ations were observed between visual ERPs and premorbid or global outcome measures or illness duration

182 D2 receptor densities in drug users, whether premorbid or the consequence of substance misuse, imply

183 High rates of premorbid overweight and higher BMIs at various stages o

184 sence of a relative decline in IQ during the premorbid period in individuals with schizophrenia.

185 ors compared the patterns and specificity of premorbid personality dimensions in first-episode schizo

186 Premorbid personality may reflect subtle changes in cere

187 d 2) determine the feasibility of extracting premorbid physical activity (step and global position sy

188 Obtaining premorbid physical activity data from the current-genera

189 ators, including 1) familial aggregation, 2) premorbid presence, 3) syndromal specificity, 4) trait s

190 o are given a diagnosis of CRS have a higher premorbid prevalence of anxiety, headaches, gastroesopha

191 Patients with CRSsNP had a higher premorbid prevalence of infections of the upper and lowe

192 contrast, mood disorders were predicted by a premorbid psychiatric history (2.3 [1.4-3.9]), an emotio

193 Inclusion criteria were 1) premorbid psychometric measures of IQ in subjects who we

194 r to what extent this relationship is due to premorbid psychosis among people who use the drug.

195 In contrast, macrophages derived from premorbid rats do not exhibit a strong UPR or evidence o

196 ding below eighth grade level despite intact premorbid reading ability.

197 hase post-event blood pressure readings with premorbid readings from 10-year primary care records in

198 Outcomes were adjusted for premorbid residence and function, caregiver availability

199 Finding predisposition genes may improve premorbid risk assessment, genetic counseling, and manag

200 owever, whether exaggerated impulsivity is a premorbid risk factor or a consequence of alcohol intake

201 study aims to investigate the prevalence of premorbid risk factors and comorbid diseases and its ass

202 The prevalence of premorbid risk factors and comorbid diseases was signifi

203 Premorbid risk factors and comorbid diseases were more p

204 Comparison of premorbid risk factors revealed substantial reductions i

205 reventive treatments and major reductions in premorbid risk factors.

206 of the empirically derived trajectories with premorbid social adjustment, diagnosis, and 20-year outc

207 e no other significant relationships between premorbid social or motor abnormalities and the risk fac

208 There was anecdotal evidence of low premorbid social performance in the 6-OPRI but not P102L

209 with poor premorbid adaptation to school and premorbid social withdrawal relapsed earlier.

210 The patients with premorbid speech and language impairments had higher fam

211 ations) were increased for the probands with premorbid speech and language impairments, suggesting th

212 cardinal feature of the progression from the premorbid stage to the chronic form of schizophrenia, fe

213 s use early (i.e., before age 17 years) show premorbid structural abnormalities in the amygdala, hipp

214 ricular dysfunction, and clinical history of premorbid symptoms.

215 IQ measure, sample ascertainment, and age at premorbid testing, contributed minimally to the effect s

216 here was no evidence of negative change from premorbid to postmorbid assessment in any of the persona

217 chological decline in schizophrenia from the premorbid to the postonset period, but the extent and de

218 This vulnerability could be either a premorbid trait marker of the disorder or an acquired co

219 ence of malnutrition and unlikely to reflect premorbid trait markers or permanent scars, but longitud

220 As a premorbid trait, vulnerability to unpredictability could

221 istic, and anxious personality styles may be premorbid traits that contribute to this pathogenesis.

222 AN and BN tend to have premorbid traits, such as perfectionism and anxiety that

223 via messenger RNA sequencing to identify the premorbid transcriptome and the binge-induced transcript

224 tolic blood pressures and major increases in premorbid treatment with antiplatelet, lipid-lowering, a

225 chaemic attack and stroke, risk factors, and premorbid use of preventive treatments from 1981-84 (Oxf

226 ggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in

227 accounting for half or more of the presumed premorbid volume, was unlikely to have contained domain-

228 whether heightened amygdala reactivity is a premorbid vulnerability or a consequence of the disorder

229 These may either represent premorbid vulnerability or a plasticity phenomenon relat

230 e role of the superior temporal gyrus in the premorbid vulnerability to schizophrenia.

231 ment between patients and surrogates for all premorbid walking metrics (mean bias 108% [99% lower to