ライフサイエンスコーパス: prenyl

1 ither wild-type or abz1 mutant yeast to form prenyl-[(13)C(6)]pABA.

2 is of the enol ether afforded methyl 6-oxo-1-prenyl-2-cyclohexenecarboxylate.

3 The common precursor 1-methoxy-2-prenyl-3-carbomethoxycarbazole was synthesized from dime

4 a novel novobiocin analogue, in which the 3-prenyl-4-hydroxybenzoate of novobiocin is replaced with

5 ophosphate (FPP) to their protein or peptide prenyl acceptor substrates.

6 rotein to react with C2,3 double bond in the prenyl acceptor to form PSPP, with the lower two-thirds

7 Mimetics of the C-terminal tetrapeptide of prenyl acceptors have been previously shown to inhibit m

8 tool, 38 potential substrates were tested as prenyl acceptors in assays with three prenyltransferases

9 This study indicates that certain prenyl alcohol analogues can act as prenyltransferase in

10 xidizes farnesol more efficiently than other prenyl alcohol substrates.

11 Substitution of different prenyl anchors on Rab GTPases does not lead to correct f

12 Enzymatic prenyl and glycosyl transfer are seemingly unrelated rea

13 MTPT to protect linear peptides by attaching prenyl and methyl groups at their free N- and C-termini.

14 d monolayer lipoprotein particles containing prenyl and neutral lipids and several dozen proteins mos

15 ro, tertiary amino, and N-alkyl, N-benzyl, N-prenyl, and N-silyl tert-butyl carbamate groups were tol

16 The prenyl binding is enabled by a unique "loop-out" conform

17 d proteins is likely due to sequestration of prenyl binding protein delta (PrBPdelta) by ARL3-Q71L as

18 l organization of K-Ras is controlled by the prenyl binding protein PDEdelta, which enhances Ras diff

19 The mouse Pde6d gene encodes a ubiquitous prenyl binding protein, termed PrBP/delta, of largely un

20 pocket and renders the protein incapable of prenyl binding, is supported by molecular dynamics simul

21 We developed a prenyl-binding assay and show that RabGGTase has a preny

22 n the domain suggested to form a hydrophobic prenyl-binding pocket for the gamma subunit's prenyl gro

23 novel, unrelated chemotype that binds to the prenyl-binding pocket of PDEdelta with high affinity, th

24 t the small-molecule Deltarasin binds to the prenyl-binding pocket of PDEdelta, and impairs Ras enric

25 se (PDEdelta), which possesses a hydrophobic prenyl-binding pocket, is able to function as a potentia

26 ereas soluble PDE6 is purified with a 17-kDa prenyl-binding protein (PDEdelta) tightly bound.

27 A structure of PDE6 in complex with prenyl-binding protein (PrBP/delta) indicated the locati

28 tions with its inhibitory gamma-subunit, the prenyl-binding protein (PrBP/delta), and activated trans

29 ctor of phosphodiesterase 6 Delta (PDE6D), a prenyl-binding protein and chaperone of prenylated prote

30 pha and PDE6beta and can form a complex with prenyl-binding protein delta (PrBP/delta), an isoprenyl-

31 ments establish that PDEdelta functions as a prenyl-binding protein interacting with multiple prenyla

32 The prenyl-binding protein PDEdelta is crucial for the plasm

33 lium through a motif near the C terminus and prenyl-binding protein phosphodiesterase 6D (PDE6D)-depe

34 prenylated substrate, whereas the homologous prenyl-binding protein PrBP/delta did not interact with

35 delta (delta subunit of phosphodiesterase; a prenyl-binding protein) and INPP5E (inositol polyphospha

36 Furthermore, the 17-kDa prenyl-binding protein, abundant in retinal cells, selec

37 protein prenyl transferases contain a single prenyl-binding site and suggests that RabGGTase transfer

38 finity technique for the characterization of prenyl-binding sites.

39 rolidine amide of 2-methoxybenzoic acid with prenyl bromide afforded (-)-vibralactone confirming the

40 alkylation of methyl 2-methoxybenzoate with prenyl bromide and hydrolysis of the enol ether afforded

41 h an arylcopper intermediate is reacted with prenyl bromide to afford a key intermediate that was con

42 -binding assay and show that RabGGTase has a prenyl carrier function similar to the CAAX prenyl trans

43 r prenyl pyrophosphate substrates, acting as prenyl carriers.

44 and arginine residues are non-equivalent and prenyl chain length modifies nascent polybasic domain li

45 biquinone-8 as well as quinones with shorter prenyl chains (ubiquinone-1 and ubiquinone-2).

46 ng blocks are stitched together by means of 'prenyl coupling', followed by enzymatically controlled m

47 AFC (a specific inhibitor of prenyl-cysteine carboxyl methyl transferases) blocked th

48 phan fluorescence of PDEdelta and dansylated prenyl cysteines as fluorescent ligands, we show that PD

49 The prenyl-dependent binding of Narf to prelamin A is an imp

50 approach to complex terpenes whereby simple prenyl-derived chains are cyclized using radical, rather

51 of downstream mevalonate products, including prenyl-derived lipids, and prevented membrane localizati

52 Herein it is shown that certain novel prenyl diphosphate analogues are potent inhibitors of ma

53 nes from the corresponding C10, C15, and C20 prenyl diphosphate precursors, and at the gene level by

54 rpenoid classes is the transformation of the prenyl diphosphate precursors, geranyl diphosphate, farn

55 S-e/f subfamily that utilize the unusual cis-prenyl diphosphate substrates neryl diphosphate and 2z,6

56 erestingly, LOS uses alternative C15 and C20 prenyl diphosphate substrates to produce combinatorial h

57 nylated in vitro with natural and nonnatural prenyl diphosphate substrates.

58 osphate is utilized by a membrane-associated prenyl diphosphate synthase activity to generate decapre

59 d functional characterization of a novel cis-prenyl diphosphate synthase cDNA, termed Lavandula x int

60 Rv1086 is a unique prenyl diphosphate synthase in that it adds only one iso

61 630 is the only Arabidopsis trans-long-chain prenyl diphosphate synthase that clusters with the Coq1

62 he product specificity of a trans-long-chain prenyl diphosphate synthase that elongates an allylic di

63 This is the first report of a bacterial Z-prenyl diphosphate synthase that preferentially utilizes

64 a dedicated type III polyketide synthase, a prenyl diphosphate synthase, and an aromatic prenyltrans

65 m tuberculosis H37Rv genome encodes a unique prenyl diphosphate synthase.

66 Z-prenyl diphosphate synthases catalyze the sequential con

67 The specific activities of the prenyl diphosphate synthases in M. tuberculosis are 10-

68 In Mycobacterium tuberculosis, two related Z-prenyl diphosphate synthases, E,Z-farnesyl diphosphate s

69 te is the allylic substrate for two distinct prenyl diphosphate synthases, one located in the cell me

70 20-carbon prenyl group, respectively, from a prenyl diphosphate to a cysteine residue at the carboxyl

71 processive manner to generate the 50-carbon prenyl diphosphate, which is then dephosphorylated to ge

72 PS genes in the Solanum cluster encoding cis-prenyl diphosphate-utilizing enzymes are closely related

73 ral conserved sequence motifs found in other prenyl-diphosphate synthases are present in both TgFPPSs

74 (C25) diphosphate (F113S), and longer chain prenyl diphosphates (F112A/F113S).

75 ions in substrate specificity to utilize cis-prenyl diphosphates and through the acquisition of CPT g

76 that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormo

77 te and dimethylallyl diphosphate to form C10 prenyl diphosphates that can be elongated by the additio

78 id biosynthesis is the conversion of acyclic prenyl diphosphates to terpenoid compounds by specific t

79 esis of monoterpenes and diterpenes from cis-prenyl diphosphates, substrates that are synthesized by

80 PFTase discriminates between FPP and larger prenyl diphosphates, we have examined the interactions b

81 atic substrates in the presence of different prenyl diphosphates.

82 tilizes 3,3-dimethylallyl pyrophosphate as a prenyl donor and prenylates resveratrol to form arachidi

83 sis, whereas phytyl diphosphate (PDP) is the prenyl donor for tocopherol synthesis.

84 Geranylgeranyl diphosphate (GGDP) is the prenyl donor for tocotrienol synthesis, whereas phytyl d

85 nant LaPT1 for the dimethylallyl diphosphate prenyl donor is in a similar range to that of other flav

86 ino acids surrounding the allyl group of the prenyl donor.

87 el use of an iodolactone to protect both the prenyl double bond and carboxylic acid, no protecting gr

88 ariety of acyclic or cyclic monoketones with prenyl ether-tethered aldehydes in the presence of 1,8-d

89 cpsE gene is likely to encode the phosphate-prenyl glycosyl-1-phosphate transferase catalyzing the f

90 is the covalent attachment of a hydrophobic prenyl group (either farnesyl or geranylgeranyl), which

91 , a dimer containing a gamma subunit with no prenyl group (gamma(2)-C68S) decreased binding by nearly

92 renyl-binding pocket for the gamma subunit's prenyl group (prenyl pocket mutants) and the other set i

93 The method utilizes simple chemistry on the prenyl group and cleavable properties of a sulfoxide gro

94 The CAAX isoform contains a C-terminal prenyl group and is tightly bound to endoplasmic reticul

95 eraction between the G protein gamma subunit prenyl group and PLCbeta isozymes.

96 the tail is not simply a linker between the prenyl group and the protein but that it also provides a

97 nction is independent of the identity of the prenyl group and, therefore, that FTI inhibition of K-Ra

98 both a hydrophilic cofactor and a lipophilic prenyl group attached to a polar protein substrate.

99 the penetratin vehicle and the nature of the prenyl group attached.

100 prenyltransferases (PTases) responsible for prenyl group attachment have only recently been isolated

101 structurally reminiscent of the binding of a prenyl group by a regulatory protein, the Rho guanine nu

102 The precise amino acid sequence and prenyl group define a combinatorial code for lipid bindi

103 ts support the structural model in which the prenyl group escapes contact with the aqueous milieu by

104 ase I (GGTase I) catalyzes the transfer of a prenyl group from geranylgeranyl diphosphate to the carb

105 product bearing different placements of the prenyl group in the A-ring have shown selectivity for ei

106 to the incorporation of a prenyl or reverse-prenyl group into a bicyclo[2.2.2]diazaoctane framework,

107 presumably with insertion of the C-terminal prenyl group into the membrane.

108 a-receptor interactions, suggesting that the prenyl group is an important domain in the beta gamma di

109 e that a major function of the gamma subunit prenyl group is to facilitate direct protein-protein int

110 the composition of the gamma subunit and its prenyl group markedly affects the ability of the betagam

111 Furthermore, the nature of the prenyl group on Ggamma may play an important role in the

112 The prenyl group on the G protein gamma subunit is an import

113 The role of the prenyl group on the gamma subunit in determining the act

114 These data suggest that the prenyl group on the gamma subunit is an important determ

115 o acid sequence of the gamma subunit and its prenyl group play a role in determining the activity of

116 We have determined the specific prenyl group present on the beta1gamma1, beta1gamma2, an

117 ues that play a dominant role in determining prenyl group specificity.

118 din-2, whereas another, AhR3'DT-1, added the prenyl group to C-3' of resveratrol.

119 a phenol to the terminal olefin of a reverse prenyl group to give a dihydrobenzofuran product.

120 Furthermore, the position of the prenyl group within the phenolic skeleton also influence

121 talyze the transfer of a 15- and a 20-carbon prenyl group, respectively, from a prenyl diphosphate to

122 cPLA2gamma contains a prenyl group-binding site motif and appears to be largel

123 s through membrane insertion of a C-terminal prenyl group.

124 the hydrophobicity of the palmitate and the prenyl groups and the spacing between them.

125 Switching prenyl groups from farnesyl to geranylgeranyl or vice ve

126 translational modification with myristoyl or prenyl groups is essential for membrane association of m

127 was used to examine the effect of different prenyl groups on the gamma subunits in the activation of

128 Prenylation is the addition of prenyl groups to peptide chains or metabolites via the c

129 ral basis for the successive addition of two prenyl groups to Rab proteins by the homologous enzyme g

130 bsence of statins and subsequent cleavage of prenyl groups with Raney nickel revealed that the enzyme

131 ltered to direct modification with different prenyl groups, recombinant betagamma dimers expressed in

132 In contrast, prenyl groups, which are as hydrophobic as acyl chains b

133 y mevinolin, which inhibits the synthesis of prenyl groups.

134 anchored to the membrane through C-terminal prenyl groups.

135 ltered to direct modification with different prenyl groups.

136 es their post-translational modifications by prenyl groups.

137 Two "reverse prenyl" hexahydropyrroloindole alkaloids, 5-N-acetylarde

138 his study we have identified new halogenated prenyl-indole alkaloids from an invertebrate-derived Mal

139 ein-protein interactions rather than protein-prenyl interactions.

140 rfamily catalyze the attachment of prenyl or prenyl-like moieties to diverse acceptor compounds.

141 V virion assembly is critically dependent on prenyl lipid modification, or prenylation, of its nucleo

142 carotenoid formation and the channelling of prenyl lipid precursors in tomato (and its potential man

143 o the inner membrane provides access for the prenyl lipid substrate.

144 Isolated PGs from k1 k3 showed a modified prenyl-lipid composition, suggesting reduced activity of

145 C1K1/3 complex contributes to PG function in prenyl-lipid metabolism, stress response, and thylakoid

146 is reversible and mediated by the polybasic-prenyl membrane targeting motif of KRas.

147 ctive palladium(0)-catalyzed decarboxylative prenyl migration and aromatization sequence as the key s

148 alter the position of the post-translational prenyl modification at the C terminus of the gamma subun

149 To determine the role of the prenyl modification in the interaction of beta gamma dim

150 To determine the role of the gamma subunit prenyl modification in this interaction, the CaaX motifs

151 Prenyl modification of the gamma subunit is necessary fo

152 s in living cells revealed that acyl but not prenyl modifications promote clustering in lipid rafts.

153 isoprenoid compounds involve transfer of the prenyl moiety in allylic diphosphates to electron-rich (

154 synthetic pathways, we demonstrated that the prenyl moiety on the prenylated stilbenoids derives from

155 ion energy, indicating direct binding of the prenyl moiety to PLCbeta.

156 d menaquinones, both containing an essential prenyl moiety, are key electron carriers in respiratory

157 We conclude that the polybasic-prenyl motif acts as a Ca2+/CaM-regulated molecular swit

158 ccurs through sequestration of the polybasic-prenyl motif by Ca2+/calmodulin (Ca2+/CaM) and subsequen

159 using prenylated peptides which mimicked the prenyl motifs in the proteins.

160 P-MurNAc-pentapeptide (Park's nucleotide) to prenyl-MurNAc-pentapeptide (lipid I), the first membrane

161 MATS) superfamily catalyze the attachment of prenyl or prenyl-like moieties to diverse acceptor compo

162 equences that lead to the incorporation of a prenyl or reverse-prenyl group into a bicyclo[2.2.2]diaz

163 f oxindoles to afford selectively either the prenyl or reverse-prenyl product has been demonstrated.

164 lse-labeling analyses show that formation of prenyl-pABA occurs within minutes and precedes the synth

165 A hexaprenylated form of pABA (prenyl-pABA) is normally present in wild-type yeast crud

166 activity was also exquisitely sensitive to a prenyl peptide analogue that had been previously describ

167 We recently identified a prenyl peptide-binding protein in microsomal membranes f

168 inability of a 15-C FPP to displace the 20-C prenyl-peptide product.

169 mino group; N-acetylated prenylcysteines and prenyl peptides are not substrates.

170 Prenyl peptides bind to purified tubulin with a Kd of 40

171 of the minimum structure requirement of the prenyl phosphate in the MraY/MurX-catalyzed lipid I anal

172 is the first bacterium reported to utilize a prenyl phosphate other than undecaprenyl phosphate as th

173 f IL-15, a T cell growth factor, to modulate prenyl phosphate-induced gamma delta T cell proliferatio

174 particular a class of compounds known as the prenyl phosphates.

175 nge (beta), and residues lining the proposed prenyl pocket (beta).

176 n order to accurately predict the effects of prenyl pocket amino acid substitutions.

177 ith the aqueous milieu by inserting into the prenyl pocket and stabilizing the Pdc-binding conformati

178 substitution of certain residues within the prenyl pocket caused only minor decreases in binding, wh

179 sertion of the geranylgeranyl group into the prenyl pocket in order to accurately predict the effects

180 The prenyl pocket mutants expressed with gamma(2) were 10-fo

181 pocket for the gamma subunit's prenyl group (prenyl pocket mutants) and the other set in a domain bet

182 ord selectively either the prenyl or reverse-prenyl product has been demonstrated.

183 ucted to show how the growth of a long chain prenyl product may proceed by creation of a hydrophobic

184 ously described as a potent inhibitor of the prenyl protease activity in mammalian tissues.

185 infected Sf9 cells exhibited a high level of prenyl protease activity.

186 domains of life, including the type II CAAX prenyl proteases and their prokaryotic homologs with put

187 tography of extracts from cells in which the prenyl protein pool was metabolically labeled revealed t

188 hasis in this review is on the enzymology of prenyl protein processing and the functional significanc

189 The additional modifications in the prenyl protein processing pathway also affected the inte

190 A putative prenyl protein protease in yeast, designated Rce1p, was

191 d by its sensitivity to RPI, an inhibitor of prenyl protein protease.

192 d the human RCE1 gene products are bona fide prenyl protein proteases and suggest that they play a ma

193 rt due to the ability of tubulin to bind the prenyl protein reaction product.

194 This enzymatic activity, termed prenyl protein-specific endoprotease (PPEP) activity, ha

195 reviously been shown to be recognized by any prenyl:protein transferase (PTase), but which most close

196 pool was metabolically labeled revealed that prenyl proteins bound to the immobilized microtubules; o

197 lying the presence of a pool of unmethylated prenyl proteins in these cells under normal conditions.

198 ing evidence that C-terminal modification of prenyl proteins, rather than being purely a constitutive

199 -nonreactive TCR abrogated reactivity to the prenyl pyrophosphate Ag isopentenyl pyrophosphate and to

200 1 chain from an Ag-nonreactive TCR yielded a prenyl pyrophosphate Ag-nonreactive TCR.

201 Human gamma delta T cells recognize prenyl pyrophosphate Ags and their analogues in a V gamm

202 uctural requirements for recognition of such prenyl pyrophosphate Ags by gamma delta T cells.

203 , we show that gamma delta TCR reactivity to prenyl pyrophosphate Ags is dependent upon the junctiona

204 to achieve stable association of nonpeptide prenyl pyrophosphate Ags with the presenting molecule.

205 acterial supernatant containing a mixture of prenyl pyrophosphate Ags.

206 junctional region sequences on reactivity to prenyl pyrophosphate Ags.

207 elta2 antigen receptors recognize nonpeptide prenyl pyrophosphate and alkylamine antigens.

208 was observed in response to stimulation with prenyl pyrophosphate antigens (isopentenyl pyrophosphate

209 T cells are stimulated by self- and foreign prenyl pyrophosphate intermediates in isoprenoid synthes

210 sponses to microbial pathogens by monitoring prenyl pyrophosphate isoprenoid metabolites.

211 These results show that prenyl pyrophosphate recognition is primarily by germlin

212 BTN3A1 proteins for their ability to mediate prenyl pyrophosphate stimulation of Vgamma2Vdelta2 T cel

213 philin (BTN)3A1 was shown to be required for prenyl pyrophosphate stimulation.

214 the enzymes form stable complexes with their prenyl pyrophosphate substrates, acting as prenyl carrie

215 delta T cells are stimulated when exposed to prenyl pyrophosphate, bisphosphonate, and alkylamine Ags

216 Thus, recognition of nonpeptide prenyl pyrophosphate, bisphosphonate, and alkylamine Ags

217 Although a prenyl pyrophosphate-binding site was defined by Lys109

218 ding V regions of the B30.2 domain abrogated prenyl pyrophosphate-induced proliferation.

219 did not preferentially bind a photoaffinity prenyl pyrophosphate.

220 of HMBPP, meta/para-benzophenone-(methylene)-prenyl pyrophosphates (m/p-BZ-(C)-C(5)-OPP), can crossli

221 Longer prenyl pyrophosphates also retained bioactivity.

222 amma2Vdelta2(+) T cells recognize nonpeptide prenyl pyrophosphates and alkylamines.

223 Several findings suggest that prenyl pyrophosphates are presented by an Ag-presenting

224 Thus, BTN3A1 is required for stimulation by prenyl pyrophosphates but does not bind the intermediate

225 se findings support intracellular sensing of prenyl pyrophosphates by BTN3A1 rather than extracellula

226 features that determine the antigenicity of prenyl pyrophosphates by testing synthetic analogs for b

227 quirements of TCR gamma delta recognition of prenyl pyrophosphates distinguish this reactivity from t

228 at the extracellular BTN3A1 IgV domain binds prenyl pyrophosphates, leading to the proposal that the

229 e intracellular B30.2 domain of BTN3A1 binds prenyl pyrophosphates, resulting in a change in the extr

230 ing Vgamma2Vdelta2 TCRs recognize nonpeptide prenyl pyrophosphates.

231 e existence of an Ag-presenting molecule for prenyl pyrophosphates.

232 g infections by recognizing small nonpeptide prenyl pyrophosphates.

233 (BTN3)/CD277 Ig superfamily proteins mimics prenyl pyrophosphates.

234 ive to statin inhibition than stimulation by prenyl pyrophosphates; however, the continuous presence

235 Prenyl Rab-GDI complexes contain all of the information

236 The late endosomal, prenyl Rab9 binds GDI with very high affinity, which led

237 of 4-hydroxy-3-prenylbenzoate with different prenyl side chain lengths.

238 n of the 7-hydroxyl group and removal of the prenyl side chain.

239 redox active benzoquinone ring attached to a prenyl side chain.

240 sion of prenylated proteins as measured with prenyl-specific antibody, and inhibits parasite differen

241 A prenyl substituent was incorporated at the C3 position o

242 The prenyl-substituted aryl ester of 3,5-dihydroxychroman-3-

243 yme could utilize solanesyl diphosphate, the prenyl substrate for plastoquinone-9 synthesis.

244 rmed by converting farnesyltransferase (15-C prenyl substrate) into GGTase-I (20-C prenyl substrate)

245 (15-C prenyl substrate) into GGTase-I (20-C prenyl substrate) with a single point mutation.

246 f the chiral catalyst and the stereoisomeric prenyl substrate, full control of the stereo- and enanti

247 lgeranyl transferase inhibitor GGTI-298, and prenyl substrates (farnesyl pyrophosphate [FPP] and gera

248 The biological role of prenyl substrates has made these reactions significant t

249 ture is similar to that of the bacterial cis-prenyl synthase, undecaprenyl diphosphate synthase (UPPS

250 nd structure-based mechanism of this unusual prenyl synthase.

251 Plasmodium falciparum using a library of 560 prenyl-synthase inhibitors.

252 etergent micelles, whereas that with a short prenyl tail (CoQ(1)) remains in solution.

253 simultaneously to the plasma membrane via a prenyl tail and to the E2 in planta.

254 .FPP.protein ternary complex for the ensuing prenyl transfer reaction.

255 tudies led us to propose a mechanism for the prenyl transfer reaction.

256 the five-carbon isoprene unit for subsequent prenyl transfer reactions.

257 reaction is limited by a step subsequent to prenyl transfer such as release of products from the enz

258 at are synthesized by enzymes encoded by cis-prenyl transferase (CPT) genes also located within the s

259 roblems in cellular isoprenoid metabolism or prenyl transferase activity were investigated, but none

260 The protein adopts the zeta or cis-prenyl transferase fold but remarkably, unlike tuberculo

261 Ad, and its crystal structure revealed a cis-prenyl transferase fold with hydrophobic residues for is

262 e critical structural properties determining prenyl transferase specificity and in metabolic engineer

263 e sensitivity to existing drugs, and the cis-prenyl transferase undecaprenyl diphosphate synthase (UP

264 prenylation of K-Ras by the closely related prenyl transferase, geranyl geranyl transferase I, and t

265 ns of the protein structure indicated that a prenyl-transferase domain and several transmembrane heli

266 erculosinol adenosine synthase and other cis-prenyl transferases (e.g. cis-farnesyl, decaprenyl, unde

267 as to the mechanism of action of many other prenyl transferases and may also be of use in engineerin

268 mechanism and inhibition of the head-to-head prenyl transferases and should aid future drug design.

269 s generated considerable interest in protein prenyl transferases as possible anticancer targets.

270 his study establishes that all three protein prenyl transferases contain a single prenyl-binding site

271 progress has been made in understanding how prenyl transferases distinguish between related target p

272 Previous characterization of CAAX prenyl transferases showed that the enzymes form stable

273 om C(5) precursors; the epsilon head-to-head prenyl transferases that convert these diphosphates into

274 terpene synthases; the zeta head-to-tail cis-prenyl transferases that produce the cis-isoprenoid diph

275 alphaalpha and alphadelta head-to-tail trans-prenyl transferases that produce trans-isoprenoid diphos

276 Small molecule inhibitors of prenyl transferases, enzymes that catalyze the post-tran

277 Three distinct protein prenyl transferases, one protein farnesyl transferase (F

278 ket distinguishes Rv3378c from classical cis-prenyl transferases, providing a unique model for the pr

279 prenyl carrier function similar to the CAAX prenyl transferases.

280 l-CoA, carbamoyl-P), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose)

281 This rearrangement may be conducted with prenyl-type selenosulfides to give isoprenyl alkyl sulfi

282 Lipid I isolated from Mtb contains the C50-prenyl unit that shows very poor water solubility; thus,

283 a noncanonical route to the construction of prenyl units and serves as a prototype for the intersect

284 hates, including those bearing repeating cis-prenyl units.