ライフサイエンスコーパス: prenylated

1 n X-114 partition revealed that this pool is prenylated.

2 protein gamma subunits, are predicted to be prenylated.

3 e 42), however, only associates with PS when prenylated.

4 nd RhoA do not bind to PS even when they are prenylated.

5 sting that this pool of VP22-Rab9 had become prenylated.

6 from purified virions does not appear to be prenylated.

7 TPase regulator and Arl2/Arl3, which are not prenylated.

8 cles, providing that Cdc42 was GTP-bound and prenylated.

9 and/or palmitoylated, and gamma subunits are prenylated.

10 The protein appears to be microsomal and prenylated.

11 C-terminal residue) are posttranslationally prenylated.

12 Both GCY-33 and GCY-35 are predicted to be prenylated.

13 S are not affected as they are alternatively prenylated.

14 is step that occurs during biogenesis of the prenylated a-factor mating pheromone.

15 rminal tripeptide from the CAAX motif of the prenylated a-factor precursor.

16 pecific preparation of the C-2, C-5, and C-6 prenylated A-ring regioisomers.

17 refers to the cysteine residue that becomes prenylated, "a" refers to any aliphatic amino acid, and

18 ole in nuclear lamin biology by cleaving the prenylated and carboxylmethylated 15-amino acid tail fro

19 orismate to 4-hydroxybenzoate, which is then prenylated and decarboxylated.

20 kade only occurred if the peptides were both prenylated and methylated.

21 partners and act as displacement factors for prenylated and myristoylated cargo.

22 and SmgGDS-558 use to differentiate between prenylated and nonprenylated GTPases has not been charac

23 Prenylated and palmitoylated brain Cdc42 did not interac

24 equence influence whether the protein can be prenylated and proteolyzed.

25 Our approach to the preparation of these prenylated and reverse-prenylated indole alkaloids is bi

26 The resulting prenylated and reverse-prenylated products were transfor

27 RhoGDI with the active and inactive forms of prenylated and unprenylated RhoA.

28 s (Arabidopsis thaliana), AGG1 and AGG2, are prenylated, and AGG2 is S-acylated.

29 involved in signal transduction pathways are prenylated, and inhibition of prenylation can be useful

30 d a key intermediate that was converted to a prenylated aromatic aldehyde.

31 iological activities distinct from their non-prenylated aromatic precursors.

32 found that Drosophila Ras1 is inefficiently prenylated as a consequence of a lysine in the A(1) posi

33 neral belief that PBR-possessing GTPases are prenylated as soon as they are synthesized.

34 Rab13, Ras, Rap, and Rho6, all of which are prenylated, as well as the N-terminal portion of retinit

35 nylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, wher

36 ationships were investigated surrounding the prenylated benzamide side chain of the natural product.

37 on plants containing high concentrations of prenylated benzoic acid.

38 f beta(1)gamma dimers for Galpha(t), the non-prenylated beta(1)gamma(2) dimer had significantly dimin

39 Prenylated betagamma subunits were excluded from rafts,

40 the yeast a-factor mating pheromone) and non-prenylated biological peptides (Abeta and insulin chains

41 2 was examined by fluorescence spectroscopy, prenylated but not unprenylated peptide increased PLCbet

42 In the dual lipidation pathway, bCdc42 was prenylated, but it bypassed proteolysis and carboxymethy

43 These results indicate that Cx32 is prenylated, but that prenylation is not required for pro

44 ggest that the tryptophan residue is reverse prenylated by CymD prior to release of the cyclic peptid

45 Both can be prenylated by either protein geranylgeranyltransferase I

46 mily, containing a C-terminal CAAX motif are prenylated by farnesyltransferase to facilitate localiza

47 that Cdc42p and Rho1p of C. albicans can be prenylated by FTase when GGTase I is absent or limiting

48 treatment with FTIs, they are alternatively prenylated by geranylgeranyl transferase-1.

49 with a CLLL motif permits this protein to be prenylated by geranylgeranyltransferase I but not II bot

50 All nascent Rab proteins are prenylated by geranylgeranyltransferase II, which recogn

51 ptide N-dansyl-GCVLL was first enzymatically prenylated by human PGGTase-I with either (S)-[1-(2)H]fa

52 tion of the delta subunit is the methylated, prenylated C-terminus of the phosphodiesterase catalytic

53 ty of yRce1p was determined for a variety of prenylated CaaX peptides including farnesylated and gera

54 Thus, prenylated CAAX proteins do not associate directly with

55 broad role for this gene in processing other prenylated CAAX proteins.

56 ither a polybasic domain or an alternatively prenylated CAAX renders Ras prenylation, Ras-induced Elk

57 rough a conical cavity that accommodates the prenylated CAAX substrate.

58 Prenylated CaM53 associates with the plasma membrane, bu

59 odiesterase (PDE) and shown to interact with prenylated, carboxymethylated C-terminal Cys residues.

60 The alternative processing of prenylated CCaX motif proteins by palmitoylation or by e

61 lel in vitro assays, we demonstrate that the prenylated cellular GTPase Cdc42 is necessary and suffic

62 Xanthohumol (XN), a prenylated chalcone isolated from hop plant, exhibits an

63 imum inhibitory concentration of 10microg/ml prenylated compounds, followed by cPta pool (25microg/ml

64 ore, has the capacity to generate a range of prenylated compounds.

65 o IRS-1-mediated signaling, we constructed a prenylated, constitutively membrane-bound IRS-1 by addin

66 or essential oil constituents (monoterpenes, prenylated coumarins, and polymethoxylated flavonoids).

67 prenylated stilbenoids (cSti), one in chain prenylated (cPta) and one in ring-closed prenylated pter

68 ersity of cyanobactins to include tryptophan-prenylated cyclic peptides.

69 and that both palmitoylated cysteine 192 and prenylated cysteine 193, but not palmitoylated cysteine

70 is tethered to cellular membranes through a prenylated cysteine in a flexible C-terminal region; how

71 onstrate that YopT cleaves N-terminal to the prenylated cysteine in RhoA, Rac, and Cdc42 and that the

72 X tripeptide and methylation of the carboxyl-prenylated cysteine residue.

73 rboxymethylation of the resultant C-terminal prenylated cysteine.

74 s substrate as well and converted it to an O-prenylated derivative.

75 After HPLC purification, the prenylated dipeptide products were analyzed by (1)H NMR

76 The recombinant AtGGT-I prenylated efficiently CaaL box fusion proteins in which

77 Rabs are thought of as independent, prenylated entities that reside either on membranes or i

78 nd unsaturated aliphatic acids and utilize a prenylated flavin mononucleotide (prFMN) as cofactor, bo

79 ylic acid using a newly identified cofactor, prenylated flavin mononucleotide (prFMN).

80 d that it requires a new type of cofactor: a prenylated flavin synthesized by the associated UbiX/Pad

81 -obesity mechanism(s) of xanthohumol (XN), a prenylated flavonoid from hops.

82 Prenylated flavonoids and isoflavonoids possess antimicr

83 bolites that changed during storage included prenylated flavonoids, purines, and peptides, and all sh

84 d that AroY utilizes the recently discovered prenylated FMN (prFMN) cofactor, and requires oxidative

85 le decarboxylase enzyme Fdc1 is dependent on prenylated FMN (prFMN), a recently discovered cofactor.

86 decarboxylase enzyme that requires the novel prenylated FMN cofactor for activity.

87 We demonstrate that RhoGDI binds the prenylated form of RhoA.GDP with unexpectedly high affin

88 MUBs remain unknown, the discovery of these prenylated forms further expands the diversity and poten

89 When interaction of prenylated gamma subunit peptide to fluorophore-tagged P

90 sein) as a substrate, both palmitoylated and prenylated GRK6 display significantly higher activity th

91 ation activity of the palmitoylated, but not prenylated, GRK6 kinase.

92 d GTPases, whereas SmgGDS-558 interacts with prenylated GTPases in cells.

93 It is involved in the synthesis of the prenylated hydroxybenzoate moiety of the antibiotic, spe

94 rated that wild-type human connexin32 can be prenylated in COS7 cells, in contrast to disease-associa

95 -(13)C(6)]benzoic acid ([(13)C(6)]pABA)), is prenylated in either wild-type or abz1 mutant yeast to f

96 of Ki-Ras is blocked by FTIs, Ki-Ras remains prenylated in FTI-treated cells because of its modificat

97 erfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the

98 Although both proteins are prenylated in the human tumor cell line DLD-1, their pre

99 ince all the Rab5 isoforms were more rapidly prenylated in vitro using cytosol from IFN-gamma-treated

100 et ("CAAX box") sequences were enzymatically prenylated in vitro with natural and nonnatural prenyl d

101 sis thaliana, suggesting that these MUBs are prenylated in vivo.

102 P dissociation inhibitor (GDI) that binds to prenylated inactive (GDP-bound) Rab proteins.

103 icient total synthesis of notoamide J, a new prenylated indole alkaloid and potential biosynthetic pr

104 To verify the role of this reverse-prenylated indole alkaloid as an intermediate along the

105 total synthesis of congeners in the reverse-prenylated indole alkaloid family related to stephacidin

106 stablish the early steps for creation of the prenylated indole alkaloid structure and suggest a schem

107 Prenylated indole alkaloids are a diverse group of funga

108 oamide natural products belong to a group of prenylated indole alkaloids containing a core bicyclo[2.

109 preparation of these prenylated and reverse-prenylated indole alkaloids is bioinspired, and may also

110 Seven new prenylated indole alkaloids, taichunamides A-G, were iso

111 tem to understand the biosynthesis of fungal prenylated indole alkaloids.

112 [2.2.2]diazaoctane core shared among several prenylated indole alkaloids.

113 le metalation and alkylation provided the C2-prenylated indole.

114 One pool was rich in chain prenylated isoflavones (cIsf), one in chain prenylated s

115 major site for constitutive accumulation of prenylated isoflavones in white lupin.

116 The pool enriched in chain prenylated isoflavones permeabilized the bacterial membr

117 Extracts rich in prenylated isoflavonoids and stilbenoids showed potent a

118 at may enable PDEdelta to bind both forms of prenylated KRAS4b.

119 dation revealed the identification of a C(3)-prenylated l-tyrosine as enzyme product.

120 Ste24, has a parallel role in processing of prenylated mating pheromone a-factor.

121 , beta-CD-Sepharose FPLC was used to isolate prenylated mCherry-CAAX from crude HeLa cell lysate as a

122 Here we report that the prenylated membrane-anchored ubiquitin-fold protein (MUB

123 iving cells, including the question of where prenylated molecules localize.

124 Consideration of prenylated molecules that could potentially be involved

125 topic expression of wild-type CaM53 or a non-prenylated mutant protein in plants causes distinct morp

126 ciates with the plasma membrane, but the non-prenylated mutant protein localizes to the nucleus, indi

127 In total, seven C(5)- or C(10)-prenylated naphthacenedione compounds were generated.

128 anal, their 7-methoxy derivatives, and the O-prenylated natural products boropinols A and C.

129 Numerous prenylated natural products have been isolated from dive

130 insight into the engineered biosynthesis of prenylated natural products.

131 Prenylated PDE6 subunits and G-protein coupled receptor

132 A prenylated peptide specific to the G protein gamma5 subu

133 This effect extends to a prenylated peptide that includes a full "CAAX box" seque

134 Using recombinant proteins and prenylated peptides corresponding to the C-terminal sequ

135 characteristic masses lost from the modified prenylated peptides distinguished the types of prenylati

136 Interestingly, prenylated peptides lacking penetratin are able to enter

137 for detection and distinction of large-scale prenylated peptides using mass spectrometry-cleavable ap

138 concept of this method was established using prenylated peptides which mimicked the prenyl motifs in

139 iched form, the first total synthesis of the prenylated phenol (+)-fornicin C.

140 Prenylated phenolic compounds were significantly (p<0.01

141 prenylation, were molecular features of main prenylated phenolics found in pools with high antibacter

142 Overall, prenylated phenolics from legume seedlings can serve mul

143 Prenylated phenolics from the Fabaceae are promising lea

144 Pools enriched in prenylated phenolics were made from lupine, peanut and s

145 rising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomar

146 sphatases constitute a novel class of small, prenylated phosphatases that are implicated in promoting

147 PrBP/delta also binds other prenylated photoreceptor proteins in vitro, including op

148 However, to date, the turnover of prenylated plant proteins and the fate of the prenylcyst

149 ls (mono- and sesquiterpenes), bitter acids (prenylated polyketides), and prenylflavonoids are the pr

150 c compounds and enables genome mining of new prenylated polyketides.

151 bstrate does suggest UbiD might act on a non-prenylated precursor.

152 ite, resulting in expression of a truncated, prenylated prelamin A called progerin.

153 erimental orientation, which gives the major prenylated product of 1,6-dihydroxynaphthalene, correspo

154 Chromatographic analysis of prenylated products after single turnover reactions by u

155 The prenylated products were then degraded to dipeptides usi

156 The resulting prenylated and reverse-prenylated products were transformed into ent-flustramid

157 B was accomplished through the union of a C-prenylated proline derivative and a substituted indole p

158 multimeric rod phosphodiesterase 6 (PDE6), a prenylated protein and RCE1 substrate, was unable to be

159 ol polyphosphate-5-phosphatase E (INPP5E), a prenylated protein associated with JBTS, and its ciliary

160 methylation of the carboxyl terminus of the prenylated protein by isoprenylcysteine carboxylmethyltr

161 es, based on the C-terminus of the naturally prenylated protein CDC42.

162 hich may be important for the development of prenylated protein function inhibitors.

163 ), a prenyl-binding protein and chaperone of prenylated protein in photoreceptors.

164 not squalene, indicating that an inhibitory prenylated protein is involved in endothelial responses

165 The prenylated protein products could then be isolated from

166 his study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cell

167 s an enigmatic member of the Ptp4a family of prenylated protein tyrosine phosphatases that are highly

168 Rab5a is a prenylated protein, and newly synthesized Rab5a was rapi

169 ificantly more than EGFP-GG or an endogenous prenylated protein, Cdc42.

170 protein substrate to form a thioether-linked prenylated protein.

171 a in the transport and membrane targeting of prenylated proteins (including PDE6) from their site of

172 6delta regulates the traffic and activity of prenylated proteins (Zhang et al., 2004; Norton et al.,

173 Notable among them were 62 prenylated proteins and 45 Ras family proteins.

174 chemical reporters for proteomic analysis of prenylated proteins and reveal a role for protein prenyl

175 role in the final step in the degradation of prenylated proteins and will allow further physiological

176 In plants, prenylated proteins are involved in actin organization,

177 The fact that many prenylated proteins are involved in signaling processes

178 As S-prenylated proteins are often key effectors for oncogene

179 Subsequently, prenylated proteins are proteolytically cleaved at the C

180 Recently, we have shown that prenylated proteins are sorted according to their affini

181 e ring stage by 50%, decreases expression of prenylated proteins as measured with prenyl-specific ant

182 ilitates membrane targeting of Ras and other prenylated proteins by releasing the carboxyl-terminal 3

183 As prenylated proteins comprise up to 2% of the total prote

184 The largest class of prenylated proteins contain a so-called CaaX motif at th

185 Prenylated proteins contain either a 15-carbon farnesyl

186 Prenylated proteins contain either a 15-carbon farnesyl

187 Prenylated proteins contain either a 15-carbon farnesyl

188 The largest group of prenylated proteins contains a CAAX motif at the C-termi

189 de HeLa cell lysate as a model for purifying prenylated proteins from cell extracts.

190 ed, there are few good methods for isolating prenylated proteins from their nonprenylated relatives.

191 Within the human genome 10% of predicted prenylated proteins have aromatic amino acids in their C

192 Isoprenoids and prenylated proteins have been implicated in the pathophy

193 ism for membrane association and function of prenylated proteins in Arabidopsis.

194 d function coupled with the critical role of prenylated proteins in malignant transformation has prom

195 mental evidence for a total of only thirteen prenylated proteins in P. falciparum, with suggestive ev

196 ansferase genes have also revealed roles for prenylated proteins in phytohormone signaling and merist

197 ntally characterize the entire complement of prenylated proteins in the human malaria parasite.

198 ethyl esterifies the alpha carboxyl group of prenylated proteins including Ras and related GTPases.

199 Defective trafficking of prenylated proteins is likely due to sequestration of pr

200 However, as the total complement of prenylated proteins is unknown, the FTase substrates res

201 in determining the impact of non-canonically prenylated proteins on cell function.

202 Our results show that prenylated proteins play key roles in P. patens developm

203 The degradation of prenylated proteins raises a metabolic challenge to the

204 ated cells into S phase and was dependent on prenylated proteins such as those of the rho gene family

205 ab GTPases, in addition to a small number of prenylated proteins that also appear to function primari

206 ndent migration we focused on RhoA and Rac1, prenylated proteins that are important mediators of cell

207 Structure and sequence analysis of various prenylated proteins that have been previously tested for

208 Prenylated proteins undergo a series of post-translation

209 thods available for large-scale detection of prenylated proteins using mass spectrometry and no metho

210 The identity of the prenylated proteins was probed by N-terminal sequence an

211 Identifying novel prenylated proteins within the human proteome constitute

212 al reporter enables large-scale profiling of prenylated proteins, as well as the discovery of unannot

213 The cellular abundance of prenylated proteins, as well as the stability of the thi

214 activity of hRCE1 activity was specific for prenylated proteins, because unprenylated peptides did n

215 Prenylated proteins, detected by [3H]mevalonate labeling

216 he correct localization and function of many prenylated proteins, most notably GTPases in the Ras sup

217 of PrBP/delta in retina impairs transport of prenylated proteins, particularly GRK1 and cone PDE, to

218 o PDEdelta provides a rationale for why some prenylated proteins, such as KRAS4a, RalA, RalB, and Rac

219 The processing of two other prenylated proteins, the farnesylated Ggamma1 subunit of

220 , ubiquinone, heme, isopentenyl adenine, and prenylated proteins.

221 mely effective in affinity chromatography of prenylated proteins.

222 bes for the investigation of the function of prenylated proteins.

223 rsor of sterols, dolichols, ubiquinones, and prenylated proteins.

224 on of the C-terminal prenylcysteine found on prenylated proteins.

225 events required for functional expression of prenylated proteins.

226 yl-binding protein interacting with multiple prenylated proteins.

227 for Zmpste24 in the processing of CAAX-type prenylated proteins.

228 igned to act as a mimic of the C-terminus of prenylated proteins.

229 a major role in the processing of CAAX-type prenylated proteins.

230 uble protein were the only other significant prenylated proteins.

231 P. falciparum possesses a restricted set of prenylated proteins.

232 tructures of PDEdelta complexed with various prenylated proteins/peptides shows the presence of addit

233 he synthesis of cholesterol, ubiquinone, and prenylated proteins; consequently, much effort has gone

234 ain prenylated (cPta) and one in ring-closed prenylated pterocarpans (rPta), as characterized by RP-U

235 The prenylated pyrazole analogue 11 selectively inhibited 5-

236 h as chlorophylls, carotenoids, tocopherols, prenylated quinones and hormones are synthesised in chlo

237 The mouse prenylated Rab acceptor (mPRA1) is associated with the G

238 ty of positive clones (50 of 54) encoded the prenylated Rab acceptor (PRA1).

239 We report here that prenylated Rab acceptor protein (PRA1), which others pre

240 Prenylated Rab GTPases cycle between membrane-bound and

241 GDP dissociation inhibitor (GDI) solubilizes prenylated Rab GTPases from and shuttles them between me

242 a function of features contained within the prenylated Rab itself (with REP serving as a "passive" c

243 ssociated with Golgi membranes that binds to prenylated Rab proteins in their GTP-bound state.

244 anylated Rab and does not interact with mono-prenylated Rab proteins.

245 d immunofluorescence studies reveal that the prenylated Rab1B(Y78D)CLLL, which remains deficient in R

246 fingers were found to interact with the dual prenylated rab3A and VAMP2/Synaptobrevin II receptor PRA

247 However, although prenylated Rab5 can be cross-linked to two unknown membr

248 lize Rab9 directly, as liposomes loaded with prenylated Rab9 showed decreased extractability with inc

249 Prenylated Rabs also occur in the cytosol bound to GDI (

250 plex requires simultaneous interactions with prenylated Rac-GTP and acidic phospholipids, as well as

251 onstitution of membrane vesicles loaded with prenylated Rac1 demonstrates that the PBR is required fo

252 e and GGTase I activities and the amounts of prenylated Ras and RhoA proteins in CHO-hIR-WT (but not

253 ase and GGTase I and subsequent increases in prenylated Ras and RhoA proteins.

254 nique receptor that promotes accumulation of prenylated Ras at the plasma membrane and promotes EGF p

255 The localization of prenylated Ras at the plasma membrane promotes activatio

256 rane accumulation of Ras by directly binding prenylated Ras at the plasma membrane.

257 delta with high affinity, thereby displacing prenylated Ras proteins in cells.

258 cial for the plasma membrane localization of prenylated Ras.

259 cellular membranes through their C-terminal prenylated regions.

260 (RhoGDI), which forms a stable complex with prenylated Rho GTPases.

261 RhoGDI (GDI), a protein which interacts with prenylated Rho proteins, suggest that the GDI is in dire

262 Increased availability of prenylated Rho-A significantly augmented the abilities o

263 in IQGAP1 interacts directly with GTP-bound, prenylated RhoA and RhoC, but not with RhoB.

264 DHT-dependent growth arrest, suggesting that prenylated RhoB might function to inhibit HT-AR1 cell pr

265 hat farnesylated rhodopsin kinase (GRK1) and prenylated rod PDE6 catalytic subunits partially misloca

266 On the other hand, many prenylated secondary metabolites have been described as

267 sed for the preparation of the novel reverse-prenylated serine and threonine side chains as well as a

268 motif (CCFV), suggesting that Wrch-1 may be prenylated similarly to Cdc42.

269 ant (SmgGDS-558) selectively associates with prenylated small GTPases and facilitates trafficking of

270 e report the characterization of rat ykt6, a prenylated SNARE selectively expressed in brain neurons.

271 Pawhuskin A is a prenylated stilbene that functions as an antagonist of t

272 ianin, an active metabolite of the family of prenylated stilbenes named schweinfurthins, is only loca

273 ricanine A and piceatannol to arachidin-5, a prenylated stilbenoid identified, to our knowledge, for

274 prenylated isoflavones (cIsf), one in chain prenylated stilbenoids (cSti), one in chain prenylated (

275 eps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.

276 e demonstrated that the prenyl moiety on the prenylated stilbenoids derives from a plastidic pathway.

277 cal importance, the biosynthetic pathways of prenylated stilbenoids remain to be elucidated, and the

278 Structural analysis of the prenylated stilbenoids suggested that these two prenyltr

279 Prenylated stilbenoids synthesized in some legumes exhib

280 iry root cultures produce a diverse array of prenylated stilbenoids upon treatment with elicitors.

281 alyzes a key reaction in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylat

282 nd abiotic stresses include the synthesis of prenylated stilbenoids.

283 Galpha(t1) with much higher affinity than a prenylated substrate, whereas the homologous prenyl-bind

284 Ste24p can cleave both isoprenylated and non-prenylated substrates in vitro, indicating that the isop

285 nsducin, and rhodopsin kinase 1 (GRK1), also prenylated substrates of RCE1, was unaffected by Rce1 de

286 ' is aliphatic in both isoprenylated and non-prenylated substrates, although this is not necessarily

287 ficantly different for prenylated versus non-prenylated substrates, strongly suggestive of a role for

288 some and interacts with the membrane via its prenylated tail.

289 osomal fraction containing recombinant LaPT1 prenylated the isoflavone genistein at the B-ring 3' pos

290 and the yeast a-factor mating pheromone, are prenylated, trimmed of their last three amino acids, and

291 s catalyze the formation of a diverse set of prenylated tryptophan and diketopiperazines, leading to

292 lar structures in fibroblasts, and an active prenylated version of Rab1 bound directly to an N-termin

293 yme kinetics are significantly different for prenylated versus non-prenylated substrates, strongly su

294 pecificity of the SmgGDS splice variants for prenylated versus nonprenylated GTPases is diminished in

295 tion motif, human ECE-1 did not appear to be prenylated when labeled in vivo using various isoprenoid

296 In addition, when mCherry-CAAX was prenylated with a nonnatural, functional isoprenoid subs

297 essed as predicted, and a major one that was prenylated without further processing.

298 griffipavixanthone from a readily accessible prenylated xanthone monomer.

299 is necessary and sufficient for stabilizing prenylated Ypt7 on membranes.

300 ab-GDP dissociation inhibitor (GDI) complex (prenylated Ypt7-GDI), and a Rab effector complex (HOPS).