ライフサイエンスコーパス: prenylation

1 EBP-2) cleavage, causing decrease of protein prenylation.

2 afficking secondary to inhibition of protein prenylation.

3 se (FPPS) in osteoclasts, preventing protein prenylation.

4 -terminal mutation used to eliminate protein prenylation.

5 logy because many oncogenic proteins undergo prenylation.

6 s of post-translational modifications termed prenylation.

7 strate binding that define reverse or normal prenylation.

8 he community of researchers studying protein prenylation.

9 xpressed without C-terminal processing after prenylation.

10 ffect of alendronate or zoledronate on Rap1A prenylation.

11 hosphate synthase (FPPS) and inhibit protein prenylation.

12 fied at their C terminus by a process termed prenylation.

13 ion was not altered by inhibitors of protein prenylation.

14 y SCH66336, indicating a lack of alternative prenylation.

15 farnesylation, geranylgeranylation, or dual prenylation.

16 minal domain, even in the absence of protein prenylation.

17 Rho, which remains active in the absence of prenylation.

18 isoprenyl lipid via a process called protein prenylation.

19 banions in enantioselective carbonyl reverse prenylation.

20 disease by additionally inhibiting progerin prenylation.

21 enylated peptides distinguished the types of prenylation.

22 aracterized by a severe reduction in protein prenylation.

23 of the interaryl linker, and (iii) (dihydro)prenylation.

24 c effects determine the position and type of prenylation.

25 regioselectivity in Orf2-catalyzed aromatic prenylations.

26 ndicated the location of the PDE6 C-terminal prenylations.

27 ylation 1c-6c, and carbonyl reverse 2-methyl prenylation 1d-6d.

28 iridium-catalyzed alcohol C-H tert-(hydroxy)prenylation - a byproduct-free process that forms an all

29 t combine to form products of tert-(hydroxy)-prenylation, a motif found in >2000 terpenoid natural pr

30 ic acid monohydrate, an inhibitor of protein prenylation, act synergistically to reverse outcomes of

31 We conclude that protein prenylation, acting downstream of Hmgcr1b and possibly t

32 geranylgeranyl transferase 1 (GGT1) protein prenylation activity also resulted in abnormal germ cell

33 Y42X/y) fibroblasts, there was a recovery of prenylation activity following treatment with either PTC

34 vage activity for phylloquinone but a strong prenylation activity for menadione (vitamin K3), which h

35 link between a mutation in p53 and cellular prenylation activity.

36 e bisphosphonate-induced inhibition of Rap1A prenylation, an effect that was reversed by addition of

37 nflammation and target enzymes essential for prenylation, an important process in the activation and

38 statin was associated with disruption of Ras prenylation and activation.

39 es, and linear peptides as substrates for C4-prenylation and also acts as regiospecific O-dimethylall

40 s of a C-terminal CAAX sequence that include prenylation and are thought to be required for biologica

41 ddition, aplexone treatment inhibits protein prenylation and blocking the activity of geranylgeranyl

42 stigated the effect of lovastatin on protein prenylation and cell signaling.

43 an important characterization of prokaryotic prenylation and demonstrate that this process is central

44 optosis pathway via inhibition of Rho family prenylation and depletion of GGPP, in a variety of diffe

45 4-position, resulting in direct carbinol C-H prenylation and geranylation, respectively.

46 yristoylation, S-acylation (palmitoylation), prenylation and GPI anchors but until recently little wa

47 ficant inhibitory effect of Abeta on protein prenylation and identify SREBP-2 as a target of oAbeta(4

48 mod5p contains a signal for carboxy-terminal prenylation and in wild-type cells is associated with th

49 B binding to SmgGDS-607 and diminishes Rap1B prenylation and membrane localization.

50 Unlike prenylation and myristoylation, palmitoylation is a reve

51 enzyme, mevalonate, and are required for the prenylation and normal function of GTP-binding proteins.

52 that should be useful in studies of protein prenylation and other structurally related biological pr

53 acid that serves as substrate for subsequent prenylation and oxidative cyclization to the five ring C

54 n: classical CaaX processing or novel tandem prenylation and palmitoylation at the CCaX cysteines.

55 binding properties, GDI cannot assist in Rab prenylation and REP cannot retrieve Rab proteins from th

56 eagents in enantioselective carbonyl reverse prenylation and represents the first use of allenes in e

57 R115777 inhibited HDJ-2 prenylation and suppressed the activity of FTase, but no

58 cytosis of proteins may be caused by reduced prenylation and thereby decreased function of one or mor

59 reported that SmgGDS splice variants promote prenylation and trafficking of GTPases containing a C-te

60 tin induced a significant inhibition of RhoB prenylation, and a combination of these drugs at 1 micro

61 sylation, is not a substrate for alternative prenylation, and plays a role in SCH66336 enhancement of

62 bbranch of the pathway important for protein prenylation, and showed improved mitochondrial function

63 ion correctly Rho requires posttranslational prenylation, and this can be inhibited by depleting the

64 Significant to AD, reduced levels of protein prenylation are present in the cerebral cortex of the Tg

65 s potential utility for the study of protein prenylation, are discussed.

66 ellular phenotypes, as well as to the use of prenylation as a biomarker.

67 ap1, which is dictated by post-translational prenylation as well as by a stretch of basic residues wi

68 mical function as confirmed through in vitro prenylation assays (98 +/- 2% [PTC124] and 68 +/- 5% [PT

69 h was confirmed by western blot and in vitro prenylation assays.

70 equivocally the highly regiospecific regular prenylation at C-5 of the indole nucleus of the simple i

71 n synthase catalyzed both normal and reverse prenylation at C3 of the indole ring and normal prenylat

72 an, another alternate substrate, gave normal prenylation at C5 and C7.

73 an was an alternate substrate, giving normal prenylation at C5 as the major product.

74 fications at a carboxyl-terminal CaaX motif: prenylation at cysteine, proteolysis of the aaX tripepti

75 pimer of hapalindole U, and catalyzes normal prenylation at its C-2 position.

76 the indole nucleus, with normal and reverse prenylation at one of the sites, is consistent with a di

77 of FPP could not be accounted for by protein prenylation, because inhibition of farnesylation did not

78 The ability to measure protein prenylation before and after FTI and GGTI treatment is i

79 atients were assessable for analysis of HDJ2 prenylation before and after therapy.

80 muM) of lovastatin inhibit Ras, Rho, and Rap prenylation but that therapeutic levels of lovastatin (5

81 rovide evidence that isoprenoids and protein prenylation, but not cholesterol, are required in OPCs t

82 Activation of GPCRs suppresses Rap1A prenylation, but unlike this effect on Rap1B, the GPCR-m

83 e protocols to measure the degree of protein prenylation by farnesyl transferase or geranylgeranyl tr

84 r cells were analyzed for inhibition of HDJ2 prenylation by Western blot analysis at baseline and on

85 ent of an isoprenoid lipid (a process termed prenylation) by protein farnesyltransferase (FTase) or g

86 a effectors encode a prototypical eukaryotic prenylation CAAX motif (where C represents a cysteine re

87 n pathways are prenylated, and inhibition of prenylation can be useful as a therapeutic intervention.

88 ap1B, the GPCR-mediated suppression of Rap1A prenylation can occur independently of Rap1A phosphoryla

89 g that increased cellular demand for protein prenylation cannot explain increased statin sensitivity.

90 structural basis for the normal and reverse prenylations catalyzed by a single enzyme, and it offers

91 sphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, followed b

92 nhibitors of protein palmitoylation, but not prenylation, caused Chp to mislocalize to the cytoplasm.

93 ith lovastatin, a drug that disrupts protein prenylation, changed the relative electrophoretic mobili

94 proteinaceous membrane anchor but contains a prenylation consensus motif (CAAX box) and exists in an

95 A prenylation-deficient mutant of C17orf37 is functionally

96 ents and characterizing proteins involved in prenylation-dependent cellular pathways.

97 utes an important step towards understanding prenylation-dependent cellular processes.

98 We show herein that Cdc42, in a prenylation-dependent manner, targets MLK3 from a perinu

99 eracts with a newly identified EhRhoGDI in a prenylation-dependent manner.

100 creased expression of KLF2 through a HMG-CoA/prenylation-dependent pathway.

101 Posttranslational prenylation (e.g., farnesylation) of small G-proteins is

102 ation due to reduced expression of the Rho-A prenylation enzyme geranylgeranyltransferase-I (GGTase-I

103 en proposed as the recognition motif for two prenylation enzymes, protein farnesyltransferase (FTase)

104 anylgeranyl lipids, a process called protein prenylation, facilitates interactions of proteins with m

105 To determine whether protein prenylation (farnesyl/geranylgeranylation) regulates mat

106 t Chp depends on palmitoylation, rather than prenylation, for association with cellular membranes.

107 he position of the exocyclic acyl group, the prenylation grade of the core, and the relative configur

108 c residues could cooperate with the adjacent prenylation group to anchor PRL-1 on the acidic inner me

109 inhibitors of small G-protein methylation or prenylation had no effect on the early aldosterone-induc

110 Although the biological consequences of prenylation have been characterized extensively, the con

111 pic effects that establish roles for protein prenylation in abscisic acid (ABA) signaling and meriste

112 Rheb prenylation in cell culture was completely inhibited by

113 o system for studying the functional role of prenylation in eukaryotes.

114 lated proteins and reveal a role for protein prenylation in host defense against viral infections.

115 ED 3 microM) than (-)-3-E2 in inhibiting Rab prenylation in J774 cells and >26x more active in the ce

116 1, 3 selectively inhibited Rab11 vs. Rap 1A prenylation in J774 cells, and decreased cell viability,

117 eptides open the door for studies of protein prenylation in living cells, including enzymatic process

118 duction and elucidate the effects of protein prenylation in monocytes.

119 The role of prenylation in patients with mevalonate kinase deficienc

120 otes, little is known about the influence of prenylation in prokaryotic species.

121 fication and differentiation of the types of prenylation in proteins in large-scale studies and will

122 that Ral GTPases do not undergo alternative prenylation in response to GGTI treatment.

123 and in vitro transcription, translation and prenylation in reticulocyte lysates.

124 specificity and functional roles for protein prenylation in Rho GTPase function.

125 improved mitochondrial function and protein prenylation in the presence of statins.

126 gress has been made in understanding protein prenylation in vitro, we have been interested in studyin

127 eriovenous-dependent requirement for protein prenylation in zebrafish and human endothelial cells.

128 identifying and differentiating large-scale prenylations in vivo or in vitro.

129 phosphate (GGPP), which are used for protein prenylation, including the oncoproteins of the RAS super

130 Although it is clear that prenylation increases membrane affinity of CAAX proteins

131 alytic activity and is induced by Cdc42 in a prenylation-independent manner, arguing that Cdc42 bindi

132 ical data supporting the in vivo efficacy of prenylation inhibition as a novel antiviral therapy with

133 r smaller potency difference in the RGGT and prenylation inhibition assays.

134 active as 7 in J774 cell viability and Rab11 prenylation inhibition assays.

135 oviding further evidence for the efficacy of prenylation inhibition in chronic HDV.

136 es RAB activity because treatment with a RAB prenylation inhibitor and transfection of dominant negat

137 RNA levels, safety, and tolerability of the prenylation inhibitor lonafarnib in patients with chroni

138 Such mice were then treated with the prenylation inhibitors FTI-277 and FTI-2153.

139 Protein prenylation is a common post-translational modification

140 Protein prenylation is a post-translational modification that ha

141 Protein prenylation is a post-translational modification whereby

142 Prenylation is a posttranslational modification essentia

143 Prenylation is a posttranslational modification whereby

144 -propanol, enantioselective carbonyl reverse prenylation is achieved directly from the alcohol oxidat

145 Inhibiting protein prenylation is an attractive means to modulate cellular

146 S-prenylation is an important lipid modification that targ

147 Protein prenylation is carried out by a pair of cytosolic enzyme

148 Prenylation is essential for HDV and inhibition abrogate

149 dividuals, is one pathogen for which protein prenylation is essential for survival.

150 arnesylated rhodopsin kinase (GRK1) and that prenylation is essential for this interaction.

151 These results support the notion that prenylation is necessary for AChR clustering and the NMJ

152 s indicate that Cx32 is prenylated, but that prenylation is not required for proper trafficking of Cx

153 Here we demonstrate that C-terminal prenylation is not required for Rab13 to associate with

154 Protein prenylation is required for a variety of growth and deve

155 transferase inhibitors indicate that protein prenylation is required for malaria parasite development

156 the shift in molecular mass, and that rab17 prenylation is required for sumoylation.

157 These findings demonstrate that prenylation is required for the function of the C17orf37

158 Prenylation is the addition of prenyl groups to peptide

159 Prenylation is the posttranslational modification of a c

160 Since prenylation is thought to enhance the bioactivity of man

161 Although protein prenylation is widely studied, there are few good method

162 ent attachment of a single isoprenoid lipid (prenylation), is carried out by the CaaX prenyltransfera

163 AT reduced prenylation levels of GTPases, abolished T-bet expressio

164 tein does not contain the myristoylation and prenylation lipid-anchoring motifs that are present in h

165 Perturbation of the host prenylation machinery during infection adversely affecte

166 radigm of microbial exploitation of the host prenylation machinery for anchoring of injected effector

167 ta indicate that Legionella utilize the host prenylation machinery to facilitate targeting of effecto

168 n, underlining the unique ability of the Rab prenylation machinery to process the Rab family with div

169 or-2147 (GGTI-2147), an inhibitor of protein prenylation, markedly increased cytosolic accumulation o

170 o studies suggest that inhibition of protein prenylation may underlie the myotoxic effects of statins

171 pecific targeting of enzymes responsible for prenylation mimicked the inhibitory effects of statins o

172 ospholipase A(2) that possesses a C-terminal prenylation motif (-CCLA) whose covalent structure canno

173 Both the polybasic residues and the adjacent prenylation motif are required for proper PRL1 subcellul

174 features include a long hydrophobic tail and prenylation motif in Hex-1, and a long hydrophilic inser

175 ly relevant C(x)3X proteins begins, this new prenylation motif nearly doubles the number of proteins

176 C terminus of human Cx32 contains a putative prenylation motif that is conserved in Cx32 orthologs.

177 n kinase A phosphorylation sites, and a CAAX prenylation motif was isolated.

178 olybasic region that precedes the C-terminal prenylation motif.

179 mutations that are predicted to disrupt the prenylation motif.

180 ion is partially dependent on its C-terminal prenylation motif.

181 The selective reverse prenylation of 3-substituted-1H-indoles at C3 is describ

182 carbon-carbon-based and carbon-oxygen-based prenylation of a diverse collection of hydroxyl-containi

183 Studies indicate GGTI-DU40 blocks prenylation of a number of geranylgeranylated CaaX prote

184 yl protein transferase inhibitor that blocks prenylation of a number of proteins important in cell pr

185 potentially manipulating the regio-specific prenylation of aromatic small molecules using this struc

186 Arabidopsis Rab-GGTs may have preference for prenylation of C-terminal cysteines in particular positi

187 ansferases, providing a unique model for the prenylation of diverse metabolites.

188 ocopherol forms of vitamin E is initiated by prenylation of homogentisate.

189 Despite the failure to abrogate prenylation of K- and N-Ras, growth of many tumors in pr

190 ation of Rac1, and does not detectably alter prenylation of K-Ras.

191 At a fundamental level, the mechanism of C4-prenylation of l-tryptophan recently has surfaced to eng

192 , this is the first report on an enzymatic C-prenylation of l-tyrosine as free amino acid and alterin

193 esyltransferase (FTase), which catalyzes the prenylation of many cellular signaling proteins includin

194 nylation at C3 of the indole ring and normal prenylation of N1.

195 Pd-catalyzed asymmetric prenylation of oxindoles to afford selectively either th

196 Membrane binding is a consequence of prenylation of PDE6 catalytic subunits, whereas soluble

197 Prenylation of protein (farnesylation and geranylgeranyl

198 mones derived from isoprenoid intermediates; prenylation of proteins (with C15 or C20 isoprenoid moie

199 and farnesylpyrophosphate (FPP) used in the prenylation of proteins.

200 We suggest that prenylation of PRV Us2 protein is required for proper me

201 Prenylation of Rab GTPases regulating vesicle traffic by

202 l transferase (RGGT), selectively preventing prenylation of Rab GTPases.

203 l transferase (RabGGTase) is responsible for prenylation of Rab proteins.

204 This protein is essential for the normal prenylation of Rabs.

205 shes prenylation of Rap1A and RhoA, enhances prenylation of Rac1, and does not detectably alter preny

206 These events depend on the prenylation of Rap1, which promotes its membrane localiz

207 ation to inhibit GDP/GTP exchange diminishes prenylation of Rap1A and RhoA, enhances prenylation of R

208 unsuspected differences in the regulation of prenylation of Rap1A versus Rap1B, due in part to their

209 nces in the ability of GPCRs to regulate the prenylation of Rap1B compared to Rap1A.

210 cancer effect of statins is independent from prenylation of RAS family proteins and is associated wit

211 ferase I (GGTase-I), enzymes involved in the prenylation of Ras.

212 argely based upon their ability to block the prenylation of Rho GTPases, including RhoA.

213 , a mevalonate product that provides for the prenylation of Rho GTPases.

214 These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis

215 ects of statins are attributed to inhibiting prenylation of RhoA and effects on other intracellular s

216 rnesyl monophosphate) have been evaluated on prenylation of RhoB and on the cell cycle in a human mal

217 This results in prenylation of RHOC, which is concomitantly induced by i

218 These results implicate prenylation of RPGR as a critical modification for its l

219 rily influences cholesterol biosynthesis and prenylation of signaling proteins.

220 biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho an

221 hase (hFPPS) controls the post-translational prenylation of small GTPase proteins that are essential

222 ellular levels of FPP and post-translational prenylation of small GTPase proteins, which are essentia

223 It is not clear how protein prenylation of small GTPases relates to GTP hydrolysis a

224 ays a crucial role in the post-translational prenylation of small GTPases that perform a plethora of

225 e, they support our original hypothesis that prenylation of specific G-proteins may be necessary for

226 Post-translational lipidation by prenylation of the CaaX-box C-terminal motif in eukaryot

227 yzes the final step of CAAX processing after prenylation of the cysteine residue and endoproteolysis

228 These reactions involve prenylation of the cysteine residue, cleavage at the AAX

229 spergillus fumigatus catalyze C(4)- and C(7)-prenylation of the indole ring, respectively.

230 PPi release is equal to the rate constant of prenylation of the peptide, as measured by other assays,

231 h triggered by statins can be uncoupled from prenylation of the RAS superfamily of oncoproteins.

232 renyltransferase AmbP3 catalyzes the reverse prenylation of the tetracyclic indole alkaloid hapalindo

233 Surprisingly, we find that C-terminal prenylation of these GTPases both promotes the interacti

234 upstream polybasic region enhances the dual prenylation of these substrates, by decreasing the catal

235 e in Claviceps purpurea catalyzes the normal prenylation of tryptophan at C4 of the indole nucleus in

236 These results suggest a common mechanism for prenylation of tryptophan by all of the members of the s

237 In addition, a diastereoselective reverse prenylation of tryptophan methyl ester is disclosed, and

238 y dependent on prenyl lipid modification, or prenylation, of its nucleocapsid-like protein large delt

239 were treated with some inhibitors of protein prenylation or by further monoterpenes.

240 ation, exposing the C-terminal extension for prenylation or enabling OsCaM61 to be transferred to the

241 PBR of Rap1A does not detectably inhibit its prenylation or its binding to SmgGDS-607.

242 (3,4,5)-trisphosphate-binding domain; (iv) a prenylation/palmitoylation tag, and (v) a type-1 plasma

243 The prenylation pathway consists of three enzymatic steps; t

244 l avenue for probing both the selectivity of prenylation pathway enzymes and the effects of prenylati

245 d passage of these small GTPases through the prenylation pathway is regulated by two splice variants

246 enylation pathway enzymes and the effects of prenylation pathway modifications on the cellular functi

247 rain nonprenylated GTPases from entering the prenylation pathway, leading to the general belief that

248 of PBR-possessing small GTPases through the prenylation pathway.

249 the entry of Rap1A, RhoA, and Rac1 into the prenylation pathway.

250 ltransferase (Icmt) is the final step in the prenylation pathway.

251 ing are post-translationally modified by the prenylation pathway.

252 bling the creation of bioengineered parallel prenylation pathways with altered substrate selectivity

253 a(2)X sequence and would likely generate the prenylation pattern described here.

254 ositol metabolism, AMPylation, deAMPylation, prenylation, polyubiquitination, proteasomal degradation

255 of indole prenyltransferases regarding their prenylation positions.

256 ate, the product of HMGCoAR activity, or the prenylation precursors farnesol and geranylgeraniol.

257 of the three-step posttranslational protein prenylation process for the so-called CaaX proteins, whi

258 both sterol metabolite synthesis and protein prenylation processes.

259 nzoic acid, and (S)-SEGPHOS delivers reverse-prenylation products 4a-i in good to excellent isolated

260 posttranslational modifications that include prenylation, proteolysis, and carboxyl methylation.

261 post-translational modifications, including prenylation, proteolysis, and methylation.

262 an alternatively prenylated CAAX renders Ras prenylation, Ras-induced Elk-1 activation, and anchorage

263 reaction, reflected by decreases in both the prenylation rate constant and kcat/KM.

264 Here we demonstrate that the prenylation rate constant catalyzed by wild type GGTase

265 Specifically, the prenylation rate constant decreases 7-fold at 5 mM MgCl2

266 The synthesis features an optimized aromatic prenylation reaction in which an arylcopper intermediate

267 One particular prenylation reaction, farnesylation of an mCherry-CAAX f

268 ccording to the current understanding of the prenylation reaction.

269 This work indicates that post-prenylation reactions can generate multiple products det

270 (42)-treated neurons recovers normal protein prenylation, reduces cholesterol sequestration, and prev

271 by covalent attachment of isoprenoid lipids (prenylation) regulates the functions and biological acti

272 Inhibition of protein prenylation represents a mechanism of oAbeta(42)-induced

273 us farnesol, which enhances membrane protein prenylation, reversed viperin-mediated inhibition of HIV

274 This work expands our understanding of prenylation's impact within the proteome, establishes th

275 Defects in prenylation, seen in HIDS, led to RhoA inactivation and

276 utively targeted to the plasma membrane by a prenylation signal (CAAX).

277 ompounds are micromolar inhibitors of Rab11A prenylation, simultaneously being inactive against Rap1A

278 le Hex-1 protein, supporting that the unique prenylation site in Hex-1 facilitates covalent JH bindin

279 Whereas the C-terminal prenylation site is critical for ZAP70 interaction, subc

280 palmitoylation sites) and cysteine 193 (the prenylation site) point mutations abolish RhoB functions

281 r both the PRL-2 catalytic functionality and prenylation site.

282 lated by C-terminal motifs, including a CKIF prenylation site.

283 1 bears a unique C-terminal extension with a prenylation site.

284 We also introduced epoxy groups in the prenylation sites of the proteins to make them more hydr

285 these are likely to be palmitoylation and/or prenylation sites.

286 phytyltransferase (HPT), which catalyzes the prenylation step in tocopherol synthesis.

287 onsequences of loss of function of all known prenylation subunits in the moss Physcomitrella patens.

288 esyltransferase to K-Ras and increased K-Ras prenylation, suggesting that KRAS mutation might synergi

289 study, a variety of proteins with C-terminal prenylation target ("CAAX box") sequences were enzymatic

290 re caused primarily through impaired protein prenylation that results in mitochondria dysfunction.

291 Following prenylation, the last three amino acids are cleaved off

292 nate the potential for in vivo regulation of prenylation through modulation of STO versus MTO peptide

293 re, we investigated the contribution of RhoA prenylation to the biochemical pathways that underlie MK

294 The PEGylated Rab proteins undergo normal prenylation, underlining the unique ability of the Rab p

295 ize most K-ras mutant tumors, although K-Ras prenylation was not blocked.

296 ty of the intermediates required for protein prenylation was responsible for decreased gammaherpesvir

297 Bent conformation and chain prenylation, were molecular features of main prenylated

298 bility to bind guanine nucleotides and their prenylation with a geranylgeranyl or farnesyl isoprenoid

299 cent human fibroblasts by inhibiting protein prenylation, without affecting the senescent growth arre

300 bout whether any treatment targeting protein prenylation would be particularly effective.