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1 ytic event and methylation of the C-terminal prenylcysteine.
2 of the carboxyl group of the now C-terminal prenylcysteine.
3 s been identified that degrades a variety of prenylcysteines.
4 s enzyme plays in the cellular metabolism of prenylcysteines.
5 is capable of cleaving the thioether bond of prenylcysteines.
6 closure, consistent with the hypothesis that prenylcysteine alpha-carboxyl methylation is necessary f
10 siae, confirming its identity as a bona fide prenylcysteine alpha-carboxyl methyltransferase gene.
11 Arabidopsis thaliana possesses a functional prenylcysteine alpha-carboxyl methyltransferase involved
13 ation neutralizes the negative charge of the prenylcysteine and thereby increases membrane affinity.
14 hey possess a free amino group; N-acetylated prenylcysteines and prenyl peptides are not substrates.
15 rates a novel function for carboxyl-terminal prenylcysteine carboxyl methylation in protecting RhoA a
17 enzyme did not require NADPH as cofactor for prenylcysteine degradation, thus distinguishing it from
21 Additionally, RhoG mislocalization by the prenylcysteine endoprotease YopT was demonstrated by two
23 ase does play a physiologic role in cleaving prenylcysteines in mammals, but the absence of this acti
29 The open reading frame of the gene encoding prenylcysteine lyase is 1515 base pairs and has a nearly
32 Here we show that the isoprenoid product of prenylcysteine lyase is the C-1 aldehyde of the isopreno
33 These findings strengthen the notion that prenylcysteine lyase plays an important role in the fina
34 ents, suggest that the reaction catalyzed by prenylcysteine lyase proceeds through a sequential mecha
36 tly identified and isolated an enzyme termed prenylcysteine lyase that cleaves the prenylcysteine to
37 utilized product and dead end inhibitors of prenylcysteine lyase to probe the kinetic mechanism of t
40 characterized a novel enzyme, which we term prenylcysteine lyase, that is capable of cleaving the th
42 teine lyase is a specific enzyme involved in prenylcysteine metabolism in mammalian cells, most likel
45 racterized extensively, the contributions of prenylcysteine methylation to the functions of the modif
46 Our findings are discussed in the context of prenylcysteine methylation/demethylation as a potential
47 Collectively, these modifications generate a prenylcysteine methylester at the carboxyl terminus and
49 ific esterases catalyze the demethylation of prenylcysteine methylesters in Arabidopsis membranes.
50 reater specificity for biologically relevant prenylcysteine methylesters than the activity found in A
51 bitory factor-related protein 8, lysosome C, prenylcysteine oxidase 1, paraoxonase 1, transthyretin,
52 renylated plant proteins and the fate of the prenylcysteine (PC) residue have not been described.
53 raises the question of how cells dispose of prenylcysteines produced during the normal turnover of p
54 rategies: translocation of the Yersinia YopT prenylcysteine protease into host cells, inactivation of
56 ansferase (ICMT) methylesterifies C-terminal prenylcysteine residues of CaaX proteins and some RAB GT
58 ethyltransferase with lower apparent Kms for prenylcysteine substrates and higher specific activities
60 termed prenylcysteine lyase that cleaves the prenylcysteine to free cysteine and an isoprenoid produc
61 To test whether Pcly deficiency would cause prenylcysteines to accumulate in tissues and result in p
62 teine lyase has been identified that cleaves prenylcysteines to cysteine and an unidentified isopreno
63 e lyase (Pcly) cleaves the thioether bond of prenylcysteines to yield free cysteine and the aldehyde
64 se synthesis protocol for the preparation of prenylcysteines using 2-chlorotrityl chloride resin as a
65 d-type fibroblasts to growth inhibition when prenylcysteines were added to the cell culture medium.
66 me activity levels led to an accumulation of prenylcysteines within cells, mass spectrometry was used
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