ライフサイエンスコーパス: preparative

1 heptaprenol 4 in gram quantities will enable preparative access to key reagents for the study of the

2 Access to preparative amounts of discrete charged species allows f

3 o devise a procedure for the purification of preparative amounts of in vivo-synthesized apocatalase.

4 ising approach to quickly and easily produce preparative amounts of proteins.

5 lasma (NTP) is investigated as an innovative preparative analytical technique enabling classification

6 or the integration of sample processing with preparative and analytical separations for biology and c

7 uch covalent modifications involve extensive preparative and post-preparative chemistry that poses da

8 e loaded catalyst are in line with a host of preparative and spectral data and with the structures of

9 ids and particles for various analytical and preparative applications and may hold potential for sepa

10 obilization with AMD3100 may provide a safer preparative approach for HSC transplantation in genetic

11 free-floating products may be a general and preparative approach to access 2D nanomaterials.

12 bionanoparticles in vacuum is potentially a preparative approach to separate heterogeneous mixtures

13 Within this context, different preparative approaches for PDC-NCs as well as some of th

14 been investigated from both mechanistic and preparative aspects.

15 for applications ranging from analytical to preparative bioseparations.

16 A preparative biotransamination process has been developed

17 ound in the Athabasca oil sands region using preparative capillary gas chromatography (PCGC) followed

18 Preparative capillary gas chromatography (PCGC) is the c

19 n signature of C(ex) added from two sources: preparative capillary gas chromatography (PCGC, C(PCGC))

20 saccharides are one of the central goals of preparative carbohydrate chemistry.

21 To identify those biomarkers, we employ preparative CE, enabling direct infusion ESI MS analysis

22 Preparative centrifugal partition chromatography (CPC) i

23 tions are widespread in nature, yet only one preparative chemical method addresses this challenge in

24 A combination of preparative chemistry and experimental results from NMR

25 e ligands, a widespread investigation on the preparative chemistry and properties of such compounds h

26 tions involve extensive preparative and post-preparative chemistry that poses daunting limitations in

27 tical when patients receive reduced doses of preparative chemotherapy and/or radiation compared with

28 anced follicular lymphoma by administering a preparative chemotherapy regimen followed by autologous

29 family history or newborn screening, use of preparative chemotherapy, or the type of donor used, did

30 mmunoglobulin were improved after the use of preparative chemotherapy, other immunologic reconstituti

31 00 iU/kg of interleukin-2 to tolerance after preparative chemotherapy.

32 yl-3-hydroxy-4-benzyloxy-5,6-epoxyazepane by preparative chiral HPLC and subsequent elaboration allow

33 Nitrile (+/-)-9 was resolved via preparative chiral HPLC to afford optically pure nitrile

34 This fraction was further purified by semi-preparative chromatography and characterised by HPLC-MS/

35 exoglycosidase digestion arrays, analytical/preparative chromatography and mass spectrometric detect

36 of practical applications of analytical and preparative chromatography employ a stationary adsorbent

37 Preparative chromatography of peptides should preferenti

38 ial), including solvent partitioning through preparative chromatography, ranged from approximately 40

39 afforded diastereomers that were resolved by preparative chromatography.

40 f nanoliters and cannot be scaled up for the preparative collection of charge variants.

41 preparation is subsequently fractionated via preparative column chromatography using cellulose-based

42 sence of NK cells is a strong indicator that preparative conditioning is required for engraftment of

43 ure challenges lie in determining the safest preparative conditioning regimen, minimizing graft-versu

44 ansduced with the SIN-gammac vector, without preparative conditioning.

45 lamp and allows for analytical pulse flow or preparative continuous flow reactions.

46 with the low computed barriers, spectral and preparative data show that the reaction is not only poss

47 specificity, suitable for application in the preparative deracemisation of primary, secondary and ter

48 These studies illustrated the low preparative efficacy of biotransformations and the inabi

49 o our knowledge, migration assay with little preparative effort.

50 In preparative electrolysis experiments with a series of al

51 plored through a combination of voltammetry, preparative electrolysis, thiol-electrode modifications,

52 tigram scalable, these transformations are a preparative expansion of the pinane family.

53 l chemistry, mass-spectrometric studies, and preparative experiments.

54 ution of chemically dissimilar components in preparative fractionations such as prep TREF (which norm

55 Now, using a new preparative gas chromatography approach coupled with ele

56 s to several analytical approaches including preparative gas chromatography, p-menth-1-en-3-one (pipe

57 n media can mimic the results obtained using preparative gas-phase FVP protocols.

58 Sequences obtained from preparative gels had similarity to the C-20-immunizing p

59 With semi-preparative GPC the LMWDF (DP3) fractions in the wheat g

60 or either analytical (<50 microg protein) or preparative (>250 microg protein) applications.

61 ted CK-expressing hepatocytes was induced by preparative hepatic irradiation and expression of hepato

62 o direct structural analysis by analytic and preparative high pressure liquid chromatography, by mult

63 tion of the amino acid hydroxyproline, using preparative high-performance liquid chromatography (Prep

64 for radiolabeling were obtained using chiral preparative high-performance liquid chromatography and u

65 ary chromatographic techniques consisting of preparative high-speed countercurrent chromatography (HS

66 Thus, preparative HIR could be potentially useful to augment h

67 ding counter current chromatography and semi-preparative HPLC due to its low concentration and the pr

68 A two-stage preparative HPLC protocol was subsequently developed for

69 malic acid involved more than 20 steps and a preparative HPLC separation of diastereomeric intermedia

70 The combination of chiral preparative HPLC separation, VCD measurements, and theor

71 using SPE C-18 cartridges, purified by semi-preparative HPLC then analysed by HPLC/DAD/HRMS in both

72 g intermediates, subsequent fractionation by preparative HPLC, and final hydrogenation.

73 mic isomers, 4a and 4b, were separated using preparative HPLC, and structural analysis and self-aggre

74 The racemic mixture was separated by chiral preparative HPLC, and the resulting lead compound (3R,5S

75 ning all the detected flavonoids obtained by preparative HPLC, in terms of MICs for Staphylococcus au

76 alamondin peel was fractionated using a semi-preparative HPLC.

77 ola leaves and flowers were produced by semi-preparative HPLC.

78 diastereomers 7a-1, 7a-2, 7b-1, and 7b-2 by preparative HPLC.

79 tracted proteins, solid-phase extraction and preparative HPLC.

80 nd hybrid oligomer tetramers was achieved by preparative HPLC.

81 lowing fractionation of methanol extracts by preparative HPLC.

82 omer was cleanly isolated without the aid of preparative HPLC.

83 IVTQTMK and VLVLDTDYK) were fractionated via preparative-HPLC and incubated with MDA at 37 degrees C

84 This work shows that a preparative IEF method using immobilized pH gradients ca

85 Therefore, preparative IEF methods are needed to fractionate charge

86 A variety of preparative IEF methods have been developed over the yea

87 Preparative immunoprecipitation demonstrated that EpCAM

88 ul tool for the rapid quantification and the preparative immunoseparation of the target proteins.

89 Owing to its tremendous preparative importance, rhodium carbene chemistry has be

90 omatographic fractionations of extracts from preparative incubations with the 2Z,6E substrate afforde

91 Here, we have evaluated a preparative irradiation-based method of liver repopulati

92 hemical solvolytic reactivity studied, using preparative irradiations, fluorescence measurements, nan

93 This mixture was fractionated using preparative isoelectric focusing by free-flow electropho

94 ophoresis, an emerging separation method for preparative isoelectric focusing of complex peptide mixt

95 Preparative isolation of complex mixtures of compounds f

96 ossible, as well as those who seek advice on preparative issues, up to people having a certain applic

97 Using this approach, we demonstrate preparative labeling under mild conditions for up to ~16

98 Unlike previously described preparative LC/MS techniques, we have employed a dynamic

99 subjected to comprehensive lipid profiling (preparative liquid chromatography [LC] gas chromatograph

100 ncentration and fractionation of a sample by preparative Liquid Chromatography, identification experi

101 (87 wt.%) were successfully fractionated by preparative liquid chromatography.

102 ation of total body irradiation (TBI) to the preparative lymphodepleting chemotherapy regimen in sequ

103 Increasing intensity of host preparative lymphodepletion consisting of cyclophosphami

104 s potential for increasing overall yields in preparative mass spectrometry is explored briefly.

105 A preparative method for the synthesis of functionalized 2

106 e amount of included methanol depends on the preparative method used.

107 As a preparative method, FVP is used mainly to induce intramo

108 ules and materials, and despite a variety of preparative methods being available, processes which int

109 Preparative methods for stable coatings on smooth substr

110 However, to date, these preparative methods have typically been based on the dir

111 preparation of synthetic ultramarine, using preparative methods that would have been available to al

112 We show that preparative methods used previously in studying nucleoso

113 A series of novel preparative methods were developed to address the proble

114 n describes structural features, utility and preparative methods.

115 t will ultimately be determined by efficient preparative methods.

116 romatography systems and both analytical and preparative microfluidic systems that require highly eff

117 er reactions and give comparable yields in a preparative Mitsunobu reaction.

118 The reaction operates under preparative, operationally simple conditions (1 equiv of

119 o compartmentalize and access for integrated preparative or analytical operations on-chip.

120 Recent progress in the preparative organic and organometallic chemistry of poly

121 ration procedures and evaluate the different preparative parameters, such as time of saponification,

122 ethyl ester (bis-[60]PCBM) isomer mixture by preparative peak-recycling, high-performance liquid chro

123 Preparative photohydration and trapping reactions by thi

124 nd naphthyl phenols 5-8 were investigated by preparative photolyses in CH3CN-D2O, fluorescence spectr

125 photochemical reactivity was investigated by preparative photolyses, fluorescence spectroscopy, and l

126 y LFP, whereas the adducts were isolated via preparative photolyses.

127 Steady-state, preparative photooxidation experiments show that aryltri

128 fraction of bikunin GAG mixture obtained by preparative polyacrylamide gel electrophoresis, allowed

129 uired in order to take full advantage of the preparative potential of these transformations.

130 Key variables of the preparative process (e.g. chitosan and HA molecular weig

131 vetiver essential oil, was subjected to the preparative process, with the scope of isolating two low

132 A preparative protein alkaline hydrolysis procedure, as pa

133 A preparative protocol, based on the conversion into diast

134 cations ranging from metabolomic analysis to preparative purifications.

135 a coli is widely employed for laboratory and preparative purposes.

136 Using this approach, preparative quantities of hybrid and complex-type N-glyc

137 ly in expansion of the endosteal niche after preparative radioablation and in the engraftment of dono

138 ic route scouting to identify conditions for preparative reaction scale-up would be a transformative

139 After a uniform preparative regimen (fludarabine 40 mg/m(2) x 5, cycloph

140 The present data show that the Pc 26.1 preparative regimen allows thalassemia patients to safel

141 ts the choice of bone marrow transplantation preparative regimen and can prevent morbidity.

142 Preparative regimen and HLH activity affected outcomes,

143 eceiving fludarabine/melphalan (FluMel) as a preparative regimen and patients with unrelated donors (

144 The preparative regimen consisted of X-irradiation of the ho

145 The addition of ATG to the preparative regimen did not significantly improve the ou

146 d hepatocyte growth factor, can be used as a preparative regimen for liver repopulation of transplant

147 in a clinical setting after a myeloablative preparative regimen for stem cell transplantation, the t

148 The optimum preparative regimen for unrelated donor marrow transplan

149 The preparative regimen included busulfan, cyclophosphamide,

150 lantation has been attempted with degrees of preparative regimen intensity, but graft rejection and g

151 Mice receiving a preparative regimen of nonmyeloablating (5 Gy) total bod

152 assess donor hepatocyte proliferation with a preparative regimen of partial liver irradiation that al

153 For the clinical application of HT, a preparative regimen that allows preferential proliferati

154 in a subset of patients treated with an NMA preparative regimen that included antithymocyte globulin

155 hout any statistically significance with the preparative regimen they received.

156 Use of ATG in recipients of an NMA preparative regimen warrants close monitoring for eviden

157 Total body irradiation-containing preparative regimen was the only variable favorably infl

158 historical control group receiving the same preparative regimen without rituximab.

159 Methods Patients received a lymphodepleting preparative regimen, followed by adoptive transfer of pu

160 oduction of novel antileukemia agents in the preparative regimen, maintenance of remission treatment

161 ll children were given a fully myeloablative preparative regimen.

162 d donors, with the use of a nonmyeloablative preparative regimen.

163 selective proliferative stimuli offered by a preparative regimen.

164 ntation with an MA or nonmyeloablative (NMA) preparative regimen.

165 radiation and chemotherapeutic agents in the preparative regimen.

166 d a mouse model to investigate the effect of preparative regimens at primary BMT on outcome for secon

167 ablative (or reduced intensity) conditioning preparative regimens before haemopoietic cell transplant

168 ummary, recipients of URD-PBSC HCT receiving preparative regimens differing in intensity experienced

169 ronic phase), not eligible for myeloablative preparative regimens due to older age or comorbid condit

170 e added to myeloblative and non-myeloblative preparative regimens for haemopoietic cell transplantati

171 usulfan with total body irradiation (TBI) in preparative regimens for hematopoietic transplantation a

172 in hematopoietic cell transplantation (HCT) preparative regimens for lymphoma.

173 Novel nonmyeloablative fludarabine-based preparative regimens have demonstrated low risks of toxi

174 Preparative regimens included myeloablative (MA; N = 611

175 tion of chemotherapy and radiotherapy in HCT preparative regimens is not feasible due to dose-limitin

176 hepatocyte transplantation after appropriate preparative regimens may permit sufficient repopulation

177 Preparative regimens were ablative (n = 7) and nonablati

178 nt-related mortality (TRM) were seen for all preparative regimens when CD34(+) cell doses exceeded 4.

179 an be safely combined with reduced-intensity preparative regimens with encouraging results in a singl

180 Results were similar using chemotherapy preparative regimens with or without addition of TBI.

181 Advances in preparative regimens, donor selection, and supportive ca

182 nts with contraindications to high-intensity preparative regimens, reduced intensity conditioning sho

183 Transplantation-preparative regimes were mostly cyclophosphamide with or

184 Their preparative relevance is underscored by an application t

185 on (SPE) using a C18 matrix followed by semi-preparative reverse phase-high performance liquid chroma

186 ion on Amberlite(R) XAD16 polyamide and semi-preparative reverse-phase HPLC columns.

187 A new preparative route was developed to synthesize new phosph

188 Herein we review the simplicity of the preparative routes available, and their influence over t

189 as the potential to provide more sustainable preparative routes to catalysts than the current multist

190 A classification of the preparative routes to these synthetic targets according

191 Hyv(O-TBDMS) diastereomers were separated by preparative RP-HPLC in 13% yield from D-Val.

192 I and Id were separated by preparative RP-HPLC.

193 yst loadings as low as 0.01 mole percent and preparative scalability (25 grams) are demonstrated.

194 These techniques constitute a preparative, scalable method for separating nanotubes by

195 demonstrated by performing the reaction on a preparative scale (88 g).

196 formation of a key advanced intermediate on preparative scale absent any atropisomerization.

197 = m-OMe phenyl) (9) have been isolated on a preparative scale and fully characterized including an X

198 To identify the oxidation products, preparative scale bulk electrolysis experiments were und

199 This monomer is easily prepared on a preparative scale by a catalytic, enantioselective appro

200 methyl jasmonate (MJ) were isolated at semi-preparative scale by HPLC, using a permethylated beta-cy

201 Here, methodology for the efficient, preparative scale construction of covalent TM complexes

202 ed with an enantiospecific acylase to give a preparative scale dynamic kinetic resolution which allow

203 uction of the Mn(I) center, as observed with preparative scale electrolysis and verified with (13)CO2

204 The preparative scale electrolysis generated epoxide-ring-op

205 activity is robust, and PikDH2 was used on a preparative scale for the chemoenzymatic synthesis of un

206 are highly effective; however, their use on preparative scale has minimal precedent because they req

207 ll as peel and fruit pulp were evaluated for preparative scale implementation.

208 ity for acetylcholine could be isolated on a preparative scale in 67% yield.

209 sis of Au(102)(p-MBA)(44) nanoparticles on a preparative scale in high yield is described.

210 thod may also be useful to explore on a more preparative scale in the future.

211 e objective of this research is to implement preparative scale obtention of mangiferin and lupeol fro

212 Preparative scale peptide couplings of two N-Boc amino a

213 flavonoid scaffolds and provides a basis for preparative scale production of flavonoid 4 '-O-glucosid

214 n (TFA catalysis, 100 mM) was performed on a preparative scale providing TpFPPhl in a yield of 45% (1

215 A preparative scale reaction to deliver 25 g of product is

216 We also demonstrate preparative scale reductive aminations with wild-type an

217 A reliable preparative scale synthesis of 1-bromo-1-lithioethene is

218 uct inhibition of the evolved enzyme enabled preparative scale synthesis of a single product diastere

219 The reaction has been demonstrated on the preparative scale with 72% isolated yield and 99% Markov

220 Reductions can be accomplished on a preparative scale with as little as 0.05 mol % Ru cataly

221 nic oxo imido complexes can be obtained on a preparative scale, and an X-ray crystal structure of [Re

222 d amide) is accomplished in good yield, on a preparative scale, and with complete stereocontrol.

223 aphic techniques, both at the analytical and preparative scale, are used also in the identification o

224 h catalyst and microbe, and can be used on a preparative scale, represents a new strategy for chemica

225 unusual thermodynamic cycle is employed on a preparative scale, where mechanical energy is used to bu

226 high levels of enantioselectivity, even on a preparative scale.

227 e at promoting the cyclization reaction on a preparative scale.

228 olubility of 4 prevented its resolution on a preparative scale.

229 m7dG moiety site-specifically into DNA on a preparative scale.

230 ds for the synthesis of such polymers on the preparative scale.

231 synthesis of the phlorin were performed on a preparative scale.

232 94 % ee; >98 % de) and can be performed on a preparative scale.

233 he utility of the system was demonstrated by preparative-scale applications.

234 protocol describes a method for the one-tube preparative-scale assembly of a specific DNA molecule, t

235 Preparative-scale aziridinations can be easily achieved

236 The preparative-scale catalytic aminooxygenation reaction (g

237 ueous-organic, solvent than LC (important in preparative-scale chromatography) and provides an altern

238 Strategies for optimized preparative-scale electrolyses may then be devised on th

239 Preparative-scale electrolyses showed that carbon monoxi

240 f methanol or formate could be detected upon preparative-scale electrolysis of CO2 on the same electr

241 extraction, flash column chromatography, and preparative-scale high performance liquid chromatography

242 e areas of ultrafast protein separations and preparative-scale protein chromatography.

243 dition (InCl(3), 0.32 mM) was performed on a preparative-scale providing the 5-isocorrole in an isola

244 A preparative-scale reaction provided HPO in an isolated y

245 A preparative-scale reaction to deliver >90 mmol of produc

246 In a preparative-scale reaction, unreacted (S)-(+)-butanoate

247 s often a limitation in adopting enzymes for preparative-scale synthesis, reaction with demanding sub

248 A novel preparative-scale triple gas chromatographic system, equ

249 Here we describe the preparative-scale, enantioselective, total syntheses of

250 s to the desired hydroxylated derivatives at preparative scales (0.4 g) and in high isolated yields (

251 asymmetric methods have seen limited use on preparative scales (more than a gram).

252 ubstituted derivatives can be synthesized on preparative scales, using a chemoenzymatic approach.

253 mbered ring systems stereoselectively and on preparative scales.

254 Using preparative SDS-PAGE, in-gel tryptic digestion, high pre

255 chromatography (SEC) and easily purified by preparative SEC.

256 r concentration of the polyphenols from PSP, preparative separation into two fractions, designated an

257 Preparative separation of membrane protein loaded nanodi

258 designed mass spectrometer which allows for preparative separation of mixtures is described.

259 sma-treated metal surfaces can be useful for preparative separation of organic and biological molecul

260 can be a vital tool for characterization and preparative separation of PAMAM dendrimers.

261 Preparative separation of the mixture of regioisomeric m

262 superior performance for both analytical and preparative separation of various physiologically releva

263 Counter-current chromatography (CCC) is a preparative separation technique working with the two li

264 ility" and therefore has great potential for preparative separations.

265 date without using biochemical techniques or preparative separations.

266 ficant production rate improvements in (semi)preparative SFC.

267 from a water extract of Se-rich yeast using preparative size exclusion, anion exchange, and capillar

268 The mAb HMW fractions were collected using preparative size-exclusion chromatography (SEC) and exte

269 We used anion-exchange chromatography and preparative sodium dodecyl sulfate-polyacrylamide gel el

270 or types and their successful application in preparative solar syntheses.

271 All sample preparative steps including magnetic stirring assisted D

272 (MALDI-ToF), REIMS based methods require no preparative steps nor time-consuming cell extractions.

273 hondrial activity and efficiency, and, after preparative steps, it takes 6-8 h to complete.

274 n be obtained from commercial sources in two preparative steps.

275 linical laboratories without any preanalysis preparative steps.

276 ite materials, critically examine the viable preparative strategies geared to craft intimate CP-NC na

277 cal synthesis of AMPDs, through nanoparticle preparative strategies, to the most recent applications

278 Finally, we demonstrate a preparative strategy for obtaining pure bioorthogonally

279 entary methods: a MALDI-MS method and a semi-preparative sub-fractionation.

280 ic trans-dinaphthyl isomers were resolved by preparative supercritical fluid chromatography (SFC) on

281 Also, at low ethylene pressures, preparative syntheses of several 2,3-disubstituted 1,3-b

282 ed solution that is more characteristic of a preparative synthetic reaction.

283 ent evolution of a multidimensional GC-GC-GC preparative system, now combined with an online LC prese

284 With preparative tandem affinity purification followed by MS

285 ayer-compression mechanism revealed a simple preparative technique to produce nanosheets in 95% overa

286 F-enzyme composites with special emphasis on preparative techniques and the synergistic effects of en

287 alyzers and should allow the use of many new preparative techniques for collecting and purifying nonv

288 Preparative therapy for the transplant consisted of high

289 ed and purified by liquid chromatography and preparative TLC.

290 n mass spectrometry based proteomics or as a preparative tool for analyte purification, fractionation

291 At week 12, LDL-C reduction measured by preparative ultracentrifugation (least squares mean [sta

292 xylate carbene series that enjoys widespread preparative use, or to the class of mononuclear half-san

293 To demonstrate the preparative utility of this method in the context of bio

294 onalization, few intermolecular processes of preparative value exist.

295 Separations can be broadly categorized as preparative, where the objective is to extract purified

296 ing materials has facilitated the underlying preparative work.

297 xy-6,6-dimethylbicyclo[3.1.1]heptan-2-one in preparative yield (65% on a multigram scale).

298 xides, giving quantitative conversions, high preparative yields and excellent chemoselectivity.

299 able catalyst-controlled site-selectivity in preparative yields over a range of topologically diverse

300 didichlorophosphorylated diamondoids in high preparative yields.