ライフサイエンスコーパス: prepulse inhibition

1 etamine-induced hyperactivity; disruption of prepulse inhibition).

2 revious findings, Fmr1KO mice have increased prepulse inhibition.

3 hanced susceptibility to stress and impaired prepulse inhibition.

4 ects were tested on both P50 suppression and prepulse inhibition.

5 significantly affect startle habituation or prepulse inhibition.

6 startle response but exhibit a deficiency in prepulse inhibition.

7 A/2J mice, a strain with low basal levels of prepulse inhibition.

8 ited any impairment in startle reactivity or prepulse inhibition.

9 pment of temporal processing, assessed using prepulse inhibition.

10 s, motor coordination, pain sensitivity, and prepulse inhibition.

11 vant to exploratory locomotion, startle, and prepulse inhibition.

12 erstimulus interval, stimulus intensity, and prepulse inhibition.

13 more evident in measures of right eye-blink prepulse inhibition.

14 ersonality disorder showed less asymmetry of prepulse inhibition.

15 enic patients showing the expected deficient prepulse inhibition.

16 ng was examined operationally via the use of prepulse inhibition.

17 of neurotensin had no significant effect on prepulse inhibition.

18 social interaction, locomotor activity, and prepulse inhibition.

19 el and potent mechanism of sensory gating in prepulse inhibition.

20 exhibited increased sociability and impaired prepulse inhibition.

21 Rab3A or synaptotagmin 1 only show decreased prepulse inhibition.

22 d-amphetamine- and DOI-induced disruption of prepulse inhibition.

23 t mice show increased aggression and reduced prepulse inhibition.

24 tial working memory, social interaction, and prepulse inhibition.

25 23), sensorimotor dexterity (2q24 and 2q32), prepulse inhibition (5p15), the California Verbal Learni

26 out mice had a sexually dimorphic deficit in prepulse inhibition, a gene dosage-dependent decrease in

27 the rotorod, but not to any abnormalities in prepulse inhibition, a measure of sensorimotor gating.

28 term plasticity are linked to alterations in prepulse inhibition, a measure of sensorimotor gating.

29 o showed overgrooming as well as deficits of prepulse inhibition, a widely used endophenotype of schi

30 iors, less depression-like conduct, impaired prepulse inhibition, amphetamine hypersensitivity, and i

31 alpha deficient mice displayed a decrease in prepulse inhibition, an increase in grooming behaviors,

32 ith impaired sensorimotor gating measured by prepulse inhibition--an established endophenotype of sch

33 ld-type hosts, SCZ glial mice showed reduced prepulse inhibition and abnormal behavior, including exc

34 ell-characterised neural mechanisms, such as prepulse inhibition and antisaccades, to substantially a

35 icits in translational inhibitory biomarkers-prepulse inhibition and antisaccades-that occur after sl

36 ecreased anxiety-related behavior, increased prepulse inhibition and delayed acquisition of rewarded

37 ormal cerebellar and hippocampal morphology, prepulse inhibition and fear conditioning.

38 he PDE4B(Y358C) mutation was observed in the prepulse inhibition and forced swim tests.

39 se and adaptability of the startle response (prepulse inhibition and habituation) have been observed

40 eased social interaction, and impairments in prepulse inhibition and latent inhibition.

41 rs of early auditory information processing: prepulse inhibition and mismatch negativity (MMN) in SZ

42 The comparison subjects showed greater prepulse inhibition and prepulse facilitation during the

43 nvestigated the effects of antipsychotics on prepulse inhibition and startle habituation in acutely h

44 Screens such as prepulse inhibition and startle have been adapted for mi

45 gnosed with 90.8% accuracy using measures of prepulse inhibition and temporal sensitivity.

46 aze, inhibitory avoidance, acoustic startle, prepulse inhibition, and hot plate assays.

47 diminished startle response, as measured by prepulse inhibition, and impaired social recognition.

48 evelopment decreased startle habituation and prepulse inhibition, and increased avoidance (particular

49 sures were startle responsivity, reactivity, prepulse inhibition, and startle habituation.

50 phenotypes, such as perseveration, disrupted prepulse inhibition, and strong withdrawal from social i

51 of SKF 81297 to disrupt acoustic startle and prepulse inhibition appeared to be attenuated in D5-/- m

52 hether abnormal P50 suppression and abnormal prepulse inhibition are independent neurophysiological c

53 ) and Disc1-Q31L(+/-) offspring, and reduced prepulse inhibition at 16 but not 8 weeks of age.

54 Prepulse inhibition at the other interstimulus intervals

55 containing the human FMR1 gene had levels of prepulse inhibition comparable to WT mice, indicating no

56 iors, with male Val/Val mice exhibited lower prepulse inhibition compared with Met/Met mice, whereas

57 Deficient prepulse inhibition correlated significantly with 2 of t

58 Deficient prepulse inhibition correlated with both positive and ne

59 w rescue of key SCZ-related deficits, namely prepulse inhibition decrease, working memory impairment,

60 Mice expressing AAV-DN1 have prepulse inhibition deficits and impairments in working

61 edicated or unmedicated at admission, showed prepulse inhibition deficits compared with healthy subje

62 served as prepulses in published reports of prepulse inhibition deficits in schizophrenia.

63 Prepulse inhibition deficits in schizophrenic patients c

64 The pattern of prepulse inhibition deficits in schizophrenic patients r

65 hat the neurobiological substrate underlying prepulse inhibition deficits may be dysregulated during

66 should probably focus on the relationship of prepulse inhibition deficits to measures such as thought

67 s robust as that in previous reports linking prepulse inhibition deficits with other measures, such a

68 patients with schizophrenia would also have prepulse inhibition deficits, thereby reflecting a genet

69 conditions, schizophrenia-linked deficits in prepulse inhibition detected with a relatively strong pr

70 that produce an enhanced sensitivity to the prepulse inhibition-disruptive effects of the DA agonist

71 d that abnormal P50 suppression and abnormal prepulse inhibition do not necessarily occur together.

72 the rotarod test, acoustic startle response, prepulse inhibition, elevated plus-maze, light <--> dark

73 DCN induces hearing using a novel electrical prepulse inhibition (ePPI) of startle reflex behavior mo

74 In this study, gap prepulse inhibition (gap-PPI) of the acoustic startle re

75 Gap prepulse inhibition (gap-PPI), a translational experimen

76 in a novelty-induced open field, deficits in prepulse inhibition, hypersensitivity to amphetamine, an

77 nce reflects a common endophenotype and that prepulse inhibition identifies a separate endophenotype

78 erlocomotion, restored amphetamine-disrupted prepulse inhibition, improved social behavior, and novel

79 Measuring P50 suppression and prepulse inhibition in a single session is feasible and

80 ging and ameliorated a behavioral deficit in prepulse inhibition in adulthood in a DISC1 knockdown mo

81 lation also reduced swim test immobility and prepulse inhibition in P rats and increased locomotor st

82 Patients showed reduced P50 suppression and prepulse inhibition in relation to healthy comparison su

83 f prepulses should not contribute to reduced prepulse inhibition in schizophrenia patients versus con

84 cluding hyperlocomotor activity, deficits in prepulse inhibition, increased anxiety, impaired social

85 Prepulse inhibition is a type of sensorimotor gating tha

86 ld test, it restored d-amphetamine-disrupted prepulse inhibition, it induced cognitive improvements i

87 y, the effector mechanisms underlying neural prepulse inhibition itself were unaffected by antagonist

88 impaired neurovascular coupling; attenuated prepulse inhibition (males); and hyperkinetic behavior.

89 ndings suggest that antipsychotic effects on prepulse inhibition may not be evident at a time when sc

90 ndently accounted for 60% of the variance in prepulse inhibition measures and contributed 35% of the

91 immobility in the forced swim test, reduced prepulse inhibition, mild motor coordination impairments

92 ate that BACE1(-/-) mice exhibit deficits in prepulse inhibition, novelty-induced hyperactivity, hype

93 The levels of both P50 suppression and prepulse inhibition obtained in the combined session wer

94 ing was abnormal, as measured by deficits in prepulse inhibition of acoustic and tactile startle.

95 ehavioral phenotypes in open-field activity, prepulse inhibition of acoustic startle response and con

96 r the effects of amphetamine (2-10 mg/kg) on prepulse inhibition of acoustic startle responses.

97 of behavioral alterations and of deficits in prepulse inhibition of acoustic startle, a measure of se

98 ated acoustic startle responses, deficits in prepulse inhibition of acoustic startle, and motor hyper

99 were also observed in locomotor activity and prepulse inhibition of acoustic startle, behaviors that

100 ia assesses the neurophysiologic measures of prepulse inhibition of acoustic startle, P50 event-relat

101 Prepulse inhibition of startle declined at a faster rate

102 ntitative MRI, and sensorimotor gating using prepulse inhibition of startle in a subset of 12 individ

103 ed sensorimotor gating as measured using the prepulse inhibition of startle response.

104 The prepulse inhibition of startle responses by a weaker pre

105 tory tasks such as frequency discrimination, prepulse inhibition of startle responses, or fear condit

106 Changes in prepulse inhibition of startle was tested after MK-801 (

107 cits in auditory-evoked response adaptation, prepulse inhibition of startle, and evoked gamma-activit

108 startle amplitudes and similar magnitudes of prepulse inhibition of startle, suggesting that CREBalph

109 weight, spontaneous locomotor activity, and prepulse inhibition of startle.

110 Recently prepulse inhibition of the acoustic startle reflex (ASR)

111 the PV neuron population, robustly impaired prepulse inhibition of the acoustic startle reflex (PPI)

112 uisition of contextual fear conditioning and prepulse inhibition of the acoustic startle reflex.

113 ine system increases locomotion and disrupts prepulse inhibition of the acoustic startle response (PP

114 Prepulse inhibition of the acoustic startle response (PP

115 ften studied in humans and rodents using the prepulse inhibition of the acoustic startle response (PP

116 typical antipsychotic clozapine and enhanced prepulse inhibition of the acoustic startle response in

117 Chemospecific ablation of THINs impairs prepulse inhibition of the acoustic startle response sug

118 ater sensitivity to a D2 agonist and smaller prepulse inhibition of the acoustic startle response tha

119 ylyl)methyl]propanamide dihydrochloride), on prepulse inhibition of the acoustic startle response.

120 ng a temporary-threshold shift model and gap-prepulse inhibition of the acoustic startle to assess ti

121 veloped tinnitus as indicated by gap-induced prepulse inhibition of the acoustic startle.

122 e normal comparison subjects were tested for prepulse inhibition of the eyeblink component of the sta

123 h as those reported in studies that measured prepulse inhibition of the human startle response and ha

124 potential was significantly correlated with prepulse inhibition of the P13 potential, the N40 potent

125 These results demonstrate the presence of prepulse inhibition of the P13 potential, the N40 potent

126 prepulse intensity and the background level, prepulse inhibition of the SR was reduced or absent whil

127 mice deficient in TIMP-2 (knockout) exhibit prepulse inhibition of the startle reflex, suggesting de

128 s of schizophrenia are demonstrated by using prepulse inhibition of the startle reflex.

129 -HT)2A receptors are known to be involved in prepulse inhibition of the startle response (PPI), a mea

130 We show that fear conditioning and prepulse inhibition of the startle response are also dis

131 er, heterozygous mice display an increase in prepulse inhibition of the startle response, a manifesta

132 ial P50 response to repeated stimuli and the prepulse inhibition of the startle response.

133 schizophrenia patients: P50 suppression and prepulse inhibition of the startle response.

134 ficits in sensorimotor gating as assessed by prepulse inhibition of the startle response.

135 ivity in a novel environment and deficits in prepulse inhibition of the startle response.

136 motor gating impairments, as assessed by the prepulse inhibition of the startle.

137 udy, we used elevated plus-maze, startle and prepulse inhibition, open field, and novel object recogn

138 differ from each other in startle magnitude, prepulse inhibition, or habituation.

139 rate deficits in inhibition when assessed on prepulse inhibition, P50 suppression, and antisaccade pa

140 Prepulse inhibition, P50 suppression, and antisaccade pa

141 were compared on a silent gap variant of the prepulse inhibition paradigm.

142 deficits in working memory, sociability, and prepulse inhibition, paralleled by locomotor hyperactivi

143 digm, while hearing status was assessed with prepulse inhibition (PPI) and auditory brainstem respons

144 hors introduce a real-time model of acoustic prepulse inhibition (PPI) and facilitation (PPF) in anim

145 f IL-6 on day 12.5 of mouse pregnancy causes prepulse inhibition (PPI) and latent inhibition (LI) def

146 They were also tested for prepulse inhibition (PPI) and locomotor activity in the

147 Previous analyses of prepulse inhibition (PPI) and P50 gating measures in thi

148 CCK-1 receptors play a role in prepulse inhibition (PPI) by modulating mesolimbic dopam

149 nd lead times (20-40 ms) and was replaced by prepulse inhibition (PPI) for higher values, especially

150 ring on startle reactivity, habituation, and prepulse inhibition (PPI) in male Lewis, Sprague-Dawley,

151 sure the acoustic startle response (ASR) and prepulse inhibition (PPI) in mice.

152 autism, these offspring display deficits in prepulse inhibition (PPI) in the acoustic startle respon

153 Clozapine increased prepulse inhibition (PPI) in wild-type mice.

154 Prepulse inhibition (PPI) is an example of sensorimotor

155 Prepulse inhibition (PPI) is an operational measure of s

156 Prepulse inhibition (PPI) is an operational measure of s

157 Prepulse inhibition (PPI) is an operational measure of s

158 ty to dopamine agonist-induced disruption of prepulse inhibition (PPI) may be a useful model for the

159 Prepulse inhibition (PPI) occurs when a weak prestimulus

160 Prepulse inhibition (PPI) of acoustic startle has been u

161 Prepulse inhibition (PPI) of acoustic startle is a genet

162 rally active causing a dramatic reduction in prepulse inhibition (PPI) of acoustic startle response.

163 tactile startle as well as the magnitude of prepulse inhibition (PPI) of both tactile and acoustic s

164 Prepulse inhibition (PPI) of startle is being explored b

165 In humans, prepulse inhibition (PPI) of startle is greater during a

166 Prepulse inhibition (PPI) of startle is impaired in schi

167 t deficient sensorimotor gating (measured by prepulse inhibition (PPI) of startle) and mismatch negat

168 ensory gating of auditory evoked potentials, prepulse inhibition (PPI) of startle, and startle amplit

169 vestigated whether individual differences in prepulse inhibition (PPI) of the acoustic startle reflex

170 examine core and shell function, we measured prepulse inhibition (PPI) of the acoustic startle reflex

171 Prepulse inhibition (PPI) of the acoustic startle reflex

172 ry spatial acuity was measured in mice using prepulse inhibition (PPI) of the acoustic startle reflex

173 Rats were tested for prepulse inhibition (PPI) of the acoustic startle respon

174 ulation of the dopamine (DA) system disrupts prepulse inhibition (PPI) of the acoustic startle respon

175 locomotor activity in a novel open field and prepulse inhibition (PPI) of the acoustic startle respon

176 In animals, LSD disrupts prepulse inhibition (PPI) of the acoustic startle respon

177 Translational biomarkers, such as prepulse inhibition (PPI) of the acoustic startle respon

178 Prepulse inhibition (PPI) of the acoustic startle respon

179 tive probe associated with this circuitry is prepulse inhibition (PPI) of the acoustic startle respon

180 d schizophrenia patients exhibit deficits in prepulse inhibition (PPI) of the acoustic startle respon

181 Sensorimotor gating was measured by prepulse inhibition (PPI) of the acoustic startle respon

182 e than Long Evans (LE) rats to disruption of prepulse inhibition (PPI) of the startle reflex by the d

183 Prepulse inhibition (PPI) of the startle reflex has been

184 Prepulse inhibition (PPI) of the startle reflex is a mea

185 Sensorimotor gating, measured by prepulse inhibition (PPI) of the startle reflex, is redu

186 deficient sensorimotor gating as measured by prepulse inhibition (PPI) of the startle response, exhib

187 important measure of sensorimotor gating is prepulse inhibition (PPI) of the startle response, impai

188 nformation, a process which is studied using prepulse inhibition (PPI) of the startle response.

189 ed into the nucleus accumbens of rats on the prepulse inhibition (PPI) of their acoustic startle refl

190 Prepulse inhibition (PPI) refers to a reduction in the s

191 ity, impaired working memory, and deficit in prepulse inhibition (PPI) that was ameliorated by diazep

192 After AAE treatment, prepulse inhibition (PPI) to tone prepulses (4-24 kHz, 7

193 nt is preceded by a stimulus; this is called prepulse inhibition (PPI) when the prestimulus is weak a

194 etion (Df1) that models 22q11DS have reduced prepulse inhibition (PPI), a behavioral abnormality and

195 Prepulse inhibition (PPI), a form of sensorimotor gating

196 f3b-null mice also have a profound defect in prepulse inhibition (PPI), a measure of sensorimotor gat

197 whether intra-Acb amylin signaling modulates prepulse inhibition (PPI), a measure of sensorimotor gat

198 Prepulse inhibition (PPI), a phenomenon in which a weak

199 Prepulse inhibition (PPI), an operational measure of sen

200 n amygdala systems that modulate startle and prepulse inhibition (PPI), an operational measure of sen

201 rlocomotion, increased stereotype, defective prepulse inhibition (PPI), and disability in nest buildi

202 ibition of startle by sensory stimuli, i.e., prepulse inhibition (PPI), and is disrupted in patients

203 function demonstrated consistent deficits in prepulse inhibition (PPI), as well as higher startle res

204 The mGlu5 KO mice showed reduced prepulse inhibition (PPI), long-term memory deficits, an

205 In prepulse inhibition (PPI), startle responses to sudden,

206 In prepulse inhibition (PPI), the startle response to a str

207 the hypothesis that PPD in rats would alter prepulse inhibition (PPI), which is an operational measu

208 ed alternation memory tasks, and deficits in prepulse inhibition (PPI).

209 the sensorimotor gating phenomenon known as prepulse inhibition (PPI).

210 sensorimotor gating deficits, as measured by prepulse inhibition (PPI).

211 automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex.

212 This phenomenon, termed "prepulse inhibition" (PPI), appears to function to reduc

213 oups differed significantly in the amount of prepulse inhibition produced by the 16-dB prepulse, with

214 15 mg/kg, partially reversed the deficits in prepulse inhibition produced by the mutation.

215 or the improvement or whether differences in prepulse inhibition reflect other factors, such as acuit

216 zotypal personality disorder all had reduced prepulse inhibition relative to comparison subjects, and

217 ophrenia-relevant behavioral tasks including prepulse inhibition, response to psychotomimetic drugs,

218 These open-field and prepulse inhibition results suggest that the mGAT1 KO mi

219 suggest a genetically transmitted deficit in prepulse inhibition (sensorimotor gating) in patients wi

220 Prepulse inhibition, sensory gating, antisaccade, spatia

221 testing in a carefully designed combined P50/prepulse inhibition session using stimulus characteristi

222 ion without delays, spontaneous alternation, prepulse inhibition, social interaction, anxiety-, stres

223 s displayed more climbing behavior and lower prepulse inhibition, suggesting an increase in central n

224 ry avoidance, increased startle responses in prepulse inhibition tasks, and increased MK-801-induced

225 eline startle responses in the course of the prepulse inhibition test, and lower hedonic responses in

226 ss sensitive to an amphetamine disruption of prepulse inhibition than WT mice but were more sensitive

227 underlie certain core deficits (startle and prepulse inhibition) that are observed in post-traumatic

228 ficits in sensorimotor gating as measured by prepulse inhibition, to the authors' knowledge P50 senso

229 Prepulse inhibition was also investigated.

230 Prepulse inhibition was impaired in both mice and humans

231 Prepulse inhibition was measured by using a series of pr

232 Prepulse inhibition was most prominent at the 120-msec i

233 Prepulse inhibition was not affected by darkness and did

234 Prepulse inhibition was not correlated significantly wit

235 At the 500-msec interstimulus interval, prepulse inhibition was significantly but negatively cor

236 hyperactivity; sensorimotor gating (startle prepulse inhibition) was unaffected.

237 Social memory, spatial working memory and prepulse inhibition were also impaired.

238 The magnitude of startle and prepulse inhibition were assessed in alternating periods

239 in previous experiments, P50 suppression and prepulse inhibition were not significantly correlated.

240 nstrated greater right versus left eye-blink prepulse inhibition, whereas the probands, their relativ

241 Transgenic mice were deficient in prepulse inhibition, which was restored by clozapine but