ライフサイエンスコーパス: presomitic

1 H-2 transcripts localized to the presumptive presomitic and lateral plate mesoderm and CYP26 mRNA to

2 Furthermore, ectopic expression of Gas1 in presomitic cells attenuates the response of these cells

3 Lateral presomitic cells remain deep in the myotome and they dif

4 ion of cells in the segmental plate, lateral presomitic cells.

5 When presomitic explants are confronted with cells secreting

6 nic axis by sequential segmentation from the presomitic mesoderm (PSM) and differentiate into the seg

7 During this process, cells in the presomitic mesoderm (PSM) are first patterned into segme

8 ming of SHH and BMP signals controls whether presomitic mesoderm (PSM) cells will adopt either a chon

9 (NM) stem cells generate neural and paraxial presomitic mesoderm (PSM) cells, which are the respectiv

10 ock, a molecular oscillator expressed within presomitic mesoderm (PSM) cells.

11 We show here that presomitic mesoderm (psm) cultured in the presence of Sh

12 Lunatic fringe (Lfng) expression in the presomitic mesoderm (PSM) cycles in the posterior PSM, i

13 e continuously produced posteriorly from the presomitic mesoderm (PSM) during body formation.

14 by an ENU-induced mutation that disrupts the presomitic mesoderm (PSM) expression of Notch pathway ge

15 togenesis, cells are recruited to the caudal presomitic mesoderm (PSM) from the primitive streak (and

16 hicken embryo to demonstrate that the caudal presomitic mesoderm (PSM) has a key role in axis elongat

17 use embryo, timely somite formation from the presomitic mesoderm (PSM) is controlled by the "segmenta

18 ion of the Mesp genes within segments of the presomitic mesoderm (PSM) of different vertebrate specie

19 lunatic fringe (lfng) expression within the presomitic mesoderm (PSM), a hes6a gradient in the PSM n

20 e/notochord and surface ectoderm in cultured presomitic mesoderm (PSM), and is accompanied by a marke

21 Xena) localizes to the cell periphery in the presomitic mesoderm (PSM), and is enriched at intersomit

22 This operates in each cell of the presomitic mesoderm (PSM), but the individual cells drif

23 ng this process, paired somites bud from the presomitic mesoderm (PSM), in a process regulated by a g

24 oth genes are transcribed in the unsegmented presomitic mesoderm (PSM), newly formed somites, adaxial

25 f Snail 1 and Snail 2 in the mouse and chick presomitic mesoderm (PSM), respectively.

26 terior-to-anterior signaling gradient in the presomitic mesoderm (PSM), which controls cell maturatio

27 ythmic activity of signaling pathways in the presomitic mesoderm (PSM).

28 rm by an iterative process from unsegmented, presomitic mesoderm (PSM).

29 the somites, are rhythmically produced from presomitic mesoderm (PSM).

30 d DeltaD in the zebrafish nervous system and presomitic mesoderm (PSM).

31 n of epithelial somites from the mesenchymal presomitic mesoderm (PSM).

32 ior positioning of boundary formation in the presomitic mesoderm (PSM).

33 ion, known as the segmentation clock, in the presomitic mesoderm (PSM).

34 ols the timing of maturation of cells in the presomitic mesoderm (PSM).

35 velike along the anteroposterior axis of the presomitic mesoderm (PSM).

36 es arise from somites, which derive from the presomitic mesoderm (PSM).

37 itiation of transcription in the unsegmented presomitic mesoderm (PSM).

38 es cause them to detach from the unsegmented presomitic mesoderm [1-3].

39 we show that beta1-integrin in the anterior presomitic mesoderm activates canonical Wnt signalling i

40 o, transcripts for Mf3 are restricted to the presomitic mesoderm and anterior neurectoderm and mesode

41 onic axis by regulating cell motility in the presomitic mesoderm and by controlling specification of

42 2 to restrict the anterior boundaries of the presomitic mesoderm and caudal progenitor pool.

43 pressed in a dynamic pattern in paraxial and presomitic mesoderm and developing somites during mouse

44 her1 and Delta D expression in the anterior presomitic mesoderm and disrupts myogenic differentiatio

45 inal cord, which is maintained by underlying presomitic mesoderm and FGF signalling, and neuronal dif

46 ph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites.

47 fic manner in the presumptive somites of the presomitic mesoderm and is required for normal somitogen

48 cs the inducing effects of notochord on both presomitic mesoderm and neural plate explants of amniote

49 Co-cultures between presomitic mesoderm and neural tube also supported vascu

50 e dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites.

51 of the DSL gene family, is expressed in the presomitic mesoderm and posterior halves of somites.

52 of gene expression by microarray between the presomitic mesoderm and the 5 most recently formed somit

53 erior Hox genes and that of marker genes for presomitic mesoderm and the chordoneural hinge.

54 ral tube, and by myogenic progenitors in the presomitic mesoderm and the hypaxial somites.

55 are expressed at the transition zone between presomitic mesoderm and the segmented somites.

56 the presumptive somite from the rest of the presomitic mesoderm and the subsequent morphological cha

57 ri somites formed without convergence of the presomitic mesoderm and were composed of only two cells

58 n somite number and size, restriction of the presomitic mesoderm anterior border, somite chevron morp

59 border, decreased adhesion at the notochord-presomitic mesoderm border, and tension at boundaries wi

60 We provide direct evidence that presomitic mesoderm cells oscillate asynchronously in ze

61 is to keep the oscillations of neighbouring presomitic mesoderm cells synchronized.

62 nscriptional oscillations of cyclic genes in presomitic mesoderm cells.

63 Dynamic expression of FGF8 in the presomitic mesoderm constitutes the wavefront of determi

64 By employing explants of presomitic mesoderm cultured with constant levels of Wnt

65 ic mesoderm exhibits RALDH-2-IR but thoracic presomitic mesoderm does not.

66 Adaxial cells become distinguishable in the presomitic mesoderm during late gastrulation by their ex

67 eriodic cleavage of somites from unsegmented presomitic mesoderm during vertebrate segmentation.

68 Cervical presomitic mesoderm exhibits RALDH-2-IR but thoracic pre

69 ollagen explant model was developed in which presomitic mesoderm explants formed a vascular plexus in

70 yoD activation by recombinant Shh protein in presomitic mesoderm explants is defective in Myf5 null e

71 and induce dermomyotome marker expression in presomitic mesoderm explants, supporting the hypothesis

72 enous Myf5 expression in 10T1/2 cells and in presomitic mesoderm explants.

73 ovirus to overexpress Gli1, Gli2 and Gli3 in presomitic mesoderm explants.

74 mites of Shh null embryos and in explants of presomitic mesoderm from wild-type and Myf5 null embryos

75 Mouse-avian chimeras with mouse presomitic mesoderm grafts had graft-derived endothelial

76 trikingly, X-Delta-2 is expressed within the presomitic mesoderm in a set of stripes that corresponds

77 nction in stimulating the differentiation of presomitic mesoderm into dermomyotome.

78 role in the translation of the patterning of presomitic mesoderm into somites.

79 It is likely that presomitic mesoderm is a vertebrate innovation made poss

80 eling, we demonstrate that C&E of the medial presomitic mesoderm is achieved by cooperation of planar

81 Notch pathway activity in the presomitic mesoderm is fundamental for management of syn

82 derm and neural plate, but its expression in presomitic mesoderm is initially unchanged.

83 nos, expression of genes in undifferentiated presomitic mesoderm is initiated, but not maintained.

84 Expression of terra in presomitic mesoderm is restricted to cells that lack exp

85 ing model of somitogenesis supposes that the presomitic mesoderm is segmented into somites by a clock

86 a segmental prepattern is established in the presomitic mesoderm of all these mutants and hox gene ex

87 When ectopically expressed in the presomitic mesoderm of chick embryos in ovo, Wnt-1 diffe

88 ature Hes7 transcripts are stabilized in the presomitic mesoderm of mutant mice, suggesting that both

89 tures dramatic loss of expression within the presomitic mesoderm of Notch/Delta pathway components an

90 in the Notch pathway were not altered in the presomitic mesoderm of paraxis(-/-) embryos.

91 h required for transcription in the anterior presomitic mesoderm of paraxis, Mesp1, Mesp2, Hes5, and

92 of Dll1 transcripts is also increased in the presomitic mesoderm of PS1(-/-) embryos, while the level

93 ate Notch ligand, is markedly reduced in the presomitic mesoderm of PS1-/- embryos compared to contro

94 a similar cycling expression pattern in the presomitic mesoderm of somite stage mouse embryos.

95 Marker analysis revealed that in the presomitic mesoderm of the mutant embryos, sharply demar

96 The presomitic mesoderm of vertebrates undergoes a process o

97 es not alter the expression of AmphiHox-1 in presomitic mesoderm or of alkali myosin light chain (Amp

98 The asymmetrical expression of Nr2f2 in the presomitic mesoderm overlaps with the asymmetry of the r

99 Paraxial tissues (presomitic mesoderm plus neural plate and notochord) wer

100 is is established at the anterior end of the presomitic mesoderm prior to overt somitogenesis in resp

101 to (i) maintain the Fgf8 'wavefront' in the presomitic mesoderm that underpins axial elongation, (ii

102 lated to continuously release cells into the presomitic mesoderm throughout somitogenesis is not unde

103 Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscill

104 These genes are thought to act in the presomitic mesoderm when cells form prospective somites,

105 Cadherins are expressed in presomitic mesoderm where they delineate cells.

106 s towards definitive endoderm, precardiac or presomitic mesoderm within the first 24 h of differentia

107 ensive zone of unsegmented mesenchyme (i.e., presomitic mesoderm) intervening between the tail bud an

108 d in a dynamic, segmental pattern within the presomitic mesoderm, and alterations in the function of

109 ') intrinsic to the cells in the unsegmented presomitic mesoderm, and is manifested in cyclic transcr

110 bx6 is expressed in the primitive streak and presomitic mesoderm, and is sharply down-regulated upon

111 of Gdf11 expression in the primitive streak, presomitic mesoderm, and tail bud.

112 tablishment of a segmental prepattern in the presomitic mesoderm, anteroposterior patterning of each

113 erative manner in the developing somites and presomitic mesoderm, as is the Eph receptor EphA4.

114 ricted to the rostral-most somitomere of the presomitic mesoderm, at the times corresponding to the e

115 s demonstrated that Cerr1-expressing somitic-presomitic mesoderm, but not older Cerr1-nonexpressing s

116 ght to an end through a process in which the presomitic mesoderm, having first increased in size, gra

117 ownstream targets of Notch activation in the presomitic mesoderm, including EphA4, were transcribed n

118 Expression of Thylacine is restricted to the presomitic mesoderm, localising to the anterior half of

119 and HRT3 exhibited dynamic expression in the presomitic mesoderm, mirroring the expression of other c

120 in a complex pattern that includes paraxial presomitic mesoderm, notochord, branchial arches and neu

121 xamined cell survival and gene expression in presomitic mesoderm, somites and neural tube of developi

122 rtebral patterning, Btg2 is expressed in the presomitic mesoderm, tail bud, and somites during somito

123 entation clock) operates in the cells of the presomitic mesoderm, the immature tissue from which the

124 fng, Hes1, Hes5 and Hey1 is disrupted in the presomitic mesoderm, we suggest that the somitic aberrat

125 w normal expression of Wnt inhibitors in the presomitic mesoderm, which in turn constrain the levels

126 s are less severe for gene expression in the presomitic mesoderm, yet severe segmentation phenotypes

127 ding the primitive streak, the node, and the presomitic mesoderm.

128 be readouts of a "segmentation clock" in the presomitic mesoderm.

129 rated by internal cells or compaction of the presomitic mesoderm.

130 regionalisation when located in the anterior presomitic mesoderm.

131 recently formed somites and in the anterior presomitic mesoderm.

132 marker genes X-Delta-2 and X-ESR5 within the presomitic mesoderm.

133 ains the pool of caudal progenitor cells and presomitic mesoderm.

134 sic helix-loop-helix (bHLH) gene, within the presomitic mesoderm.

135 slow muscle differentiation from uncommitted presomitic mesoderm.

136 ion of the transcriptome taking place in the presomitic mesoderm.

137 d activates Notch signalling in the anterior presomitic mesoderm.

138 expression of a number of clock genes in the presomitic mesoderm.

139 he period of cyclic gene oscillations in the presomitic mesoderm.

140 llate in mouse do not cycle across the chick presomitic mesoderm.

141 rarp expression was completely absent in the presomitic mesoderm.

142 nals now elicit RA synthesis in neighbouring presomitic mesoderm.

143 f Drosophila and somitogenesis in vertebrate presomitic mesoderm.

144 somites, are rhythmically produced from the presomitic mesoderm.

145 derm and the posterior neural plate, not the presomitic mesoderm.

146 myotome of developing somites but not in the presomitic mesoderm.

147 rget gene expression throughout the node and presomitic mesoderm.

148 al for establishing segmental pattern in the presomitic mesoderm.

149 o, and loss of cyclic gene expression in the presomitic mesoderm.

150 olecular segmentation clock operating in the presomitic mesoderm.

151 ion coordination among adjacent cells in the presomitic mesoderm.

152 sequentially in a rhythmic fashion from the presomitic mesoderm.

153 -1 is no longer expressed in the somites and presomitic mesoderm.

154 omites (0 and -1) at the anterior end of the presomitic mesoderm.

155 ressed in a segmental pattern in the rostral presomitic mesoderm.

156 the oscillations of neighboring cells in the presomitic mesoderm.

157 ssion of genes such as lunatic fringe in the presomitic mesoderm.

158 n clock that intrinsically oscillates within presomitic mesoderm.

159 -8 is normally downregulated within lateral (presomitic) mesoderm following gastrulation.

160 onomous function in stimulating migration of presomitic mesodermal cells away from the PS and a secon

161 odissected embryonic tissue from somitic and presomitic mesodermal tissue, we identified new genes en

162 evelopment, Tbx6 expression is restricted to presomitic, paraxial mesoderm and to the tail bud, which

163 lateral halves of newly formed somites, and presomitic (segmental plate) mesenchyme -- to participat

164 re used to identify MyoD expressing cells in presomitic tissues in vivo.

165 rface between the inductive axial and target presomitic tissues.