ライフサイエンスコーパス: presomitic mesoderm

1 ding the primitive streak, the node, and the presomitic mesoderm.

2 be readouts of a "segmentation clock" in the presomitic mesoderm.

3 rated by internal cells or compaction of the presomitic mesoderm.

4 regionalisation when located in the anterior presomitic mesoderm.

5 recently formed somites and in the anterior presomitic mesoderm.

6 marker genes X-Delta-2 and X-ESR5 within the presomitic mesoderm.

7 sic helix-loop-helix (bHLH) gene, within the presomitic mesoderm.

8 slow muscle differentiation from uncommitted presomitic mesoderm.

9 ains the pool of caudal progenitor cells and presomitic mesoderm.

10 ion of the transcriptome taking place in the presomitic mesoderm.

11 d activates Notch signalling in the anterior presomitic mesoderm.

12 expression of a number of clock genes in the presomitic mesoderm.

13 he period of cyclic gene oscillations in the presomitic mesoderm.

14 llate in mouse do not cycle across the chick presomitic mesoderm.

15 rarp expression was completely absent in the presomitic mesoderm.

16 nals now elicit RA synthesis in neighbouring presomitic mesoderm.

17 f Drosophila and somitogenesis in vertebrate presomitic mesoderm.

18 somites, are rhythmically produced from the presomitic mesoderm.

19 derm and the posterior neural plate, not the presomitic mesoderm.

20 myotome of developing somites but not in the presomitic mesoderm.

21 rget gene expression throughout the node and presomitic mesoderm.

22 al for establishing segmental pattern in the presomitic mesoderm.

23 o, and loss of cyclic gene expression in the presomitic mesoderm.

24 olecular segmentation clock operating in the presomitic mesoderm.

25 ion coordination among adjacent cells in the presomitic mesoderm.

26 sequentially in a rhythmic fashion from the presomitic mesoderm.

27 -1 is no longer expressed in the somites and presomitic mesoderm.

28 omites (0 and -1) at the anterior end of the presomitic mesoderm.

29 ressed in a segmental pattern in the rostral presomitic mesoderm.

30 the oscillations of neighboring cells in the presomitic mesoderm.

31 ssion of genes such as lunatic fringe in the presomitic mesoderm.

32 n clock that intrinsically oscillates within presomitic mesoderm.

33 es cause them to detach from the unsegmented presomitic mesoderm [1-3].

34 we show that beta1-integrin in the anterior presomitic mesoderm activates canonical Wnt signalling i

35 o, transcripts for Mf3 are restricted to the presomitic mesoderm and anterior neurectoderm and mesode

36 onic axis by regulating cell motility in the presomitic mesoderm and by controlling specification of

37 2 to restrict the anterior boundaries of the presomitic mesoderm and caudal progenitor pool.

38 pressed in a dynamic pattern in paraxial and presomitic mesoderm and developing somites during mouse

39 her1 and Delta D expression in the anterior presomitic mesoderm and disrupts myogenic differentiatio

40 inal cord, which is maintained by underlying presomitic mesoderm and FGF signalling, and neuronal dif

41 ph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites.

42 fic manner in the presumptive somites of the presomitic mesoderm and is required for normal somitogen

43 cs the inducing effects of notochord on both presomitic mesoderm and neural plate explants of amniote

44 Co-cultures between presomitic mesoderm and neural tube also supported vascu

45 e dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites.

46 of the DSL gene family, is expressed in the presomitic mesoderm and posterior halves of somites.

47 of gene expression by microarray between the presomitic mesoderm and the 5 most recently formed somit

48 erior Hox genes and that of marker genes for presomitic mesoderm and the chordoneural hinge.

49 ral tube, and by myogenic progenitors in the presomitic mesoderm and the hypaxial somites.

50 are expressed at the transition zone between presomitic mesoderm and the segmented somites.

51 the presumptive somite from the rest of the presomitic mesoderm and the subsequent morphological cha

52 ri somites formed without convergence of the presomitic mesoderm and were composed of only two cells

53 d in a dynamic, segmental pattern within the presomitic mesoderm, and alterations in the function of

54 ') intrinsic to the cells in the unsegmented presomitic mesoderm, and is manifested in cyclic transcr

55 bx6 is expressed in the primitive streak and presomitic mesoderm, and is sharply down-regulated upon

56 of Gdf11 expression in the primitive streak, presomitic mesoderm, and tail bud.

57 n somite number and size, restriction of the presomitic mesoderm anterior border, somite chevron morp

58 tablishment of a segmental prepattern in the presomitic mesoderm, anteroposterior patterning of each

59 erative manner in the developing somites and presomitic mesoderm, as is the Eph receptor EphA4.

60 ricted to the rostral-most somitomere of the presomitic mesoderm, at the times corresponding to the e

61 border, decreased adhesion at the notochord-presomitic mesoderm border, and tension at boundaries wi

62 s demonstrated that Cerr1-expressing somitic-presomitic mesoderm, but not older Cerr1-nonexpressing s

63 We provide direct evidence that presomitic mesoderm cells oscillate asynchronously in ze

64 is to keep the oscillations of neighbouring presomitic mesoderm cells synchronized.

65 nscriptional oscillations of cyclic genes in presomitic mesoderm cells.

66 Dynamic expression of FGF8 in the presomitic mesoderm constitutes the wavefront of determi

67 By employing explants of presomitic mesoderm cultured with constant levels of Wnt

68 ic mesoderm exhibits RALDH-2-IR but thoracic presomitic mesoderm does not.

69 Adaxial cells become distinguishable in the presomitic mesoderm during late gastrulation by their ex

70 eriodic cleavage of somites from unsegmented presomitic mesoderm during vertebrate segmentation.

71 Cervical presomitic mesoderm exhibits RALDH-2-IR but thoracic pre

72 ollagen explant model was developed in which presomitic mesoderm explants formed a vascular plexus in

73 yoD activation by recombinant Shh protein in presomitic mesoderm explants is defective in Myf5 null e

74 and induce dermomyotome marker expression in presomitic mesoderm explants, supporting the hypothesis

75 enous Myf5 expression in 10T1/2 cells and in presomitic mesoderm explants.

76 ovirus to overexpress Gli1, Gli2 and Gli3 in presomitic mesoderm explants.

77 -8 is normally downregulated within lateral (presomitic) mesoderm following gastrulation.

78 mites of Shh null embryos and in explants of presomitic mesoderm from wild-type and Myf5 null embryos

79 Mouse-avian chimeras with mouse presomitic mesoderm grafts had graft-derived endothelial

80 ght to an end through a process in which the presomitic mesoderm, having first increased in size, gra

81 trikingly, X-Delta-2 is expressed within the presomitic mesoderm in a set of stripes that corresponds

82 ownstream targets of Notch activation in the presomitic mesoderm, including EphA4, were transcribed n

83 ensive zone of unsegmented mesenchyme (i.e., presomitic mesoderm) intervening between the tail bud an

84 nction in stimulating the differentiation of presomitic mesoderm into dermomyotome.

85 role in the translation of the patterning of presomitic mesoderm into somites.

86 It is likely that presomitic mesoderm is a vertebrate innovation made poss

87 eling, we demonstrate that C&E of the medial presomitic mesoderm is achieved by cooperation of planar

88 Notch pathway activity in the presomitic mesoderm is fundamental for management of syn

89 derm and neural plate, but its expression in presomitic mesoderm is initially unchanged.

90 nos, expression of genes in undifferentiated presomitic mesoderm is initiated, but not maintained.

91 Expression of terra in presomitic mesoderm is restricted to cells that lack exp

92 ing model of somitogenesis supposes that the presomitic mesoderm is segmented into somites by a clock

93 Expression of Thylacine is restricted to the presomitic mesoderm, localising to the anterior half of

94 and HRT3 exhibited dynamic expression in the presomitic mesoderm, mirroring the expression of other c

95 in a complex pattern that includes paraxial presomitic mesoderm, notochord, branchial arches and neu

96 a segmental prepattern is established in the presomitic mesoderm of all these mutants and hox gene ex

97 When ectopically expressed in the presomitic mesoderm of chick embryos in ovo, Wnt-1 diffe

98 ature Hes7 transcripts are stabilized in the presomitic mesoderm of mutant mice, suggesting that both

99 tures dramatic loss of expression within the presomitic mesoderm of Notch/Delta pathway components an

100 in the Notch pathway were not altered in the presomitic mesoderm of paraxis(-/-) embryos.

101 h required for transcription in the anterior presomitic mesoderm of paraxis, Mesp1, Mesp2, Hes5, and

102 of Dll1 transcripts is also increased in the presomitic mesoderm of PS1(-/-) embryos, while the level

103 ate Notch ligand, is markedly reduced in the presomitic mesoderm of PS1-/- embryos compared to contro

104 a similar cycling expression pattern in the presomitic mesoderm of somite stage mouse embryos.

105 Marker analysis revealed that in the presomitic mesoderm of the mutant embryos, sharply demar

106 The presomitic mesoderm of vertebrates undergoes a process o

107 es not alter the expression of AmphiHox-1 in presomitic mesoderm or of alkali myosin light chain (Amp

108 The asymmetrical expression of Nr2f2 in the presomitic mesoderm overlaps with the asymmetry of the r

109 Paraxial tissues (presomitic mesoderm plus neural plate and notochord) wer

110 is is established at the anterior end of the presomitic mesoderm prior to overt somitogenesis in resp

111 nic axis by sequential segmentation from the presomitic mesoderm (PSM) and differentiate into the seg

112 During this process, cells in the presomitic mesoderm (PSM) are first patterned into segme

113 ming of SHH and BMP signals controls whether presomitic mesoderm (PSM) cells will adopt either a chon

114 (NM) stem cells generate neural and paraxial presomitic mesoderm (PSM) cells, which are the respectiv

115 ock, a molecular oscillator expressed within presomitic mesoderm (PSM) cells.

116 We show here that presomitic mesoderm (psm) cultured in the presence of Sh

117 Lunatic fringe (Lfng) expression in the presomitic mesoderm (PSM) cycles in the posterior PSM, i

118 e continuously produced posteriorly from the presomitic mesoderm (PSM) during body formation.

119 by an ENU-induced mutation that disrupts the presomitic mesoderm (PSM) expression of Notch pathway ge

120 togenesis, cells are recruited to the caudal presomitic mesoderm (PSM) from the primitive streak (and

121 hicken embryo to demonstrate that the caudal presomitic mesoderm (PSM) has a key role in axis elongat

122 use embryo, timely somite formation from the presomitic mesoderm (PSM) is controlled by the "segmenta

123 ion of the Mesp genes within segments of the presomitic mesoderm (PSM) of different vertebrate specie

124 lunatic fringe (lfng) expression within the presomitic mesoderm (PSM), a hes6a gradient in the PSM n

125 e/notochord and surface ectoderm in cultured presomitic mesoderm (PSM), and is accompanied by a marke

126 Xena) localizes to the cell periphery in the presomitic mesoderm (PSM), and is enriched at intersomit

127 This operates in each cell of the presomitic mesoderm (PSM), but the individual cells drif

128 ng this process, paired somites bud from the presomitic mesoderm (PSM), in a process regulated by a g

129 oth genes are transcribed in the unsegmented presomitic mesoderm (PSM), newly formed somites, adaxial

130 f Snail 1 and Snail 2 in the mouse and chick presomitic mesoderm (PSM), respectively.

131 terior-to-anterior signaling gradient in the presomitic mesoderm (PSM), which controls cell maturatio

132 ythmic activity of signaling pathways in the presomitic mesoderm (PSM).

133 rm by an iterative process from unsegmented, presomitic mesoderm (PSM).

134 the somites, are rhythmically produced from presomitic mesoderm (PSM).

135 d DeltaD in the zebrafish nervous system and presomitic mesoderm (PSM).

136 n of epithelial somites from the mesenchymal presomitic mesoderm (PSM).

137 ior positioning of boundary formation in the presomitic mesoderm (PSM).

138 ion, known as the segmentation clock, in the presomitic mesoderm (PSM).

139 ols the timing of maturation of cells in the presomitic mesoderm (PSM).

140 velike along the anteroposterior axis of the presomitic mesoderm (PSM).

141 itiation of transcription in the unsegmented presomitic mesoderm (PSM).

142 es arise from somites, which derive from the presomitic mesoderm (PSM).

143 xamined cell survival and gene expression in presomitic mesoderm, somites and neural tube of developi

144 rtebral patterning, Btg2 is expressed in the presomitic mesoderm, tail bud, and somites during somito

145 to (i) maintain the Fgf8 'wavefront' in the presomitic mesoderm that underpins axial elongation, (ii

146 entation clock) operates in the cells of the presomitic mesoderm, the immature tissue from which the

147 lated to continuously release cells into the presomitic mesoderm throughout somitogenesis is not unde

148 Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscill

149 fng, Hes1, Hes5 and Hey1 is disrupted in the presomitic mesoderm, we suggest that the somitic aberrat

150 These genes are thought to act in the presomitic mesoderm when cells form prospective somites,

151 Cadherins are expressed in presomitic mesoderm where they delineate cells.

152 w normal expression of Wnt inhibitors in the presomitic mesoderm, which in turn constrain the levels

153 s towards definitive endoderm, precardiac or presomitic mesoderm within the first 24 h of differentia

154 s are less severe for gene expression in the presomitic mesoderm, yet severe segmentation phenotypes