ライフサイエンスコーパス: preterm

1 tant global health benefits for infants born preterm.

2 accentuated differences from women born very preterm.

3 n was particularly marked in women born very preterm.

4 reported neonatal data, 6 neonates were born preterm.

5 d in fetuses that would subsequently be born preterm.

6 0 adults and 32 preschool children born very preterm.

7 m (pooled RR 1.20, 95% CI 1.01-1.44) or very preterm (1.53, 1.22-1.92), or to have low-birthweight in

8 en wild-type (WT) and Nrf2(-/-) mice in both preterm and control samples.

9 Their increase at preterm and in response to oxidative stress may indicate

10 ls for estimating the risk of EOS among late preterm and term infants based on objective data availab

11 ive cohort investigation of moderate to late preterm and term infants born at risk of hypoglycemia.

12 randomized clinical trial included 540 late preterm and term infants born vaginally at a tertiary ho

13 infection that presents as a diffuse rash in preterm and term infants.

14 no differences between women born moderately preterm and those born at term but accentuated differenc

15 ower cBF volume in adults who were born very preterm and/or with very low birth weight was specifical

16 In adults who were born very preterm and/or with very low birth weight, cBF volumes w

17 logical problems more frequent in those born preterm are expressed prior to birth, but owing to techn

18 ks of gestation), 8,247 were born moderately preterm (at least 32 weeks but <37 weeks), and 192,472 w

19 Infant death due to NEC in preterm babies was identified from the US Linked Livebir

20 ased risks of infant mortality due to NEC in preterm babies, especially in white race and female babi

21 interval [CI]: 7.96 to 36.3) after extremely preterm birth (<28 weeks) and 3.58 (95% CI: 1.57 to 8.14

22 d any severe adverse outcome, including very preterm birth (<32 weeks), very SGA (<3rd percentile of

23 Preterm birth (<37 gestational weeks), small for gestati

24 om investigator groups on the association of preterm birth (<37 weeks' gestation) and maternal GBS co

25 the risk of low birth weight (<2,500 g) and preterm birth (<37 weeks' gestation), we compared betwee

26 adverse birth outcome, including stillbirth, preterm birth (<37 weeks), small size for gestational ag

27 n was associated with reductions in rates of preterm birth (-3.77% [95% CI -6.37 to -1.16]; ten studi

28 ; hazard ratio, 0.71; 95% CI, 0.45 to 1.14), preterm birth (116 cases among 1774 exposed pregnancies

29 ) and 3.58 (95% CI: 1.57 to 8.14) after very preterm birth (28 to 31 weeks).

30 There was no risk increase after moderately preterm birth (32 to 36 weeks) (relative risk: 1.36; 95%

31 iciency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99,

32 endoscopy during pregnancy was not linked to preterm birth (ARR, 1.03; 95% CI, 0.84-1.27).

33 doscopy during pregnancy was associated with preterm birth (ARR, 1.16) but not with small for gestati

34 ncy was associated with an increased risk of preterm birth (ARR, 1.54; 95% confidence interval [CI],

35 wer birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks).

36 This nested case-control study of preterm birth (n = 130 cases, 352 controls) included wom

37 antidepressant exposure was associated with preterm birth (OR, 1.34 [95% CI, 1.18-1.52]) but not wit

38 had a significantly increased prevalence of preterm birth (prevalence ratio [PR], 1.52; 95% CI, 1.34

39 Preterm birth (PTB) contributes significantly to infant

40 Preterm birth (PTB) is commonly accompanied by in utero

41 Preterm birth (PTB) is the leading cause of neonatal mor

42 Preterm birth (PTB) is the leading cause of neonatal mor

43 osition methods to understand disparities in preterm birth (PTB) prevalence between births of non-His

44 egnancy has high potential for prediction of preterm birth (PTB), a problem affecting 15 million newb

45 Molecular mechanisms regulating preterm birth (PTB)-associated cervical remodeling remai

46 h outcomes [small for gestational age (SGA), preterm birth (PTB)].In an observational study in 987 ne

47 eks gestation provided greater reductions in preterm birth (RR 0.89, 95% CI 0.85-0.93; p=0.03).

48 fied 30 of 410 women (7.3%) with spontaneous preterm birth and 31 of 384 (8.1%) at 22 to 30 weeks.

49 -based pregnancy dating to assess impacts on preterm birth and fetal growth in all studies.

50 Other factors associated with preterm birth and low birth weight included treatment wi

51 ncer survivors may have an increased risk of preterm birth and low birth weight, suggesting that addi

52 paration of the placenta) is associated with preterm birth and perinatal mortality, but associations

53 udy was to determine the association between preterm birth and risk of incident heart failure (HF) in

54 The association between preterm birth and risk of incident HF was analyzed by us

55 e examined by conditioning on intermediates (preterm birth and small for gestational age) with sensit

56 s contributing to chronic lung disease after preterm birth are incompletely understood.

57 The primary end point was spontaneous preterm birth at less than 34 weeks of gestation.

58 pessary would reduce the rate of spontaneous preterm birth at less than 34 weeks of gestation.

59 Spontaneous preterm birth at less than 37 weeks was the primary outc

60 There was a strong association between preterm birth before 32 weeks of gestation and HF in chi

61 with preterm birth before 37 weeks and with preterm birth before 34 weeks were characterized by an i

62 tinuous associations of arginine intake with preterm birth before 37 weeks and with preterm birth bef

63 ngleton pregnancies and no prior spontaneous preterm birth but with short cervical length on transvag

64 ween phthalate exposure during pregnancy and preterm birth by oxidative stress.

65 As preterm birth causes plasma estrogen level to drop 100-f

66 , 95% uncertainty range [UR] 28 400-45 200), preterm birth complications (30 900 deaths, 24 200-40 80

67 The contribution of preterm birth complications to mortality decreased after

68 Here, we show that preterm birth disrupts interneuron neurogenesis in the m

69 ts (n=477) in a nested case-control study of preterm birth drawn from a prospective birth cohort of p

70 Preterm birth explained 89% of the association of matern

71 h a preterm first birth and at least 1 later preterm birth had a HR of CVD of 1.65 (95% CI, 1.20-2.28

72 remature cervical ripening and prevention of preterm birth in humans.

73 f universal screening to predict spontaneous preterm birth in nulliparous women using serial measurem

74 Preterm birth incorporates an increased risk for cerebel

75 Preterm birth is a common adverse birth outcome known to

76 Spontaneous preterm birth is a leading cause of infant mortality.

77 Spontaneous preterm birth is a major cause of perinatal morbidity an

78 is review, there is evidence to suggest that preterm birth is associated with maternal GBS colonizati

79 Conversely, the risk of preterm birth is reported to correlate with size of cerv

80 Preterm birth is the leading cause of neonatal mortality

81 low in young age, our findings indicate that preterm birth may be a previously unknown risk factor fo

82 neurodevelopmental disorders associated with preterm birth may result from neurological insults that

83 Preterm birth occurred less frequently among pregnancies

84 outcomes compared with unexposed offspring (preterm birth odds ratio [OR], 1.47 [95% CI, 1.40-1.55];

85 Survivors of preterm birth often present with medical morbidities; ho

86 gnesium treatment, given to women at risk of preterm birth on important maternal and fetal outcomes,

87 Preterm birth places infants in an adverse environment t

88 nthropometrics, gestational weight gain, and preterm birth rate, but not in maternal age, parity, soc

89 This demonstrates mediation of the phthalate-preterm birth relationship by oxidative stress, and the

90 IRS protection, >90% IRS protection reduced preterm birth risk (risk ratio, 0.35; 95% confidence int

91 n and meteorological parameters, to increase preterm birth risk has received significant attention wo

92 Preterm birth risk tended to increase with first-trimest

93 Our study lends support for an increase in preterm birth risk with atmospheric pressure.

94 ere was also some evidence of an increase in preterm birth risk with first-trimester average temperat

95 Main models were stratified by preterm birth status.The prevalence of exclusive breastf

96 distributions were compared for spontaneous preterm birth vs all other births.

97 In small clinical studies, preterm birth was associated with altered cardiac struct

98 Preterm birth was associated with GBS bacteriuria in coh

99 The positive association with preterm birth was due to iatrogenic instead of spontaneo

100 inal follow-up of all survivors of extremely preterm birth who were born in Victoria, Australia, in t

101 1, EEFSEC, and AGTR2 showed association with preterm birth with genomewide significance.

102 We estimated the risk ratio (RR) for preterm birth with maternal GBS colonization to be 1.21

103 and child anthropometry and haemoglobin and preterm birth) and socioenvironmental determinants (ie,

104 es, including eclampsia, stroke, stillbirth, preterm birth, and low birth weight; screening and risk

105 ully adjusted models, impaired fetal growth, preterm birth, breech presentation and cesarean section

106 s a key role in brain injury associated with preterm birth, but little is known about the microglial

107 matory condition that increases the risk for preterm birth, death, and disability because of persiste

108 tcomes of interest were perinatal mortality, preterm birth, hospital attendance for asthma exacerbati

109 Prevalence of preterm birth, low birth weight, small-for-gestational-a

110 tically transmitted, have been implicated in preterm birth, neonatal infections, and chronic lung dis

111 r sex, parental education, low birth weight, preterm birth, parental social class, maternal smoking a

112 to the duration of gestation and the risk of preterm birth, robust associations with genetic variants

113 se activity, we examined pregnancy outcomes (preterm birth, stillbirth, small for gestational age, or

114 ittle by the reason the woman was at risk of preterm birth, the gestational age at which magnesium su

115 iratory disease during early childhood after preterm birth, we performed a prospective, longitudinal

116 such as the reason the woman was at risk of preterm birth, why treatment was given, the gestational

117 Benefit is seen regardless of the reason for preterm birth, with similar effects across a range of pr

118 ta suggest associations with infertility and preterm birth, yet the attributable risk for female geni

119 with fetal growth restriction and iatrogenic preterm birth.

120 nts at the EBF1, EEFSEC, and AGTR2 loci with preterm birth.

121 al ripening in the second trimester predicts preterm birth.

122 e for gestational age, low birth weight, and preterm birth.

123 had low predictive accuracy for spontaneous preterm birth.

124 was due to iatrogenic instead of spontaneous preterm birth.

125 ginal colonization, ascending infection, and preterm birth.

126 alternatives to progesterone for preventing preterm birth.

127 as associated with a 16% increase in odds of preterm birth.

128 problems in children and adults that survive preterm birth.

129 rment of the function of this barrier during preterm birth.

130 come the educational burdens that may follow preterm birth.

131 ymase to systemic GBS infection and rates of preterm birth.

132 cal conditions are suspected to be causes of preterm birth.

133 eproductive outcomes such as infertility and preterm birth.

134 er-individual susceptibility to injury after preterm birth.Inflammation mediated by microglia plays a

135 ent supplements also had a greater effect on preterm births among underweight pregnant women (BMI <18

136 Up to 3.5 million preterm births may be attributable to GBS.

137 ation, the increase in GBS dissemination and preterm births observed in MCPT4-deficient mice was abol

138 Small-for-gestational-age (SGA) and preterm births were examined as secondary outcomes.

139 onally, increased GBS systemic infection and preterm births were observed in MCPT4-deficient mice ver

140 % other), of whom 474 (5.0%) had spontaneous preterm births, 335 (3.6%) had medically indicated prete

141 m births, 335 (3.6%) had medically indicated preterm births, and 8601 (91.4%) had term births.

142 ingleton gestations, no previous spontaneous preterm births, and cervical lengths of 25 mm or less at

143 embrane (pPROM) is associated with 30-40% of preterm births.

144 d caudal ganglionic eminences (CGEs) between preterm-born [born on embryonic day (E) 29; examined on

145 Many Preterm-born children suffer from neurobehavioral disord

146 Previously, we showed that preterm-born infants fed an isocaloric protein- and mine

147 Sera from term- and preterm-born infants were also collected and levels of I

148 l interventions may modulate health risks in preterm-born infants.

149 smaturation.SIGNIFICANCE STATEMENT The human preterm brain commonly sustains blood flow and oxygenati

150 which offer new insights into the nature of preterm brain injury.

151 that altered functional connectivity in the preterm brain is identifiable before birth.

152 jury are important risk factors for impaired preterm cerebellar biochemistry.

153 tabolism-resistant dimethyl-PGE2 resulted in preterm cervical ripening and delivery in mice.

154 On the other hand, preterm cervical ripening in the second trimester predic

155 quate ffERG recordings were obtained from 52 preterm children (19 girls and 33 boys; mean [SD] age at

156 elopment Program, a US longitudinal study of preterm children born in 1985.

157 t racial differences in blood pressure among preterm children emerge in early childhood and that neig

158 Moderate and late preterm children exhibited developmental delay compared

159 The patients included preterm children with a history of ROP who had undergone

160 We examined 54 eyes of 29 preterm children with ROP and 134 eyes of 67 children bo

161 ix metalloproteinase 2, compared to term and preterm controls.

162 r, 14.5%; 95% CI, 4.0-41.1), as was the very-preterm-CVD relationship (13.1%; 95% CI, 9.0-18.7).

163 elivery (360 [35.4%]), preterm labor without preterm delivery (269 [26.4%]), and miscarriage (262 [25

164 The 3 most frequent adverse events were preterm delivery (360 [35.4%]), preterm labor without pr

165 ear dose-response relationships with risk of preterm delivery (S-shaped, p<0.0001) and low birthweigh

166 We compared preterm delivery and birth weight (BW) outcomes (low BW

167 Severe disease is complicated by spontaneous preterm delivery and stillbirth.

168 Preterm delivery has been shown to be associated with in

169 prepregnancy lifestyle and CVD risk factors, preterm delivery in the first pregnancy was associated w

170 Preterm delivery is independently predictive of CVD and

171 association between maternal PHIV status and preterm delivery or infant BW outcomes is reassuring.

172 Assessment of any effect on preterm delivery should be included in future maternal G

173 fetal growth and cautious decision making on preterm delivery should therefore be reinforced.

174 GH vs no HDP, 1.62 (95% CI, 1.46-1.79) after preterm delivery, and 1.86 (95% CI, 1.15-3.02) after sti

175 14) for Q3, and 8.86 (5.66-13.86) for Q4 for preterm delivery, and 2.29 (95% CI 1.08-4.84) for Q2, 3.

176 r hemorrhagic stroke, and oophorectomy, HDP, preterm delivery, and stillbirth for any stroke.

177 esity are associated with increased risks of preterm delivery, asphyxia-related neonatal complication

178 y 31 operations associated with 1 additional preterm delivery, every 39 operations associated with 1

179 atory nicotine inhalation is associated with preterm delivery, low birth weight, fetal growth retarda

180 ssociations between maternal PHIV status and preterm delivery, SGA, or LBW were observed.

181 on during pregnancy may be a risk factor for preterm delivery.

182 The associations are similar for the risk of preterm delivery.

183 placental insufficiency against the risks of preterm delivery.

184 l pessary can reduce the risk of spontaneous preterm delivery.

185 s) used during pregnancy on fetal growth and preterm delivery.

186 ed: maternal and fetal death; malformations; preterm delivery; small for gestational age (SGA) baby;

187 high complication rate (consisting mainly of preterm emergency cesarean section) of 11% per treated p

188 We used a preterm fetal sheep model using both sexes that reproduc

189 f which were delivered at term, women with a preterm first birth and at least 1 later preterm birth h

190 The association between moderate preterm first birth and CVD was accounted for in part by

191 irth, with similar effects across a range of preterm gestational ages and different treatment regimen

192 The increased rate of CVD in the very preterm group persisted even among women whose first pre

193 ation with retinopathy of prematurity in the preterm group, which suggests that being born extremely

194 nal age or retinopathy of prematurity in the preterm group.

195 ature (<155.4 cm), and those born moderately preterm had 1.43 times higher odds.

196 were born at term, those who were born very preterm had 2.9 times higher odds of short stature (<155

197 of rods and cones in children born extremely preterm has not yet been fully investigated.

198 ssociated with structural differences in the preterm infant brain.

199 ently implicated in nosocomial infection and preterm infant gut colonization.

200 Assisted ventilation for extremely preterm infants (<28 weeks of gestation) has become less

201 A prospective observational study of preterm infants (birth weight <1500 g and/or gestational

202 , we measured top-down sensory prediction in preterm infants (born <33 weeks gestation) before infant

203 als published in English, enrolled intubated preterm infants (born <37 weeks' gestation), and reporte

204 Sixty preterm infants (gestation <32 weeks and weight <1500 g

205 0 ppm on postnatal days 5 to 14 to high-risk preterm infants and continued for 24 days, appears to be

206 e prevalence of P. jirovecii colonization in preterm infants and its possible association with medica

207 ize and quantify early foveal development in preterm infants and to compare this development between

208 Preterm infants are at risk for a broad spectrum of neur

209 Every year, 15 million preterm infants are born, and most spend their first wee

210 Clinicians aim to extubate preterm infants as early as possible, to minimize the ri

211 rtality or moderate/severe BPD among similar preterm infants born at 28 weeks or younger following NS

212 Preterm infants born at less than 29 weeks' gestation be

213 ut associated cerebral lesions are common in preterm infants currently not regarded as at highest ris

214 a separate behavioral control confirmed that preterm infants detect pattern violations at the same ra

215 Approximately 1 in 5 preterm infants examined had IOHs, generally unilateral.

216 Preterm infants exhibit different microbiome colonizatio

217 ficits in this ability may be the reason why preterm infants experience altered developmental traject

218 Following oxygen exposure, preterm infants frequently develop chronic lung disease

219 Whereas preterm infants had typical neural responses to presente

220 er early hydrocortisone therapy in extremely preterm infants is associated with neurodevelopmental im

221 o drop 100-fold, the estrogen replacement in preterm infants is physiological.

222 eferred timing of umbilical-cord clamping in preterm infants is unclear.

223 ssociation study (GWAS) included 174 Finnish preterm infants of gestational age 24-30 weeks.

224 Preterm infants should be extubated to noninvasive respi

225 te matter injury (NWMI) is a lesion found in preterm infants that can lead to cerebral palsy.

226 One hundred thirty-one preterm infants undergoing retinopathy of prematurity (R

227 The prevalence of exclusive breastfeeding in preterm infants was lower than in term infants at 4 mo p

228 elial cells (HUVECs) obtained from extremely preterm infants were associated with risk for BPD or dea

229 Preterm infants who develop neurodevelopmental impairmen

230 Preterm infants who were exposed to maternal smoking had

231 on (particularly for proteins and lipids) in preterm infants who were fed their mothers' own milk eit

232 atent ductus arteriosus (PDA) ligation among preterm infants with adverse neonatal outcomes and neuro

233 Preterm infants with birth weight (BW) </=1250 g.

234 Currently no treatments exist for preterm infants with diffuse white matter injury (DWMI)

235 In this cross-sectional study, 239 former preterm infants with gestational age (GA) </= 32 weeks a

236 med a prospective, longitudinal study of 587 preterm infants with gestational age less than 34 weeks

237 This retrospective cohort study of preterm infants younger than 28 weeks gestational age bo

238 Among preterm infants, delayed cord clamping did not result in

239 of a randomized clinical trial of extremely preterm infants, early low-dose hydrocortisone was not a

240 m (SNP)-based genotypes from a cohort of 272 preterm infants, using Sparse Reduced Rank Regression (s

241 timodal brain MRI to study a large cohort of preterm infants.

242 spiratory and neurodevelopmental outcomes in preterm infants.

243 ll children with cerebral palsy, but not for preterm infants.

244 rican and European-American low-birth-weight preterm infants.

245 cluding bronchopulmonary dysplasia (BPD), in preterm infants.

246 rum levels of IL-5 and IL-13 but not IL-4 in preterm infants.

247 to improve rates of successful extubation in preterm infants.

248 le is known about the microglial response in preterm infants.

249 and inflammation cause 30-40% of spontaneous preterm labor (PTL), which precedes PTB.

250 for such outcomes are cervical incompetence, preterm labor during current pregnancy, vaginitis or vul

251 he causes of pregnancy complications such as preterm labor requires greater insight into how the uter

252 taste receptors as targets for tocolytics in preterm labor therapy.

253 ulphate (MgSO4) are administered to women in preterm labor to reduce neurologic morbidity.

254 events were preterm delivery (360 [35.4%]), preterm labor without preterm delivery (269 [26.4%]), an

255 gestive heart failure (CHF), length of stay, preterm labor, anemia complicating pregnancy, placental

256 disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease.

257 of oxidative stress on membranes at term or preterm labor, term not in labor samples in an organ exp

258 ly used therapeutically for the treatment of preterm labor.

259 the women in our cohort, 663 were born very preterm (<32 weeks of gestation), 8,247 were born modera

260 etween history of having delivered an infant preterm (<37 weeks) and CVD in 70 182 parous women in th

261 l duration as a continuous trait and term or preterm (<37 weeks) birth as a dichotomous outcome.

262 up, which suggests that being born extremely preterm may be one of the main reasons for a general ret

263 In a prospective cohort study, 155 very preterm neonates (82 males, 73 females) born 24-32 weeks

264 Due to improved care of preterm neonates and increased recognition by advanced i

265 In extremely preterm neonates early pain was associated with decrease

266 s aimed at improving neurological outcome in preterm neonates with hypoxia-induced DWMI.SIGNIFICANCE

267 Patent ductus arteriosus ligation among preterm neonates younger than 28 weeks gestational age w

268 higher birth anti-pertussis toxin titers in preterm neonates.

269 athway maturation, particularly in extremely preterm neonates.

270 Placentas from preterm Nrf2(-/-) mice showed elevated levels of markers

271 shorter than women who were born moderately preterm (P < 0.0001) and 17 mm shorter than women born a

272 015 and is now performed on younger and more preterm patients, often with catheter-based intervention

273 on were significantly more likely to deliver preterm (pooled RR 1.20, 95% CI 1.01-1.44) or very prete

274 Similarly, preterm preeclampsia in a previous pregnancy, but not te

275 pregnancy were also strongly associated with preterm preeclampsia in subsequent pregnancies (early pr

276 Preterm preeclampsia occurred in 13 participants (1.6%)

277 h low-dose aspirin in women at high risk for preterm preeclampsia resulted in a lower incidence of th

278 gleton pregnancies who were at high risk for preterm preeclampsia to receive aspirin, at a dose of 15

279 offspring congenital heart defects or early preterm preeclampsia, late preterm preeclampsia, term pr

280 defects or early preterm preeclampsia, late preterm preeclampsia, term preeclampsia, and gestational

281 eclampsia: OR, 2.37; 95% CI, 1.68-3.34; late preterm preeclampsia: OR, 2.04; 95% CI, 1.52-2.75) but w

282 reeclampsia in subsequent pregnancies (early preterm preeclampsia: OR, 2.37; 95% CI, 1.68-3.34; late

283 eclampsia: OR, 7.91; 95% CI, 6.06-10.3; late preterm preeclampsia: OR, 2.83; 95% CI, 2.11-3.79; term

284 al heart defects in later pregnancies (early preterm preeclampsia: OR, 7.91; 95% CI, 6.06-10.3; late

285 Preterm premature rupture of membrane (pPROM) is associa

286 estingly, in some pregnancies complicated by preterm premature rupture of membranes (pPROM), membrane

287 mpare the cerebellar biochemical profiles in preterm (PT) infants evaluated at term equivalent age (T

288 itors were also more numerous in the LGEs of preterm pups at D3 compared with term rabbits at D0.

289 GA (IRR, 4.9; 95% CI, 2.2 to 11.0), and with preterm SGA births (relative risk 3.0; 95% CI, 2.1 to 4.

290 for hypoglycemia, including diabetic mother, preterm, small, large, or acute illness.

291 Preterm subjects acquired significantly less conditioned

292 Using a panel of preterm transgenic mice, we show that epidermis-targeted

293 d birth cohort and a restricted subcohort of preterm, very low birth weight (P-VLBW) infants.

294 We examined whether being born preterm was associated with changes in adult anthropomet

295 < 0.0001), so that women who were born very preterm were on average 12 mm shorter than women who wer

296 tion were reduced in children born extremely preterm when compared with children born at term.

297 data to investigate the role of microglia in preterm white matter damage.

298 ings in 6.5-year-old children born extremely preterm with children born at term.

299 We compared adults who were born very preterm with perinatal brain injury to those born very p

300 th perinatal brain injury to those born very preterm without perinatal brain injury, and age-matched