ライフサイエンスコーパス: prevalent

1 ase (38%), and diabetes (33%) being the most prevalent.

2 s losses at the expense of gains, are highly prevalent.

3 fluorotelomer carboxylic acid (7:3 FTCA) was prevalent.

4 Perceptions of bias are prevalent.

5 polyunsaturated fatty acids (PUFAs) are very prevalent.

6 buse, and domestic violence are increasingly prevalent.

7 yeast and human cells, RNA abasic sites are prevalent.

8 rved in mitosis, but quantitatively far less prevalent.

9 , as opposed to microscale examples that are prevalent.

10 Keratoconus is a highly prevalent (1 in 2000), genetically complex and multifact

11 rt, concomitant acute infections were highly prevalent (30%), despite only a minority (25%) of these

12 The LG AS pattern was highly prevalent (36.5%) in the PARTNER 2 trial and registry.

13 ll, IgE sensitization to extracts was highly prevalent (43%-73%) but allergen arrays indicated that t

14 en illicit Onion/Hidden Services use is more prevalent (~7.8%) in "free" countries than in either "pa

15 tbreaks, GII genogroup noroviruses were most prevalent (90.1% and 83.3%), with GII.4 being the domina

16 , p < 0.001), whereas taste loss was equally prevalent (90.2% versus 89.0%, p = 0.738).

17 Analysis of the most prevalent ABCA4 variant in Spain, c.3386G>T; p.(Arg1129L

18 Notably, the dissociation is prevalent across a number of node-centric measures and i

19 Research waste is highly prevalent across biomedical investigations.

20 d demonstrate that phenazine biosynthesis is prevalent across habitats and preferentially enriched in

21 CFS instability, however, these features are prevalent across the genome.

22 other rural health disparities and are more prevalent across the Great Plains.

23 Glycosyltransferases (GTs) are prevalent across the tree of life and regulate nearly al

24 s restricted to Beringia while the other was prevalent across western Eurasia.

25 We have previously shown that the highly prevalent acute myeloid leukemia (AML) mutation, Arg882H

26 ordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ethe

27 Any CAC was more prevalent after preeclampsia than after a normotensive p

28 ignant to malignant disease and becomes less prevalent after therapy, in which it is associated with

29 Baseline chronic diseases were prevalent (all >30%); 66% developed pneumonia, 80% of wh

30 Exercise intolerance is prevalent among childhood cancer survivors and associate

31 Role misidentification is more prevalent among female residents and surgical residents,

32 tional repertoire for Hsp33 that may be more prevalent among holdases and dispels the notion of a str

33 Myopia was less prevalent among immigrants than Israeli-born controls.

34 ommon neurologic disorder that is especially prevalent among older people.

35 Diabetes mellitus was found to be more prevalent among SARS-CoV-2 stroke patients compared to n

36 Comorbidities were more prevalent among women and sexual minorities, particularl

37 ive ribosomal binding seems to be especially prevalent amongst upstream short ORFs located in the 5'

38 Treatment-resistant depression (TRD) is prevalent and associated with a substantial psychosocial

39 Insomnia is one of the most prevalent and burdensome mental disorders worldwide, aff

40 ition of receptors by odorants is comparably prevalent and combinatorial.

41 Skeletal muscle atrophy is a highly-prevalent and debilitating condition that remains poorly

42 Late-life depression (LLD) is a prevalent and disabling condition in older adults that i

43 -of-function allele PIEZO1 E756del is highly prevalent and enriched in Africans, raising the possibil

44 The differences in genetic associations with prevalent and incident CAD between men and women were in

45 For both prevalent and incident CAD, the associations of comprehe

46 The overall rate of MG resistance (prevalent and incident cases) to AZM and FQ was 67.6% an

47 Aminoacylase-1 was associated with both prevalent and incident type 2 diabetes.

48 Lung cancer is a prevalent and lethal cancer type that leads to more deat

49 Itch is a highly prevalent and multidimensional symptom.

50 ent, tasks, organization, and equipment were prevalent and observed in equal measure, whereas support

51 ng EGA, homeobox factor binding becomes more prevalent and requires embryonic transcription.

52 s and poor water quality are two of the most prevalent and severe pressures faced by coral reefs.

53 e enriched in genomes where zinc fingers are prevalent and specificity transitions would be limited i

54 lenediamine (TMEDA) has been one of the most prevalent and successful additives used in iron catalysi

55 Allergies are highly prevalent, and allergic responses can be triggered even

56 ural community in Ecuador, where stunting is prevalent, and to evaluate the associations between bone

57 tigation strategies amongst some of the most prevalent, and vulnerable scenarios surgeons encounter.

58 The top 3 prevalent ARI syndromes included: viral upper respirator

59 Cyanoformamides are prevalent as versatile building blocks for accessing syn

60 found at buccal sites (51%) and proved less prevalent at mesio-lingual sites (16.7%).

61 MGEfinder to 12,374 sequenced isolates of 9 prevalent bacterial pathogens, including Mycobacterium t

62 nd Mycoplasma genitalium (MG) are two highly prevalent bacterial sexually transmitted infections (STI

63 One of the earliest and most prevalent barriers to successful reproduction is polyspe

64 P) to detect PIK3CA c.3140 A > G (H1047R), a prevalent BC missense mutation that is attributed to BC

65 a, and neuropathic pain disorders, is highly prevalent but remains poorly treated.

66 In the tropics, positive IgE tests are also prevalent, but rarely associated with ARD.

67 Using two baseline subsamples of UK Biobank: prevalent CAD cases (N = 10 287) and individuals without

68 Additionally, among prevalent CAD cases, we found an evidence of an inverse

69 We report the prevalent cancer detection rate (CDR) from the first cli

70 Breast cancer (BC) is one of the most prevalent cancers in women.

71 albicans and Candida glabrata are the 2 most prevalent Candida species causing bloodstream infections

72 Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia and cause of significant mo

73 It is one of the most prevalent carrier lineages but also frequently causes se

74 transmissibility in intervention facilities, prevalent case count in the state 3 years after importat

75 Prevalent cases of total CVD nearly doubled from 271 mil

76 7 FSW and MSM together accounted for 9.3% of prevalent cases.

77 a-lactamase inhibitors that disable the most prevalent cause of antibiotic resistance in Gram-negativ

78 A nonameric peptide derived from a prevalent CBFB-MYH11 fusion protein was found to be immu

79 Asthma and obesity are among the most prevalent chronic health conditions in children.

80 This novel finding indicates that the highly prevalent circulating MC contribute directly to the endo

81 s of interprovincial spread of the five most prevalent circulating types.

82 n TNFR-1, TNFR-2, and KIM-1 in patients with prevalent CKD and provide new insights into the influenc

83 R-loop structures are a prevalent class of alternative non-B DNA structures that

84 R-loops are a prevalent class of non-B DNA structures that have been a

85 Frailty is a complex and prevalent clinical syndrome.

86 ominate at low T, while global events become prevalent closer to T(m).

87 t issue in the study of consciousness is the prevalent confound of conscious perception with the requ

88 Bicuspid aortic valve (BAV) is the most prevalent congenital heart defect affecting 1% to 2% of

89 T Open spina bifida (OSB) is one of the most prevalent congenital malformations of the CNS.

90 lied by segmental arteries with PTE showed a prevalent consolidation pattern (25/37 [67.6%]).

91 Of 2294 MESA Lung participants without prevalent COPD, 98 (4.3%) had incident COPD at a median

92 The DNN achieved an area under the curve for prevalent diabetes of 0.766 in the primary cohort (95% c

93 eloped a deep neural network (DNN) to detect prevalent diabetes using smartphone-based photoplethysmo

94 ower CD38+ CD4+ T cells were associated with prevalent diabetes, and had a similar effect size, in bo

95 ttainable, non-invasive digital biomarker of prevalent diabetes.

96 Prevalent diagnoses in the year prior to the inpatient a

97 es were determined in 3-year intervals among prevalent dialysis patients in the United States between

98 14 serum trace metals in 29 incident and 79 prevalent dialysis patients recruited prospectively.

99 ction, with special focus on South-East, the prevalent direction of the plume, and conducted a regres

100 s, psychomotor and sensory abnormalities are prevalent, disabling, and intertwined with emotional and

101 yet the neuronal mechanisms underlying this prevalent disease remain elusive.

102 Chronic pain is a highly prevalent disease with poorly understood pathophysiology

103 The expanded CTG mutation is one of the most prevalent disease-causing mutations, making it possible

104 ty and mortality associated with this highly prevalent disease.

105 Obstructive sleep apnea (OSA) is a highly prevalent disorder also involving elastic tissue dysfunc

106 Status epilepticus (SE) is a prevalent disorder associated with significant morbidity

107 vegetables is associated with lower risk of prevalent diverticulosis.

108 ate the mechanisms at play in this extremely prevalent DP disorder and provide further support demons

109 y-drug conjugates (ADCs) are an increasingly prevalent drug class utilized as chemotherapeutic agents

110 ) pollutants were positively associated with prevalent DSPN in obese participants, whereas correspond

111 pothesize that the E2 lineage, which is more prevalent during epidemics, exhibits a combination of al

112 ulmonary artery systolic pressure (PASP) and prevalent echocardiographic PH.

113 ally hyper- and hypothyroidism, are the most prevalent endocrine disorders.

114 ptic circuit mechanism that may underlie the prevalent essential tremor disorder.

115 Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the e

116 wo isoforms, GSK3beta, simply because of its prevalent expression in the brain.

117 presents a major risk factor for glaucoma, a prevalent eye disease characterized by death of retinal

118 We first tested this on the two most prevalent FLG variants.

119 In contrast, "looping" conformations are prevalent for A blocks of BAB amphiphiles.

120 totemporal dementia (FTD) is the second most prevalent form of pre-senile dementia after Alzheimer's

121 The two most prevalent forms of eukaryotic cell motility are flagella

122 ltiomics single-cell sequencing and identify prevalent genetic alterations in colorectal cancer strom

123 The beta-thalassemia syndromes are the most prevalent genetic disorder globally, characterised by re

124 ineage 4, the Cameroon genotype was the most prevalent genotype (n = 20, 26%), followed by the Ghana

125 al diversity with isolates from 22/23 of the prevalent global lineages (96%).

126 polychlorinated biphenyls (PCBs), a globally prevalent group of regulated persistent organic pollutan

127 The highly prevalent GSTM1 deletion variant is associated with kidn

128 Endometriosis is a highly prevalent gynecological disease with severe negative imp

129 election were used to identify correlates of prevalent HCV, and Bayesian phylogenetic analysis was us

130 (2), use of hypertension treatment, and with prevalent heart failure had a predicted mean time alive

131 -n'-(1-methylethyl)-triazine-2,4-diamine), a prevalent herbicide in the United States, is often used

132 rial (Action for Health in Diabetes) without prevalent HF were included.

133 rial (Action for Health in Diabetes) without prevalent HF were included.

134 and non-protective laws are associated with prevalent HIV infection and that stigmas and sex work la

135 ficiency syndrome, is distinct from the more prevalent HIV-1 in several features including its evolut

136 n a study cohort in Delhi on one of the most prevalent HLA-B alleles, HLA-B*52:01, present in 22.5% o

137 fficile infections (CDIs) are among the most prevalent hospital-associated infections (HAIs), particu

138 erve (AN) afferent cochlear innervation is a prevalent human condition that does not affect audiometr

139 the settings where such conditions are most prevalent (ie, jails and prisons for SUDs and chronic in

140 h has largely focused on the few HLA alleles prevalent in a subset of ethnic groups.

141 ort that oral/systemic corticosteroid use is prevalent in asthma management, and the risks of acute a

142 ota, Community State Type IV-B, was the most prevalent in both HIV-negative (38% at baseline, 30% at

143 axis (relative risk = 2.0; P < .05) and more prevalent in both idiopathic anaphylaxis (n = 8 of 47; [

144 Viscous bubbles are prevalent in both natural and industrial settings.

145 rium, UCYN-A and its prymnesiophyte host was prevalent in both population and single-cell sorts.

146 ing transcript compartmentalization are also prevalent in brain development, the extent to which subc

147 ding known AAV serotypes (AAV1 to AAV11) are prevalent in cats living in the Northeastern United Stat

148 Neutrophils were the most prevalent in CF, with a dominant immature proinflammator

149 uninfected individuals and were particularly prevalent in children and adolescents.

150 virus 4 (Epstein-Barr virus [EBV]) were more prevalent in children with caries.

151 ontuberculous mycobacterium, is increasingly prevalent in chronic lung disease, including cystic fibr

152 Allele (A) was highly prevalent in CRC tissues represented 0.56 (P < 0.001).

153 t with tastants, and this phenomenon is most prevalent in deep-layer inhibitory neurons.

154 The metabolic syndrome is prevalent in developed nations and accounts for the larg

155 -origin H3N2 canine influenza viruses (CIVs) prevalent in dogs are thought to pose a public health th

156 ur randomly sampled population, CIN was more prevalent in domestic cat versus domestic dog (51%, n =

157 nclusively demonstrate EBV type 1 to be more prevalent in eBL patients than in geographically matched

158 Although prevalent in Ethiopia, its magnitude and distribution is

159 ced by mis-splicing of PgABCA2 pre-mRNA were prevalent in field-selected larvae from India and in bot

160 We find that the phage community is prevalent in honey bees across space and time and target

161 ges are double-stranded DNA viruses that are prevalent in human gut microbiomes.

162 her, hippocampal-cortical discoordination is prevalent in individuals with AD.

163 guts were enriched in some of the same taxa prevalent in infant humans (e.g., Bifidobacterium, Strep

164 SPPB impairment was highly prevalent in KT candidates.

165 this work shows this phenomenon can be quite prevalent in layered materials and reveals how to identi

166 n of the transcription factor AP-1 is highly prevalent in leiomyomas, the functional consequence of A

167 In primary UCB, GULP1 silencing was more prevalent in muscle-invasive UCB compared to nonmuscle-i

168 have been identified in most cancers but are prevalent in Myelodysplastic Syndrome (MDS) and Acute My

169 evalent in the subfamily Colubrinae and less prevalent in Natricinae.

170 Exponentially growing systems are prevalent in nature, spanning all scales from biochemica

171 differences in DNA methylation patterns are prevalent in neurons and may affect the progression and

172 ook data revealed that harmful elements were prevalent in news articles about suicide shared on socia

173 New loss of smell was more prevalent in participants with SARS-CoV-2 antibodies, co

174 POBEC3 degradation and that this activity is prevalent in patient-derived Vif isolates.

175 cells) in 61 (66%) of 93 patients, and most prevalent in patients with ABL2 fusions (six [86%] of 7

176 and chronic kidney disease, are increasingly prevalent in patients with diabetes; therefore, they als

177 al fibrillation, and heart failure, was more prevalent in patients with higher troponin concentration

178 cted against oncogenic drivers that are more prevalent in patients with light exposure to tobacco smo

179 the signal peptide was found to be the most prevalent in patients with recent-onset T1D.

180 nts and maternal CFH/C3 variants were highly prevalent in PE patients compared to normotensive pregna

181 hese data provide a mechanism as to how TIH, prevalent in people with impaired glucose metabolism, co

182 yes of patients with unilateral RVO are most prevalent in perifoveal regions supplied by side branche

183 IOL decentration at 5 years was equally prevalent in PEX and control eyes (1.0% vs 1.1%, respect

184 Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive compounds.

185 earch has identified two distinct SDs highly prevalent in PTSD; insomnia and nightmares.

186 ions by possessing two characteristics, both prevalent in real world organizations: exclusivity of me

187 o those with colour-vision deficiency remain prevalent in science.

188 iole number-a phenotype that is particularly prevalent in several types of cancer.

189 uniformly fatal condition that is especially prevalent in skin, cardiovascular, and musculoskeletal s

190 entional HIF1alpha or Notch signaling routes prevalent in solid tumors were not activated.

191 The E571K mutation of CRM1 is highly prevalent in some cancers, but its mechanism of tumorige

192 AAV6-binding antibodies were highly prevalent in SPF cats (83%), but this was primarily due

193 Phosphorus-rich foods are prevalent in the American diet, and low-phosphorus foods

194 Hz oscillations, but these signals are more prevalent in the anterior hippocampus and their frequenc

195 s genetic exchange can take place, one means prevalent in the archaeon Haloferax volcanii involves th

196 Obesity (BMI > 30 kg/m2) was more prevalent in the class Diet (41.2%, 95% CI 37.7%-44.7%)

197 Comorbidities prevalent in the endophthalmitis population included pre

198 ateral femoral cartilage thickness were more prevalent in the hemiplegic knees compared to the health

199 ed by membrane-intercalating agents that are prevalent in the host gastrointestinal tract and which a

200 Thus, contrary to the interpretation prevalent in the literature, the statistical properties

201 miologic data are becoming increasingly more prevalent in the literature.

202 arent ophidiomycosis; this category was more prevalent in the subfamily Colubrinae and less prevalent

203 has risen in both countries but is twice as prevalent in the UK (39% of transplants) vs the US (20%)

204 he most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and app

205 the SDC to describe the genomic alterations prevalent in this disease.

206 may indicate that CANVAS will be especially prevalent in this group.

207 Peri-implant diseases are prevalent in this North African patient population.

208 2001-2002 survey, but was significantly more prevalent in those with than without pain in the 2012-20

209 sCoVs were prevalent in winter months in most temperate sites excep

210 etriosis is a chronic painful disease highly prevalent in women that is defined by growth of endometr

211 498 members of these case's households found prevalent infection among 57%, excluding first-reported

212 identify, visually and algorithmically, two prevalent influences on fMRI signals during 440 h of res

213 significantly associated with lower odds of prevalent insomnia.

214 We find that snow droughts became more prevalent, intensified, and lengthened across the wester

215 during translation helps to avoid otherwise prevalent inter-domain misfolding.

216 As prenatal vaccinations become more prevalent, it is important to assess potential safety ev

217 f representative strains from the three most prevalent LASV lineages (II, III and IV).

218 Nonalcoholic fatty liver disease is the most prevalent liver disease worldwide, affecting 20%-25% of

219 ne metastases are common, especially in more prevalent malignancies such as breast and prostate cance

220 The most prevalent malignancies were breast (191 [21%]) and prost

221 re, apramycin is not susceptible to the most prevalent mechanisms of aminoglycoside resistance includ

222 Contrary to the prevalent meiotic origin of whole-chromosome aneuploidie

223 Arterial hypertension is the most prevalent modifiable risk factor associated with cardiov

224 ess, and insufficient sleep are increasingly prevalent modifiable risk factors for cardiovascular dis

225 he rate of synonymous changes, demonstrating prevalent molecular adaptations.

226 Models found prevalent Mtb infection and migration to be more signifi

227 The most prevalent mycotoxins were deoxynivalenol-3-glucoside (63

228 accine test animals by priming with the most prevalent N-terminal 8 residues of the HIV-1 fusion pept

229 We employed a prevalent new-user design to propensity-score match, in

230 the management of prostate cancer, the most prevalent non-cutaneous cancer in men.

231 We found that a prevalent nonsynonymous single-nucleotide polymorphism (

232 tal for Sick Children (2002-2011), excluding prevalent obesity.

233 Artifacts are highly prevalent on both circumpapillary RNFL and macular scans

234 data corrupted by technical noise remains a prevalent open problem.

235 Essential oral health care covers the most prevalent oral health problems through an agreed-on set

236 Cisterns became more prevalent over the course of the first 20 years (r = 0.4

237 Both parasites are staggeringly prevalent, particularly in tropical and subtropical area

238 Acinetobacter baumannii is a prevalent pathogen that can rapidly acquire resistance t

239 , nickel, cadmium, and tin were increased in prevalent patients.

240 The model is designed to be compatible with prevalent payment models and reforms being implemented t

241 the effects of exposure to PCB-153, the most prevalent PCB congener in human tissues, on SXR knockout

242 Rhabdomyosarcoma (RMS) is the most prevalent pediatric soft-tissue sarcoma.

243 In summary, FLI was associated with prevalent periodontitis.

244 hosphoric acid esters (diPAPs) were the most prevalent PFAS in both fire station and house dust sampl

245 association between HIV/HCV coinfection and prevalent PH.

246 nt to the pyridine ring of pharmacologically prevalent picolyl amides with an allenyl sulfone, 1-meth

247 se at a frequency <0.1, and five of the most prevalent polymorphisms in the guide RNA target site in

248 The classical and most prevalent polyubiquitin chains are those that tag a subs

249 Protein ubiquitination is one of the most prevalent post-translational modifications, controlling

250 1-associated neurocognitive disorders remain prevalent potentially due to persistent viral replicatio

251 es related to atrial fibrillation are highly prevalent, presenting with severe neurologic syndromes a

252 ld's highest levels of air pollution, highly prevalent pretransition forms of HF such as rheumatic he

253 Obesity is a prevalent prothrombotic risk factor marked by enhanced f

254 implications for the comprehension of highly prevalent psychiatric disorders and symptoms.

255 Anxiety disorders are the most prevalent psychiatric disorders in youth and are associa

256 The most prevalent psychosocial risk factor was substance abuse i

257 Of 10,254 prevalent RAS inhibitor users (median age 72 years, 36%

258 posttransplant assessments were from period prevalent, rather than incident, cohorts with more timel

259 s at the transcriptional level were the most prevalent response.

260 However, rare FQ resistance among the more prevalent rifampin-susceptible TB accounted for 50% of F

261 The most prevalent risk factors included a history of ocular surg

262 crop-reporting districts with versus without prevalent rotation-resistant rootworm populations.

263 Out of 511 prevalent rounds of AB-MR examinations, 36 women were ex

264 Individually, the 2 most prevalent sCJD subtypes, MM1 and VV2, were diagnosed wit

265 The earliest and most prevalent sensory experience includes tactile, thermal,

266 cterium Neisseria gonorrhoeae, is a globally prevalent sexually transmitted infection.

267 rarchical spectral clustering different from prevalent single-resolution clustering methods.

268 The most prevalent source of clinical resistance to the antibioti

269 netic variation of alternative splicing is a prevalent source of transcriptomic and proteomic diversi

270 of drugs at diseased sites, when compared to prevalent spray techniques.

271 een fluorescent protein (GFP)-tagging is the prevalent strategy to monitor protein dynamics in living

272 rophic cardiomyopathy as clinically the most prevalent symptom caused by biallelic mutations within t

273 A considerable proportion of the most prevalent T cells in tumors are also prevalent in the un

274 Alcoholic myopathy is more prevalent than all inherited muscle diseases combined.

275 oding, although continuous encoding was more prevalent than bursting near movement initiation or term

276 er adults with HLH we found that CH was more prevalent than in control cohorts.

277 oscillations are lower in frequency and less prevalent than in rodents, suggesting interspecies diffe

278 d abortion was 3 to 4 percentage points more prevalent than it would have been were traditional-famil

279 Context-specific signaling is a prevalent theme in cancer biology wherein individual mol

280 ne deficiency, particularly in pregnancy, is prevalent; this is of concern because observational stud

281 tudied, non-canonical synapse types that are prevalent throughout the brain and significantly contrib

282 Evidence is reviewed on the prevalent toxifying function of N-ribosyldihydronicotina

283 However, they did exhibit prevalent transcriptional changes particularly in extrac

284 in HIV-KSHV interactions.IMPORTANCE KS is a prevalent tumor associated with infections with two dist

285 Association analysis of prevalent type 2 diabetes revealed 24 replicated protein

286 ng 16S rRNA sequencing data, which is a more prevalent type of data set in metagenomics studies.

287 The most prevalent type, clear cell renal cell carcinoma (ccRCC),

288 The two most prevalent types of hormones associated with contraceptio

289 Background Osteoporosis is a prevalent, under-diagnosed, and treatable disease associ

290 Our results showed that in an area with prevalent undernutrition, protein-calorie food supplemen

291 We investigated whether, in an area with prevalent undernutrition, supplemental nutrition offered

292 platforms available for yeast despite their prevalent use in industry and academia.

293 One of the most effective and prevalent ways to enhance memory is by regulating the sy

294 red vaccines might invade despite the highly prevalent wild-type virus.

295 on support systems are becoming increasingly prevalent with advances in data collection and machine l

296 hiles); (ii) sigma-bond metathesis mediated (prevalent with B-H and B-R electrophiles).

297 on, (i) electrophilic aromatic substitution (prevalent with B-X electrophiles); (ii) sigma-bond metat

298 Injunctive non-smoking norms were more prevalent, with 60-77% of adults (17-48% of smokers) vie

299 hough vivid memories of drug experiences are prevalent within clinical contexts and addiction folklor

300 circadian disruption has become increasingly prevalent within today's society due to many factors inc