ライフサイエンスコーパス: previously unidentified

1 y complexities and interactions of the model previously unidentified.

2 o 72 h and increasing de novo synthesis of a previously unidentified 17-kDa protein beginning at 24 h

3 This paper reports on the synthesis of a previously unidentified 19 carbon furan-containing fatty

4 d transcripts, differential use of exons and previously unidentified 3' ends across development, new

5 Here, we developed a previously unidentified 3D migration and differentiation

6 /Ser/Thr repeats exemplified by a prominent, previously unidentified, 43 kDa protein in the solubiliz

7 Taken together, this study reveals a previously unidentified ability of pneumolysin to induce

8 Here we report the previously unidentified ability of the soil bacterium Ps

9 One of these was a previously unidentified Aboriginal Australian haplotype

10 production and establish these effects as a previously unidentified activity associated with several

11 l regeneration at older ages, and identify a previously unidentified age-dependent role for mitochond

12 Our description of a previously unidentified allele for the gloving pigmentat

13 rial mutations of tyrosine residues reveal a previously unidentified allosteric mechanism in which th

14 ome leakage from the capsid is achieved by a previously unidentified allosteric mechanism: gp16 bindi

15 h the protein establishes the existence of a previously unidentified allosteric regulatory site.

16 carried out an unbiased analysis to identify previously unidentified alterations in gastrointestinal

17 ine 5'-phosphate (PAP) phosphatase SAL1 as a previously unidentified and conserved oxidative stress s

18 Hence, our study identifies a previously unidentified and conserved Sufu-binding motif

19 y poly(ADP-ribose) polymerase 1 (PARP1) as a previously unidentified and critical mediator of multipl

20 f this diatom-derived sulfonate represents a previously unidentified and likely sizeable link in both

21 The creation of a previously unidentified antibiotic binding site raises t

22 This demonstration presents a previously unidentified approach for controlling nanomag

23 tment of diabetes and, thereby, represents a previously unidentified approach to efficient cell repla

24 excess, offering 11beta-HSD1 inhibition as a previously unidentified approach to treat Cushing syndro

25 croscopic mechanisms, allowing us to uncover previously unidentified aspects of collective online beh

26 ncer-related gene databases and reveals many previously unidentified aspects of transcriptional regul

27 Like other Plks, Plk4 possesses a previously unidentified autoinhibitory mechanism mediate

28 Here we describe the discovery of a previously unidentified bacteriophage present in the maj

29 tive genes on mobile elements, and suggest a previously unidentified benefit of horizontal gene trans

30 Our findings suggest a previously unidentified biomimetic design strategy in wh

31 ogical investigation revealed widespread and previously unidentified burden ofT. evansiin local cattl

32 ociated with the transient expression of two previously unidentified C-terminal fragments (CTFs) of O

33 cal role in this condition, and we provide a previously unidentified candidate for therapeutic interv

34 and genomic context identified this PC as a previously unidentified capsid protein from multiple unc

35 e results suggest that host VHA is part of a previously unidentified carbon concentrating mechanism f

36 These findings show a previously unidentified causal role for AVP in social ap

37 e of R. flavefaciens The data identified six previously unidentified CBM families that targeted beta-

38 In addition, five previously unidentified CD4 T cell epitopes were discove

39 Herein, we report a previously unidentified cell-autonomous Stat1 function,

40 We propose that these previously unidentified cells, designated "rogue GC B ce

41 These studies reveal previously unidentified cellular and molecular mechanism

42 nt intrinsic behaviors of tumors, offering a previously unidentified characteristic for studying canc

43 Our discovery unveils previously unidentified chemistry in the nonheme Fe(II)

44 binds directly to H3K4 methylation through a previously unidentified chromatin-binding module related

45 s of protein stability and reveal Siah2 as a previously unidentified circadian clockwork regulator th

46 y parallel reporter assay (MPRA) uncovered a previously unidentified cis-regulatory element 12 kb ups

47 Overall, these molecules constitute a previously unidentified class of positive modulators and

48 nsitivity to agonist, thereby establishing a previously unidentified class of tools to study this rec

49 The previously unidentified clusters were often widely geogr

50 from northern Australia, our study reveals a previously unidentified coherence between the austral an

51 As part of this previously unidentified complex,SNORD27 regulates the al

52 show that a heat shock protein, HSP105, is a previously unidentified component of the beta-catenin de

53 monstrate BCCIP, especially BCCIPalpha, as a previously unidentified component of the mitotic spindle

54 These findings add a previously unidentified component to the regulatory netw

55 The three previously unidentified compounds, gerumycins A-C, have

56 rcuit in each mushroom body compartment with previously unidentified connections: reciprocal Kenyon c

57 Here we discover previously unidentified consequences of band-inversion o

58 Our study empirically estimates previously unidentified contributions of ecotourism and

59 Recent discoveries of previously unidentified CRISPR-Cas systems have uncovere

60 We present a previously unidentified Cu(+) chaperone that evolved ear

61 recognition receptors, and thereby assign a previously unidentified danger-associated function to a

62 These data identify a previously unidentified defect in lysosomal maturation t

63 ling of strain in soft materials and suggest previously unidentified designs of LC-based responsive a

64 of Ca(2+) flux in immune cells and define a previously unidentified DHHC/Selk complex responsible fo

65 The present work adds a previously unidentified dimension to the classical textb

66 Our work opens up a previously unidentified direction toward achieving high

67 rial DNA, perturbation of which represents a previously unidentified disease mechanism.

68 t both Saci_0568 and Saci_0748 are part of a previously unidentified DNA importer.

69 a GPCR-Autoproteolysis-Inducing domain and a previously unidentified domain that we term Pentraxin/La

70 eins therefore indicates the presence of two previously unidentified domains which represent an emerg

71 pmentally downregulated 4-Like (NEDD4L) as a previously unidentified downstream gene regulated by DDB

72 tional validation highlighted both known and previously unidentified drug targets and resistance gene

73 ovo and cell-line mutations or reside within previously unidentified duplications and deletions.

74 These studies reveal previously unidentified dynamic changes in the conformat

75 and activator of transcription 3 (STAT3), a previously unidentified EDNRB transcriptional activator.

76 trifugal tubular organization and identify a previously unidentified effector of Shh in axon guidance

77 s from previous theoretical proposals, and a previously unidentified enhancer competition step.

78 ggest that airborne pollen might represent a previously unidentified environmental risk factor for my

79 imited structural metamorphosis represents a previously unidentified environmentally responsive mecha

80 tyrosine kinase (RTK) signaling output by a previously unidentified epigenetic mechanism unrelated t

81 These results also provide previously unidentified evidence consistent with a uniqu

82 temperature to the circadian clock, and show previously unidentified evidence for coupling between th

83 995 Israelis, and 1,266 Palestinians provide previously unidentified evidence of a fundamental bias,

84 This is previously unidentified evidence that biochemistry could

85 Here, we document in Drosophila a previously unidentified example of sensory exploitation

86 These findings imply a previously unidentified extrinsic function for TERRA and

87 Novel proxies using TracMouse revealed previously unidentified features of movement and may aid

88 human 26S holocomplex described here reveals previously unidentified features of the AAA-ATPase heter

89 se in dryland surface albedo may represent a previously unidentified feedback to future climate.

90 ery similar overall structures, displaying a previously unidentified fold comprised of a compact 12-s

91 Here we document a previously unidentified form of deep-brain photoreceptio

92 +)-permeable AMPARs, which in turn induced a previously unidentified form of LTP as a compensatory re

93 andem duplicate overactivity appears to be a previously unidentified form of position effect.

94 These results expose a previously unidentified function for Bcl-3 in DC surviva

95 ly couples to G12/13 versus Gq and defines a previously unidentified function for N-linked glycosylat

96 aintain cAMP/CaMKII homeostasis, revealing a previously unidentified function for PDE4D as a critical

97 endent transcription terminator represents a previously unidentified function for the enzyme, which i

98 thway to CcO and, surprisingly, link it to a previously unidentified function of CcO subunit Cox12 in

99 Our results reveal an important, previously unidentified function of DDM1 and MOM1 in rap

100 In addition to revealing previously unidentified functions of the retromer comple

101 We found a previously unidentified gene (flagrante delicto Y, FDY)

102 This study reports previously unidentified genes highly responsive to P str

103 edge, the first cultured representative of a previously unidentified genus of the Ruminococcaceae fam

104 Our study shows previously unidentified germline variants in SEMA4A pred

105 lidated this system by identifying known and previously unidentified GIs between modifiers of ricin t

106 The previously unidentified Gut-Liver-Bone Axis intriguingly

107 Five subjects (12.5%) shared the identical, previously unidentified, heterozygous CACNA1H(M1549V) mu

108 These findings highlight a previously unidentified, highly ordered interaction betw

109 mmobility, and does so in association with a previously unidentified hippocampus-wide network pattern

110 strategy results in the prediction of three previously unidentified homogeneously auxetic materials

111 Exome sequencing revealed a previously unidentified homozygous premature termination

112 The hydrophobic linker binds to a previously unidentified hydrophobic crevice in mdm2.

113 We report a previously unidentified, hypervariable family of PDIs th

114 These findings define previously unidentified hypotheses on the genomic proces

115 analysis could lead to the identification of previously unidentified IBD-associated variants.

116 Thus, we define a previously unidentified impact of inhibitory myelomonocy

117 In summary, we characterized previously unidentified imprinted genes in bovines and i

118 e identified, adding a new list of compounds previously unidentified in lion urine.

119 cooperating genetic alterations and provide previously unidentified insights into functional analysi

120 Overall, the findings of this work provide previously unidentified insights into the complex biogen

121 These data provide a structural basis for previously unidentified insights into the molecular mech

122 Together, these findings provide previously unidentified insights into the relationship b

123 g the fetal neocortex data reveals known and previously unidentified interactions among genes central

124 Via two previously unidentified intermediate states, the RNA cha

125 mote inflammatory resolution and represent a previously unidentified internal regulatory system gover

126 and one that would appear to be due to pfp's previously unidentified involvement in male mammary glan

127 emodeling of the sarcotubular system to form previously unidentified junctions between the sarcoplasm

128 We provide a previously unidentified kind of data identifying childre

129 We detected and located 48 previously unidentified large early aftershocks triggere

130 om all three assemblies, we characterized 36 previously unidentified large repetitive regions in the

131 amic changes in GR stoichiometry represent a previously unidentified level of regulation in steroid r

132 These previously unidentified ligand-receptor systems should b

133 phylogenetic analyses showed that MRE form a previously unidentified lineage sister to the hominis gr

134 Using the CMap we have identified a previously unidentified lineage-specific, bone anabolic

135 These results unravel a previously unidentified link between O-GlcNAcylation, li

136 We identify four previously unidentified loci including two loci at 13q22

137 ther substituting at the Ca(2+) site or in a previously unidentified, low-symmetry site.

138 d suggests that the lower mantle may contain previously unidentified major phases.

139 We propose that AIF and AMID are previously unidentified mammalian NDH-2 enzymes, whose b

140 Our survey highlights previously unidentified markers and programs, associates

141 tification of a novel 3MC patient carrying a previously unidentified MASP-3 G665S mutation prompted u

142 study reveals m(6)A-dependent RNA decay as a previously unidentified maternally driven mechanism that

143 Thus, these results reveal the previously unidentified mechanism behind Moco biosynthes

144 These results suggest a previously unidentified mechanism by which a cell can us

145 egulate alternative splicing and establish a previously unidentified mechanism by which cells can ada

146 These results provide evidence for a previously unidentified mechanism by which organic aeros

147 tudy has not only identified mTOR/IL-10 as a previously unidentified mechanism for beta-catenin-depen

148 Together, our results suggest a previously unidentified mechanism for regulating microtu

149 ified by CD44v3 overexpression, represents a previously unidentified mechanism governing malignant pr

150 1 responds to respiration-derived H2O2 via a previously unidentified mechanism involving H2O2-activat

151 The previously unidentified mechanism is demonstrated in a h

152 CV induces chain termination and elucidate a previously unidentified mechanism of antiviral drug resi

153 Our results highlight a previously unidentified mechanism of bacterial pathogene

154 We demonstrate a previously unidentified mechanism of IL-33 activity that

155 Here, we define a previously unidentified mechanism of mTOR-independent 4E

156 Together, our findings have uncovered a previously unidentified mechanism that BCL11A may use to

157 indicated that polar flagella rotation is a previously unidentified mechanism that confers bacteriop

158 Together, our data uncover a previously unidentified mechanism that links ApoE4-induc

159 teractions between particles and points to a previously unidentified mechanism that may play a role i

160 Overall, these results define a previously unidentified mechanism that modulates iNKT ce

161 his study reveals ribosome inactivation as a previously unidentified mechanism through which the stri

162 Here, we unravel a previously unidentified mechanism underlying this parado

163 Thus, we have uncovered a previously unidentified mechanism used by intracellular

164 P promotes the down-regulation of Spry4 by a previously unidentified mechanism, i.e. post-transcripti

165 This interaction is a previously unidentified mechanism, in which mutations in

166 This is a previously unidentified mechanism, suggested by the stru

167 es lining the RNA binding groove, and offers previously unidentified mechanistic and evolutionary ins

168 of alphaL207P mutant closed dimers provided previously unidentified mechanistic insight into how thi

169 tion, and proinsulin processing, and provide previously unidentified mechanistic insight into the dev

170 ne whether our proteomic screen could reveal previously unidentified mediators of heart development.

171 of new bacteria and viruses which represent previously unidentified members of the human microbiome.

172 Previously unidentified membrane vesicles lying immediat

173 phase, additionally this material exhibits a previously unidentified mesophase.

174 Our results identify a previously unidentified metabolic pathway from NaAD usin

175 gluconeogenesis in Mtb virulence and reveals previously unidentified metabolic redundancy at the FBPa

176 reconstruction identified a large number of previously unidentified metabolite classes, including th

177 Furthermore, we propose a previously unidentified method based on strontium and ca

178 atterning and neuronal function, revealing a previously unidentified mode of posttranslational microt

179 Here, we report a previously unidentified model of resistance to Fas recep

180 ene-activation screen in vivo and discovered previously unidentified modulators of tumor growth and t

181 This previously unidentified molecular cascade could be a the

182 e and dynamic portions of cMyBP-C, providing previously unidentified molecular insight into the modul

183 Here, we uncover a previously unidentified molecular mechanism in which dir

184 hus, fluctuations in KYNA levels emerge as a previously unidentified molecular mechanism linking long

185 ur results implicate S6K1 dysregulation as a previously unidentified molecular mechanism underlying s

186 This promoter directs transcription of a previously unidentified MTMR2 transcript that is enriche

187 one participant's HSV-2 isolate, we found a previously unidentified mutation close to the putative r

188 Surprisingly, a previously unidentified mutation in the double-stranded

189 A previously unidentified mutation in the dsRNA-binding do

190 We discovered previously unidentified mutations in the ligand-interact

191 ynthesis, enabling the targeted isolation of previously unidentified natural products directly from c

192 Our study reveal C5orf30 to be a previously unidentified negative regulator of tissue dam

193 resolves known binding partners, as well as previously unidentified network components.

194 HD phenotype associated with a prominent and previously unidentified neurobiological impairment.

195 vated T-cell (NFAT) signaling pathway, and a previously unidentified NFAT binding site is identified

196 -1) and calamari (cali), were expressed in a previously unidentified non-neural CNS cell type.

197 studies and ethnic groups, we identified 49 previously unidentified, nonsynonymous PPARG variants (M

198 We therefore suspect that this previously unidentified nutrient sensing paradigm may be

199 CR binding to different states, the latter a previously unidentified, open-but-inactive conformation.

200 lized and propagating surface plasmons and a previously unidentified optical mode type called absorpt

201 under cyclohexamide stress and also detects previously unidentified oxidative stress sensitivity acr

202 Representing a previously unidentified paradigm in OM transport, CymA m

203 This study identifies a previously unidentified pathway in decidual senescence,

204 Here, we describe a previously unidentified pathway in the KO hippocampus th

205 tured programmable liquid wires that present previously unidentified pathways for the design of new h

206 wn to change with cell-material interaction, previously unidentified pathways, such as apoptosis and

207 We found evidence for a previously unidentified period of rapid ring contraction

208 These data provide a previously unidentified perspective on the role of ORs i

209 This study opens previously unidentified perspectives for an effective ph

210 We have identified a previously unidentified phosphoprotein encoded by MDV OR

211 t Anthoceros punctatus, we also discovered a previously unidentified phototropin gene that likely rep

212 report the identification of claudin-8 as a previously unidentified physiologic target for KLHL3 and

213 In conclusion, we identify miR-3151 as a previously unidentified player in MM and PTC pathogenesi

214 ot required for centriole duplication, but a previously unidentified Plk4-binding domain in the C ter

215 Our findings have resolved a previously unidentified population of inhibitory interne

216 We have identified a previously unidentified pore-scale event during capillar

217 arum erythrocyte invasion and offers it as a previously unidentified potent target for antimalarial s

218 identification and characterization of five previously unidentified prokaryote homologs with high se

219 (CASP7) maintains uterine quiescence through previously unidentified proteolytic targeting of the gap

220 lysis of the Y. pestis sRNA-ome, we found 63 previously unidentified putative sRNAs in this species.

221 To identify previously unidentified putative targets in pathogenic T

222 rug targets for lipid lowering, and identify previously unidentified rare alleles associated with lip

223 t, we interrogated the potential of CFH as a previously unidentified regulator of Bruch's membrane li

224 catalytic subunit of PP2A holoenzymes, as a previously unidentified regulator of formative cell divi

225 ssion through its 3'UTR, and we identified a previously unidentified regulatory element in the UTR.

226 CERES readily identified known and previously unidentified regulatory elements, some of whi

227 This study links Ki-Ras and ISG15 in a previously unidentified regulatory loop that may underli

228 Here, we present a previously unidentified regulatory mechanism of Paneth c

229 This previously unidentified regulatory mechanism was observe

230 This study demonstrates a previously unidentified regulatory pathway in fibrogenes

231 This receptor-ligand topology defines a previously unidentified regulatory protein-lipid surface

232 mTFs function at a previously unidentified regulatory tier downstream of fa

233 ORMDL proteins are thus previously unidentified responders to excess cholesterol

234 y the composition of the gut microbiota as a previously unidentified risk factor for severe malaria a

235 ties, specifically obesity and diabetes, are previously unidentified risk factors for severe malaria

236 In essence, PKM2 serves a previously unidentified role as a molecular integrator o

237 Our work uncovers a previously unidentified role for 3'-end processing and t

238 of cellular targets for 53BP1 and suggest a previously unidentified role for 53BP1 in regulating pRb

239 Here, we report a previously unidentified role for AFPs in effectively inh

240 Collectively, our data highlight a previously unidentified role for CD300f in IL-4Ralpha-in

241 These results suggest a previously unidentified role for CeuE within the Fe(III)

242 Taken together, our studies uncover a previously unidentified role for Hh as an inhibitor of B

243 These results uncover a previously unidentified role for MBs besides memory stor

244 We uncover a previously unidentified role for Nebula/DSCR1 in modulat

245 cific Panx1 knockout mouse line, we report a previously unidentified role for Panx1 channels in promo

246 Our data revealed a previously unidentified role for perivascular cells in p

247 In conclusion, our findings identify a previously unidentified role for peroxisomes in macropha

248 These results reveal a previously unidentified role of an FSI-embedded circuit

249 We report a previously unidentified role of ECM confinement in EMT i

250 In all, our results uncover a previously unidentified role of IKKbeta in regulating gl

251 Our study reveals a previously unidentified role of NS3/4A in regulation of

252 These data unveil a previously unidentified role of OGG1-driven DNA BER in t

253 lly regulated by InsP6 binding, suggesting a previously unidentified role of the eukaryote-specific c

254 These findings unravel the previously unidentified role that transcriptional repres

255 These results reveal previously unidentified roles for Tiparp, MacroD1, and A

256 For instance, recent studies have discovered previously unidentified roles of PXR in inflammatory res

257 Our work opens a previously unidentified route for developing compliant s

258 n through these internal states, providing a previously unidentified route to self-organization of a

259 These fragment inhibitors represent previously unidentified scaffolds for development of nov

260 oss movements, drive conservation predicts a previously unidentified scaling law between the overall

261 Here, we identify a previously unidentified signal transduction cascade that

262 mployed in the geosciences, we identify new, previously unidentified, signal types.

263 actor (PDGF)-DD, opened the possibility of a previously unidentified signaling pathway involved in tu

264 Thus, the unoccupied IR and IGF1R generate previously unidentified signals that control expression

265 on of PIP2 and the calcified CaM N lobe to a previously unidentified site in Kv7.1 helix B, also know

266 Mobile phone data therefore offer a valuable previously unidentified source of data for measuring key

267 d regulated IFN-beta via direct binding to a previously unidentified specific regulatory site distal

268 We detected previously unidentified strains producing known anabaeno

269 se-directed STAT3 inhibition may represent a previously unidentified strategy for antifibrotic drug d

270 Our results reveal a previously unidentified strategy for HIV-1 to antagonize

271 This previously unidentified structure type has an intermedia

272 (II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric

273 Our data reveal a previously unidentified sub-clinical prion-positive port

274 Previously unidentified superstructure and immiscibility

275 we identified nine individuals affected by a previously unidentified syndrome characterized by growth

276 kappaB, and miR-155 function as members of a previously unidentified system that has the potential to

277 ng comparative proteomics, we identified two previously unidentified T6SS effectors that contained a

278 Here, we found a novel, previously unidentified TA system in Escherichia coli na

279 his study reveals the glucagon receptor as a previously unidentified target for GLP-1 receptor agonis

280 ved in AMPA receptor trafficking, suggesting previously unidentified targets for therapeutic interven

281 econdary bacterial infection and may provide previously unidentified targets to combat bacterial biof

282 s cancer cell state changes and also provide previously unidentified therapeutic implications for PKC

283 of BCR-ABL1(+) B-ALL cells, and suggesting a previously unidentified therapeutic strategy for this di

284 n is abnormal in TSC may provide insights to previously unidentified therapeutic targets.

285 ight that FXR agonists represent a potential previously unidentified therapy for MS.

286 The high sensitivity of the method reveals previously unidentified tight binding states for Taq and

287 Our results reveal a previously unidentified tolerance defense strategy invol

288 Our findings reveal a previously unidentified transitional zone in the epithel

289 We found hundreds of previously unidentified TSS and PAS which revealed two i

290 ays interspersing the euchromatin provides a previously unidentified type of centromeric chromatin or

291 aerobic conditions effectively, indicating a previously unidentified type of regulatory mechanism.

292 We recently reported the isolation of previously unidentified vaccine-elicited, CD4 binding si

293 heterozygous missense variants in IL10RA and previously unidentified variants in MSH5 and CD19.

294 omain-containing protein, and both known and previously unidentified variants in PCSK9, LDLR and APOB

295 also report electron microscopic evidence of previously unidentified vesicular trafficking of phospho

296 ,500 human proteins, we find and validate 51 previously unidentified virus-host interactions.

297 hogen emergence" encompasses everything from previously unidentified viruses entering the human popul

298 These previously unidentified VZ characteristics suggest alter

299 More broadly, our work provides a previously unidentified way of envisioning highly concen

300 Herein, a previously unidentified zinc ion and its coordination by