ライフサイエンスコーパス: prickle

1 red and reversed by the products of the gene prickle.

2 polarity proteins including Dishevelled and Prickle.

3 wo other tissue polarity genes, flamingo and prickle.

4 and the cytoplasmic proteins Dishevelled and Prickle.

5 interactions with mutations in frizzled and prickle.

6 For example, a missense mutation in Prickle 1 (Pk1) is associated with progressive myoclonus

7 of NTD prevalence in humans and ascribes to Prickle-1 a critical role in lower spinal cord formation

8 Moreover, the planar-cell-polarity member, Prickle-1, is recruited specifically during junctional n

9 de-mediated knockdown of PCP genes including prickle-1a (pk1a) led to developmental biliary abnormali

10 ing function of Prickle on Frizzled requires Prickle activity in neighboring cells.

11 ed by mutations in disheveled, inturned, and prickle all make hair patterns globally irregular yet lo

12 rast the cytoplasmic components Dishevelled, Prickle and Diego are not needed for intercellular commu

13 Asymmetrical localization of Prickle and Dishevelled to the opposite cell edges in ze

14 Strabismus binds directly to Dishevelled and Prickle and is able to recruit them to membranes.

15 y the core proteins Strabismus, Dishevelled, Prickle, and Diego.

16 nts, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteris

17 genes) and upstream genes such as frizzled, prickle, and starry night (frizzled-like genes).

18 ge from pleasantly cool to painfully aching, prickling, and burning.

19 that isoforms of the Fz PCP pathway protein Prickle are differentially required for the two PCP Phas

20 the planar polarity proteins Dishevelled and Prickle are mislocalised in the cell.

21 In the second phase, Dishevelled and Prickle are required for these proteins to become asymme

22 evel is similar to frizzled, dishevelled and prickle, as many cells form a single hair of abnormal po

23 tubules are not required for accumulation of Prickle at the anterior cell edge.

24 However, Prickle axonal localization depends on Frizzled and Stra

25 la melanogaster, the cytoplasmic PCP protein Prickle binds Van Gogh and regulates its function.

26 Y1Rs are present in the parabasal prickle cell layer and the granular layer, while differe

27 that basal cells predominantly expressed m3, prickle cells had equally high levels of m4 and m5, and

28 We show that a VANG-1/Van Gogh and PRKL-1/Prickle containing PCP pathway and a Slit-independent SA

29 type is similar to frizzled, dishevelled and prickle, dachsous mutant wings display a unique and dist

30 We describe a Prickle-dependent intercellular feedback loop that gener

31 last DNA phylogeny indicates that thorn-like prickles evolved at least four times and leaf dimorphism

32 In the absence of Prickle, Frizzled and Dishevelled remain symmetrically d

33 r data suggest that Strabismus, Flamingo and Prickle function together to regulate the establishment

34 , dishevelled (dsh), Van Gogh/strabismus and prickle, function to regulate wing hair, bristle and omm

35 subdomains within r4, with one gene, a novel prickle homolog (pk1b), expressed specifically within th

36 Conversely, Prickle in the same cell has a destabilizing effect on F

37 (Pk3), a vertebrate homologue of Drosophila Prickle, in Xenopus gastrocoel roof plate (GRP).

38 marily active in the Early PCP Phase and the Prickle isoform in the Late PCP Phase.

39 merely altering the balance of the two adult prickle isoforms in neurons can predispose flies to seiz

40 We report that the putative PCP protein Prickle-like 2 (Pk2) is distributed in crescents on the

41 ns is required for the other's localization, Prickle localization is influenced by Strabismus functio

42 mesoderm C&E, the noncanonical Wnt component Prickle localizes at the anterior cell edge, whereas Dis

43 Prickle localizes to the proximal side of pupal wing cel

44 more generalized cellular mechanism whereby Prickle mediates polarity by influencing microtubule-med

45 Additionally, we show that seizure-prone prickle mutant flies have electrophysiological defects s

46 ar, we show that the stabilizing function of Prickle on Frizzled requires Prickle activity in neighbo

47 s or signs were experienced by 27 patients; 'prickling' or 'asleep numbness' in 20, mild pain in 13 a

48 ed for a gradient of frizzled, starry night, prickle, or spiny-legs expression to repolarize wing cel

49 Here, we show that Prickle organizes microtubule polarity and affects their

50 brafish, and humans showed that mutations in prickle orthologs result in epileptic phenotypes, althou

51 ebrafish homologs of the Drosophila PCP gene prickle (pk) [8], both of which show discrete and dynami

52 the planar cell polarity (PCP) gene products prickle (pk) and dishevelled (dsh) show M/L polarization

53 (Fzd), as well as the cytoplasmic effectors Prickle (Pk) and Dishevelled (Dvl).

54 The PCP genes prickle (pk) and strabismus (stbm) are thought to antago

55 This function of Dgo is redundant with Prickle (Pk) and Strabismus (Stbm), and only appreciable

56 olarity (PCP), with anterior localization of Prickle (Pk) and Strabismus (Stbm).

57 Here we show that the tissue polarity gene prickle (pk) encodes a protein with a triple LIM domain

58 acterise a zebrafish homologue of Drosophila prickle (pk), a gene that is implicated in the regulatio

59 One of the key members of this pathway is Prickle (Pk), a protein that regulates cell movement thr

60 ed (Fz)/PCP core components, Diego (Dgo) and Prickle (Pk), and screened these against the DrosDel gen

61 We study four polarity genes, frizzled (fz), prickle (pk), Van gogh/strabismus (Vang/stbm) and starry

62 ity (PCP) proteins, we find that alternative Prickle (Pk-Sple) protein isoforms control the polarity

63 y signaling components Van Gogh (VANG-1) and Prickle (PRKL-1).

64 PET-LIM proteins such as Prickle regulate cell behavior during gastrulation in Xe

65 in ascidians, the planar cell polarity gene prickle regulates sequential establishment of cell polar

66 t simultaneous depletion of Xtes and Xenopus Prickle results in axial defects that are more severe th

67 tongue or lips, elicits painful burning and prickling sensations through unknown mechanisms.

68 ugh characterization of the contributions of Prickle, Spiny-legs, Dachsous, Fat, and Dachs to PCP in

69 Prickle-Spiny-Legs (Pk) is an essential component of the

70 nected through the Spiny-legs isoform of the Prickle-Spiny-legs locus.

71 including interactions with Dishevelled and Prickle that function in a context-dependent manner.

72 Prickle therefore functions in a feedback loop that ampl

73 d/Dishevelled/Diego (Fz/Dsh/Dgo) or Van Gogh/Prickle (Vang/Pk) complexes within the same cell, stabil

74 im), a mutation in the PCP pathway component Prickle, which has a severe defect in early mediolateral

75 ssays and key Wnt/PCP factors (RhoA, Vangl2, Prickle, Wnt11) rescued Gsc-mediated NTDs.