ライフサイエンスコーパス: primary

1 may be profoundly affected by the states of primary afferent neuron mechanics.

2 r determining membrane mechanics of cultured primary afferent neurons of the dorsal root ganglia (DRG

3 ABSTRACT: Primary ageing markedly attenuates cutaneous vasodilatat

4 and propylene oxide, using a functionalized primary alcohol initiator and magnesium 2,6-di-tert-buty

5 ession of MCC clinically resembling multiple primaries, allowing appropriate staging of the patient.

6 crucial in the host's innate defence against primary alphaherpesvirus infections.

7 e determined how the chemical composition of primary ambient PM2.5 sources varies across cities.

8 placing an amine group (K side chain) with a primary amide group (Q side chain) weakens the hydrophob

9 a series of decoy peptides derived from the primary amino acid sequence in the SOD2-binding site in

10 lture of the AML cell lines MOLM-4, THP-1 or primary AML cells with donor peripheral blood mononuclea

11 Under the optimistic assumptions in the primary analysis, the incidence of multidrug-resistant t

12 n FCM, compared with standard of care in the primary analysis, this effect was highly sensitive to th

13 zation and 4919 (98.5%) were included in the primary analysis.

14 ients in the sham group were included in the primary analysis.

15 ) in the control group provided data for the primary analysis.

16 We identified 79 associations influencing 13 primary and 19 secondary metabolites with large effects

17 A defining hallmark of primary and metastatic cancers is the migration and inva

18 Gene expression profiling revealed primary and metastatic cells as two distinct cell popula

19 Our findings were validated in both primary and metastatic models of pancreatic cancer.

20 virus middle T-driven tumors showed altered primary and metastatic profiles in previous studies, dep

21 ased whereas Streptococcus decreased in both primary and metastatic samples.

22 dy dynamic tumour-stroma interactions within primary and metastatic sites, including the lung.

23 We present the coupling of primary and secondary benzyl alcohols with indoles to fo

24 er discharge by serving as a liaison between primary and secondary health services to ensure they are

25 ic resonance imaging-confirmed NHS including primary and secondary intracerebral hemorrhage, hemorrha

26 g protein 1 (Xpp1) in the regulation of both primary and secondary metabolism of Trichoderma reesei X

27 Meta-estimates for primary and secondary outcomes were derived using a bino

28 In addition, it was necessary to pool primary and secondary outcomes.INT that is provided by a

29 rombosis and aspirin with anticoagulants for primary and secondary prevention of venous thrombosis.

30 id sensing elicits interferon production for primary antiviral defense through cascades controlled by

31 Cognitive behavioral therapy reduced primary anxiety symptoms more than fluoxetine and improv

32 wever, contrasting findings were reported in primary APS patients with regard to the increased number

33 Subsequent analyses showed a primary association with HLA class II alleles encoding f

34 Feedback signals from the primary auditory cortex (A1) can shape the receptive fie

35 The gustatory, primary auditory, primary visual, rostrolateral visual,

36 Primary authors provided individual participant data fro

37 propose a new view on the pathophysiology of primary biliary cholangitis and PSC in the hope that the

38 Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) duri

39 of 20 BrM retained the PAM50 subtype of the primary BrCa.

40 1 expression exhibits strong correlations in primary breast carcinomas.

41 reased with activation of the ERK pathway in primary cancer specimens in vivo and in cancer cell line

42 is variable, often lower than the KM of the primary carboxylating enzyme Rubisco, and in order to ph

43 blasts, cardiomyoblasts, neuronal cells, and primary cardiomyocytes.

44 proteins are the leading cause of inherited primary cardiomyopathies.

45 sion and abstinence over 3 months among male primary care attendees with harmful drinking in a settin

46 o perform HCV screening for patients seen in primary care clinic (1) born between 1945 and 1965, (2)

47 tified SQ-LNS to ill children presenting for primary care in rural Gambia had a very small effect on

48 As primary care is the first point of healthcare contact fo

49 s to effectively deploy registered nurses in primary care needed to assure efficient, evidence-based,

50 Lack of knowledge about effective primary care nursing roles and responsibilities challeng

51 iagnosis and treatment of HCV infection in a primary care patient panel with and without the implemen

52 s seen in an office visit by a UPMC-employed primary care physician (PCP) in 2014.

53 ented well-controlled asthma in this study's primary care population increased from 48% to 54%.

54 on on medication adherence among a sample of primary care providers and their black and white hyperte

55 "best practice advisory" (BPA) that prompted primary care providers to perform HCV screening for pati

56 ubscale, the incidence of the NPs serving as primary care providers with their own patient panel doub

57 INTERPRETATION: In China's primary care setting, pragmatic interventions on antimic

58 m questionnaire, CAPTURE (COPD Assessment in Primary Care to Identify Undiagnosed Respiratory Disease

59 Clusters were primary care township hospitals in two counties of Guang

60 Among adults presenting to primary care with acute sore throat, a single dose of or

61 more likely to be securely attached to their primary caregiver (odds ratio [OR] = 1.7, p = 0.029, 95%

62 55 patients): 227 patients (73.5%) underwent primary catheter drainage and 82 patients (26.5%) underw

63 obacterium tuberculosis is recognised as the primary cause of human tuberculosis worldwide.

64 The primary cause of KOS is autosomal recessive mutations in

65 ctor (VEGF) expression) from 9 patients with primary ccRCC.

66 pecific knockdowns of genes of interest from primary CD34(+) hematopoietic stem cells (cRBCs).

67 onfirmed and putative restriction factors in primary CD4(+) T cells from rhesus macaques under variou

68 ommonly used, immortalized TB cell lines and primary cells from term placenta.

69 Primary cells revealed one substitution severely impaire

70 feration followed by premature senescence in primary cells, an initial barrier to tumor development.

71 ssue throughout postnatal development and in primary cerebellar medulloblastoma tissues.

72 implications for human disorders related to primary cilia dysfunctions, such as ciliopathies and cer

73 y functions, confirming the central role for primary cilia in Hh signaling.

74 nsport of membrane and cytosolic proteins in primary cilia is thought to depend on intraflagellar tra

75 s called ciliopathies is caused by defective primary cilia morphology or signal transduction.

76 In addition, primary cilia seem to functionally modulate effects of E

77 pha-tubulin and SOX9 proteins, the number of primary cilia(+) LPCs, and increased active gamma-glutam

78 cylation is essential for the homeostasis of primary cilia, which has important implications for huma

79 sults thus define a specific requirement for primary cilia-mediated GPCR signaling in interneuronal c

80 hog (Hh) signaling in vertebrates depends on primary cilia.

81 s with which we detected glycylation in many primary cilia.

82 Primary ciliary dyskinesia (PCD) is an autosomal recessi

83 study, we report for the first time that the primary cilium acts as a crucial sensor for electrical f

84 dromes, is essential for the function of the primary cilium and maintenance of phosphoinositide balan

85 segment (OS) is a unique modification of the primary cilium, specialized for light perception.

86 Hh signaling is triggered at the primary cilium.

87 vironments using single-cell RNA-seq from 11 primary colorectal tumors and matched normal mucosa.

88 PA was related to the primary composite outcome (HF hospitalization, cardiovas

89 Primary consumers are under strong selection from resour

90 ly heterogeneous, even in layers 3b/4 of the primary cortical areas, where the thalamic input is domi

91 Primary cultures of hepatocytes derived from wild-type o

92 for the modulation of HCN4 by cAMP, i.e. the primary cyclic nucleotide modulator of HCN channels.

93 Computer simulations utilizing primary data explored UF's ability to reduce these footp

94 a small contribution to odontoblasts during primary dentinogenesis.

95 Children who developed caries in their primary dentition had a very different caries trajectory

96 Influenza and RSV were listed primary diagnoses in 56 (30%) vs 7 (6%), respectively (P

97 y general internists were estimated from the primary diagnosis for 13832 office visits (2010-2013 Nat

98 the maintenance period were included in the primary efficacy and safety analyses.

99 The primary efficacy end point was a composite of adjudicate

100 ere significantly more likely to achieve the primary efficacy end point: in trial A, 188 of 254 (74.0

101 The primary efficacy endpoint was the percentage of patients

102 The primary efficacy measure was the proportion of patients

103 atment significantly reduced the risk of the primary end point (1344 patients [9.8%] vs. 1563 patient

104 o association between stent fracture and the primary end point (P=0.86) or with restenosis (P=0.53).

105 eters was compared between the 2 arms as the primary end point and overall survival (OS) as the secon

106 cal testing strategy was used for the second primary end point and the secondary end points in the fi

107 ing a mean follow-up of 3.9+/-2.4 years, the primary end point of death, transplant, or admission for

108 The primary end point was death, myocardial infarction, or u

109 The primary end point was PFS; secondary end points included

110 The primary end point was the detection of bone lesions at d

111 The primary end point was the development of asthma until ag

112 The primary end point was the identification of the maximum

113 The primary end point was the incidence of somatic mutations

114 t the clinical response criteria for the two primary end points than did those who received placebo.

115 The two primary end points were a four-component composite of de

116 ival, and progression-free survival were the primary end points.

117 to establish the effect of MABp1 with a new primary endpoint in patients with advanced colorectal ca

118 There was no difference in the primary endpoint of day 1 dyspnea reduction, despite sig

119 The primary endpoint was a composite global rank score (hier

120 The primary endpoint was all-cause mortality at 30 days.

121 The primary endpoint was clinical cure at the test-of-cure v

122 The primary endpoint was overall survival in the intention-t

123 The primary endpoint was proportion of responders.

124 The primary endpoint was the proportion of participants with

125 omarkers (the combination being our a priori primary endpoint), to provide context and enhance precis

126 Primary endpoints were DSM265 safety, tolerability, and

127 culture of murine fibroblast cell lines and primary fibroblasts and human epithelial cell lines or p

128 We isolated 10 primary fibrotic and 7 non-fibrotic conjunctival fibrobl

129 The primary focus of this article is to assist hospitals in

130 he principal causal interactions between the primary, genetically based organic processes of evolutio

131 Reducing GAD1 in metastatic cells by primary glia cell coculture abolished the capacity of me

132 restoring high levels of SOX5/6/21 in human primary glioblastoma cells enabled expression of CDK inh

133 by cultured ELISPOT, in pregnant women with primary HCMV infection, in association with avidity inde

134 mentation of T cruzi screening programmes at primary health centres in European countries hosting Lat

135 , and their associations with individual and primary health-care site characteristics, using mixed mo

136 routine immunization (RI) and other selected primary healthcare (PHC) services using dedicated mobile

137 rs (y) presenting with an illness at a rural primary healthcare centre in The Gambia.

138 y predicts lineage choice in differentiating primary hematopoietic progenitors using image patches fr

139 o and in vivo in two murine tumor models, in primary human breast and lung cancer cells, and in depos

140 ortantly, NPM-ALK is capable of transforming primary human CD4(+) T cells into immortalized cell line

141 broblasts and human epithelial cell lines or primary human epithelial cells exposed to IL-13, IL-17A,

142 fenylation of SIRT6 occurs in THP1 cells and primary human promonocytes during inflammation and in sp

143 years; range, 58-82 years) with biochemical primary hyperparathyroidism and inconclusive results at

144 initial localization study for patients with primary hyperparathyroidism.

145 1 proposed reanalysis of the original study primary hypothesis.

146 The Primary Immune Deficiency Treatment Consortium (PIDTC) i

147 with higher peripheral blood viral loads in primary infection and greater changes in viral diversity

148 In pregnant women with primary infection, the cultured ELISPOT assay detected a

149 on discharge diagnosis and 647 patients with primary inflammatory skin condition admission diagnosis

150 A total of 413 patients with a primary inflammatory skin condition discharge diagnosis

151 f-function mutations have been discovered in primary leukemia/lymphoma and gastric cancer by human ca

152 36 patients with CLRT and 4119 patients with primary LT).

153 e suppression of NFS1, whereas metastatic or primary lung tumours do not.

154 Knocking down TTP in primary macrophages leads to an increased induction of N

155 nocked down with small hairpin RNAs in human primary macrophages.

156 AT1 is the predominant BCAT isoform in human primary macrophages.

157 SE and NW lava fields to be consistent with primary magmatic processes, such as mantle heterogeneity

158 s in established B-cell tumor cell lines and primary malignant cells.

159 Patients with clinically designated multiple primary MCC were identified from the multidisciplinary M

160 tations is useful in distinguishing multiple primary MCCs from progression of MCC clinically resembli

161 storage compartment to the sarcolemma as the primary mechanism of excessive myocellular lipid import.

162 by fluid flow has been considered to be the primary mechanism underlying such impedance based microf

163 7 impaired stem cell-like characteristics in primary MECs and spontaneous tumor cells.

164 The primary mediators of this activity are the SMAD proteins

165 Using human primary melanocytes and a highly pigmented melanoma cell

166 Primary metabolism can be measured by the universally co

167 play essential roles in enzymes involved in primary metabolism including energy transduction and deo

168 both transcription and Drosha/DGCR8-mediated primary miRNA (pri-miRNA) processing.

169 However, its primary molecular mechanisms remain incompletely underst

170 Nature precisely manipulates primary monomer sequences in biopolymers.

171 s influence can be exerted directly upon the primary motor (M1) and somatosensory (S1) cortical areas

172 bility in the spike-field coherence of a rat primary motor cortical neuron to the LFP theta rhythm.

173 e largely precedes dendritic arborization of primary motor neurons, suggesting that the structured ne

174 t aberrant ribonucleotide incorporation is a primary mtDNA abnormality that can result in pathology.

175 ues to examine chromosomal rearrangements in primary murine B cells and discovered that RAG1/2 causes

176 ransgenic mice in vivo and in cell lines and primary neuronal culture derived from timed pregnant rat

177 SK2656157 or overexpression of PERK-K618A in primary neurons rescues the loss of dendritic outgrowth

178 Based on multivariable analysis, the risk of primary nonadherence was 16 percentage points lower amon

179 The overall rate of primary nonadherence was 31.6% (n = 788).

180 The ability to predict graft failure or primary nonfunction at liver transplant decision time as

181 Primary nut allergy presents most commonly in the first

182 Primary NVRMs were infected with lentivirus containing C

183 The primary objective of this study was to obtain insights i

184 The primary objective of this trial was to evaluate safety o

185 The primary objective was to demonstrate the clinical applic

186 Primary objectives were to assess the safety of rovalpit

187 brain and provide a limited understanding of primary odor detection.

188 h saline (5.54, 3.42), had no benefit on the primary outcome (HVLT-R-DR; difference in means -0.43 [9

189 The primary outcome for the phase 3 stage of the trial was o

190 27-hydroxycholesterol levels in serum as the primary outcome measure.

191 mg, at baseline and every 4 weeks, with the primary outcome measured at 6 months.

192 The primary outcome measures were positive donor rim fungal

193 The primary outcome occurred in 325 patients (8.5%) in the d

194 The primary outcome of the trial was the rate of corneal per

195 Primary outcome was 30-day mortality rate for all hospit

196 The primary outcome was a composite of long-term CV events o

197 The primary outcome was all-cause mortality until 28 days.

198 The primary outcome was all-cause mortality; myocardial infa

199 The primary outcome was best-corrected visual acuity (BCVA)

200 Primary outcome was change from baseline in best-correct

201 The primary outcome was change from baseline to 8 weeks in a

202 The primary outcome was change in mean total TRS score at th

203 Primary outcome was combined symptom medication score (C

204 he clinical usefulness of each score and the primary outcome was in-hospital mortality.

205 The primary outcome was membership in high-symptom trajector

206 Primary outcome was mortality at 28-days.

207 The primary outcome was reported using the modified Rankin S

208 The primary outcome was the incidence of adverse events amon

209 The primary outcome was the number of laboratory-confirmed v

210 assessed by parent report and child report (primary outcome), and blood was collected from children

211 Recruitment was powered for the primary outcome, and analysis was based on intention to

212 referred for transplant within 1 year as the primary outcome, and disparity in the referral of black

213 ng were associated with a higher odds of the primary outcome, whereas treatment in a facility with an

214 All enrolled patients were assessed for the primary outcome, which was testing completeness within 3

215 care at 6 months (defined as 1-LTFU) as the primary outcome.

216 All 377 infants were assessed for the primary outcome.

217 trength of evidence for association with the primary outcome: age, vasopressor requirement, thrombocy

218 Our primary outcomes of interest were perinatal mortality, p

219 The primary outcomes of the model were changes in life-years

220 Primary outcomes were rates of severe hypoglycemia and d

221 Primary outcomes were repeat clinic presentations and gr

222 The primary outcomes were the incremental cost-effectiveness

223 Our primary outcomes were the projected number of additional

224 Primary outcomes were time from presentation to document

225 In the retrospective cohort, the primary outcomes were treatment failure and adverse even

226 etween traditional or improved stove use and primary outcomes, stratifying households by proximity to

227 ults are important to document properties of primary particles from combustion sources, which can be

228 for accelerated and superior engraftment of primary patient-derived acute myeloid leukemia (AML) and

229 Despite less procedural complexity, shorter primary percutaneous coronary intervention time was asso

230 cute myocardial infarction (MI) treated with primary percutaneous coronary intervention were randomiz

231 c phenotypes of PHD2-deficient RAW cells and primary PHD2 knockout bone marrow-derived macrophages (B

232 ven by the engine of ciliary beating, is the primary physical airway defense against inhaled pathogen

233 fy age-onset rhythmicity in several putative primary piRNA transcripts overlapping antisense transpos

234 ds against the use of estrogen alone for the primary prevention of chronic conditions in postmenopaus

235 Among the US primary prevention population represented by 3416 indivi

236 early adulthood to inform discussions about primary prevention.

237 the effect of ocean acidification on algae (primary producers) can have a strong, indirect positive

238 We calculate that increased net primary production due to Ndep has enhanced detrital inp

239 croalgae contribute approximately 15% of the primary productivity in coastal marine ecosystems, fix u

240 ncreasing demand for N, the element limiting primary productivity in temperate forests, which could b

241 med could be predicted based on Na, N or net primary productivity.

242 diagnosis in a large cohort of patients with primary progressive aphasia (PPA) variants defined by cu

243 The primary purpose of this trial was to assess the effectiv

244 bers impact overall interconnectivity as the primary reason for the appearance of neural maps, which

245 at surfactant precipitation can be used as a primary recovery method for BLIS from a complex fermenta

246 r drainage and 82 patients (26.5%) underwent primary relaparotomy.

247 ) and by cardiac catheterization (n=5) after primary repair (n=4) or after surgical RV revalvulation

248 A descriptive analysis of a sample of primary research articles published in three high-impact

249 overexuberant systemic inflammation plays a primary role in ACLF progression.

250 The increase in the primary safety outcome with 24- versus 6-month DAPT was

251 0 000-50 000, and >/= yen50 000], education [primary school and below, middle school, high school, an

252 cently demonstrated in biliary lithiasis and primary sclerosing cholangitis, two cholangiopathies reg

253 onitrile at -78 degrees C in the presence of primary, secondary and tertiary alcohols affords the cor

254 dorants by olfactory sensory neurons (OSNs), primary sensory neurons that physically contact odor mol

255 ndary structure element rather than by local primary sequence.

256 The features may come from the primary sequences, secondary or three dimensional struct

257 Identification of the primary sheddase has allowed the characterization of a n

258 s, and bone, that have disseminated from the primary site, are reported.

259 and 0.84 per 100000 in NETs with an unknown primary site.

260 nequivocally identifying the ampullae as the primary sites of viral persistence, combined with the fa

261 ns) and other autoimmune diseases, including primary Sjogren's syndrome (OR = 2.45 in Chinese, OR = 2

262 is method allowed for discrimination between primary SLCs and less frequent, long-latency startle res

263 atotopically distinct neuroplasticity in the primary somatosensory cortex following therapy.

264 As these primary somatosensory cortex subregions are distinctly t

265 e Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance.

266 rather than hepatic synthesis of C3, as the primary source of C3 driving these effects.

267 y affected include rice and wheat, which are primary sources of dietary protein for many countries.

268 much less drastically in space or with local primary sources.

269 ed nodal (n = 151), extranodal (n = 28), and primary splenic (n = 27) MCL cases.

270 We defined two major genomic subtypes of primary stage Ta tumors.

271 ntly whole exome sequencing (WES) has become primary strategy for sequencing patient samples and stud

272 ing group (n = 147) in the following defined primary study outcomes: coping behavior with respect to

273 nt PCS versus 93 (94%) of 99 patients in the primary surgery group.

274 cites, liver disease, diabetes, obesity, and primary suture repair without mesh are associated with i

275 study, we characterized the DNA methylome in primary T cells of patients with systemic sclerosis.

276 ty chromatography experiments identified the primary target of the compounds as the T3SS needle pore

277 tomography (micro-CT) analyses of extracted primary teeth from 3 GACI subjects revealed 4-fold incre

278 The two primary theories of peripheral pitch coding involve stim

279 e mucosal layer of conducting airways is the primary tissue exposed to inhaled microorganisms, allerg

280 E6 and E7 are the primary transforming proteins in HPV that drive tumor pr

281 ollows: RNA or DNA genome, enveloped or not, primary transmission pathway, temperature, pH, light lev

282 This ordered assembly process shepherds primary transposase binding to the inner 12DRs (where cl

283 tients who were scheduled for enucleation as primary treatment for uveal melanoma.

284 lls recapitulate the antiviral properties of primary trophoblasts through the constitutive release of

285 and VEGFR2 rapidly formed tumors outside the primary tumor microenvironment in nude mice, exhibited s

286 py, platinum-refractory disease, mediastinal primary tumor site, nonseminoma histology, intermediate-

287 values of cholinesterase, bilirubin, type of primary tumor, age at radioembolization, hepatic tumor b

288 tested for somatic BRCA1/2 mutations of the primary tumor.

289 ion of chromosomal alterations in pancreatic primary tumors and liver metastases.

290 We show that a high LOX expression in primary tumors from patients with colorectal cancer was

291 Cancer cell invasion from primary tumors is mediated by a complex interplay betwee

292 The primary tumors were breast cancer (92 patients, 426 scan

293 d-derived suppressor cells infiltrate in the primary tumour and distant organs with different time ki

294 Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systema

295 pharmacologically induced focal seizures in primary visual cortex (V1) of awake mice, and compared t

296 redictions of the SSN have been confirmed in primary visual cortex (V1), its computational principles

297 on, with the glutamate measure lowest in the primary visual cortex and highest in the dorsolateral pr

298 stsynaptic cortical cells in input layers of primary visual cortex.

299 ecordings from superficial layers of macaque primary visual cortex.

300 The gustatory, primary auditory, primary visual, rostrolateral visual, and medial entorhi