ライフサイエンスコーパス: primary cilia

1 s with which we detected glycylation in many primary cilia.

2 in UNx-mice and prevented the elongation of primary cilia.

3 ciliogenesis and in localization of cargo to primary cilia.

4 Finally, we also applied the sensor to primary cilia.

5 athway through facilitating the formation of primary cilia.

6 w concentrations of H2O2 treatment elongated primary cilia.

7 genetically encoded calcium indicator in all primary cilia.

8 h factor (PDGF)-AA/alphaalpha, are linked to primary cilia.

9 ccurs in neurons with and without detectable primary cilia.

10 ansduction, and it shares many features with primary cilia.

11 was found to regulate Hedgehog signaling in primary cilia.

12 heterogeneous disorders caused by defects in primary cilia.

13 lties in cataloguing proteins from mammalian primary cilia.

14 etic disorders linked to the deregulation of primary cilia.

15 extreme geometries, including filopodia and primary cilia.

16 ated aberrant organization and morphology of primary cilia.

17 s required for the genesis or maintenance of primary cilia.

18 ds to stunted cilia and inhibition of PC1 on primary cilia.

19 specifically recruited to the basal body of primary cilia.

20 s VPS4 and LIP5 to transiently accumulate in primary cilia.

21 is involved in neural-specific functions of primary cilia.

22 in genes encoding proteins that localize to primary cilia.

23 cell-derived neuroprogenitors (NPs) develop primary cilia.

24 cting protein 2 (SSX2IP), in the assembly of primary cilia.

25 tissues, and localizes to the centrosome and primary cilia.

26 demonstrate that RGS5 is present with Smo in primary cilia.

27 hared by both autophagy and the formation of primary cilia.

28 d enrichment of the somatostatin receptor in primary cilia.

29 retrograde intraflagellar transport (IFT) in primary cilia.

30 ty of which encode proteins that localize to primary cilia.

31 que structural features that are not seen in primary cilia.

32 hog (Hh) signaling in vertebrates depends on primary cilia.

33 ses Hh signaling and increases the length of primary cilia.

34 n using independent approaches to manipulate primary cilia.

35 localization of SDCCAG3 to the basal body of primary cilia.

36 or our understanding of protein transport in primary cilia, a critically affected process in many gen

37 Primary cilia ablation led to disruption of Hh signaling

38 l division apparatus between cell divisions, primary cilia also serve as specialized compartments for

39 osure to chloral hydrate to damage or remove primary cilia and 2 short bouts (2 h on consecutive days

40 lar satellites, leading to fewer and shorter primary cilia and a defective recruitment of BBS4 (Barde

41 istent with our previous studies implicating primary cilia and AC6 in a novel mechanism of osteocyte

42 They formed primary cilia and also responded to hormonal stimulation

43 ng duct cells from mutant mice have abnormal primary cilia and are unable to form spheroid structures

44 re, we show that brown preadipocytes possess primary cilia and can respond to Hedgehog (Hh) signaling

45 Proteins associated with primary cilia and centrosomes have been demonstrated to

46 , and that Cby1 facilitates the formation of primary cilia and ciliary recruitment of the Joubert syn

47 nced accumulation of Smoothened (Smo) within primary cilia and elevated levels of full-length Gli3.

48 S cells, and embryonic stem cells elaborated primary cilia and expressed PC1, PC2, and FPC at similar

49 are different in motile cilia as compared to primary cilia and flagella.

50 ghts into the effects of LiCl on chondrocyte primary cilia and Hedgehog signaling and shows for the f

51 In this review, we discuss the role of primary cilia and IFT proteins in the development of bon

52 lopment and highlight the current advance of primary cilia and IFT proteins in the pathogenesis of ca

53 TPase Cdc42 co-localizes with the exocyst at primary cilia and interacts with the exocyst component S

54 Signaling occurs predominantly in primary cilia and is initiated by the entry of the G pro

55 nslocation of the key effector Smoothened to primary cilia and its downstream signaling activities.

56 tive PKD2-L1 channel subunits are present in primary cilia and other restricted cellular spaces.

57 enal disease have elongated and disorganized primary cilia and that this ciliary phenotype is specifi

58 rotein complexes direct both the assembly of primary cilia and the trafficking of signaling molecules

59 ls lining the biliary tree, normally express primary cilia and their interaction with bile components

60 As expected, Sas4(-/-) mutants lack primary cilia and therefore cannot respond to Hedgehog s

61 participate in the formation and function of primary cilia and usually result from disruption of retr

62 -traffic with Smoothened into the developing primary cilia and we identify EHD1 as a direct binding p

63 rA, which promotes acetylation of tubulin in primary cilia and, potentially, neural processes.

64 th CSPP1 mutations showed reduced numbers of primary cilia and/or short primary cilia, as well as red

65 ishes membrane association of aPKC, restores primary cilia, and accelerates neural process formation.

66 uorophore and use it to record directly from primary cilia, and demonstrate that PKD1L1 and PKD2L1 fo

67 target of this signaling in tumors that lack primary cilia, and find that IFT20 mediates the ability

68 imilarities between components of motile and primary cilia, and identifies new links between cilia pr

69 ich functions to target membrane proteins to primary cilia, and interferes with efficient accumulatio

70 Primary cilia are antenna-like sensory microtubule struc

71 Primary cilia are built and maintained by intraflagellar

72 Defective primary cilia are causative to a wide spectrum of human

73 Primary cilia are cellular appendages that coordinate di

74 Primary cilia are complex subcellular structures that pl

75 The structure and function of primary cilia are critically dependent on intracellular

76 In the brain, the primary cilia are crucial for early patterning, neurogen

77 Primary cilia are essential conveyors of signals underly

78 In particular, primary cilia are essential for Hedgehog (Hh) signaling,

79 Primary cilia are essential sensory and signaling organe

80 The assembly and maintenance of primary cilia are facilitated by intraflagellar transpor

81 Primary cilia are hairlike extensions of the plasma memb

82 Primary cilia are highly specialized small antenna-like

83 pathways, and recent evidence suggests that primary cilia are important in development and cancer.

84 in vitro and in vivo systems, we showed that primary cilia are important mediators of fluid flow to s

85 We conclude that primary cilia are important mediators of OFF-induced min

86 Primary cilia are key coordinators of various signaling

87 Primary cilia are located in the dental epithelium and m

88 Primary cilia are multisensory organelles recently found

89 Primary cilia are organelles that have recently been imp

90 Here, we show that primary cilia are predominantly present on basal cells o

91 cholangiocarcinoma as a model, we found that primary cilia are reduced in cholangiocarcinoma by a mec

92 hh signaling is impaired in null embryos and primary cilia are reduced in multiple tissues.

93 esults indicate that structurally integrated primary cilia are required for detection of electrical f

94 We conclude that primary cilia are required in a specific Hh-regulated su

95 Primary cilia are restricted subcellular compartments, a

96 Primary cilia are sensors of electrical field stimulatio

97 Primary cilia are sensory organelles indispensable for o

98 Primary cilia are sensory organelles located at the cell

99 Primary cilia are sensory organelles on the surface of e

100 Primary cilia are sensory organelles present on most mam

101 Primary cilia are single, nonmotile, antenna-like struct

102 Primary cilia are solitary, generally non-motile, hair-l

103 Primary cilia are solitary, non-motile extensions of the

104 Primary cilia are ubiquitous mammalian cellular substruc

105 Primary cilia are ubiquitous sensory organelles that med

106 Primary cilia are ubiquitous, microtubule-based organell

107 Although primary cilia are well established as important sensory

108 ilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory physiology and m

109 ubert syndrome, particularly the function of primary cilia, are still incompletely understood.

110 Primary cilia arise in most cell types but have not been

111 Fast forward 10 years and we now recognize primary cilia as key integrators of extracellular ligand

112 educed numbers of primary cilia and/or short primary cilia, as well as reduced axonemal localization

113 vide evidence for an essential role for both primary cilia assembly and disassembly in the control of

114 Conversely, increased primary cilia assembly in MSCs cultured on the grooves w

115 the G2-to-M transition and in regulation of primary cilia at the G1-to-S transition.

116 ng is known about the role of glycylation in primary cilia because of limitations in detecting this m

117 we show that Notch activity promotes longer primary cilia both in vitro and in vivo.

118 Rhodopsin was depleted from primary cilia but gained access, without being enriched,

119 Lymphocytes do not form primary cilia, but we found and describe here that Hh si

120 Loss of primary cilia causes a group of human pleiotropic syndro

121 at the cell center, near the Golgi, forming primary cilia confined or submerged in a deep narrow pit

122 Visualization of signal transduction in live primary cilia constitutes a technical challenge owing to

123 Primary cilia contain specific receptors and channel pro

124 nescent cell plasma membrane, which leads to primary cilia defects and a resultant failure to inhibit

125 at knockdown of IFT139 in podocytes leads to primary cilia defects, abnormal cell migration, and cyto

126 d ventricle floor, apical profiles with only primary cilia define an additional uniciliated (E3) epit

127 Appropriate physiological signaling by primary cilia depends on the specific targeting of parti

128 ocele) that were associated with the loss of primary cilia, diminished Shh signalling and dorsalizati

129 te ciliogenesis, but mechanisms that promote primary cilia disassembly before mitosis are largely unk

130 Although primary cilia dysfunction accounts for aneurysm formatio

131 e organelles is highlighted by the fact that primary cilia dysfunction is associated with numerous ne

132 Causative mutations lead to primary cilia dysfunction, which often results in variab

133 implications for human disorders related to primary cilia dysfunctions, such as ciliopathies and cer

134 ced by a reduction of renal mass, results in primary cilia elongation, and this elongation is associa

135 enesis of the skin in which Hh signaling and primary cilia exert important functions.

136 ignal transduction and ubiquitous marker for primary cilia, exhibits location-dependent gene expressi

137 We review these advances in our knowledge of primary cilia, focusing on brain development, and discus

138 known that Shh responding cells need intact primary cilia for signal transduction, the roles of indi

139 ane during killing, in a manner analogous to primary cilia formation [1, 4].

140 l carcinoma (BCC), coinciding with increased primary cilia formation and activated hedgehog (Hh) sign

141 show that MaSC and MaTIC EMT programs induce primary cilia formation and Hedgehog (Hh) signaling, whi

142 ted the formation of BCC through suppressing primary cilia formation and Hh signaling, suggesting tha

143 icle morphogenesis likely through regulating primary cilia formation and the hedgehog signaling pathw

144 Induction of primary cilia formation by serum starvation led to a two

145 nt upregulation is likely a prerequisite for primary cilia formation during Hh-dependent tumorigenesi

146 defects, inducing a significant increase in primary cilia formation in VHL-deficient cells.

147 nin and elevated AURKA expression, decreased primary cilia formation, and caused significant shorteni

148 ber 3A (Kif3a), a gene that is essential for primary cilia formation, at will in transplanted cells a

149 olar cell division, spindle orientation, and primary cilia formation.

150 Importantly, PHD1 is also required for primary cilia formation.

151 cell migration, focal adhesion dynamics, and primary cilia formation.

152 We probed the mechanical responses of primary cilia from kidney epithelial cells [Madin-Darby

153 In differentiated human cells, primary cilia fulfill essential functions in converting

154 ta demonstrate a role for ARL2BP and ARL2 in primary cilia function and that this role is essential f

155 Here, we demonstrate that disruption of primary cilia function following the selective loss of c

156 In vertebrates, dysregulation of primary cilia function has been strongly linked to devel

157 Nevertheless, the role of primary cilia function in corticogenesis remains largely

158 The emerging evidence implicates primary cilia function in tooth development.

159 Implications of OCRL and TRPV4 in primary cilia function may also shed light on mechanosen

160 ich play roles in cell cycle progression and primary cilia function.

161 ts autophagy, blockage of autophagy enhances primary cilia growth and cilia-associated signalling dur

162 nd delivery processes that are essential for primary cilia growth and maintenance and for hedgehog si

163 e constituents, development, and function of primary cilia has advanced considerably in recent years,

164 (2+)-responsive mechanosensor hypothesis for primary cilia has been invoked to explain a large range

165 Primary cilia have been implicated in the generation of

166 Primary cilia have been linked to signaling pathways inv

167 Primary cilia have pivotal roles as organizers of many d

168 Fuzzy affects PCP signaling and formation of primary cilia; however, the mechanisms underlying these

169 How primary cilia impact epidermal growth and differentiatio

170 Glycylation accumulates in primary cilia in a length-dependent manner, and depletio

171 f radial glia, which resulted in ablation of primary cilia in a subset of B1 cells.

172 coupled receptor, Gpr161, which localizes to primary cilia in a Tulp3/IFT-A-dependent manner.

173 elopment, consistent with the known roles of primary cilia in brain patterning, hydrocephalus inciden

174 quired for the normal assembly of motile and primary cilia in Chlamydomonas, planaria and mice.

175 Both approaches restored the expression of primary cilia in cholangiocarcinoma cell lines and decre

176 glycylating enzymes modulates the length of primary cilia in cultured cells.

177 the current evidence for the localization of primary cilia in dental tissues and the impact of disrup

178 LI3 in the nucleus is independent of loss of primary cilia in Dzip1 mutant cells.

179 Here, we investigate the role of primary cilia in EFS-enhanced osteogenic response of hum

180 ther, these results suggest a novel role for primary cilia in HBC activation, proliferation, and diff

181 y functions, confirming the central role for primary cilia in Hh signaling.

182 w that SSX2IP localizes to the basal body of primary cilia in human and murine ciliated cells.

183 We demonstrate significant elongation of primary cilia in IS patient bone cells.

184 Our data support a key role for primary cilia in malignant transformation, provide a pla

185 n facing the ventricular lumen suggests that primary cilia in NSCs could play an important role in re

186 The recently discovered role of primary cilia in nutrient sensing and signalling motivat

187 Here we implicate primary cilia in proliferation, hedgehog (Hh) signaling,

188 l dysplasias, implying the important role of primary cilia in skeletal development and homeostasis.

189 d tongue agenesis, following the loss of the primary cilia in the CNC-derived palatal mesenchyme.

190 Here we delineate the functions of primary cilia in the construction of cerebral cortex and

191 t ciliary mutants indicates a novel role for primary cilia in the formation of the corticothalamic/th

192 Our findings suggest a role of primary cilia in the memory function of mature dentate g

193 catenin in regulating AURKA and formation of primary cilia in the setting of VHL deficiency, opening

194 Prior studies on the functions of primary cilia in the skin were based on the investigatio

195 Thus, mechanotransduction by primary cilia in TM cells is implicated in how the eye s

196 Primary cilia in TM cells shorten in response to fluid f

197 We also include the role of primary cilia in tooth development and highlight the cur

198 involvement, and suggest that restoration of primary cilia in tumor cells by HDAC6 targeting may be a

199 The Hedgehog (Hh) pathway depends on primary cilia in vertebrates, but the signaling machiner

200 mulates on the cell surface in Drosophila or primary cilia in vertebrates, which is thought to be ess

201 mice and play a role in polyglutamylation of primary cilia in vitro.

202 , functioning as an AKAP, recruits PKA RI to primary cilia in zebrafish embryos.

203 of mechanically induced calcium increases in primary cilia, in tissues upon which this hypothesis has

204 Damage or removal of primary cilia inhibited OFF-induced PGE2 release into th

205 Primary cilia interpret vertebrate Hedgehog (Hh) signals

206 The formation of primary cilia is a highly choreographed process that can

207 protein Smoothened (Smo) in the membrane of primary cilia is an essential step in Hedgehog (Hh) sign

208 The length of primary cilia is associated with normal cell and organ f

209 r findings indicate that Arl13b signaling in primary cilia is crucial for the initial formation of a

210 ic organization of signaling cascades inside primary cilia is key to signal propagation.

211 Moreover, ablation of these primary cilia is sufficient to repress Hh signaling, the

212 nsport of membrane and cytosolic proteins in primary cilia is thought to depend on intraflagellar tra

213 e that mechanosensation, if it originates in primary cilia, is not via calcium signalling.

214 iliated cell, and the numbers of neural tube primary cilia; it also led to abnormal development of th

215 Dysfunction of renal primary cilia leads to polycystic kidney disease.

216 stigate whether renal mass reduction affects primary cilia length and function.

217 ibition is associated with a 97% increase in primary cilia length from 2.09 +/- 0.7 mum in untreated

218 r in hair cell kinocilia and supporting cell primary cilia length regulation likely via its role in m

219 pha-tubulin and SOX9 proteins, the number of primary cilia(+) LPCs, and increased active gamma-glutam

220 s during EFS, our findings also suggest that primary cilia may potentially function as a crucial calc

221 sults thus define a specific requirement for primary cilia-mediated GPCR signaling in interneuronal c

222 al signals promote osteogenic fate through a primary cilia-mediated mechanism.

223 The ionic conditions, permeability of the primary cilia membrane, and effectiveness of the diffusi

224 s called ciliopathies is caused by defective primary cilia morphology or signal transduction.

225 In the new century, interest in nonmotile (primary) cilia, never lost from the cradle, was rekindle

226 We then measured responses to flow in primary cilia of cultured kidney epithelial cells, kidne

227 d balance in the nonperiodic fluctuations of primary cilia of epithelial cells.

228 An ion current has been measured from primary cilia of kidney cells, but the responsible genes

229 A direct link between the primary cilia of mature dentate granule cells and behavi

230 Primary cilia of MDCK cells lack interdoublet dynein mot

231 6 (AC6), a membrane-bound enzyme enriched in primary cilia of MLO-Y4 osteocyte-like cells, may play a

232 eta2AR) and co-localizes with beta2AR on the primary cilia of neurons in the brain.

233 the kinocilia of sensory hair cells and the primary cilia of nonsensory supporting cells.

234 8 has a highly conserved function within the primary cilia of the CNC-derived mesenchyme in the lip a

235 We show for the first time the presence of primary cilia on a quiescent population of basal stem ce

236 The architecture of primary cilia on neuroepithelial cells in Pam(-/-) mouse

237 subtype 3 (Sstr3) is selectively targeted to primary cilia on neurons in the mammalian brain and is i

238 e majority of mammalian cells have nonmotile primary cilia on their surface that act as antenna-like

239 idence has shown that loss or malfunction of primary cilia or ciliary proteins in bone and cartilage

240 ial polydactyly, as seen with dysfunction of primary cilia or Gli3-repressor.

241 ns in proteins of the transition zone of the primary cilia or the closely associated distal end of ce

242 of OFF followed by morphological analysis of primary cilia; or exposure to chloral hydrate to damage

243 Here, we show that primary cilia (PC) formation is decreased in fibroblasts

244 Primary cilia perceive the extracellular environment thr

245 ital syndrome, altogether demonstrating that primary cilia play a critical role in regulation of both

246 Primary cilia play central roles in signaling during met

247 Primary cilia play critical roles in development and dis

248 Primary cilia, present on most mammalian cells, function

249 ons that affect the structure or function of primary cilia result in ciliopathies, a group of develop

250 Detailed analysis of primary cilia revealed region-specific changes in ciliar

251 f miR-219 function accelerates the growth of primary cilia, revealing a possible mechanistic link bet

252 In addition, primary cilia seem to functionally modulate effects of E

253 The transition zone (TZ) of primary cilia serves as a diffusion barrier to regulate

254 evidence indicates the important role of the primary cilia signaling pathway in bone elongation.

255 , in vitro and in vivo, from the membrane of primary cilia--solitary hair-like organelles that projec

256 Primary cilia start forming within the G1 phase of the c

257 Importantly, we show that ablation of primary cilia strongly suppresses Hh signaling and myoge

258 erived stem cells (hASCs) by knocking down 2 primary cilia structural proteins, polycystin-1 and intr

259 MSC) wnt signaling through the regulation of primary cilia structure and function.

260 These FAPs dynamically produced primary cilia, structures that transduce intercellular c

261 Rsg1 mutant embryos have fewer primary cilia than wild-type embryos, but the cilia that

262 SPG co-receptors are located adjacent to the primary cilia that act as Shh signaling organelles.

263 ation of basal stem cells uniquely possesses primary cilia that are aligned in an apical orientation

264 cells, which are defective in glaucoma, have primary cilia that are critical for response to pressure

265 Moreover, the loss of primary cilia that results from CEP290 dysfunction was r

266 MSCs cultured on grooves expressed elongated primary cilia, through reduced actin organization.

267 es with the C terminus of Ptch1 (Ptch1-C) in primary cilia to inhibit Ptch1-mediated cell death.

268 urthermore, OCRL is found to be required for primary cilia to respond to pressure stimulation.

269 CDK10 in transducing signals received at the primary cilia to sustain embryonic and postnatal develop

270 ing Gli transcription factors, accumulate at primary cilia to transduce the Hh signal, but the mechan

271 of Smo induces translocation of Miz1 to the primary cilia together with Smo and Gli2.

272 Primary cilia undergo cell-cycle-dependent assembly and

273 Defects in primary cilia underlie a class of human diseases collect

274 Defects in the function and/or structure of primary cilia underlie a large number of human syndromes

275 ted 1 or of 40 kDa), which also localizes to primary cilia upon Hh stimulation and positively regulat

276 izes with the SHH receptor Smoothened in the primary cilia upon ligand stimulation.

277 Surprisingly, ablation of primary cilia using conditional alleles for genes essent

278 This H2O2-induced elongation of primary cilia was also prevented by MnTMPyP treatment.

279 lacking both Tgifs, the number of cells with primary cilia was significantly decreased, and we observ

280 The percentage of cells with primary cilia was significantly reduced compared to the

281 ically encoded calcium indicator targeted to primary cilia, we visualized calcium signaling in cilia

282 tic MT mechanisms and indeed, centrosome and primary cilia were altered and spindles were found to be

283 We confirmed that primary cilia were disrupted in talpid(2) mutants.

284 Primary cilia were elongated in proximal tubule cells, c

285 Primary cilia were shorter and there were fewer cilia pe

286 Primary cilia were the largely neglected nonmotile count

287 Remarkably, T-box3 is present in primary cilia where it colocalizes with Gli3.

288 The regulatory GTPase Arl13b localizes to primary cilia, where it regulates Sonic hedgehog (Shh) s

289 Specific proteins are concentrated within primary cilia, whereas others remain excluded.

290 suggest that Cdc42 localizes the exocyst to primary cilia, whereupon the exocyst targets and docks v

291 Pkd2 is mainly localized in the primary cilia, which also function as mechanoreceptors i

292 Primary cilia, which are essential for normal developmen

293 Here we show that this depends on primary cilia, which are nonmotile, cell-surface structu

294 Because Shh reception occurs at primary cilia, which are positioned within the apical me

295 otherwise-forbidden actin polymerization in primary cilia, which excises cilia tips in a process we

296 cylation is essential for the homeostasis of primary cilia, which has important implications for huma

297 equired for the assembly and function of the primary cilia, which mediate the activity of key develop

298 with Cby1 at the centrioles/basal bodies of primary cilia, while FAM92B is undetectable.

299 ic proteins in the 250-nm-wide shaft of live primary cilia with a spatiotemporal resolution of 2 ms a

300 To directly study the role of B1 cells' primary cilia without the confounding effects of hydroce