ライフサイエンスコーパス: primary cilium

1 Hh signaling is triggered at the primary cilium.

2 is involved in vesicular trafficking to the primary cilium.

3 onsistent with the developmental role of the primary cilium.

4 e receptors, Patched and Smoothened, and the primary cilium.

5 he receptors patched-1 and Smoothened in the primary cilium.

6 e, destabilizes axonemal microtubules in the primary cilium.

7 in genes encoding proteins localising to the primary cilium.

8 ration by promoting protein removal from the primary cilium.

9 specific trafficking events to and from the primary cilium.

10 Rilpl2 regulate protein localization in the primary cilium.

11 sis by delivering Rab8 to the basal body and primary cilium.

12 networks/modules that build and maintain the primary cilium.

13 ivity, a signaling pathway that requires the primary cilium.

14 elocalizes from centriolar satellites to the primary cilium.

15 edgehog signaling by Evc proteins within the primary cilium.

16 that Sec15 co-localized with Rab8 along the primary cilium.

17 (Smo), a seven-transmembrane protein, to the primary cilium.

18 and that Cdc42 colocalizes with Sec10 at the primary cilium.

19 tivation result in a rapid elongation of the primary cilium.

20 gehog (Shh) signal transduction requires the primary cilium.

21 been shown to be partially controlled by the primary cilium.

22 i-organ diseases caused by disruption of the primary cilium.

23 ndidate for regulation of the exocyst at the primary cilium.

24 hosphate transients apparent at the neuronal primary cilium.

25 adation of AURKA is required to maintain the primary cilium.

26 retaining receptor-signaling pathways in the primary cilium.

27 l geometry can regulate the elaboration of a primary cilium.

28 ing of how signal transduction occurs at the primary cilium.

29 ntriole, which becomes the basal body of the primary cilium.

30 he renal epithelial cell and membrane of the primary cilium.

31 requires a microtubule-based organelle, the primary cilium.

32 cysts contain relatively fewer cells with a primary cilium.

33 y but not sufficient to target cystin to the primary cilium.

34 ssociated with absence or dysfunction of the primary cilium.

35 st that PKD arises from abnormalities of the primary cilium.

36 ns in membrane trafficking to and inside the primary cilium.

37 st Evc locate the protein at the base of the primary cilium.

38 specialized cell surface projection called a primary cilium.

39 cal membrane and consequent formation of the primary cilium.

40 mo activity, suggesting that Smo acts at the primary cilium.

41 ntial for Hh signalling, is expressed on the primary cilium.

42 s SMO activation and its localization to the primary cilium.

43 y mediator of cargo protein targeting to the primary cilium.

44 anscriptional regulation and function of the primary cilium.

45 hies are clinically diverse disorders of the primary cilium.

46 on of the Hh signaling pathway relies on the primary cilium.

47 bral cortical progenitors and neurons have a primary cilium.

48 elerated by the combined loss of Vhl and the primary cilium.

49 A hallmark of ccRCC is loss of the primary cilium.

50 ) activities, which drive disassembly of the primary cilium.

51 ne, in histone deacetylase 6 delivery to the primary cilium.

52 tion, and blocks accumulation of Rab8 at the primary cilium.

53 1 cells) neural stem cells (NSCs) contains a primary cilium.

54 either precursor results in the loss of the primary cilium.

55 rosomes and spindle poles, as well as to the primary cilium.

56 thermore, we found that the formation of the primary cilium, a cellular organelle that is essential f

57 These data link PtdIns signaling to the primary cilium, a cellular structure that is becoming in

58 The primary cilium, a hair-like extension from a cell's surf

59 eover, we show that NRP1 localization to the primary cilium, a key platform for HH signal transductio

60 The membrane protein composition of the primary cilium, a key sensory organelle, is dynamically

61 basal cell carcinoma, are transduced by the primary cilium, a microtubular projection found on many

62 The primary cilium, a microtubule-based signaling center, is

63 prompted us to analyze the formation of the primary cilium, a non-motile organelle that is specializ

64 The primary cilium, a sensory appendage that is present in m

65 PKD arises from abnormalities of the primary cilium, a sensory organelle located on the cell

66 The primary cilium, a sensory organelle, regulates cell prol

67 We found that the primary cilium, a signaling structure that arises from t

68 ebrate Hh signaling is its dependence on the primary cilium, a vestigial organelle that is largely ab

69 The primary cilium acts as a cellular antenna, transducing d

70 study, we report for the first time that the primary cilium acts as a crucial sensor for electrical f

71 The primary cilium acts as a transducer of extracellular sti

72 Although the primary cilium also participates in each of these pathwa

73 ith BBS, which encode proteins active at the primary cilium, an antenna-like organelle that acts as t

74 rpiosin exhibit compromised formation of the primary cilium, an organelle that functions as an assemb

75 ast, fly Smo is unable to translocate to the primary cilium and activate the mammalian Hh pathway.

76 ly colocalize at the plasma membrane and the primary cilium and can be reciprocally coimmunoprecipita

77 Rilpl1 and Rilpl2 both localize to the primary cilium and centrosome, Rilpl1 specifically to th

78 is a necessary antecedent for removal of the primary cilium and cessation of Hh signaling during myog

79 dromes, we examined the role of USP9X in the primary cilium and found that endogenous USP9X localizes

80 The primary cilium and Hh signaling are required for GNP pro

81 vances contributing to the ascendancy of the primary cilium and how the extraordinary complexity of t

82 We propose that localization to the primary cilium and interaction with Wwtr1 are key elemen

83 ne protein 107 (TMEM107) is localized in the primary cilium and is enriched at the transition zone wh

84 dromes, is essential for the function of the primary cilium and maintenance of phosphoinositide balan

85 racellular transport, cell architecture, and primary cilium and mitotic spindle organization.

86 membrane protein Smoothened (Smo) within the primary cilium and of the zinc finger transcription fact

87 Strikingly, Rab8(GTP) enters the primary cilium and promotes extension of the ciliary mem

88 Our data link the TSC proteins with the primary cilium and reveal a novel phenotype of enhanced

89 naling, which is negatively regulated by the primary cilium and several NPH proteins, although the me

90 and stromal fibroblasts in tumors expressed primary cilium and showed localization of the receptor S

91 e site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and

92 or gp135 protein delivery at the base of the primary cilium and suggest the existence of a novel micr

93 e of this process involving a protein of the primary cilium and suggests a novel mechanism whereby pr

94 anoctamin-1 (ANO1/TMEM16A) is located in the primary cilium and that blocking its channel function ph

95 es showed that MAPKBP1 is not present at the primary cilium and that fibroblasts from affected indivi

96 PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell membrane in NP

97 of the mitotic spindle, the function of the primary cilium and the DNA damage response.

98 Being homologous organelles, the primary cilium and the OS share common building blocks a

99 we compare the structural properties of the primary cilium and the OS, and propose a hypothesis that

100 bodies, while meckelin localized both to the primary cilium and to the plasma membrane in ciliated ce

101 er biopsies, disorders of the cholangiocytes primary cilium and various degrees of bile duct paucity

102 ertebrates, SHH signaling is mediated by the primary cilium, and genetic defects affecting either SHH

103 uces the accumulation of Gli proteins in the primary cilium, and its ability to induce Gli-dependent

104 signal transduction pathways localize to the primary cilium, and that loss of the cilium blocks ligan

105 in (TSC1) localizes to the basal body of the primary cilium, and that Tsc1(-/-) and Tsc2(-/-) mouse e

106 human diseases resulting from defects of the primary cilium, and these patients often have cleft lip

107 h as dendritic spines, the yeast bud and the primary cilium, and to serve as membrane diffusion barri

108 anges in membrane protein composition of the primary cilium are central to development and homeostasi

109 , it is shown that the effects of VHL on the primary cilium are mediated substantially via hypoxia-in

110 Growing evidence points to defects in the primary cilium as a critical mechanism underlying renal

111 ent of Ptc1 out of, and smoothened into, the primary cilium as well as up-regulation of GLI1 and PTC1

112 nctional hedgehog pathway machinery from the primary cilium, as well as GLI-dependent transcription i

113 Autophagy and primary cilium assembly have long been known to be induc

114 microtubules and for the normal kinetics of primary cilium assembly.

115 anization of satellite proteins and perturbs primary cilium assembly.

116 g regulator EHD1 as a novel regulator of the primary cilium-associated trafficking of Smoothened and

117 PCP protein Dishevelled and to position the primary cilium at the abneural edge of the apical surfac

118 Thus, we have identified a primary cilium-autophagy-Nrf2 (PAN) control axis coupled

119 Meckelin localizes to the primary cilium, basal body and elsewhere within the cell

120 embrane protein generally known to be on the primary cilium, basal body and plasma membrane.

121 PGRIP1L, TMEM67, and ARL13B) function in the primary cilium/basal body organelle.

122 ing endosome compartment in proximity to the primary cilium base.

123 her BBSome subunits, BBIP10 localizes to the primary cilium, BBIP10 is present exclusively in ciliate

124 The life cycle of a primary cilium begins in quiescence and ends prior to mi

125 taining 3 (C2cd3), an essential regulator of primary cilium biogenesis.

126 ndrome 1), at centriolar satellites promotes primary cilium biogenesis.

127 gehog signaling, localizes to the tip of the primary cilium, but the importance of its ciliary locali

128 Hedgehog signaling is transduced at the primary cilium, but the precise mechanisms underlying th

129 This fragment is then shed from the primary cilium by activation of a member of the ADAM met

130 Bromi and CCRK control the structure of the primary cilium by coordinating assembly of the axoneme a

131 rk we measure the mechanical properties of a primary cilium by using an optical trap to induce resona

132 As nucleators of the mitotic spindle and primary cilium, centrosomes play crucial roles in equal

133 s and the transition zone at the base of the primary cilium, CEP290 also localizes to the nucleus; ho

134 use mutants deficient in Polaris, a critical primary cilium component, in cartilage.

135 ogenic lineage commitmentin vivoand that the primary cilium contributes to this process.

136 As the primary cilium coordinates several signaling pathways es

137 Although the primary cilium critically influences signaling in develo

138 d transiently decreased cAMP production in a primary cilium-dependent manner.

139 4 osteocyte-like cells, may play a role in a primary cilium-dependent mechanism of osteocyte mechanot

140 from the mother centriole to the tip of the primary cilium during ciliogenesis.

141 o explore the fate and potential role of the primary cilium during myofibroblast formation.

142 Primary cilium dysfunction affects the development and h

143 Primary cilium dysfunction underlies the pathogenesis of

144 sorder with a spectrum of symptoms caused by primary cilium dysfunction.

145 Chemical disruption of the primary cilium eliminated Ca(2+) signaling in response t

146 These changes in turn cause defects in primary cilium elongation, Smo ciliary translocation, an

147 Similarly, VxPx inhibited primary cilium enrichment of a chimera of rhodopsin and

148 g the older mother centriole usually grows a primary cilium first.

149 mutations permit transposition of SMO to the primary cilium followed by enhanced expression of transc

150 ivered to a ring surrounding the base of the primary cilium, followed by microtubule-dependent radial

151 were associated with significantly decreased primary cilium formation and attenuated hedgehog signali

152 The transcriptional control of primary cilium formation and ciliary motility are beginn

153 Depletion of FOP strongly inhibits primary cilium formation in human RPE-1 cells.

154 rization and also reduces the probability of primary cilium formation, whereas USP21 knockdown in PC1

155 the regulation of vesicular trafficking for primary cilium formation.

156 L-) cells induced increased polarization and primary cilium formation.

157 acquire subdistal appendages (sDAPs) during primary cilium formation.

158 Golgi morphology and trafficking and normal primary cilium formation.

159 The primary cilium, formed in nonhematopoietic cells, is ess

160 l orientation patterns that the chondrocytic primary cilium forms in articular cartilage in the prese

161 and motile functions of cilia, including the primary cilium found on most cells in the human body, ha

162 d candidates, including a subset involved in primary cilium function.

163 The primary cilium has an important role in signaling; defec

164 The primary cilium has been found to be associated with a nu

165 The primary cilium has critical roles in human development a

166 Respect for the primary cilium has undergone a remarkable renaissance ov

167 Many cells possess a single, nonmotile, primary cilium highly enriched in receptors and sensory

168 ruption of the mechanosensing organelle, the primary cilium in a progenitor population, significantly

169 ue, and its encoded protein localizes to the primary cilium in an in vitro model of human neurogenesi

170 mponent, mainly localizes at the base of the primary cilium in developing podocytes from human fetal

171 proved understanding of the functions of the primary cilium in humans and other vertebrates.

172 The role of the primary cilium in key signaling pathways depends on dyna

173 odels essential for studying the role of the primary cilium in kidney function.

174 nce of the mechano-sensorial function of the primary cilium in kidney tubule epithelial cells and (ii

175 Thus, we have uncovered a function of the primary cilium in maintaining homeostasis of the CE by b

176 rved components of the pathway might use the primary cilium in mammals but not fly.

177 his study was to investigate the role of the primary cilium in mechanosensing by osteoblasts.

178 We investigated the role of the chondrocyte primary cilium in mechanotransduction events related to

179 e signaling through pathways mediated by the primary cilium in pancreatic cancer.

180 Our understanding of the importance of the primary cilium in renal cyst formation may guide potenti

181 ivation is associated with abrogation of the primary cilium in renal cysts of patients with VHL disea

182 C2 contribute to fluid-flow sensation by the primary cilium in renal epithelium and that they both fu

183 Mammalian Smo translocates to the primary cilium in response to Sonic hedgehog (Shh) ligan

184 sposes renal epithelial cells to loss of the primary cilium in response to specific signals.

185 overies being made about the function of the primary cilium in signaling pathways that are critical f

186 cilia and Kif7-eGFP localizes to base of the primary cilium in the absence of Shh.

187 ture to determine what we now know about the primary cilium in the developing and adult CNS and what

188 igates the role of the immotile chondrocytic primary cilium in the growth plate.

189 We examined the assembly and function of the primary cilium in the synaptic integration of adult-born

190 ith Shh signaling, and the importance of the primary cilium in this neoplastic process.

191 Here we report a role for the beta-cell primary cilium in type 2 diabetes susceptibility.

192 cilium after Gli proteins have transited the primary cilium; in this model the sequential movement of

193 In quiescent cells, the primary cilium insulates itself from contiguous dynamic

194 Thus, the primary cilium integrates Hedgehog and Wnt signaling bet

195 Regulated release from the primary cilium into the lumen may be a mechanism to dist

196 polycystins are being mapped and involve the primary cilium, intracellular calcium and cAMP regulatio

197 receptor sensory cilium, which is a modified primary cilium involved with polarized trafficking of pr

198 The primary cilium is a cellular organelle that is almost ub

199 or formation, and because the dysfunction of primary cilium is a common pathogenic mechanism in polyc

200 ssifying this disease as a "ciliopathy." The primary cilium is a critical regulator of several cell s

201 The primary cilium is a highly conserved environmental senso

202 The primary cilium is a highly conserved organelle housing s

203 The membrane of the primary cilium is a highly specialized compartment that

204 The primary cilium is a membrane protrusion that is crucial

205 The primary cilium is a microtubule-based antenna-like struc

206 The primary cilium is a microtubule-based organelle implicat

207 The primary cilium is a microtubule-based organelle that fun

208 The primary cilium is a microtubule-based organelle that sen

209 The primary cilium is a microtubule-based structure found in

210 The primary cilium is a nexus of cell signaling, and ciliary

211 The primary cilium is a paradigmatic organelle for studying

212 The primary cilium is a sensory organelle that receives both

213 Primary cilium is a solitary organelle that emanates fro

214 The primary cilium is a solitary organelle that responds to

215 A primary cilium is a solitary, slender, non-motile protub

216 The primary cilium is a ubiquitous, non-motile microtubular

217 or the first time, that the formation of the primary cilium is altered in NPC1 disease.

218 Non-motile primary cilium is an antenna-like structure whose defect

219 The primary cilium is an apically projecting solitary organe

220 The primary cilium is an evolutionarily conserved dynamic or

221 The primary cilium is an outward projecting antenna-like org

222 The membrane of the primary cilium is continuous with the plasma membrane bu

223 The primary cilium is critical for transducing Sonic hedgeho

224 With the revelation that the primary cilium is crucial for mammalian Hh signaling, th

225 The primary cilium is emerging as a crucial regulator of sig

226 The primary cilium is essential for skin morphogenesis throu

227 Our data indicate 1) the primary cilium is not a simple cantilevered beam; 2) the

228 The primary cilium is nucleated by the mother centriole-deri

229 A primary cilium is present on most eukaryotic cells and r

230 The primary cilium is required for Hedgehog signaling.

231 The primary cilium is required for Sonic hedgehog (Shh) sign

232 The primary cilium is the site where a subset of the cell's

233 The primary cilium is thought to be disassembled prior to mi

234 apical markers and displays microvilli and a primary cilium; its lumenal space is rich in Ca(2+) Time

235 Each bundle is comprised of a single primary cilium (kinocilium) flanked by multiple rows of

236 Apical abscission also dismantles the primary cilium, known to transduce sonic-hedgehog signal

237 evins perturb protein trafficking within the primary cilium, leading to their malformation and Hedgeh

238 aling is associated with a shortening of the primary cilium length and with a reduction of the fracti

239 quent protein kinase A activation, increases primary cilium length in mammalian epithelial and mesenc

240 cking PI3K-C2alpha rescues Rab11 activation, primary cilium length, and Shh pathway induction.

241 Live-cell microscopy reveals that Rilpl2 primary cilium localization is dynamic and that it is as

242 Wnt tone, and disrupts Notch1 signaling and primary cilium maintenance necessary for radial progenit

243 the gene products localize in and around the primary cilium, making JS a canonical ciliopathy.

244 st time that pharmaceutical targeting of the primary cilium may have therapeutic benefits in the trea

245 rgmann glia cells Gpr37l1 is associated with primary cilium membranes and it specifically interacts a

246 ost NPH gene products (NPHP) function at the primary cilium, NPH is classified as a ciliopathy.

247 ein Smoothened (SMO), which localizes to the primary cilium of a cell on activation and is both posit

248 show that opsin can enter and move along the primary cilium of a nonphotoreceptor cell (an hTERT-RPE1

249 Here, we show that SPATA7 localizes at the primary cilium of cells and at the connecting cilium (CC

250 Galphas is highly enriched at the primary cilium of granule neuron precursors and suppress

251 unction as a mechanosensitive channel in the primary cilium of kidney cells, an intracellular Ca(2+)

252 and colocalizes with EGFR and PIP(2) in the primary cilium of LLC-PK(1) cells.

253 lex involved in membrane trafficking, to the primary cilium of Madin-Darby canine kidney cells and sh

254 Ion channel activity in the primary cilium of renal cells may be an important compon

255 Here, we show that the primary cilium of renal epithelial cells contains a prot

256 Our results show that OCRL localizes to the primary cilium of retinal pigment epithelial cells, fibr

257 al cells of the pancreas, we did not observe primary cilium on the ductal tumor cells, suggesting dec

258 Our results suggest that the primary cilium or an associated structure influences the

259 The primary cilium originates from the mother centriole and

260 ance of the signaling pathways hosted by the primary cilium, our results suggest hitherto unrecognize

261 Hh components partially reside in the primary cilium (PC), and the small fraction of cells in

262 The primary cilium plays critical roles in vertebrate develo

263 The overall function of the primary cilium-polycystin complex may be to sense and tr

264 lian kidney nephrons have solitary nonmotile primary cilium projecting from their surface into the lu

265 The effect of VHL status on the primary cilium provides a potential mechanism for renal

266 calization of the receptor Smoothened to the primary cilium, providing evidence of active SHH signali

267 The primary cilium regulates cellular signalling including i

268 Signaling from the primary cilium regulates kidney tubule development and c

269 The orientation of the primary cilium, relative to the major axis of the chondr

270 The function of the primary cilium remains largely unknown.

271 ectively transported to and organized in the primary cilium remains unclear.

272 The motility and signaling functions of the primary cilium require a unique protein and lipid compos

273 The primary cilium's functions range from the movement of ce

274 x that transports membrane proteins into the primary cilium signaling organelle in eukaryotes and is

275 segment (OS) is a unique modification of the primary cilium, specialized for light perception.

276 Hedgehog signaling requires the primary cilium such that maintenance of this compartment

277 We demonstrate that Glis3 localizes to the primary cilium, suggesting that Glis3 is part of a ciliu

278 Because the primary cilium suppresses renal cyst formation, loss of

279 owever, its relationship to disorders of the primary cilium, termed ciliopathies, has not been explor

280 ) are significantly more likely to contain a primary cilium than wild-type controls.

281 ammalian brain possess an appendage called a primary cilium that projects from the soma into the extr

282 une synapse, even though immune cells lack a primary cilium that would be the typical setting for thi

283 aracterized center-to-edge displacement of a primary cilium, the kinocilium, at their apical surface.

284 d adjacent cellular structures of a modified primary cilium, the rod outer segment, from wild-type an

285 INPP5E is targeted to the primary cilium through a motif near the C terminus and p

286 intracellular source and may traffic to the primary cilium through an intraflagellar transport (IFT)

287 hat in renal epithelia, RP2 localizes to the primary cilium through dual acylation of the amino-termi

288 that vertebrate CK1gamma is localized at the primary cilium to promote Smo phosphorylation and Sonic

289 the outer segment structure evolved from the primary cilium to provide photoreceptor cells with vast

290 In animal cells, the primary cilium transduces extracellular signals through

291 ork, the equilibrium shape and dynamics of a primary cilium under flow are investigated by using both

292 of endogenous PD1 is similarly shed from the primary cilium upon activation of sheddases.

293 eletion of Vhl together with ablation of the primary cilium via deletion of the kinesin family member

294 docytic compartment (PRE) at the base of the primary cilium, where it regulates production of a speci

295 all localized at the plasma membrane and the primary cilium, where PC1 and PC2 contribute to fluid fl

296 in which Cdc42 localizes the exocyst to the primary cilium, whereupon the exocyst then targets and d

297 ereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, lead

298 etected for the first time in the centrosome/primary cilium, which has been implicated in diverse pol

299 ignaling and showed that the GCP possessed a primary cilium with CEP290 at its base.

300 ly little is known about ion channels in the primary cilium (with the exception of TRPP2).