ライフサイエンスコーパス: primary sequence

1 ndary structure element rather than by local primary sequence.

2 orders of magnitude simply by optimizing the primary sequence.

3 spite a lower conservation of the nucleotide primary sequence.

4 from the Nab3 RNA recognition domain in the primary sequence.

5 densis that shares less than 30% identity in primary sequence.

6 typical of such enzymes, are apparent in its primary sequence.

7 he full time range and is independent of the primary sequence.

8 rylation of two residues widely separated in primary sequence.

9 buried upon folding (AABUF) derived from the primary sequence.

10 binding site residues of a protein from its primary sequence.

11 may be separated by significant intervening primary sequence.

12 n sites that would not be predicted from the primary sequence.

13 g dipeptide pools covering the entire 369 aa primary sequence.

14 eraction of two noncontiguous regions in the primary sequence.

15 related to the protein conformation than the primary sequence.

16 motifs and a C-terminal J-domain within its primary sequence.

17 nd that this perturbation is mediated by the primary sequence.

18 redicted (e.g. secondary structure) from the primary sequence.

19 ences and ORC-free sequences based solely on primary sequence.

20 of conserved and unique elements in the Dbp5 primary sequence.

21 the position of amide side chains within the primary sequence.

22 ral integrity of its first 33 nt and not its primary sequence.

23 ing to the Bcl-2 family despite an unrelated primary sequence.

24 can be tuned via precise organization of the primary sequence.

25 anscripts, all three RLuc mRNAs had the same primary sequence.

26 tive side chains are incorporated into their primary sequence.

27 tive protein binds fibronectin with the same primary sequence.

28 an be predicted and manipulated based on the primary sequence.

29 th similar secondary structure but different primary sequences.

30 lasmic distribution, as predicted from their primary sequences.

31 ary structures among the FBAs based on their primary sequences.

32 minants and in a manner independent of local primary sequences.

33 50 nt) tertiary RNA structures starting from primary sequences.

34 R translocation, SPs have diverse but unique primary sequences.

35 ng at least two defined regions of the PfRH5 primary sequence; 3) a brief exposure window of PfRH5 is

36 o the correspondence between RNA and protein primary sequences, a correlation exists between high lev

37 Primary sequence, activating chromatin marks, and DNA-bi

38 Primary sequence alignment of different Cxs shows the pr

39 A primary sequence alignment of PNT1 with clostripain and

40 Using the crystal structure, primary sequence alignment, pH-activity profiles, and si

41 Based on primary sequence alignment, three-dimensional topology,

42 Most alignment software considers the primary sequence alone; some specialized alignment softw

43 For the primary sequences alone, the web server can compute the

44 photodissociation (UVPD) to provide detailed primary sequence analysis and PTM site localization of t

45 Finally, we argue that primary sequence analysis and structural modelling do no

46 Primary sequence analysis revealed a unique tetraproline

47 A primary sequence analysis suggested that the SdeAgu115A

48 On the basis of primary sequence analysis, MppP and MppQ are pyridoxal 5

49 uired to understand the relationship between primary sequence and biological function in this class o

50 Despite their similarity in primary sequence and cofactor content, crystallographic,

51 entified, with the demonstration of the same primary sequence and disulfide linkages between the inno

52 volve as adaptive modules that may change in primary sequence and function while maintaining three-di

53 (70) or sigma(54), that differ both in their primary sequence and in the requirement of the latter fo

54 hat is highly conserved both in terms of its primary sequence and its three-dimensional structure.

55 In particular, we assessed whether its primary sequence and length are critical for proper prot

56 ELIC is similar to the nAChR in its primary sequence and overall subunit organization, but d

57 globulin G (IgG) structure, both in terms of primary sequence and post-translational modifications (P

58 experiments to reveal information about both primary sequence and post-translational modifications.

59 egulatory network, are strongly conserved in primary sequence and rarely secondarily lost, their evol

60 The server takes primary sequence and raw crystal diffraction data as inp

61 that accommodates functional information in primary sequence and secondary and tertiary structure.

62 ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections

63 Accurate determination of the primary sequence and secondary structure of ncRNAs is im

64 al representation of the conservation of the primary sequence and secondary structure.

65 Computational analysis of the primary sequence and secondary structures of these trans

66 The primary sequence and structure of the tubulin proteins a

67 gh MAPKs are closely related with respect to primary sequence and tertiary structure, they have disti

68 ytochrome P450 alpha-helical domain both the primary sequence and x-ray structure indicate the presen

69 Based on their primary sequences and functions sortases can be partitio

70 a protein that occurs spontaneously in prone primary sequences and leads typically to an equilibrium

71 was identified by computational analysis of primary sequences and secondary structures of hnRNP A18

72 there is little apparent correlation between primary sequences and three-dimensional folding unless s

73 f cis-regulatory elements bearing particular primary sequences and/or secondary-structures.

74 perturbation of interactions distant in the primary sequence, and atomic force microscopy.

75 s of proteolysis are dominated more by local primary sequence, and less by the tertiary protein fold.

76 e in eukaryotes, yet their DNA structure and primary sequence are hypervariable.

77 atenin indicate that while variations in the primary sequence are well tolerated, an intrinsically di

78 The primary sequences around these modified residues do not

79 thways and tertiary structure using only the primary sequence as input.

80 This approach constructs a CG map of the primary sequence at a chosen resolution for an arbitrari

81 in proteins result in virtually all of their primary sequence being exposed, at least at some time, t

82 roved by using models that consider not only primary sequence but also secondary structure informatio

83 thers contain residues that are far apart in primary sequence but are close together in the tertiary

84 equences may have been selected not by their primary sequence but by their ability to form noncanonic

85 d droplet surface protein (LDSP) with unique primary sequence but structural similarities to other LD

86 c/MCAK), which are highly conserved in their primary sequences but display distinct localization and

87 select their substrates based on a protein's primary sequence, but a consensus sequence has been slow

88 urprisingly, these residues are separated in primary sequence, but cluster into a small 3D putative b

89 e clustered within the 101-110 region of the primary sequence, but they would have intermolecular spa

90 Rat IAPP and mouse IAPP have identical primary sequences, but differ from the human polypeptide

91 combinations of all the variations affecting primary sequence can be detected as they occur in combin

92 ntification of residue-residue contacts from primary sequence can be used to guide protein structure

93 man PMTs, although similar in terms of their primary sequences, can act on the distinct sets of nonhi

94 recent advances in our understanding of how primary sequence, chromatin environment, and nuclear arc

95 Selective sweeps were expected to create primary sequence clustering under positive diversifying

96 Our results demonstrate the existence of a primary sequence code characteristic to hindbrain enhanc

97 Based on primary sequence comparisons and genomic context, Npun_F

98 Primary sequence comparisons and x-ray structural analys

99 Despite low primary sequence conservation among the archaeal Nop56/5

100 ing incomplete sequences under a model using primary sequence conservation and secondary structure in

101 As, mammalian-expressed lincRNAs show higher primary sequence conservation in their promoters and exo

102 Molecular dynamics simulations and primary sequence conservation suggest that the sorting s

103 two subclassifications of proteins, based on primary sequence conservation, protein size, and domain

104 Largely ignored and distinguished by lack of primary sequence conservation, the linker is presumed to

105 Our studies support that, besides the primary sequence context, the protein structure is a maj

106 The prediction of secondary RNA folds from primary sequences continues to be an important area of r

107 The most conserved contiguous region of the primary sequence corresponds to a crystallographically d

108 Because of its primary sequence, Cos2 was initially predicted to functi

109 e the wealth of data available, ranging from primary sequence data to gene and genome structures, our

110 Using primary sequence data, we compared the genomes of these

111 ructures, and alignment of nonredundant nsp5 primary sequences, demonstrated that ts and suppressor r

112 single base change, providing evidence for a primary sequence determinant necessary, though not suffi

113 These data highlight that primary sequence determinants and RNA structure are key

114 n the CENP-A targeting domain (CATD) are the primary sequence determinants for HJURP recognition, bur

115 re, mechanisms that operate independently of primary sequence determinants must exist to ensure speci

116 These studies provide new insights into the primary sequence determinants of binding motifs, which i

117 Additionally primary sequence determinants within the intracellular d

118 cells, thereby confirming the importance of primary-sequence determinants for distinguishing pri-miR

119 ce of pairing in the stem and revealed three primary-sequence determinants, including an SRp20-bindin

120 nts distributed along the TRIM5alpha PRYSPRY primary sequence disrupted restriction activity against

121 rmination further reveals that despite their primary sequence dissimilarity, the NH2-terminal portion

122 oup A rotavirus (RVA); however, the dramatic primary sequence divergence of NSP4s across serogroups r

123 um levels, demonstrating that despite strong primary sequence divergence, RV NSP4 has maintained viro

124 ubunit of the uniporter holocomplex, but its primary sequence does not resemble any calcium channel s

125 mosaic molecules, P and Q, incorporating the primary sequence elements of the four grass pollen aller

126 The primary sequence elements responsible for carbohydrate r

127 ROK glucokinases (Pfam 02685), revealing the primary sequence elements shared between these two prote

128 Illuminating the primary sequence encryption of enhancers is central to u

129 inguished from nonfunctional motifs by local primary sequence features or by the larger genomic conte

130 mobility fragmentation is used to obtain the primary sequence for peptides of interest.

131 rmine the role of weak motifs encoded in its primary sequence for the recruitment of its ubiquitin li

132 e further into the twilight zone by aligning primary sequences for a pair of proteins to a best-fit t

133 tistically significant prediction of protein primary sequence from mRNA using purely physiochemical i

134 ombinant H1 degrees CTD mutants in which the primary sequence has been scrambled, the amino acid comp

135 , demonstrating that channels with identical primary sequence have different ligand recruitment thres

136 Based on its primary sequence, Hbp2 contains three NEAr transporter (

137 Their overall low primary sequence homology may result in functional diffe

138 Primary sequence homology to IsdH indicates that it will

139 Despite showing no primary sequence homology to TNF family cytokines, UL141

140 s known about the role of proteins that lack primary sequence homology with any known motifs (protein

141 ut Dothideomycetes, and despite their modest primary sequence identity, many are perceived by the cog

142 n superfamily despite a low level of overall primary sequence identity.

143 d cell viability, but has a highly divergent primary sequence in comparison to TFIIB in well-studied

144 nosylation suggests a limited role for local primary sequence in dictating sites of attachment.

145 e are conflicting opinions as to the role of primary sequence in their conversion to the prion form:

146 enhancer B (HLEA and HLEB), differ in their primary sequence, in their precise patterns of activity

147 n in Shaker-iVSD developed despite identical primary sequence, indicating an allosteric influence of

148 It is unclear to what extent S region primary sequence influences differential targeting of CS

149 f yielding the most comprehensive diagnostic primary sequence information about the proteins in the c

150 ters without the need for structural or even primary sequence information of the transport protein.

151 ) workflow results in acquisition of greater primary sequence information relative to conventional co

152 which the polypeptide chain can convert its primary sequence into functional structures, dysfunction

153 ated stem-loop in which the conserved exon 2 primary sequence is changed but secondary structure main

154 nts, that tetherin configuration rather than primary sequence is critical for antiviral activity.

155 c loop critical in all species but for which primary sequence is not well conserved.

156 Its primary sequence is similar to the reactive loop of plan

157 indicating that amino acid composition, not primary sequence, is the predominant feature driving [UR

158 e secondary structure is more conserved than primary sequence, it can be leveraged to improve the ali

159 However, the P22 Xis and lambda Xis primary sequences lack significant similarity at the ami

160 T domain in Hbp2 binds hemin even though its primary sequence lacks a highly conserved YXXXY motif th

161 ll represented domains recognize and bind to primary sequences less than 10 amino acids in length cal

162 SPA proteins are not homologous at the primary sequence level but share overall physical proper

163 e TFIIEbeta homologue in archaea that on the primary sequence level is related to the RNAPIII subunit

164 Although highly divergent at the primary sequence level, an atomic resolution (1.1 A) cry

165 detectable homology of the promoters on the primary sequence level, histone modification patterns we

166 gh these domains are highly divergent at the primary sequence level, the structures of dozens of PAS

167 indromic motif that can be identified at the primary sequence level, which predicts the local spacing

168 s, they appear to be rapidly evolving at the primary sequence level.

169 Though not evident from inspection of their primary sequences, many serine-threonine kinases display

170 s sequence-independent, and does not require primary sequence modification (e.g. the addition or remo

171 lterations in either LRP2 expression or LRP2 primary sequence modulate the uptake of LRP2 ligands.

172 imetic compound, c(HS4-4), containing the SE primary sequence motif QKRAA, which was synthesized usin

173 lational modification of selected targets by primary sequence motif recognition.

174 We further show that the CNNC primary sequence motif selectively enhances the processi

175 tive mass spectrometry and characterized the primary sequence motif specificity of mTOR using positio

176 Primary sequence motifs, with millimolar affinities for

177 viously identified features, including three primary-sequence motifs, yielded a unifying model defini

178 major determinants of Alu activity: (1) The primary sequence of a given Alu copy, and (2) the abilit

179 The primary sequence of a protein defines its free-energy la

180 How the primary sequence of a protein encodes conformational pre

181 for rapid and accurate determination of the primary sequence of a protein therapeutic drug product.

182 plore the link between cooperativity and the primary sequence of alpha13, we randomized seven residue

183 It is further shown that the primary sequence of an ELP can be tuned to exhibit eithe

184 The primary sequence of cartilage-associated protein is homo

185 ransiently stalls in the nanopore due to the primary sequence of charges.

186 Although the primary sequence of COPT6 contains the family conserved

187 The primary sequence of CRABP-II contains three putative SUM

188 so seen in S-crystallins suggesting that the primary sequence of crystallins may be specifically enri

189 ed questions in genome biophysics is how the primary sequence of DNA bases influences the global prop

190 of the tunnel and is directed by the unique primary sequence of each nascent peptide.

191 ly, through its constituent subunits, to the primary sequence of each protein.

192 The primary sequence of human IL-24 differs from homologous

193 ngly suggest that maquettes derived from the primary sequence of NiSOD are mechanistically distinct f

194 Two major domains are predicted from the primary sequence of P3H1: an amino-terminal domain and a

195 e gamma-carboxyl group of a glutamate in the primary sequence of proteins and additional glutamates a

196 symmetry in the CC structure, encoded in the primary sequence of rod 1B, provides a striking example

197 pped the polymorphisms spread throughout the primary sequence of ROP5 to two major surfaces, includin

198 Although the primary sequence of Rv2179c has no detectable similarity

199 The primary sequence of Son contains a concentrated region o

200 Because the primary sequence of sororin does not contain any previou

201 We found that approximately 90% of the primary sequence of the ADC conjugated with either monom

202 d whether the PIP2 sensor resides within the primary sequence of the channel itself, or, as recently

203 phate, double-stranded RNA structure, or the primary sequence of the foreign circRNA.

204 and occurs without any known changes in the primary sequence of the genome; thus the switch is epige

205 T-causing mutations dispersed throughout the primary sequence of the human glycyl-tRNA synthetase (GA

206 of approximately 30 years since the complete primary sequence of the intermediate filament (IF) prote

207 gh disordered in solution, inspection of the primary sequence of the linker reveals that positively c

208 holine) vesicles that was dependent upon the primary sequence of the peptide.

209 n of two specific recognition sites into the primary sequence of the polyprotein allows for the selec

210 ion of the peptide in a given protein or the primary sequence of the protein that bears the test pept

211 ainly resulted from the discrepancies in the primary sequence of the relatively conserved AR motifs.

212 ts indicate that HDAg does not recognize the primary sequence of the RNA; rather, the principle contr

213 that binding to AP-1 or AP-3 depends on the primary sequence of the signal and not its position with

214 Further analysis of the primary sequence of the TNT1 region revealed a unique pa

215 ab, F4ac, and F4ad) exist that differ in the primary sequence of their major adhesive subunit FaeG, a

216 the activity of SNAREs should depend on the primary sequence of their TMDs.

217 This suggests that subtle changes in the primary sequence of transporter drug binding domains cou

218 Comparative analysis of the primary sequence of TS from a number of mammalian specie

219 nction may be achieved through variations in primary sequence of tubulin isotypes.

220 sed this genome to determine the H. hammondi primary sequence of two major T. gondii mouse virulence

221 se data provide functional evidence that the primary sequences of alpha-actinin-2 and alpha-actinin-3

222 with significant net charge, the very basic primary sequences of ARMs are expected to adopt coil-lik

223 hree decades, molecular data, most obviously primary sequences of DNA and proteins, have provided an

224 pact of nonconservative substitutions in the primary sequences of drug binding domains of sea urchin

225 Without such enzymes, the highly ordered primary sequences of genes would rapidly deteriorate.

226 Although otherwise conserved, the primary sequences of Nrp1 and Nrp2 differ significantly

227 opose a novel numerical vector based on only primary sequences of organism to build their phylogeny.

228 by performing systematic mutagenesis of the primary sequences of the 12 transmembrane segments (TMSs

229 redicting small molecule structures from the primary sequences of the biosynthetic gene clusters.

230 inding to human CPEB3 in vitro, although the primary sequences of the human and C. elegans PUF protei

231 l amino acids and ribonucleotides within the primary sequences of the interacting protein and RNA cha

232 h peptides a PDZ domain will bind, given the primary sequences of the PDZ domain and the peptides.

233 The primary sequences of the Yaps reveal little similarity t

234 Thus, the primary sequences of these elements, but not their secon

235 ds on its amino acid composition but not its primary sequence or chirality.

236 fy novel tumor-homing ACPPs with no bias for primary sequence or target protease.

237 hich map the distribution of PQs in terms of primary sequence or which categorize PQs.

238 Thus, a specific primary sequence or zippering beyond the SNARE domains i

239 otifs contain residues that are neighbors in primary sequence, others contain residues that are far a

240 However, primary sequence per se is a poor predictor of function,

241 Despite divergence in primary sequence, predicted secondary structure, and fil

242 , caspase-7, which shares the same substrate primary sequence preference as caspase-3, is better at c

243 that T4 RNA ligases do not show significant primary sequence preference in RNA substrates, but are b

244 tribute to the evidence that, in addition to primary sequence, prion species barriers are controlled

245 Three chemical and physical properties of primary sequences: purine, pyrimidine and keto are also

246 sion is determined by small stretches of the primary sequence rather than the secondary structure of

247 ences in the RefSeq collection is the set of primary sequence records submitted to the International

248 myosin interface despite preservation of the primary sequence regions composing it, suggesting an evo

249 47-kDa protein containing three consecutive primary sequence regions that comprise its alpha, beta,

250 oupled to the high level of control over the primary sequence results in a system with significant po

251 and RcnR are quite similar, small changes in primary sequence reveal that the specific mechanisms inv

252 The features may come from the primary sequences, secondary or three dimensional struct

253 gical functions despite differences in their primary sequences, secondary structures, or chromosomal

254 However, their primary sequence showed no relationship to any known DNA

255 y maps based on desired confidence levels of primary sequence similarity as defined by a user.

256 ssion between species is governed in part by primary sequence similarity between the infectious prion

257 codes an open reading frame with significant primary sequence similarity to intermedilysin (ILY; 69.2

258 a targeted enzyme at a location predicted by primary sequence similarity to only the selected C-extei

259 lack of tertiary structural information and primary sequence similarity to other proteins.

260 Despite their primary sequence similarity, the contrasting localizatio

261 The database can be searched by primary sequence similarity, tRNA characteristics or phy

262 er infections) in the absence of significant primary sequence similarity.

263 ion of the MLV transgene appeared to exhibit primary sequence site specificity, targeting a gGATcc-li

264 no simple relationship between function and primary sequence, so that assigning function is challeng

265 However, despite similar primary sequences, structural folds, and affinities for

266 Analysis of the PARP-1 primary sequence suggested that phosphorylation of PARP-

267 played some similarity at the level of their primary sequence, suggesting an ancient coevolution betw

268 C is uniformly distributed along the protein primary sequence, suggesting that intermolecular coevolu

269 n coordinates two zinc ions, analysis of the primary sequence suggests an alternative classification

270 Its primary sequence suggests that the HpxO catalytic activi

271 tolysis in a pentapeptide, which matched the primary sequence surrounding Y122.

272 ino acid "full-length heme domain" (FLHD) of primary sequence T140-Q270 (BjFixLH140-270), a histidine

273 While we expect there to be elements of primary sequence that affect the process, our experiment

274 nthetic prokaryotes and that is based on the primary sequence that had been assigned as an NADPH-depe

275 structure of the amyloid core residues and a primary sequence that is almost entirely arranged in a r

276 ability of thousands of transit peptide (TP) primary sequences, the structural and/or physicochemical

277 cally to peptidyl fragments of the wild-type primary sequence, themselves obtained by solid-phase pep

278 rate that even with this limited identity in primary sequence, these two proteins share remarkable si

279 methods to predict disorder from a protein's primary sequence, they all were developed using informat

280 ts a new class of substrates that use unique primary sequence to induce allosteric binding, processiv

281 encodes information for the progression from primary sequence to secondary, tertiary, and ultimately

282 t, and length of protein sequences, from the primary sequences to predict crystallizabillity by using

283 The entries are linked, when appropriate, to primary sequence (UniProt) and structural (PDB) database

284 nomes and nuclear ribosomal DNA (nR) are the primary sequences used to understand plant diversity and

285 erent levels of heterogeneities ranging from primary sequence variants to post-translational modifica

286 erilization, (ii) protease inhibitors, (iii) primary sequence variations, (iv) the presence or absenc

287 tate to peptides and proteins with unrelated primary sequences, various chain lengths, and widely dif

288 Its primary sequence was determined by combining Edman degra

289 similarity in their membrane and N-terminal primary sequences, we homology-modeled NBCe1 onto the cr

290 Although the differences in the primary sequence were limited to the C-terminus, the obt

291 Interestingly, ribosomal primary sequences were more accurately predicted than no

292 ), a nuclear receptor most similar to CAR in primary sequence, were negligible in human fetal liver t

293 ta-CoVs have diverged significantly in their primary sequences while maintaining the same essential b

294 The inputs of the web server require RNA primary sequences, while corresponding secondary structu

295 This procedure produced an intriguing primary sequence whose structure-function analysis is de

296 of capturing both contiguity information and primary sequence with a single technology.

297 on two primary goals: (i) assimilating known primary sequences with predicted feature data and (ii) p

298 es generally lack the ability to control the primary sequence, with sequence control referred to as t

299 designed synthetic ribozymes with different primary sequences without altering the secondary structu

300 proteome contain unique insertions in their primary sequences, yet it is largely unclear what effect