ライフサイエンスコーパス: primate lentivirus

1 ionary pressure across the broad spectrum of primate lentiviruses.

2 ty factor (Vif) is a protein encoded by most primate lentiviruses.

3 an to the regulatory gene tat encoded by the primate lentiviruses.

4 rodents can modulate sensitivity to specific primate lentiviruses.

5 Tat functions in the transcription of primate lentiviruses.

6 nical courses after infection with different primate lentiviruses.

7 aque dendritic cells to capture and transmit primate lentiviruses.

8 -2/SIV(sm)/SIV(mac) and SIV(agm) lineages of primate lentiviruses.

9 ated protein is Vpr, which is present in all primate lentiviruses.

10 er vectors have also been developed from non-primate lentiviruses.

11 tically diverse family of human and nonhuman primate lentiviruses.

12 t not identical to those of other animal and primate lentiviruses.

13 ruses, including murine leukemia viruses and primate lentiviruses.

14 re resistant to infection by HIV-1 and other primate lentiviruses.

15 or successful cross-species transmissions of primate lentiviruses.

16 e evolution, which is presumably promoted by primate lentiviruses.

17 paralog, Vpr, is conserved across all extant primate lentiviruses.

18 herin, including the Vpu and Nef proteins of primate lentiviruses.

19 s an evolutionarily conserved gene among the primate lentiviruses.

20 ions for AIDS treatment and the evolution of primate lentiviruses.

21 genetic recombination is a common feature of primate lentiviruses.

22 nous retroviruses that predate the origin of primate lentiviruses.

23 ndromes utilized to initiate dimerization in primate lentiviruses.

24 ers of the HIV-2/SIV(sm)/SIV(mac) lineage of primate lentiviruses also incorporate a related protein

25 this pathway is universally conserved among primate lentiviruses and can be observed in mammalian ce

26 sts that this signal may be present in other primate lentiviruses and could be important in the patho

27 ion preferences are more similar to those of primate lentiviruses and distinct from those of Moloney

28 anti-SERINC5 activity of Nef proteins across primate lentiviruses and examined whether SERINC5 repres

29 is property is common to Nef proteins across primate lentiviruses and how antiviral immune responses

30 The Nef protein is unique to primate lentiviruses and is closely linked to accelerate

31 CD4 tropism is conserved among all primate lentiviruses and likely contributes to viral pat

32 CD4 tropism is an invariant feature of primate lentiviruses and likely plays a key role in path

33 ompared to that of MHC-A is conserved across primate lentiviruses and suggest that this property infl

34 ents N, K, or H) motif that is found in most primate lentiviruses and that shows species-specific var

35 to the virion core is a conserved feature of primate lentiviruses and that the interactions required

36 review, we focus on the interaction between primate lentiviruses and the gastrointestinal tract and

37 ted understanding of the interaction between primate lentiviruses and the host immune system complica

38 tation that allows a peaceful coexistence of primate lentiviruses and the host immune system.

39 p and discuss its impact on the evolution of primate lentiviruses and the origins of the HIV pandemic

40 eficiency virus (pSIVgml) basal to all known primate lentiviruses and, consistent with this, its geno

41 Accessory protein Vpr, found in all primate lentiviruses, and its HIV-2/simian immunodeficie

42 Several primate lentiviruses are CNP-sensitive, and CNP sensitiv

43 unodeficiency virus type 1 (HIV-1) and other primate lentiviruses are distinguished from the gammaret

44 Here, we establish that primate lentiviruses are particularly sensitive to NUP15

45 Primate lentiviruses are thought to use the chemokine re

46 Primate lentiviruses are typically apathogenic in their

47 Primate lentiviruses are unique in that they produce sev

48 Vpr, an accessory factor of primate lentiviruses, arrests cells at the DNA damage ch

49 nses, provided insight into the evolution of primate lentiviruses as they adapt to new species and un

50 permutation is one of the characteristics of primate lentiviruses, as well as other retroviruses, dur

51 Currently, several primate lentivirus-based gene transfer systems, such as

52 transport and cell cycle arrest functions in primate lentivirus biology.

53 distinct from other previously characterized primate lentiviruses but clusters in the same major line

54 ether monkeys can be repeatedly exposed to a primate lentivirus by a mucosal route and escape infecti

55 lular pathway that restricts HIV-1 and other primate lentiviruses by affecting dNTP synthesis, thereb

56 e nef gene contributes to the replication of primate lentiviruses by altering the trafficking of cell

57 utralizing antibodies can confer immunity to primate lentiviruses by blocking infection in macaque mo

58 these findings support a model in which all primate lentivirus capsids assemble by a conserved pathw

59 we were able to show that a set of divergent primate lentivirus capsids was generally not susceptible

60 bited distinct restriction specificities for primate lentivirus capsids.

61 In addition to PTAP L domains, primate lentiviruses carry Alix-binding motifs that incl

62 Primate lentiviruses code for a protein that stimulates

63 Primate lentiviruses devote a relatively large portion o

64 which potently restricts the replication of primate lentiviruses (e.g., human immunodeficiency virus

65 All primate lentiviruses encode Nef, an accessory protein th

66 tiviral cellular immune responses.IMPORTANCE Primate lentiviruses encode the Nef protein that plays a

67 HIV and related primate lentiviruses encode Vif, which counteracts A3G b

68 The nef gene of primate lentiviruses encodes a myristoylated protein tha

69 tion process, millions of years of divergent primate lentivirus evolution may be constrained to discr

70 This suggests that primate lentiviruses evolve tetherin antagonists such as

71 Primate lentiviruses exhibit narrow host tropism, reduci

72 rther evidence for the ancient nature of the primate lentivirus family.

73 ue to the greater phylogenetic distance from primate lentiviruses, feline immunodeficiency virus (FIV

74 rs described here provide a method to detect primate lentiviruses from diverse species of nonhuman pr

75 ulation of TCR-CD3, which distinguishes most primate lentiviruses from HIV type 1 (HIV-1) and its vpu

76 Taken together, our results indicate that primate lentiviruses from two different subgroups functi

77 pite remarkable evolutionary diversity among primate lentiviruses, functional constraints on receptor

78 and the second conserved region (C2) of the primate lentivirus gp120 which indicates a structural si

79 that the A3G-Vif interaction has evolved as primate lentiviruses have adapted to their hosts.

80 Primate lentiviruses have evolved specific antagonists (

81 inst invading pathogens, and Vif proteins of primate lentiviruses have evolved to overcome these host

82 Primate lentivirus HIV-1 and SIV Vif proteins form a ubi

83 ner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV.

84 s an evolutionarily conserved gene among the primate lentiviruses HIV-1, HIV-2, and simian immunodefi

85 ANCE The conserved Vif accessory proteins of primate lentiviruses HIV-1, simian immunodeficiency viru

86 The cells that are targeted by primate lentiviruses (HIV and simian immunodeficiency vi

87 All primate lentiviruses (HIV-1, HIV-2, SIV) encode Nef prot

88 measure the recombination rates of two other primate lentiviruses, HIV-2 and simian immunodeficiency

89 d function of members of two other groups of primate lentiviruses, HIV-2/simian immunodeficiency viru

90 The Nef protein of the primate lentiviruses human immunodeficiency virus (HIV)

91 Here we show that prototype primate lentiviruses human immunodeficiency virus type 1

92 The primate lentiviruses, human immunodeficiency virus types

93 Currently, HIV-1 is the only primate lentivirus in which recombination rates have bee

94 e can effectively curtail the replication of primate lentiviruses in hosts to which they are not adap

95 inhibits the replication of HIV-1 and other primate lentiviruses in human monocyte-derived macrophag

96 deficiency virus SIVsmmPBj14 is unique among primate lentiviruses in its ability to induce lymphocyte

97 y, it is possible that HIV-1 is unique among primate lentiviruses in possessing high recombination ra

98 DCs could play a role in the transmission of primate lentiviruses in the ileum and the rectum whereas

99 tant in relation to prospects for control of primate lentiviruses in the settings of both prophylacti

100 play a role in the vertical transmission of primate lentiviruses, in the enabling of HIV to traverse

101 We examined 263 Nef clones from diverse primate lentiviruses including different pandemic HIV-1

102 Primate lentiviruses including human immunodeficiency vi

103 a panel of Nef alleles isolated from diverse primate lentiviruses including pandemic HIV-1 group M su

104 the in trans infectivity of a broad range of primate lentiviruses including primary viruses produced

105 only in all HIV-1 subtypes but also in other primate lentiviruses, including HIV-2 and simian immunod

106 A nef gene is present in all primate lentiviruses, including human immunodeficiency v

107 The accessory gene vpr, common to all primate lentiviruses, induces potent G2/M arrest in cycl

108 In nature, primate lentiviruses infect humans and several Old World

109 report of control of a productive feline or primate lentivirus infection in postnatally exposed, ser

110 e to virus to prevent the establishment of a primate lentivirus infection.

111 associated with disease protection following primate lentivirus infection.

112 feature of both pathogenic and nonpathogenic primate lentivirus infections and support a model for AI

113 pecific antibodies confer resistance against primate lentivirus infections, we purified immunoglobuli

114 y involved in controlling the acute phase of primate lentivirus infections.

115 esults reveal a novel level of regulation of primate lentivirus infectivity.

116 The envelope (Env) proteins of primate lentiviruses interact sequentially with CD4 and

117 Nef of primate lentiviruses is critical for high levels of vire

118 Ms) has efficient antiviral activity against primate lentiviruses, is sensitive to inactivation by th

119 All primate lentiviruses known to date contain one or two op

120 SIVcpz/HIV-1 lineage, or represents a novel primate lentivirus lineage.

121 However, only two of eight primate lentivirus lineages encode Vpx, whereas its para

122 Most other primate lentivirus lineages, including the lineage repre

123 Our results provide new insights into how primate lentiviruses manipulate their target cells and s

124 contemporary retroviruses and indicates that primate lentiviruses may be considerably older and more

125 Like the primate lentivirus Nef and the gammaretrovirus glycoGag,

126 Among other primate lentiviruses, only the molecular mechanisms of H

127 ions lend support to the hypothesis that the primate lentiviruses originated and coevolved within mon

128 hile h-A3F, like h-A3G, was able to suppress primate lentiviruses other than HIV-1 (simian immunodefi

129 reveal that FIV RNA can be cross-packaged by primate lentivirus particles such as HIV-1 and SIV and v

130 bility of FIV RNA to get cross-packaged into primate lentivirus particles such as HIV-1 and SIV, as w

131 ccessory protein Nef plays a crucial role in primate lentivirus pathogenesis.

132 The speed with which primate lentiviruses penetrate mucosal surfaces, infect

133 Human immunodeficiency virus, a primate lentivirus (PLV), causes AIDS in humans, whereas

134 HIV and related primate lentiviruses possess single-stranded RNA genomes

135 ich are mainly macrophage tropic (M-tropic), primate lentiviruses primarily target CD4+ T lymphocytes

136 m mangabey monkeys, and clustered with other primate lentiviruses (primarily SIVcpz [from chimpanzees

137 Nef proteins of primate lentiviruses promote viral replication, virion i

138 a potent transactivator of other animal and primate lentivirus promoters.

139 s-specific, IFN-alpha-induced restriction of primate lentivirus replication occurs early in the retro

140 of macrophage lineage cells is a feature of primate lentivirus replication, and several properties o

141 potential is most likely a common feature of primate lentivirus replication.

142 virus replication, and several properties of primate lentiviruses seem to have evolved to promote the

143 has been suggested that the introduction of primate lentivirus sequences, particularly those of huma

144 meras is more straightforward in FIV than in primate lentiviruses, since FIV accessory gene open read

145 SIV(AGM), but it appears to be specific for primate lentiviruses, since Hsp70 was not detected in as

146 nce and suggests that macrophages may afford primate lentiviruses some degree of protection from immu

147 multiple APOBEC3 proteins can contribute to primate lentivirus species tropism.

148 athogenic, independent isolate from the same primate lentivirus subgrouping as SIVmac but with natura

149 Primate lentiviruses such as human immunodeficiency type

150 Vif proteins from distantly related primate lentiviruses such as SIVagm were unable to suppr

151 Vpr is conserved among all primate lentiviruses, suggesting an important role in th

152 g antibody response following infection with primate lentiviruses that cause AIDS.

153 vity but is inactive against closely related primate lentiviruses that do not interact with CyPA.

154 Nef is a multifunctional virulence factor of primate lentiviruses that facilitates viral replication

155 Nef is a virulence factor of HIV-1 and other primate lentiviruses that is crucial for rapid progressi

156 Highly conserved among primate lentiviruses, the human immunodeficiency virus t

157 macrophage tropism predict the ability of a primate lentivirus to initiate a systemic infection afte

158 Given the sensitivity of different primate lentiviruses to CPSF6-358 and apparent conservat

159 The ability of primate lentiviruses to effectively use human and rhesus

160 proteins may help govern the transmission of primate lentiviruses to new host species.

161 INC5 antagonism may determine the ability of primate lentiviruses to spread within natural hosts.

162 etermine if dendritic cells (DC) are used by primate lentiviruses to traverse the epithelial barrier

163 virus (HIV) transmission, the route used by primate lentiviruses to traverse the stratified squamous

164 Primate lentiviruses use chemokine coreceptors in additi

165 Attenuated primate lentivirus vaccines provide the most consistent

166 monstrate that the pathogenicity of nonhuman primate lentiviruses varies markedly based on the specie

167 Primate lentivirus Vif proteins function by suppressing

168 coordination site, which is conserved among primate lentivirus Vif proteins, does not correspond to

169 pr), a highly conserved accessory protein in primate lentiviruses, was previously reported to bind SL

170 characterize the interaction of DC-SIGN with primate lentiviruses, we investigated the structural det

171 shment of persistent productive infection by primate lentiviruses, we varied the time of initiation a

172 etic study, several residues conserved among primate lentiviruses were found to play important roles

173 equences represented consensus sequences for primate lentiviruses, whereas the inoculum sequences at

174 , these compounds are inactive against other primate lentiviruses which do not incorporate cyclophili

175 how that Nef proteins from diverse groups of primate lentiviruses which do not require the chemokine

176 unodeficiency virus type 1 (HIV-1) and other primate lentiviruses which enhances virion infectivity b

177 s of macrophage tropism do not predict which primate lentiviruses will produce systemic infection aft

178 lar ssDNA aptamers inhibited RT from diverse primate lentiviruses with low nM IC(50) values.

179 has important implications for understanding primate lentivirus zoonosis and should allow the develop