ライフサイエンスコーパス: prime

1 he CO2 was produced from SOM mineralization (priming).

2 onceptual activation is measured by semantic priming.

3 ion/production explains intra-/inter-speaker priming.

4 models: sequential and concurrent SV docking/priming.

5 signaling specificity through Ca(2+) sensor priming.

6 ynthesis of pro-IL-1beta during inflammasome priming.

7 ecies production was diminished by uric acid priming.

8 from transgenerational herbivore resistance priming.

9 e experimental data on periodic lateral root priming.

10 lthough it is consistent with work on motion priming.

11 ynthesis beyond simply harboring the site of priming.

12 the transition to chronic pain, hyperalgesic priming.

13 phase of pluripotency preparatory to lineage priming.

14 onformation as the underlying basis for GPCR priming.

15 T cells but necessary for full expansion of primed 1-DER T cells.

16 C-terminal to the phosphorylated Ser/Thr to prime a catalytically active conformation, facilitating

17 Hyperalgesic priming, a model of pain chronification in the rat, is m

18 Previous studies have shown that DNA prime, Ad5 boost vaccines protect against neutralization

19 However, CD8 T cells are effectively primed against CPXV by cross-presentation of viral Ags i

20 activates a network with mGlu2 receptors to prime an enhanced glutamate homeostasis that promotes bo

21 aspect of agency and show that subliminally priming an action not only influences response times, bu

22 detectable in the blood of the former group, prime and activate the NLRC4 inflammasome, induce the pr

23 se to Gagp24 regions, more conserved between prime and boost, compared to those of regions within Gag

24 erein, we demonstrate a novel role of Tat in priming and activating NLR family pyrin domain containin

25 hese findings suggest a novel role of Tat in priming and activating the NLRP3 inflammasome.

26 ulates insulin synthesis and insulin granule priming and contributes to beta-cell electrical activity

27 disease was associated with enhanced T cell priming and elevated T cell expression of the inflammato

28 rin expression leads to the diminished cross-priming and expansion of cytolytic antiviral CD8(+) T ce

29 ements in hard trials, as mediated by robust priming and fragile learning.

30 reduced when FAS was inhibited during T cell priming and not during the Tmem survival phase.

31 link between the processes of Cdk1-dependent priming and self-priming of Plk1 substrates.

32 sed on priming with multiple ASYMP epitopes (prime) and neurotropic TG delivery of the T cell-attract

33 pared to those of regions within Gagp15 (not primed) and Gagp17 (less conserved; P < 0.0001 for both)

34 esponse to olfactory cues.Plants are able to prime anti-herbivore defenses in response to olfactory c

35 6, as well as BDNF-induced hyperalgesia and priming are reduced specifically in male mice.

36 together with dendritic cell-mediated cross-priming, are the key elements.

37 s undermines their claims about the value of priming as a methodology.

38 tation, focusing primarily on cross-language priming between single-language sentences.

39 The non-primed binding mode presented here paves the way for the

40 with this compound, revealing a distinct non-primed binding mode to the active site.

41 Here, using activation tagging in the prime bioenergy crop poplar, we have identified a mutant

42 ulosis, BCG and MTBVAC delivered via various prime-boost combinations or alone were compared.

43 ara-Chiang Mai double recombinant (MVA-CMDR) prime-boost human immuonodeficiency virus (HIV) vaccine,

44 Heterologous prime-boost may provide a more effective vaccination str

45 raised using a heterologous DNA-viral vector prime-boost regimen, resulting in a high proportion of c

46 The present study investigated two prime-boost regimens, both starting vaccination with sin

47 et, the mechanisms underlying the synergy of prime-boost strategies remain incompletely defined.

48 cines should be considered a potent prime in prime-boost vaccination protocols.

49 Prime-boost vaccination via sequential s.c. and i.m. adm

50 Using a prime/boost strategy, high doses of GP/VSVDeltaG partial

51 pinpoint the nature of developmental change priming branching form diversification in mosses and pro

52 ic site and presents an appealing target for priming broadly effective antibody responses.

53 Hence, the primed but inactive state of the ZRS is induced by FGF s

54 mages, thought to be orchestrated by T cells primed by antigen-presenting cell presenting alloantigen

55 ion of genomic RNA to DNA, a process that is primed by cellular tRNAs.

56 However, until primed by inflammation, peripheral DOR is analgesically

57 ted by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develop a molecular s

58 POP2 also impairs macrophage priming by inhibiting the activation of non-canonical Ik

59 sense to EsRalpha prevented the induction of priming by low-dose IP3 in females.

60 epigenomic writers and suggest that enhancer-priming by MLL3/MLL4 followed by enhancer-activation by

61 of lymph nodes facilitates both their direct priming by resident macrophages and the localized delive

62 eceptor inhibitor prevented the induction of priming by ryanodine.

63 Specifically, because priming can occur at different, potentially conflicting

64 II) and Ce(IV) oxidation states, making them prime candidates for commercial and other applications.

65 highest deleteriousness scores making those prime candidates for phenotype-causal polymorphisms.

66 High-quality optical microcavities are prime candidates for sensing applications because of the

67 ical and electrochemical stability, they are prime candidates for the development of safe and sustain

68 innate and adaptive immune system represent prime candidates that impact on the pathogenesis of immu

69 I then consider cases in which evidence from priming cannot distinguish between competing syntactic a

70 es migration to draining lymph nodes and Th2 priming capacity.

71 responses to autologous blasts in vitro, and primed CD56bright cells controlled leukemia cells in viv

72 Primed CD56bright cells from leukemia patients demonstra

73 retention in mature spermatozoa, potentially priming certain regions of the genome for rapid activati

74 entiated the inflammatory function of TNF by priming chromatin to prevent the silencing of target gen

75 lts in impaired NADPH production, provides a prime 'collateral lethality' therapeutic strategy for th

76 nhibitory homodimerization forming monomeric priming-competent Munc13.

77 of our proposal, justify the versatility of priming, consider alternative approaches, and discuss ho

78 alent G1-like M gene were demonstrated to be prime contributors to enhanced infectivity.

79 Primed conversion has been reported only for Dendra2 and

80 and use this knowledge to create "pr"- (for primed convertible) variants of most known green-to-red

81 esting that autophosphorylation functions to prime CPK28 for Ca(2+) activation and might also allow C

82 encing (mRNAseq) is generally done by random priming, creating multiple sequencing fragments along ea

83 using blue light induced oxidative bursts to prime crop plants against the deleterious effects of env

84 Our data show that TLR4 ligation in LPS-primed DCs, induced higher levels of both IDO isoforms t

85 ancient origin of organohalogens could have primed development of metabolic machineries for their de

86 in TP which plays a specific role in protein-primed DNA synthesis beyond simply harboring the site of

87 revealing generation of R-lesions by R-loop-primed DNA synthesis.

88 ficant source of energy for cells and also a prime donor of nitrogen in the biosynthesis of many amin

89 esponse to an otherwise subthreshold cocaine priming dose (2.5 mg/kg, intraperitoneal).

90 ibody inhibited infant antibody responses to priming doses for 20 of 21 antigens.

91 roteins are required for vesicle docking and priming during exocytosis.

92 defense system by regulating the SA-mediated priming effect, consequently promoting the SV-induced re

93 ckering's (B&P's) model, largely because the priming effects are more confusing and diverse than thei

94 We provide evidence that priming effects in production are characterized better a

95 ZEB1 is a prime element of a network of transcription factors that

96 In mammalian cells, active or primed enhancers are commonly marked by monomethylation

97 erase CBP to promote activation of C/EBPbeta-primed enhancers of adipogenic genes.

98 Finally, engagement of Siglec-8 on IL-5-primed eosinophils resulted in increased phosphorylation

99 s uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving reg

100 la, Cetartiodactyla, and Carnivora present a prime example for such enigmatic affiliations.

101 which the genus Espeletia (Asteraceae) is a prime example.

102 hanced reliance on glutamine utilization are prime examples of such rewiring.

103 Thus Munc13-4 is a tethering/priming factor and Ca(2+) sensor for both heterotypic SG

104 For IP3 induced priming, females were also more sensitive.

105 se), sharing a common design, were pooled as PRIME-FFR (Insights From the POST-IT and R3F Integrated

106 Thus, TF synergistically primes FIXa-dependent thrombin generation independently

107 Its early diagnosis has been remained a prime focus amongst scientists and clinicians since long

108 nrichment is also detectable in hNCC regions primed for later activity.

109 populations in vitro, including one that is primed for platelet release.

110 t sequester Pam3Cys4 (CD4(+) T(Pam3)) become primed for Th1 differentiation.

111 ted to lineage-specific enhancers during ESC priming for differentiation.

112 equires phosphorylation by Cdk1 or Cdk2 that primes FoxM1b for phosphorylation by Plk1, which trigger

113 t that the C2A domain of Munc13 inhibits the priming function by homodimerization, and that RIM disru

114 Evolutionally, this type of priming function may be essential for addressing various

115 ), but is separate from its Ca(2+)-dependent priming function.

116 s revealed enhanced transcription of "memory-primed" genes compared with naive cells.

117 Moreover, structural priming has now reached sufficient methodological maturi

118 Two phases of pluripotency, called naive and primed, have previously been described.

119 how the rapid conversion of in-house-derived primed hESCs on mouse embryonic feeder layer (MEF) to a

120 yonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X c

121 show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions

122 ia that protect from Salmonella infection by priming host IFN-gamma responses.

123 Priming, however, should still be seen as only one of th

124 ergic responses induced by naive and in vivo-primed human T helper 2 cells.

125 IFN-gamma primes human MCs to activate T cells through superantige

126 rsatility of F. succinogenes OMVs is used to prime hydrolysis by destabilising the tight networks of

127 e (LAIV H5N2) in healthy Thai adults and its priming immune responses with an H5N1 inactivated vaccin

128 can-deficient Env derivatives can be used as priming immunogens because they should engage and activa

129 Priming implies a network structure, so the grammar must

130 ly connected and edge-transitive nets are of prime importance in crystal chemistry and are regarded a

131 Of prime importance to the practical application of this te

132 based vaccines should be considered a potent prime in prime-boost vaccination protocols.

133 ere, we examined the mechanisms of apoptotic priming in ASFs and explored a combined targeting strate

134 ance of chromatin states and transcriptional priming in dictating tumor phenotypes and EMT.

135 eptual capabilities underlying plant defense priming in response to olfactory cues.Plants are able to

136 SOM priming in the native community was proportional to belo

137 results consistent with the hypothesis that priming in this interaction is mediated by a single comp

138 Further validation of NLRP3 priming in vivo involved administration of lipopolysacch

139 lpha-dependent phosphoregulation of FOXO4 is primed, in part, by the PI3K/AKT effector axis of oncoge

140 ingly, priming of PBIP1 by Plk1 itself (self-priming) increased in MYPT1-depleted cells showing that

141 rotein kinase phosphorylation, but uric acid priming induced phosphorylation of AKT and proline-rich

142 h similar physical/chemical properties is of prime industrial importance and practically entails a su

143 c receptor (alpha1-AR), suggesting that GPCR priming is a receptor-specific phenomenon.

144 mouse photoreceptor ribbon synapses, vesicle priming is Munc13 independent.

145 the transition from full potency to lineage priming is prevented by inhibition of the FGF/MAPK signa

146 In addition, swarm priming is shown to be effective at increasing the react

147 Newly constructed TP mutations revealed a priming loop in TP which plays a specific role in protei

148 Structural priming makes a valuable contribution to psycholinguisti

149 e cells before ovulation activates EcR.B2 to prime mature follicles to be responsive to neuronal ovul

150 Second, structural priming may be simply an example of hysteresis effects i

151 t that chronic sleep loss, through microglia priming, may predispose the brain to further damage.SIGN

152 IFN-gamma-primed MCs guide activation of T cells by Staphylococcus

153 Our findings therefore strongly argue for a priming mechanism at the photoreceptor ribbon synapse th

154 receptor antagonist, is antihyperalgesic in primed mice exposed to spinal administration of a D1/D5

155 IFN (IFN-I) signature unique to DCs from Nb-primed mice.

156 he high-throughput search for compounds that prime microbial pattern-induced secretion of antimicrobi

157 Priming microglia with LPS induced greater microglia act

158 These observations suggest that FGF2 priming might protect DPCs from the post-trauma microenv

159 This approach primed mitochondria to immediately increase their oxygen

160 ed by dopamine signaling in the hyperalgesic priming model, we used c-fos labeling.

161 tively different AZM mediated SV docking and priming models: sequential and concurrent SV docking/pri

162 ame at the expense of the number of lymphoid-primed MPP4s, which appeared to be compensated for by in

163 MVA-CMDR boost, the sequence-mismatched DNA-prime MVA-boost vaccine strategy induced a Gag-specific

164 ysis of whole-transcriptome data from CDCexo-primed Mvarphi implicated miR-181b as a significant (P=1

165 Thus, Cyclin A/Cdk1 phosphorylation primes MYPT1 for Plk1 binding.

166 Piperacillin-primed naive T cells from healthy volunteers also secret

167 Overall, priming naive ferrets with COBRA HA based viruses or usi

168 etter as graded than as all-or-none and that priming need not arise from a mechanism that (re)activat

169 Priming neutrophils for an enhanced respiratory burst to

170 This study shows that direct priming of a tumor tissue using photosensitization rapid

171 ntial source of Notch ligands during in vivo priming of alloreactive T cells.

172 graft rejection via direct cytotoxicity and priming of alloreactive T cells.

173 ced autoimmunity, and with unique effects on priming of autoreactive and arthritogenic T cells, provi

174 P3 was not due to transcriptional control or priming of canonical inflammasome components but, rather

175 oss-presentation ex vivo and defective cross-priming of CD8(+) T cell responses in vivo.

176 This effect is essential for priming of CD8(+) T cells that mediate systemic tumour r

177 latory molecules and promote antigenic cross-priming of CD8(+) T cells.

178 rives type I interferon production for cross-priming of CD8(+) T cells.

179 ore, while both cultivars developed systemic priming of chitosan-induced callose after single inocula

180 The priming of chromatin enabled robust transcriptional resp

181 Chromatin promotes the regular priming of lagging-strand DNA synthesis by facilitating

182 and TRPM8 hence appear to be involved in the priming of mitochondria to perform uncoupled respiration

183 epsilon and the dynamics of mTORC2-dependent priming of mutant PKCepsilon was altered.

184 appaB pathway, which in turn accentuates the priming of Nlrp3, promotes Nlrp3-ASC inflammasome assemb

185 Interestingly, priming of PBIP1 by Plk1 itself (self-priming) increased

186 processes of Cdk1-dependent priming and self-priming of Plk1 substrates.

187 adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indicating a critical regula

188 Thus, the priming of Th2 responses is associated with distinct tra

189 health via enhanced nutrient acquisition and priming of the plant immune system.

190 composition more than AM trees via microbial priming of unprotected SOM.

191 om the account, in particular in relation to priming of visual search, finding that the account gener

192 e synergistic effects on growth and systemic priming of wheat.

193 Structural priming offers a powerful method for experimentally inve

194 Here, we show that priming on physiologically soft silicone substrates supp

195 ; however, whether helminthes prevent T cell priming or skew clonal recruitment and effector differen

196 of the C9orf72 repeat expansion with repeat-primed PCR (RP-PCR).

197 Digestion of IGNIS prime peptides was optimised using trypsin and SMART Dig

198 homeostatic equilibrium following a dynamic priming period after birth.

199 hepatocytes increased immediately after PH (priming phase of liver regeneration) in control mice, bu

200 McGurk illusion, we show that visual context primes phonetic representations at the auditory cortex,

201 of MMP-2 and the mechanism through which it primes platelets to respond to subsequent stimuli are st

202 F occupancy during the transition from naive/primed pluripotency to multipotent primary neural progen

203 s undergo abrupt transitions from a naive to primed pluripotent state.

204 C phenotype, maturation status, and TH2 cell priming potential.

205 Here we determine crystal structures of the primed pre-fusion SNARE-complexin-synaptotagmin-1 comple

206 nal Munc13 proteins and the synaptic vesicle priming process that they control to the known etiologic

207 d that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, un

208 In sum, we propose that structural priming provides a new basis for understanding the natur

209 hey also call into question B&P's claim that priming "provides evidence that is directly informative

210 therapeutic immunization with an innovative prime/pull vaccine, based on priming with multiple ASYMP

211 this event is thought to play a key role in priming RAF activation, the underlying mechanism is not

212 tor binding to the helical cytokine subunits primes recruitment of the shared receptors via the IL-12

213 esis that corticosterone potentiates cocaine-primed reinstatement by blockade of OCT3.

214 ne and normetanephrine to potentiate cocaine-primed reinstatement in OCT3-deficient and wild-type mic

215 rticosterone treatment to potentiate cocaine-primed reinstatement was recapitulated by intra-PL injec

216 shift in the dose-response curve for cocaine-primed reinstatement.

217 for this claim comes from the possibility of priming relations involving subject-verb sequences, whic

218 Biallelic mutations of three prime repair exonuclease 1 (TREX1) cause the lupus-like

219 Three-prime repair exonuclease 1 (TREX1) is an anti-viral enzy

220 Three-prime repair exonuclease 1 knockout (Trex1(-/-)) mice su

221 Priming requires signals transduced through L-selectin N

222 ne responses, whereas high-dose immunization primes responses characterized by regulatory T (Treg) ce

223 m-dependent exocytosis downstream of vesicle priming, revealing a novel autoinhibitory role for the C

224 ons bore structural hallmarks of target-site primed reverse transcription (TPRT) and mobilized effici

225 sferred IRF-4-deficient DCs also effectively prime S. mansoni-specific Th2 responses.

226 M. bovis bacillus Calmette-Guerin-primed sanroque T cells transferred into Rag1(-/-) mice

227 ibody response in UK infants given a reduced priming schedule of PCV13 (ie, a 1 + 1 schedule) versus

228 ch code for previously-selected reagents, to prime second strand synthesis of a single-stranded DNA t

229 One reason is that prime sentences affect multiple representational levels

230 s differentiated in culture, MLL4 identifies primed SEs of genes fully activated in BAT such as Ucp1.

231 However, the prime side also significantly modulates DENV protease bi

232 After cytokine priming, Siglec-8 mAb or glycan ligand binding causes eo

233 that CLIC1 and CLIC4 participate both in the priming signal for IL-1beta and in NLRP3 activation.

234 Additionally, when combined with a priming signal, cGAMP activates the inflammasome through

235 olling spreading processes on networks is of prime significance in diverse contexts, ranging from the

236 ntributes to sex differences in hyperalgesic priming.SIGNIFICANCE STATEMENT The present study demonst

237 anti-Env IgG responses elicited by NYVAC-KC priming significantly more (up to a P value of 0.01) tha

238 In Drosophila melanogaster larvae, the prime site of external taste reception is the terminal o

239 rimers or targeting amplicons with conserved priming sites.

240 is dark but photochemically important, is a prime source of this difficulty.

241 econd messengers, a phenomenon we term "GPCR priming." Specifically, we find that the presence of non

242 e results in changes in pluripotency and the primed state of cells.

243 er transition of their pluripotency from the primed state using various methods and that hPGCLCs rese

244 B exerts a basal inhibition on Munc13 in the primed state, permitting calcium- and lipid-dependent co

245 s are, comparatively, in a highly activated (primed) state.

246 f FACS-sorted embryoid body (EB) cells] from primed-state induced pluripotent stem cells (iPSCs) afte

247 They mediate the priming step that renders synaptic vesicles fusion-compe

248 Doc2B plays distinct roles in two sequential priming steps in mouse adrenal chromaffin cells.

249 information", while supported by structural-priming studies of the passive, is undermined by an acce

250 DC34 is required to build chains onto the Ub-primed substrate.

251 GPCR priming suggests another layer of regulation in the clas

252 nd immune responses of the pistil makes it a prime system in which to study the consequences of plant

253 at the simultaneous absence of Nod1 and Nod2 primed T cells for activation-induced cell death.

254 Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas h

255 f T cell exhaustion, making this signature a prime target in the search for the regulatory origins of

256 ission of pain signals in humans making them prime targets for the development of new analgesics.

257 ulators of immune homeostasis and, thus, are prime targets for therapeutic interventions of diseases

258 ineered DBP immunogens, we validate that the prime targets of protective immunity are conformational

259 involves monitoring XNA synthesis on a self-priming template using high-resolution melting (HRM) flu

260 st phase of functional differentiation after priming, termed "early effector cells" (EEC), which also

261 g induces conformational changes that likely prime the channel for voltage-dependent opening.

262 ivates NF-kB, we hypothesized that Tat could prime the NLRP3 inflammasome.

263 These proteins prime the particle for removal by immune cells and may c

264 ong-lasting transcriptional alterations that prime the ventral tegmental area (VTA)-a brain reward re

265 lves major reprogramming of the epigenome to prime the zygote for totipotency.

266 We demonstrated that ten-day alcohol feeding primed the liver to LPS-induced lipid accumulation and l

267 ata strongly imply that the malaria parasite primes the erythrocyte surface through its binding antig

268 We show that UBCH7/HHARI primes the substrate with a single Ub in the presence of

269 otriene C4, explaining how substrate binding primes the transporter for ATP hydrolysis.

270 h factor (FGF) signalling in the distal limb primes the ZRS at early embryonic stages maintaining a p

271 DAT protected the host by priming the amplification loop of type I IFN signaling.

272 s the release of the solvent-derived ligand, priming the metal center for reduction and subsequent O2

273 contribute to cross-presentation of Ags and priming the pool of naive CD8(+) T cells within the live

274 e fusion is sensitive to inhibition of SNARE priming, the initial stages of autophagosome biogenesis

275 in environment at a subset of origins, which primes them for late replication.

276 murine thymic epithelium and is required to prime thymic epithelial cells (TEC) for effective Treg i

277 ed after fertilization, that the egg cell is primed to activate the translational machinery, and that

278 nted by the topology of a given MOF that are primed to form such an excited state complex.

279 Cardiac and splenic T cells in HF are primed to induce cardiac injury and remodeling, and reta

280 Cells primed to produce IFN by 5-azacytidine (5-aza) underwent

281 orm unstable aggregates and are unexpectedly primed to respond robustly to inflammatory mediators.

282 ckering's (B&P's) proposal to use structural priming to tap into this process.

283 oscillations are the major determinants for priming, triggering and yielding activated "prothromboti

284 ntigen-presenting cells and activate them to prime tumor-specific CD8(+) T cell responses.

285 lustering at the plasma membrane and thereby primes tumor cells to caspase-mediated apoptosis.

286 in and transcriptional states differentially prime tumors to EMT.

287 Thus, HDAC3 uniquely primes Ucp1 and the thermogenic transcriptional program

288 odulate both antigen presentation and T cell priming, ultimately leading to allograft rejection.

289 rough direct interaction with its mRNA three prime untranslated region (3'-UTR).

290 s functional importance, DBP is considered a prime vaccine candidate, but variation in B-cell epitope

291 erminus of E3 is necessary to inhibit an IFN-primed virus-induced necroptosis.

292 Decision confidence, consistency (primed vs unprimed), and quality (script concordance) we

293 IP3-induced priming was prevented by pretreatment with inhibitors of

294 Cytokine priming was required to elicit the unanticipated finding

295 Cells primed with a range of Pen a 1-specific IgE and challeng

296 in PCV13, post-booster responses in infants primed with a single dose are equivalent or superior to

297 Monocytes from healthy volunteers were first primed with uric acid for 24 h and then subjected to sti

298 omass, while P. australis showed much higher priming with less belowground biomass.

299 However, priming with lipopolysaccharide, followed by stimulation

300 h an innovative prime/pull vaccine, based on priming with multiple ASYMP epitopes (prime) and neurotr

301 sed transwell migration that was enhanced by priming with physiologic doses of IL-5.

302 lammatory pathways associated with uric acid priming, with NF-kappaB and mammalian target of rapamyci