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2 bind to and can block entry mediated by the primed (19-kDa) form of GP without impeding binding of t
3 oupled to antigenic payloads, anti-MHCII VHH primed Ab responses against GFP, ubiquitin, an OVA pepti
4 ific regulatory mechanisms and also uncovers primed activating components in the network, including S
6 ngths of more than 20 nucleotides cause both primed adaptation and target interference in vivo Shorte
8 ow that in Escherichia coli cells undergoing primed adaptation, spacer-sized fragments of foreign DNA
9 pacer length reduced to 14 nucleotides cause primed adaptation, while crRNAs with spacer lengths of m
10 Cas system from Escherichia coli, efficient "primed" adaptation requires Cas effector proteins and a
12 cent reports show that host T cells properly primed against tumor-specific antigens after conventiona
13 nduction of type I IFN in these cells, which primed an increased transcription of the p35 subunit of
16 pared to those of regions within Gagp15 (not primed) and Gagp17 (less conserved; P < 0.0001 for both)
21 cines promote the differentiation of disease-primed autoreactive T cells into TR1-like cells, which i
22 absence of T-cell help, transiently antigen-primed B cells do not undergo apoptosis in vivo; they re
28 transcription of the Bordetella phage DGR is primed by an adenine residue in TR RNA and is dependent
29 mages, thought to be orchestrated by T cells primed by antigen-presenting cell presenting alloantigen
30 shift in the major acting TFs appears to be primed by binding of ZIC2 in ESCs at relevant genomic po
35 ted by IL-12 and IL-18; v) as MAIT cells are primed by SAgs, they also begin to develop a molecular s
43 eage also occurs intrathymically, as myeloid-primed CD123(+) monocyte/DC and common DC progenitors, e
45 responses to autologous blasts in vitro, and primed CD56bright cells controlled leukemia cells in viv
49 creased TAZ/TEAD-dependent transcription and primed cells for enhanced TAZ activity upon a second sti
52 Sustained augmentation of glycolysis in TLR-primed cells was dependent, in part, on hypoxia-inducibl
54 we found sleep-dependent improvement in the Primed condition compared with the Quiet Wake control co
57 y fat: 16% +/- 1% (means +/- SEMs)] received primed continuous l-[ring-(2)H5]phenylalanine and l-[1-(
58 Here, we uncover the molecular mechanism of primed conversion by reporting the intermediate "primed"
60 OXA1, NKX3.1 and androgen receptor, AR) in a primed conversion strategy starting from mouse fibroblas
61 ion but also by an alternative method termed primed conversion, employing dual wavelength illuminatio
62 and use this knowledge to create "pr"- (for primed convertible) variants of most known green-to-red
64 elivery of activated M. tuberculosis antigen-primed DCs into vaccinated mice, at the time of M. tuber
66 st and stable adhesion were created on e-GSE-primed dentin surfaces, leading to a dramatic decrease o
67 ancient origin of organohalogens could have primed development of metabolic machineries for their de
70 in TP which plays a specific role in protein-primed DNA synthesis beyond simply harboring the site of
72 of single-base nucleotide incorporation into primed DNA templates covalently attached to the surface
78 ics: hypo-methylation is a unique feature of primed enhancers whereas active enhancers are generally
79 ote, systemic application of JWH-133 clearly primed eosinophil-directed migration in vivo and aggrava
81 s uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving reg
84 gesting the CLP-induced polymicrobial sepsis primed for a protective response by the SFB-specific CD4
86 m these tissues in young mice and humans are primed for apoptosis, predisposing them to undergo cell
89 ynyl)naphthalene (bpen), a diarenynyl system primed for cyclization, was exposed to iodine vapor to y
90 rs highly penetrant risk variants, making it primed for discovery of novel risk genes and pathways fo
92 biotechnology makes it an engineering field primed for inductive reasoning to complement the dominat
95 ould exacerbate a dry and alkaline phenotype primed for pathogen growth and inflammation in AD-suscep
96 ION: Spinal cord microglia lacking ABCD1 are primed for phagocytosis, affecting neurons within an alt
98 positively charged RNA binding cleft that is primed for productive interaction with RNA targets, pote
101 nclusion, DNA vaccination by electroporation primed for TCR clonotypes that were associated with HIV
103 3 KO melanomas suggests that melanocytes are primed for transformation via a mutagenic mechanism invo
105 e viral entry by targeting a proteolytically primed, fusion-competent GP intermediate (GPCL) generate
106 ride composition of the XylNapOH- and XylNap-primed GAGs, which differed between the two cell lines b
108 that this could be mediated by the xyloside-primed glycosaminoglycans (GAGs) and that these differ i
112 trated the presence of a primitive erythroid primed hemogenic endothelial cell population in the deve
113 how the rapid conversion of in-house-derived primed hESCs on mouse embryonic feeder layer (MEF) to a
114 yonic stem cells (hESCs) can be derived from primed hESCs or directly from blastocysts, but their X c
115 show that the inactive X chromosome (Xi) of primed hESCs was reactivated in naive culture conditions
116 naive state resets Xi abnormalities seen in primed hESCs, it may provide cells better suited for dow
120 in vitro ANCA did not activate NF-kappaB in primed human neutrophils, but ANCA-stimulated primed neu
124 These findings imply that a sufficiently primed immune response could prevent CMV from establishi
125 st that a set of cis-regulatory elements are primed in early postnatal life whose functions may be co
126 ingly, PMN from only a subset of donors were primed in response to the TLR2/1 agonist, Pam3CSK4, alth
128 and the integrin alpha4beta7 on CD8 T cells primed in vitro and on circulating CD8 T cells in the mi
129 lpha-dependent phosphoregulation of FOXO4 is primed, in part, by the PI3K/AKT effector axis of oncoge
130 the flow-through pool could be incompletely primed, in which case the full sequence of priming steps
138 ism by which CD45 isoforms tune low affinity-primed memory CD8(+) T cells to become potent secondary
139 that a mixed D1/D5 agonist given spinally to primed mice activates a subset of neurons in lamina III
140 adhesin Apa-specific T-cell responses in BCG-primed mice and investigated its BCG-booster potential.
141 receptor antagonist, is antihyperalgesic in primed mice exposed to spinal administration of a D1/D5
143 transfer of Treg cells from vaccinated/ppins-primed mice into PD-L1(-/-) hosts efficiently suppressed
145 t with GBS-III, booster immunization of MenC-primed mice with isolated MenC-PS, a TI Ag, or a conjuga
146 T cells in the skin draining lymph nodes of primed mice, but it is not required for the development
153 ve an early and progressive loss of lymphoid-primed MPP cells (LMPP/MPP4) with aging, concomitant wit
154 ame at the expense of the number of lymphoid-primed MPP4s, which appeared to be compensated for by in
156 to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c
157 genitor populations in cord blood - lymphoid-primed multi-potential progenitors (LMPPs), granulocyte-
159 aling, IL-1beta production and pyroptosis in primed murine bone marrow-derived macrophages that is me
160 ysis of whole-transcriptome data from CDCexo-primed Mvarphi implicated miR-181b as a significant (P=1
163 rimed human neutrophils, but ANCA-stimulated primed neutrophils activated NF-kappaB in ECs, at least
164 Exposure of SLE neutrophils, or healthy IFN-primed neutrophils, to antiribonucleotide protein autoan
165 of mTORC1 abrogated the ability of the IL-2-primed NK cells to produce IFN-gamma in response to NKG2
166 eparan sulfate derived from CCD-1095Sk cells primed on XylNapOH or XylNap had any effect on the growt
168 latory cell numbers in tissues where GvHD is primed or initiated, and consistent with this LRBA-null
173 al ASC differentiation and that only antigen-primed, peripheral GC-derived ASC infiltrate the CNS, th
174 ex vivo when multimerized on liposomes, and primed PGT121-like responses in PGT121 inferred-germline
177 e low mitochondrial function associated with primed pluripotency and in regulating one-carbon metabol
178 trols the metabolic transition from naive to primed pluripotency by directly repressing oxidative met
179 ssage through mitosis and that conversion to primed pluripotency is linked to lineage priming in the
181 fp281 as a key transcriptional regulator for primed pluripotency that also functions as a barrier tow
182 F occupancy during the transition from naive/primed pluripotency to multipotent primary neural progen
183 on severely blocks transcriptional switch to primed pluripotency, even in the absence of p53 activity
184 ls (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (m
187 Subsequently, Foxd3 needs to be silenced in primed pluripotent cells to allow re-activation of relev
188 ruct the 3D chromatin landscape of naive and primed pluripotent cells, unveiling common features as w
193 We postulated that a bolus of enhanced IL-21-primed polyclonal antigen-specific CTL combined with CTL
194 me these problems, we have developed T oligo-primed polymerase chain reaction (TOP-PCR) for full-leng
195 The overall seroprevalence among the sH3N2-primed population against 2012-2013 H3N2v viruses was >5
196 eric site that stabilizes the lever arm in a primed position resulting in accumulation of cardiac myo
197 Here we determine crystal structures of the primed pre-fusion SNARE-complexin-synaptotagmin-1 comple
200 ic influenza A virus (IAV) challenge of mice primed previously with wild-type or attenuated IAV strai
202 evidence points to a causal link between the primed profile of the aged brain and vulnerability to se
203 potent, adult somatic stem cells and lineage-primed progenitors that are required for the production
204 Shock Factor 1 (HSF1) binds to transcription-primed promoters and enhancers, and CTCF-occupied, non-t
205 d that activated HSF1 binds to transcription-primed promoters and enhancers, and to CTCF occupied, un
206 and alveolar neutrophils display a distinct primed prosurvival profile and transcriptional signature
207 f reset cells diverges markedly from that of primed PSCs and shares features with human inner cell ma
208 suppression but that their T cells exhibit a primed, rather than a suppressed, phenotype in their TCR
210 ne and normetanephrine to potentiate cocaine-primed reinstatement in OCT3-deficient and wild-type mic
212 elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following self-a
213 l plasma concentrations) potentiated cocaine-primed reinstatement of extinguished cocaine-induced con
214 dose-dependently inhibited cue- and cocaine-primed reinstatement to cocaine, but did not affect loco
215 rticosterone treatment to potentiate cocaine-primed reinstatement was recapitulated by intra-PL injec
218 ons bore structural hallmarks of target-site primed reverse transcription (TPRT) and mobilized effici
219 BVs including genome replication via protein-primed reverse-transcription and utilization of structur
222 s differentiated in culture, MLL4 identifies primed SEs of genes fully activated in BAT such as Ucp1.
224 n contrast, all mice that received untreated primed splenocytes and third-party mice that received PD
226 f the developing brain could also exist in a primed state in which the loss of a single anti-apoptoti
227 use epiblast cells transit from a naive to a primed state in which they are competent for both somati
228 leukocytes (PMN) achieve an intermediate or primed state of activation following stimulation with ce
230 ing in accumulation of cardiac myosin in the primed state prior to onset of cardiac contraction, thus
232 as well as anhedonic behavior, reflecting a primed state that results from a persistent increase in
233 er transition of their pluripotency from the primed state using various methods and that hPGCLCs rese
234 B exerts a basal inhibition on Munc13 in the primed state, permitting calcium- and lipid-dependent co
238 ed conversion by reporting the intermediate "primed" state to be a triplet dark state formed by inter
239 ration leaves the dopamine transporter in a "primed" state, which allows for cocaine-induced plastici
241 that these changes lead to an activated, or primed, state of Env (normally induced after Env interac
242 f FACS-sorted embryoid body (EB) cells] from primed-state induced pluripotent stem cells (iPSCs) afte
243 ipotent stem cells (PSCs) exist in naive and primed states and provide important models to investigat
249 work presented identifies RABEP2 as a novel primed substrate of GSK3, and thus a potential biomarker
252 of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity earlier than
254 ine mRNA induction by ex vivo stimulation of primed T cells with specific antigens is described.
257 We demonstrated that ten-day alcohol feeding primed the liver to LPS-induced lipid accumulation and l
258 lls lacked conventional CSC markers but were primed to acquire stem cell-like function by upregulatin
259 ed after fertilization, that the egg cell is primed to activate the translational machinery, and that
260 ch classes of biological questions GEVIs are primed to address and which ones are beyond their curren
264 the majority of cells are transcriptionally primed to generate exclusively single-lineage output.
268 Naive T cells from healthy volunteers were primed to piperacillin, cloned, and subjected to the sim
269 rging subspecialty of radiology, which seems primed to play a major clinical role in guiding diagnost
270 homeostasis under normal conditions, but are primed to potentiate inflammation and leukocyte recruitm
272 s, including humans, so OSN measurements are primed to provide specialized insights into neurological
273 d lymphocytes to the tumor microenvironment, primed to recognize tumor-associated antigens, can occur
275 orm unstable aggregates and are unexpectedly primed to respond robustly to inflammatory mediators.
277 naive-specific cell surface proteins during primed-to-naive resetting enabled the isolation and char
280 ons as a Ca(2+) sensor, setting the rates of primed vesicle fusion with the presynaptic plasma membra
281 ng does not inhibit initiation of capped-RNA-primed viral mRNA synthesis by the viral polymerase.
285 on dendritic cells (DCs), in rhesus macaques primed with a poxvirus vector (NYVAC-KC) expressing Env
287 in PCV13, post-booster responses in infants primed with a single dose are equivalent or superior to
288 uses among some children likely to have been primed with A/Sydney/5/97-like (145K) or A/Wuhan/359/95-
290 -specific antibody responses in participants primed with ChAd3 remained positive 6 months after vacci
291 experimental approach in other mouse strains primed with different allogeneic cell types, including e
293 riments 1 and 2) and than Swiss participants primed with individual identity or not primed (Experimen
295 s of serologic cross-reactivity among humans primed with seasonal influenza A(H3N2) (sH3N2), using po
297 ermore, CD56bright NK cells from MM patients primed with the IL-15 receptor agonist ALT-803 in vivo d
298 elease to an extent similar to that of cells primed with tumor necrosis factor alpha (TNF-alpha).
299 Monocytes from healthy volunteers were first primed with uric acid for 24 h and then subjected to sti
300 g in the WRKY6 and PDF12 regulatory regions, primed WRKY6 expression, unprimed PDF12 activation, and
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