ライフサイエンスコーパス: primitive endoderm

1 -terminal kinase as well as the formation of primitive endoderm.

2 uires a signal(s) secreted from the adjacent primitive endoderm.

3 inducing these embryonal carcinoma cells to primitive endoderm.

4 diating differentiation of P19 stem cells to primitive endoderm.

5 inase C, MAP kinase, and cell progression to primitive endoderm.

6 ontrol of phospholipase C and progression to primitive endoderm.

7 ein kinase C, MAP kinase, and progression to primitive endoderm.

8 l differentiation of their trophectoderm and primitive endoderm.

9 ively block morphogen-induced progression to primitive endoderm.

10 profile characteristic of either epiblast or primitive endoderm.

11 oliferation as well as a conspicuous lack of primitive endoderm.

12 se genes determines whether the cells become primitive endoderm.

13 divisions are strongly biased toward forming primitive endoderm.

14 and two extraembryonic, the trophoblast and primitive endoderm.

15 in the subset of ICM cells that comprise the primitive endoderm.

16 s ES cells to selectively differentiate into primitive endoderm.

17 repression upon ES cell differentiation into primitive endoderm.

18 NK cascade, thereby stimulating formation of primitive endoderm.

19 catenin-sensitive promoter, and formation of primitive endoderm.

20 ause F9 embryonic teratocarcinoma cells form primitive endoderm after stable transfection of Frizzled

21 future body, whereas others develop into the primitive endoderm, an extraembryonic tissue.

22 adenylylcyclase but abolished progression to primitive endoderm and activation of phospholipase C.

23 We show that interactions between primitive endoderm and adjacent embryonic ectoderm or na

24 because they are incapable of giving rise to primitive endoderm and have a high propensity for neural

25 se in expression causes differentiation into primitive endoderm and mesoderm.

26 e embryogenesis GATA-4 is expressed first in primitive endoderm and then in definitive endoderm deriv

27 fically, miR-93 localizes to differentiating primitive endoderm and trophectoderm of the blastocyst.

28 evelopment of both extra-embryonic lineages, primitive endoderm and trophectoderm, but not the embryo

29 e distinct populations: the inner cell mass, primitive endoderm and trophectoderm.

30 l lineages in the blastocyst: trophectoderm, primitive endoderm, and epiblast.

31 The primitive endoderm arises from the inner cell mass durin

32 scription factor Nanog and the expression of primitive endoderm-associated genes Gata6, Gata4, Sox17

33 Dab2 expression was first observed in the primitive endoderm at E4.5, immediately following implan

34 unmanipulated embryos until the epiblast and primitive endoderm became distinct.

35 nown to be required for specification of the primitive endoderm, but its role in polarisation of this

36 as also required for the displacement of the primitive endoderm by definitive endoderm.

37 Interestingly, functional primitive endoderm can be rescued in Oct4-deficient embr

38 or caused a loss of expression of markers of primitive endoderm cell fate and maintenance of the plur

39 ised epithelial cells and express markers of primitive endoderm cell fate.

40 The primitive endoderm cells and the derived parietal and vi

41 ta1 integrin-null blastocysts and found that primitive endoderm cells are present but segregate away

42 embryos deficient of Disabled-2 (Dab2), the primitive endoderm cells lose the ability to position on

43 is abundantly expressed in trophectoderm and primitive endoderm cells of human blastocyst-stage embry

44 This data shows that primitive endoderm cells of the outer layer of embryoid

45 blastocyst comprises epiblast progenitor and primitive endoderm cells of which cognate embryonic (mES

46 eta1 integrin-null embryoid bodies, in which primitive endoderm cells segregated and appeared as mini

47 a cells undergo differentiation to embryonic primitive endoderm cells, accompanied by a reduction in

48 The formation of the primitive endoderm covering the inner cell mass of early

49 nomously required for the differentiation of primitive endoderm derivatives, as long as an appropriat

50 Here, we investigate a key step in primitive endoderm development, the acquisition of apico

51 eratocarcinoma cells, a model of epiblast-to-primitive endoderm differentiation, confirmed the epibla

52 Furthermore, sodium vanadate induced primitive endoderm differentiation, even in the inner ce

53 rly activity in the blastocyst is to support primitive endoderm differentiation.

54 t into ES cells induced Nanog repression and primitive endoderm differentiation.

55 estigate the function of this pathway in the primitive endoderm, embryoid bodies were cultured in the

56 n kinase C, MAP kinase and no progression to primitive endoderm, even in the presence of retinoic aci

57 chimeric embryos composed of nodal-deficient primitive endoderm fail to develop rostral neural struct

58 gnaling and show that exogenous FGF4 rescues primitive endoderm formation and trophectoderm prolifera

59 ty of the morphogen retinoic acid to promote primitive endoderm formation from mouse P19 embryonal ca

60 noic acid to induce either JNK activation or primitive endoderm formation in P19 stem cells.

61 in-sensitive transcription, and promotion of primitive endoderm formation in response to Wnt3a.

62 gnal linkage map from Galpha13 activation to primitive endoderm formation in these stem cells require

63 her Xenopus Wnt-5a or Wnt-8 was used to test primitive endoderm formation of F9 stem cells.

64 Primitive endoderm formation stimulated by Wnt-8 acting

65 The overall pathway to primitive endoderm formation was shown to be inhibited b

66 sed to investigate the signaling upstream of primitive endoderm formation.

67 ed signaling from Q226L Galpha13 to JNK1 and primitive endoderm formation.

68 ation of Lef-Tcf-sensitive transcription and primitive endoderm formation.

69 role in the retinoic acid-induced pathway to primitive endoderm formation.

70 ic G-protein G(13) mediates the formation of primitive endoderm from mouse P19 embryonal carcinoma ce

71 ultures, including CXCR4(+) cells, expressed primitive endoderm genes.

72 Strikingly, as seen with primitive endoderm, Ihh can respecify prospective neural

73 a2/FOXA2, which we show is restricted to the primitive endoderm in both human and mouse embryos.

74 ogen retinoic acid promotes the formation of primitive endoderm in mouse F9 teratocarcinoma cells as

75 The formation of primitive endoderm in response to retinoic acid also cou

76 Tcf-sensitive transcription and formation of primitive endoderm in response to the morphogen.

77 Blocking Ihh function in primitive endoderm inhibits activation of hematopoiesis

78 tic specification to position the liver, and primitive endoderm is competent to form liver on both si

79 We propose that primitive endoderm is responsible for the initial induct

80 Fbeta-related growth factor expressed in the primitive endoderm, is critical for patterning of the an

81 Sox17, a marker of primitive endoderm, is not detected following prolonged

82 ates detached from the core spheroids, and a primitive endoderm layer failed to form on the surface.

83 The formation of the primitive endoderm layer on the surface of the inner cel

84 ually polarise, and formation of a polarised primitive endoderm layer requires the Fgf receptor/Erk s

85 egrin is essential for the attachment of the primitive endoderm layer to the epiblast during the form

86 yer is responsible for the failure to form a primitive endoderm layer.

87 f-renewal, and promotes differentiation into primitive endoderm-like cells under normal feeder-free c

88 the future embryo, but instead belong to the primitive endoderm lineage and will be displaced by defi

89 ficient for differentiation of the essential primitive endoderm lineage from embryonic stem cells.

90 a proximodistal asymmetry established in the primitive endoderm lineage.

91 ied in silico precursors of the epiblast and primitive endoderm lineages and revealed a role for MCRS

92 ribute to the extraembryonic trophoblast and primitive endoderm lineages but are excluded from the ep

93 show that a consistent ratio of epiblast and primitive endoderm lineages is achieved through incremen

94 rmation and specification of epiblast versus primitive endoderm lineages using conditional genetic de

95 of parthenogenesis on the trophectoderm and primitive endoderm lineages.

96 Also, GATA4, a primitive endoderm marker, was expressed by these cells.

97 RhoA mutant was able to promote formation of primitive endoderm, mimicking expression of the constitu

98 yonic endoderm stem (XEN) cells resemble the primitive endoderm of the blastocyst, which normally giv

99 Initially Hex is expressed in the primitive endoderm of the implanting blastocyst but by 5

100 epiblast whereas Cryptic is expressed in the primitive endoderm of the late blastocyst and the viscer

101 e Pgk-Pem ES cells do not differentiate into primitive endoderm or embryonic ectoderm, which are prom

102 , apparently in response to signals from the primitive endoderm or the extraembryonic mesoderm [1,2].

103 urface of cell aggregates and fail to form a primitive endoderm outer layer in the embryoid bodies.

104 ls of the inner cell mass (ICM) develop into primitive endoderm (PE) at the surface, while deeper cel

105 he inner cell mass (ICM), and for repressing primitive endoderm (PE) development.

106 e from outer trophectoderm (TE) and internal primitive endoderm (PE) in the blastocyst and subsequent

107 ll mass (ICM), followed by epiblast (EPI) or primitive endoderm (PE) specification within the ICM.

108 ct4 is first required for development of the primitive endoderm (PE), an extraembryonic lineage.

109 , which will form the new organism, from the primitive endoderm (PE), which will form the yolk sac, i

110 The primitive endoderm (PE)-associated transcription factor

111 gene down-regulation and differentiation to primitive endoderm (PE); however, the underlying mechani

112 pression of Gsalpha provokes, progression to primitive endoderm, permitting identification of the eff

113 re-implantation development, extra-embryonic primitive endoderm (PrE) and pluripotent epiblast precur

114 Cells of the primitive endoderm (PrE) and the pluripotent epiblast (E

115 decision between the epiblast (Epi) and the primitive endoderm (PrE) fate that occurs in the mammali

116 by-stage analysis of EPI and extra-embryonic primitive endoderm (PrE) formation during preimplantatio

117 emergence of pluripotent epiblast (EPI) and primitive endoderm (PrE) lineages within the inner cell

118 are critical to specify the epiblast versus primitive endoderm (PrE) lineages.

119 Since VE is derived from the primitive endoderm (PrE) of the blastocyst, and PrE-deri

120 ) is the key signal driving specification of primitive endoderm (PrE) versus pluripotent epiblast (EP

121 entiate into the pluripotent epiblast or the primitive endoderm (PrE), marked by the transcription fa

122 EPI), which forms the embryo proper, and the primitive endoderm (PrE), which forms extra-embryonic yo

123 the inner cell mass and the formation of the primitive endoderm (PrE).

124 comprising two lineages: epiblast (Epi) and primitive endoderm (PrE).

125 wo extra-embryonic lineages: trophoblast and primitive endoderm (PrE).

126 lineages: the pluripotent epiblast (EPI) and primitive endoderm (PrE).

127 (ICM) can be specified in epiblast (Epi) or primitive endoderm (PrE).

128 he extraembryonic trophectoderm (TE) and the primitive endoderm (PrE).

129 contain precursors of the epiblast (Epi) and primitive endoderm (PrEn) lineages.

130 embryoid bodies with elevated levels of the primitive endoderm progenitor marker Gata4 and a strongl

131 is established by interaction with anterior primitive endoderm rather than primitive streak derivati

132 We now show that Indian hedgehog (Ihh) is a primitive endoderm-secreted signal that alone is suffici

133 Therefore, primitive endoderm signaling is a critical early determi

134 Surprisingly, primitive endoderm signals can respecify anterior (prosp

135 lethality due to the disorganization of the primitive endoderm, the first epithelium in early embryo

136 of Cdkn1a (p21) and Cdkn1c (p57), and in the primitive endoderm, they prevent differentiation by main

137 genetically, whereas their trophectoderm and primitive endoderm tissues were derived from the tetrapl

138 t are derived from the trophectoderm and the primitive endoderm upon reintroduction to the blastocyst

139 F9 teratocarcinoma stem cells to progress to primitive endoderm via activation of protein kinase C an

140 ve transcription as well as the formation of primitive endoderm was accompanied by the stabilization

141 Expression of Cxcr4 in primitive endoderm was confirmed in visceral endoderm of

142 onic teratocarcinoma stem (F9 stem) cells to primitive endoderm was explored using probes of the mito