ライフサイエンスコーパス: primordial

1 rmally derived based on its correlation with primordial (3)He and dissolved Mn (dFe:(3)He of 0.9-2.7

2 ely indicates that HAT-P-26b's atmosphere is primordial and obtained its gaseous envelope late in its

3 Our findings reveal that the phenomenon is primordial and predates the evolution of the coelom.

4 obtain live births by transplanting isolated primordial and primary follicles, while also reducing th

5 Primordial and primary ovarian follicles from young fema

6 dings highlight the importance of consistent primordial and primary prevention efforts throughout mid

7 or establishing metabolic connections in the primordial Archaeplastida lineage.

8 rinsic immunity and provide insight into the primordial architecture and functional landscape of this

9 This was not the case, however, in the primordial atmosphere, when abiotic reactions likely pla

10 n heavy xenon isotopes and matches that of a primordial atmospheric component.

11 arliest surface chemistry and the low oxygen primordial biosphere.

12 rly Earth, severely limiting the size of the primordial biosphere.

13 traits in proteins involved in essential and primordial capsid/packaging functions is evidence that t

14 ating concepts that include the emergence of primordial catalysts at temperatures that were considera

15 d constituent tissues derived from different primordial cell lineages.

16 anding question in biology is how a group of primordial cells can give rise to complex organs.

17 Primordial cells presumably combined RNAs, which functio

18 ) catalyze replication of the RNA genomes of primordial cells.

19 e-impossible chemical transformations within primordial cells.

20 ire of RNAs in mammalian embryonic cells and primordial cells.

21 would have been required for early events in primordial chemistry before the advent of enzymes.

22 raging to derive the intact structure of the primordial Chlamydia trachomatis T3SS in the presence an

23 ed crustal evolution model; we find that the primordial clay is locally disrupted by impacts and buri

24 Furthermore, we explore the fate of a primordial clay-rich layer with the help of a parameteri

25 imization is most likely a by-product of the primordial code expansion driven by the diversification

26 at collagen IV and its variant, spongin, are primordial components of the extracellular microenvironm

27 both lineages exist already in teleosts, the primordial contributions of FHF and SHF to heart structu

28 Our work reveals the presence of a primordial CTD code within eukarya and indicates that pr

29 the evolutionary history and gene content of primordial cyanobacteria [7, 8].

30 ceans, may no longer represent the original (primordial) D/H ratio, owing to changes caused by water

31 chondritic meteorites and, by inference, the primordial disk from which they formed.

32 in LIG4 are a common cause of microcephalic primordial dwarfism (MPD), a phenotype characterized by

33 ing the molecular basis of two patients with primordial dwarfism (PD) in a single family through util

34 er syndrome or microcephalic osteodysplastic primordial dwarfism 1, and a hereditary intestinal polyp

35 te TUBGCP6 in individuals with microcephalic primordial dwarfism and additional congenital anomalies,

36 the number of biological pathways underlying primordial dwarfism and adds to a growing list of human

37 n multiplex family affected by microcephalic primordial dwarfism and biallelic mutation of RTTN was i

38 mily who is affected by severe microcephalic primordial dwarfism and tested negative on clinical exom

39 es, which provides a potential mechanism for primordial dwarfism associated with this lesion, since r

40 se Seckel syndrome (ATR-SS), a microcephalic primordial dwarfism disorder.

41 s presented with an apparently novel form of primordial dwarfism in which severe growth deficiency is

42 Primordial dwarfism is a state of extreme prenatal and p

43 yndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biall

44 Majewski osteodysplastic primordial dwarfism type II (MOPDII) is caused by mutati

45 order Majewski/microcephalic osteodysplastic primordial dwarfism type II, making a detailed understan

46 to polymicrogyria, to include microcephalic primordial dwarfism with a complex brain phenotype invol

47 generalized growth deficiency (microcephalic primordial dwarfism), but the genetic heterogeneity is p

48 inherited recessive disease that results in primordial dwarfism, cognitive deficiencies, and increas

49 Here, we characterized 2 patients with primordial dwarfism, extreme insulin resistance, and gon

50 Although the microcephaly- and primordial dwarfism-linked centrosomal protein CEP215 ha

51 uitin ligase, in patients with microcephalic primordial dwarfism.

52 te could have assumed these central roles on primordial Earth, given its poor geochemical accessibili

53 st accepted hypotheses for the conditions on primordial Earth.

54 FN fibrils are the primary component in primordial ECM and, as such, FN assembly is a critical c

55 s engine is driven by unknown proportions of primordial energy and heat produced in radioactive decay

56 We postulate that sex-specific primordial energy optimisation strategies exist, which d

57 and set limits on the residual proportion of primordial energy.

58 lts suggest a mechanism for the emergence of primordial enzymes and highlight the potential of ancest

59 They are considered to be primordial enzymes of ATP synthesis in the early evoluti

60 nary biologists question whether inteins are primordial enzymes or simply selfish elements, whereas b

61 Wnt5a-Fz5 signaling being a primordial event during cell differentiation, we examine

62 systems retain latent abilities to revert to primordial Fe2+-based states when exposed to pre-GOE con

63 sent-day organisms retain some record of the primordial fluid in which the first cells formed.

64 We consider a theory where a primordial flux noise field left over in unchanged form

65 Primordial follicle (PF) pool determines the availabilit

66 n with the unique characteristic of blocking primordial follicle activation that could be exploited t

67 has been proposed as a negative regulator of primordial follicle activation.

68 erm cell cyst (GCC) breakdown; (iv) advanced primordial follicle assembly and primary follicle transi

69 vironmental factors can specifically perturb primordial follicle assembly.

70 OR inhibition preserves the ovarian reserve, primordial follicle counts, serum anti-Mullerian hormone

71 otreatment, concomitant with preservation of primordial follicle counts.

72 varian insufficiency is chemotherapy-induced primordial follicle depletion, which has been proposed t

73 ole in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin j

74 significantly suppressed cyst breakdown and primordial follicle formation in cultured mouse ovaries.

75 rane-impermeable BSA-conjugated P4 inhibited primordial follicle formation similar to that by P4.

76 Progesterone (P4) inhibits primordial follicle formation under physiological condit

77 inhibition of oocyte meiotic prophase I and primordial follicle formation.

78 g is crucial for germline cyst breakdown and primordial follicle formation.

79 several somatic cells, which we refer to as primordial follicle granulosa cells (pfGCs).

80 Physiologically, the size of the primordial follicle pool determines the reproductive lif

81 In the mouse ovary, the primordial follicle pool is established through a divers

82 equired for the initial establishment of the primordial follicle reserve at birth.

83 cell cyst breakdown and establishment of the primordial follicle reserve during a critical window of

84 the somatic pfGCs initiate the activation of primordial follicles and govern the quiescence or awaken

85 ryonic exposure to ATZ reduces the number of primordial follicles and increases the incidence of mult

86 bout how the pfGCs control the activation of primordial follicles and the developmental fates of dorm

87 relatively complete picture of how mammalian primordial follicles are activated.

88 ary are dormant oocytes that are enclosed in primordial follicles by several somatic cells, which we

89 The microenvironment surrounding primordial follicles can activate mTORC1-KITL signaling

90 gnaling and KIT ligand in granulosa cells of primordial follicles for follicle activation and for rep

91 Global activation of primordial follicles in artificial ovaries can result in

92 We found significantly more primordial follicles in MIS-treated animals than in cont

93 an reserve represents the stock of quiescent primordial follicles in the ovary which is gradually dep

94 The formation of primordial follicles involves the interaction between th

95 H) induced a greater proportion of quiescent primordial follicles than control ExECs, indicating supp

96 cysts into individual oocytes housed within primordial follicles.

97 alian females, germ cells remain arrested as primordial follicles.

98 mature activation of all dormant oocytes and primordial follicles.

99 spermatogonial stem cells and the origin of primordial follicles.

100 erage that eventually give rise to about six primordial follicles.

101 BMP2-BMPR system leading to the formation of primordial follicles.

102 The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth.

103 uppression of oocyte meiotic progression and primordial folliculogenesis by decreasing intra-oocyte c

104 Well-timed progression of primordial folliculogenesis is essential for mammalian f

105 lular survival of ER stress and represents a primordial form of innate immunity.

106 and stramenopiles, seems preserved in a near-primordial form.

107 hat lack endocrine signaling, suggesting the primordial function may have been environmental sensing.

108 These data were used to reconstruct primordial functions in cyanobacteria that included nine

109 ary 'waterfalls' describing the emergence of primordial functions.

110 red EBL fluctuations have been attributed to primordial galaxies and black holes at the epoch of reio

111 uced by conditional deletion of Sox17 in the primordial gallbladder epithelia but not in fetal liver

112 Gravitational collapse of a massive primordial gas cloud is a promising initial process, but

113 Its origin was ascribed to primordial gaseous O2 incorporated into the nucleus duri

114 ce by two successive duplication events of a primordial gene pair in the last common vertebrate ances

115 n 'accessory' during an early expansion of a primordial genetic code, allowing for multiplexed protei

116 for proteins, but the vestigial remnant of a primordial genome that may have encoded a self-organizin

117 ncb mutant mice were infertile and exhibited primordial germ cell (PGC) defects during embryogenesis.

118 P granules, do not appear to be required for primordial germ cell (PGC) determination [3], but their

119 hat sox7 plays a novel and important role in primordial germ cell (PGC) development and that ephrinB1

120 The 'last cell standing' model describes primordial germ cell (PGC) development in axolotls, in w

121 Primordial germ cell (PGC) development is characterized

122 ell-Less (GCL) protein is a key regulator of primordial germ cell (PGC) formation in Drosophila embry

123 mitochondria at the posterior at the site of primordial germ cell (PGC) formation through an actin-de

124 f embryonic stem cell (ESC) pluripotency and primordial germ cell (PGC) formation.

125 nding of the molecular programs that control primordial germ cell (PGC) specification and differentia

126 te model organisms on the molecular basis of primordial germ cell (PGC) specification have revealed t

127 Primordial germ cell (PGC) specification occurs either b

128 hich they are competent for both somatic and primordial germ cell (PGC) specification.

129 aster germline determinant BLIMP1 to promote primordial germ cell (PGC) specification.

130 erm plasm inheritance correlates with higher primordial germ cell (PGC) survival probability.

131 edness to pluripotent stem cell (ESC, iPSC), primordial germ cell (PGC), and differentiated somatic r

132 lomes from mouse gametes, early embryos, and primordial germ cell (PGC), as well as single-base-resol

133 onserved regulators that are enriched at the primordial germ cell cytoplasmic bridge to ensure its st

134 og revealed that it is essential for Gryllus primordial germ cell development, and is regulated by up

135 e essential for silencing transposons during primordial germ cell development, and MIWI-bound piRNAs

136 found TE-specific endosiRNAs present during primordial germ cell development.

137 eprogramming occurs: early mouse embryos and primordial germ cell development.

138 TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating st

139 s of epiblast development for competency for primordial germ cell fate.

140 aneously initiate expression of mesoderm and primordial germ cell markers asymmetrically on the embry

141 ish deadend (dnd-MO-Vivo) effectively caused primordial germ cell mis-migration and differentiation i

142 We concluded that Rev7 is required for primordial germ cell proliferation and embryonic viabili

143 esis that this molecular mechanism regulated primordial germ cell specification in a last common bila

144 Pluripotent stem cell-derived human primordial germ cell-like cells (hPGCLCs) provide import

145 th previously reported ChIP-seq datasets for primordial germ cell-like cells and E18.5 small intestin

146 Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for developmen

147 Human primordial germ cells (hPGCs), the precursors of sperm a

148 DNA methylation patterns need to be reset in primordial germ cells (PGCs) and preimplantation embryos

149 Primordial germ cells (PGCs) and preimplantation embryos

150 or example, in Xenopus and zebrafish embryos primordial germ cells (PGCs) are specified by germ plasm

151 Primordial germ cells (PGCs) are the precursors of sperm

152 The migration of primordial germ cells (PGCs) from their place of origin

153 Primordial germ cells (PGCs) give rise to the germ line

154 In animals, primordial germ cells (PGCs) give rise to the germ lines

155 blastocysts, is also expressed in unipotent primordial germ cells (PGCs) in mice, where its precise

156 epends on the expansion of a small number of primordial germ cells (PGCs) in the early embryo.

157 patterns of Pt-vasa and Pt-piwi to show that primordial germ cells (PGCs) in the spider arise during

158 nt/beta-catenin signaling pathway in chicken primordial germ cells (PGCs) in vitro.

159 egulation of migration initiation is that of primordial germ cells (PGCs) in zebrafish embryos.

160 ome activation (ZGA) and RNA localization in primordial germ cells (PGCs) in zebrafish.

161 The migration of primordial germ cells (PGCs) is a useful model for study

162 The sex of primordial germ cells (PGCs) is determined in developing

163 We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs

164 Specification of primordial germ cells (PGCs) marks the beginning of the

165 During development, primordial germ cells (PGCs) navigate a complex journey

166 ritical chromatin modifications occur in the primordial germ cells (PGCs) of emergent starved L1 larv

167 eport that the translational activity in the primordial germ cells (PGCs) of the sea urchin embryo (S

168 In the developing embryo, primordial germ cells (PGCs) represent the exclusive pro

169 melanogaster requires directed migration of primordial germ cells (PGCs) towards somatic gonadal pre

170 protein DND1 is required for the survival of primordial germ cells (PGCs), as well as the suppression

171 obal, as seen in preimplantation embryos and primordial germ cells (PGCs), or locus specific, which c

172 m somatic lineages is the differentiation of primordial germ cells (PGCs), precursors of sex-specific

173 Primordial germ cells (PGCs), the precursors of sperm an

174 In animals, specification of the primordial germ cells (PGCs), the stem cells of the germ

175 n animal development is the specification of primordial germ cells (PGCs), which become the stem cell

176 ly embryos, embryonic stem cells (ESCs), and primordial germ cells (PGCs).

177 nt embryonic cells and, strikingly, to early primordial germ cells (PGCs).

178 onstruct to the DDX4 (vasa) locus in chicken primordial germ cells (PGCs).

179 ficially reconstructed by transplantation of primordial germ cells (PGCs).

180 Cs) provide important opportunities to study primordial germ cells (PGCs).

181 own to regulate the directional migration of primordial germ cells (PGCs).

182 with unmethylated cytosines is a hallmark of primordial germ cells (PGCs).

183 ch has key parallels with those operating in primordial germ cells and early embryos.

184 em cells and induced pluripotent stem cells, primordial germ cells and oocytes.

185 Hypomethylated primordial germ cells appear to limit this risk by expre

186 vasa and nanos orthologues, we find that the primordial germ cells are specified from at least the bl

187 h early embryogenesis and differentiation of primordial germ cells but is reduced substantially durin

188 endodermal cells interact with and regulate primordial germ cells by actively excising and digesting

189 This is the first evidence for primordial germ cells displaying these behaviours in any

190 Using the in vivo model of zebrafish primordial germ cells for studying chemokine-directed si

191 Mouse primordial germ cells form germline cysts, but the role

192 itates the trans-epithelial migration of the primordial germ cells in early embryos.

193 mutagenesis with transplantation of mutated primordial germ cells into a wild-type host.

194 We show that primordial germ cells of the cricket Gryllus bimaculatus

195 triggers widespread chromosome damage in the primordial germ cells of the nematode C. elegans.

196 guishable cells of totipotent human embryos, primordial germ cells, and stable cell lines.

197 pletion caused by defective proliferation of primordial germ cells, decreased body weight, and partia

198 interrogate the epigenetic reprogramming of primordial germ cells, defining the timings of methylati

199 Such global reprogramming occurs in primordial germ cells, early embryos, and embryonic stem

200 ripotent stem cell differentiation into late primordial germ cells, meiotic germ cells and ovarian fo

201 criptional and epigenetic landscape of human primordial germ cells, revealing a unique transcriptiona

202 , axis determination, and development of the primordial germ cells.

203 ubule-dependent process; mRNAs necessary for primordial germ-cell formation are enriched in the germ

204 n Drosophila melanogaster and other animals, primordial germ-cell specification in the developing emb

205 A new study reveals that the primordial germline is a hideout for retrotransposon tra

206 ve served as the original mammalian hosts of primordial hantaviruses.

207 dent mammals may have served as the hosts of primordial hantaviruses.

208 even time points spanning embryonic day 9.5 (primordial heart tube) to postnatal day 21 (mature heart

209 s of early lung development are expressed in primordial human lung progenitors and revealed a CD47hiC

210 nce of protometabolism and microbial life in primordial hydrothermal settings.

211 together, the present findings provide novel primordial information about actin isoforms, their funct

212 d subsequently in the emergence of potential primordial informational oligomers that would have playe

213 s leading to the chemical building blocks of primordial informational polymers.

214 interferon-inducible immunity and comprises primordial innate defense.

215 inks, peroxidasin, and hypohalous acids-is a primordial innovation of the ECM essential for organogen

216 Optical spectroscopy of a primordial isotope has traditionally formed the basis fo

217 est an unusual evolutionary trajectory for a primordial kinase that could have favored efficient bifu

218 governs mammalian heart development, from a primordial linear tube to a four-chamber organ.

219 After sorting to purity, these primordial lung progenitors exhibited lung epithelial ma

220 PSCs) in vitro to generate and isolate human primordial lung progenitors that express NKX2-1 but are

221 geophysical models and direct evidence for a primordial magnetic field in the rock record.

222 isional models based on the depletion of the primordial main belt of asteroids predict 10-15 craters

223 bably related to subducted oceanic plates or primordial material associated with Earth's formation.

224 oduced by deep isolated mantle reservoirs of primordial material that are viscously entrained by ther

225 pluripotent stem cells, the appropriation of primordial mechanisms of cell motility and invasion, and

226 ancestor of all eukaryotes and suggests that primordial meiosis may have had many characteristics in

227 Neuronal calcium sensor-1 (NCS-1) is the primordial member of a family of proteins responsible pr

228 Neuronal calcium sensor-1 (NCS-1) is the primordial member of the neuronal calcium sensor family

229 ht to be assimilated by the urogenital sinus primordial mesenchyme in males during fetal development.

230 red from various standpoints as an idealized primordial metabolic cycle.

231 How primordial metabolic networks such as the reverse tricar

232 Iron is a unique, primordial metal fundamental for earliest life forms, on

233 ligand, and antigen-processing genes in the primordial MHC.

234 Therefore, primordial Miller-Urey soup was perfectly suitable as a

235 Given that such high fractions of primordial molecular cloud material are expected to surv

236 with that expected for thermally unprocessed primordial molecular cloud material before its pollution

237 ites require significant amounts (25-50%) of primordial molecular cloud matter in their precursor mat

238 Specifically, it is not clear how the primordial mutational processes of base substitutions, i

239 ly complex and constrained by the relatively primordial nature of insect cell protein glycosylation p

240 We consider the hypothesis of the primordial nature of the non-enzymatic reverse tricarbox

241 ble that differential disruption of a common primordial neuropathological substrate causes these diff

242 Here we discuss these primordial neutrophil functions, which also play key rol

243 nked to known cardiac pathology ranging from primordial Nkx2.5 to mature cardiac Tnnt2 as the initial

244 at the time was completely submerged under a primordial northern plains ocean [corrected].

245 ibonucleotides may have played a key role in primordial nucleic acids prior to the emergence of the c

246 This suggests that primordial O2 was incorporated into the nucleus during t

247 distal growth and patterning of the skeletal primordial of the limbs.

248 tial rounds of intragenic duplication from a primordial one-domain precursor.

249 suggest that SYCP2L promotes the survival of primordial oocytes and thus provide functional evidence

250 Specifically, the pool of primordial oocytes becomes more rapidly depleted in SYCP

251 titutively active mutant PI3K was induced in primordial oocytes by Gdf9-iCre.

252 oocytes, which represent the limited pool of primordial oocytes that are formed perinatally and remai

253 r future studies and propose a model for the primordial or proto MHC.

254 Drosophila wing imaginal disc, an epithelial primordial organ that later forms the adult wing, has pr

255 The primordial origin of (3)He in OIBs has motivated hypothe

256 Given that the primordial ovarian follicular pool is established in ute

257 mulations that include a realistic model for primordial oxygen isotopic reservoirs, our results favor

258 e-temperature states during the formation of primordial planetary bodies.

259 Polyamines are primordial polycations found in most cells and perform d

260 if one takes as a source of fluctuations the primordial power spectrum of curvature fluctuations as m

261 ly emotional development may be a target for primordial prevention and for promoting lifelong cardiov

262 Primordial prevention beginning in childhood and into ea

263 ity that public health initiatives targeting primordial prevention of obesity may reduce the incidenc

264 tment of common CVD risk factors rather than primordial prevention of risk factors through health beh

265 Primordial prevention through maintenance of a healthy l

266 gs support more effective LDL-C lowering for primordial prevention, even in individuals conventionall

267 as the first step for CVD risk assessment in primordial prevention.

268 asured by CAC underscoring the importance of primordial prevention.

269 energy utilization and our understanding of primordial processes on earth.

270 lt of concurrent effects of evolutionary and primordial processes.

271 g blocks of planets, that retain a record of primordial processes.

272 usibly exist or at least have existed at the primordial protein stage.

273 tion that these endosymbiotic descendants of primordial protobacteria seem to be pursuing their own b

274 e an important tool for tracing early-Earth, primordial reservoirs that have survived in the planet's

275 ation backward in time to generate models of primordial ribosomes.

276 they represent the observable remnants of a primordial RNA-peptide world.

277 the first senses to deal with the capricious primordial sea.

278 t some classes of viruses might descend from primordial selfish genetic elements, bona fide viruses e

279 Histamine is a primordial signalling molecule, capable of activating ce

280 Histamine is a primordial signalling molecule, capable of activating ce

281 Our study suggests that primordial SKI-1/S1P likely contained a simpler prodomai

282 The spleen is the primordial SLO, and evolved concurrently with Ig/TCR:pMH

283 Prior to becoming chondritic meteorites, primordial solids were a poorly consolidated mix of mm-s

284 acids, we provide a definite proof that this primordial soup, when properly cooked, was edible for pr

285 We designed and conducted a series of primordial-soup Miller-Urey style experiments with deute

286 Thus, circulatory S1P confinement could be a primordial strategy of vertebrates in the development of

287 rly-forming cometesimals experienced similar primordial stratified accretion, even though they formed

288 osphate transporter UhpC might have been the primordial sugar transporter in the Archaeplastida ances

289 Wnt proteins operate as primordial symmetry-breaking signals.

290 talized hypertrophic cartilage, which is the primordial template for the development of most bones.

291 nderstanding of social signals is based on a primordial tendency to simulate observed actions by acti

292 Reports, Swann et al. (2014) reconstruct the primordial thymus and suggest that it was a site of comb

293 red development of their imaginal discs, the primordial tissues that form the adult epidermis.

294 Follicle development from primordial to preovulatory stage was characterized by 3

295 expansions, thus exposing the profile of the primordial tumor.

296 qual amounts of matter and antimatter in the primordial Universe after the Big Bang, but today's Univ

297 Although primordial UV addiction, mediated by the hedonic action

298 the cellular regression, escaped genes, and primordial virus world hypotheses.

299 This result strongly suggests that primordial water depletion during formation is unlikely

300 The primordial Xe component delivered to the Earth's atmosph