ライフサイエンスコーパス: primordial follicle

1 ngle layer of somatic (granulosa) cells in a primordial follicle.

2 oximately 33% of the oocytes survive to form primordial follicles.

3 BMP2-BMPR system leading to the formation of primordial follicles.

4 cysts into individual oocytes housed within primordial follicles.

5 mature activation of all dormant oocytes and primordial follicles.

6 spermatogonial stem cells and the origin of primordial follicles.

7 erage that eventually give rise to about six primordial follicles.

8 alian females, germ cells remain arrested as primordial follicles.

9 serum estradiol levels and the formation of primordial follicles.

10 nation of oocyte numbers and the assembly of primordial follicles.

11 m cells; (c) pre-granulosa cells surrounding primordial follicles.

12 , but was low in oocytes within newly formed primordial follicles.

13 the survival of germ cells in newly formed (primordial) follicles.

14 sts may ensure that oocytes destined to form primordial follicles acquire populations of functional m

15 y, homozygous Kit(Y719F) female mice undergo primordial follicle activation and are fertile, demonstr

16 sis of the contribution of Kit in regulating primordial follicle activation and early follicle growth

17 n with the unique characteristic of blocking primordial follicle activation that could be exploited t

18 3-kinase (PI3K) signalling pathway controls primordial follicle activation through the forkhead tran

19 logic role of the PI3K pathway is to control primordial follicle activation via Foxo3.

20 tudies as the critical upstream regulator of primordial follicle activation via PI3K/Akt.

21 and Foxo3 nuclear export, thereby triggering primordial follicle activation, defining the steps by wh

22 has been proposed as a negative regulator of primordial follicle activation.

23 Their growth resumes via a process known as primordial follicle activation.

24 sition, but argue that Kit is dispensable in primordial follicle activation.

25 llicles resume growth via a process known as primordial follicle activation.

26 the somatic pfGCs initiate the activation of primordial follicles and govern the quiescence or awaken

27 ryonic exposure to ATZ reduces the number of primordial follicles and increases the incidence of mult

28 bout how the pfGCs control the activation of primordial follicles and the developmental fates of dorm

29 ncreased offspring, accelerated depletion of primordial follicles, and ultimately premature infertili

30 relatively complete picture of how mammalian primordial follicles are activated.

31 Primordial follicles are formed perinatally in mammalian

32 In mammals, primordial follicles are generated early in life and rem

33 resenting two mechanisms: an initial pool of primordial follicles as the only follicle source (fixed

34 erm cell cyst (GCC) breakdown; (iv) advanced primordial follicle assembly and primary follicle transi

35 Foxo3 is imported into the nucleus during primordial follicle assembly, and is exported upon activ

36 vironmental factors can specifically perturb primordial follicle assembly.

37 mouse neonatal germline cysts and oocytes of primordial follicles but disperses as follicles begin to

38 specifically causes apoptotic cell death of primordial follicles but does not affect other periphera

39 tro, increased the number of postnatal mouse primordial follicles by 30% when administered to neonata

40 ary are dormant oocytes that are enclosed in primordial follicles by several somatic cells, which we

41 The microenvironment surrounding primordial follicles can activate mTORC1-KITL signaling

42 d a reciprocal decrease in the proportion of primordial follicles compared with normal ovaries.

43 At birth, the ovary contains primordial follicles consisting of meiotically arrested

44 OR inhibition preserves the ovarian reserve, primordial follicle counts, serum anti-Mullerian hormone

45 otreatment, concomitant with preservation of primordial follicle counts.

46 phamide injection and serially sectioned for primordial follicle counts.

47 Although there was 12% reduction in primordial follicle density by 12 h following treatment

48 in Kit(Y719F) ovaries, including accelerated primordial follicle depletion and accumulation of morpho

49 varian insufficiency is chemotherapy-induced primordial follicle depletion, which has been proposed t

50 The pool of primordial follicles determines the reproductive lifespa

51 to granulosa cells after the newly assembled primordial follicles develop into growing primary follic

52 ation to immune-deficient mice for 6 months, primordial follicles developed to the preovulatory stage

53 gnaling and KIT ligand in granulosa cells of primordial follicles for follicle activation and for rep

54 on and interaction with somatic cells before primordial follicle formation are largely unknown.

55 ole in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin j

56 significantly suppressed cyst breakdown and primordial follicle formation in cultured mouse ovaries.

57 Estradiol-17ss (E) promotes primordial follicle formation in vivo and in vitro; howe

58 rane-impermeable BSA-conjugated P4 inhibited primordial follicle formation similar to that by P4.

59 Progesterone (P4) inhibits primordial follicle formation under physiological condit

60 nerate a list of candidate genes involved in primordial follicle formation, including podocalyxin (Po

61 ment with an FSH-antiserum, which suppressed primordial follicle formation, prevented the decline in

62 signaling plays a role in cyst breakdown and primordial follicle formation, we used ovary organ cultu

63 g is crucial for germline cyst breakdown and primordial follicle formation.

64 inhibition of oocyte meiotic prophase I and primordial follicle formation.

65 during perinatal development with respect to primordial follicle formation.

66 of somatic cells into granulosa cells during primordial follicle formation.

67 0 weeks gestation, i.e. preceding and during primordial follicle formation.

68 elop around growing oocytes from the time of primordial follicle formation.

69 crucial period of development leading up to primordial follicle formation.

70 present in both oocytes and somatic cells as primordial follicles formed.

71 model illustrates the decline in the pool of primordial follicles from age 20 to menopause as reporte

72 Primordial follicles generated during fetal life are hig

73 several somatic cells, which we refer to as primordial follicle granulosa cells (pfGCs).

74 Global activation of primordial follicles in artificial ovaries can result in

75 We found significantly more primordial follicles in MIS-treated animals than in cont

76 ovary results in the formation of many fewer primordial follicles in the juvenile ovary, although the

77 and theca cell recruitment as well as fewer primordial follicles in the ovarian cortex, causing a fa

78 an reserve represents the stock of quiescent primordial follicles in the ovary which is gradually dep

79 lt female Bax-/- mice possess threefold more primordial follicles in their ovarian reserve than their

80 The formation of primordial follicles involves the interaction between th

81 e diepoxide (VCD), selective for primary and primordial follicles, is injected intraperitonelly in an

82 Prostate disease, ovarian primordial follicle loss and polycystic ovary disease we

83 , pubertal abnormalities in females, ovarian primordial follicle loss and polycystic ovary disease we

84 essential functional unit of the ovary, the primordial follicle, occurs during fetal life in humans.

85 Primordial follicle (PF) pool determines the availabilit

86 Physiologically, the size of the primordial follicle pool determines the reproductive lif

87 In the mouse ovary, the primordial follicle pool is established through a divers

88 disease (PCO) and a decrease in the ovarian primordial follicle pool size resembling primary ovarian

89 cle source (fixed pool model), or an initial primordial follicle pool supplemented by germline stem c

90 ll model was tested using a range of de novo primordial follicle production rates.

91 ng hormone on follicle growth and inhibiting primordial follicle recruitment.

92 et of menopause as measured by the number of primordial follicles remaining in the ovaries.

93 cific roles of Kit in the maintenance of the primordial follicle reserve and in the primary to second

94 equired for the initial establishment of the primordial follicle reserve at birth.

95 germ-cell toxicant busulphan eliminates the primordial follicle reserve by early adulthood without i

96 cell cyst breakdown and establishment of the primordial follicle reserve during a critical window of

97 The impact of cyclophosphamide on primordial follicle reserve in our human ovarian xenogra

98 and primordial follicles were positive, with primordial follicles showing only weak focal positivity.

99 y inactivated the mouse Smc1beta gene at the primordial follicle stage shortly after birth, when oocy

100 be expressed during prophase I prior to the primordial follicle stage to ensure SCC up to advanced a

101 H) induced a greater proportion of quiescent primordial follicles than control ExECs, indicating supp

102 The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth.

103 secondary follicles were transferred back to primordial follicles, the earliest stage of follicular d

104 us AMH show that the transfer of non-growing primordial follicles to the active state can be slowed e

105 Periodically, subsets of primordial follicles undergo further development during

106 ugh embryonic gonadogenesis appeared normal, primordial follicles were not formed at birth, and massi

107 Granulosa cells in both primary and primordial follicles were positive, with primordial foll

108 survival is dependent upon the formation of primordial follicles, which occurs during fetal life in

109 oocytes are packaged into compact structures-primordial follicles-which remain inert for prolonged in